Daniel Starr

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Kinesin-1 and dynein at the nuclear envelope mediate the bidirectional migrations of nuclei
    Heidi N Fridolfsson
    Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USA
    J Cell Biol 191:115-28. 2010
  2. pmc Laminopathies: too much SUN is a bad thing
    Daniel A Starr
    Department of Molecular and Cellular Biology, University of California at Davis, CA 95616, USA
    Curr Biol 22:R678-80. 2012
  3. pmc Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges
    Daniel A Starr
    Department of Molecular and Cellular Biology, University of California, Davis, California 95616, USA
    Annu Rev Cell Dev Biol 26:421-44. 2010
  4. pmc A nuclear-envelope bridge positions nuclei and moves chromosomes
    Daniel A Starr
    Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
    J Cell Sci 122:577-86. 2009
  5. pmc Communication between the cytoskeleton and the nuclear envelope to position the nucleus
    Daniel A Starr
    Section of Molecular and Cellular Biology, University of California Davis, Davis, CA 95616, USA
    Mol Biosyst 3:583-9. 2007
  6. pmc UNC-83 IS a KASH protein required for nuclear migration and is recruited to the outer nuclear membrane by a physical interaction with the SUN protein UNC-84
    Matthew D McGee
    The Center for Genetics and Development and the Section of Molecular and Cellular Biology, University of California Davis, Davis, CA 95616, USA
    Mol Biol Cell 17:1790-801. 2006
  7. pmc UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration
    Heidi N Fridolfsson
    Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
    Dev Biol 338:237-50. 2010
  8. pmc UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration
    Marina Meyerzon
    Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
    Development 136:2725-33. 2009
  9. ncbi request reprint KASH 'n Karry: the KASH domain family of cargo-specific cytoskeletal adaptor proteins
    Daniel A Starr
    Section of Molecular and Cellular Biology, Center for Genetics and Development, University of California, Davis, CA, USA
    Bioessays 27:1136-46. 2005
  10. pmc KDP-1 is a nuclear envelope KASH protein required for cell-cycle progression
    Matthew D McGee
    Department of Molecular and Cellular Biology, University of California, Davis, CA, USA
    J Cell Sci 122:2895-905. 2009

Research Grants

  1. Mechanisms of Nuclear Migration and Anchorage
    Daniel Starr; Fiscal Year: 2006
  2. Mechanisms of Nuclear Migration and Anchorage
    Daniel Starr; Fiscal Year: 2007
  3. Mechanisms of Nuclear Migration and Anchorage
    Daniel Starr; Fiscal Year: 2009
  4. Mechanisms of Nuclear Migration and Anchorage
    Daniel A Starr; Fiscal Year: 2010

Collaborators

  • Janice Fischer
  • Christian J Malone
  • Heidi N Fridolfsson
  • Marina Meyerzon
  • Matthew D McGee
  • Nina Ly
  • Juehua Yu
  • Min Han
  • R Mark Grady
  • Francis J McNally
  • Igor Stagljar
  • Jui Ching Wu
  • Zhizhen Gao
  • Jin Liu
  • Regina Rillo
  • Rener Xu
  • Susan M Parkhurst
  • Xiaohui Wu
  • Yuan Zhuang
  • Tian Xu
  • Amy S Anderson
  • Gail L Ackerman
  • Joshua R Sanes

Detail Information

Publications16

  1. pmc Kinesin-1 and dynein at the nuclear envelope mediate the bidirectional migrations of nuclei
    Heidi N Fridolfsson
    Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USA
    J Cell Biol 191:115-28. 2010
    ..This organization of microtubules fits with our model that kinesin-1 moves nuclei forward and dynein functions to move nuclei backward for short stretches to bypass cellular roadblocks...
  2. pmc Laminopathies: too much SUN is a bad thing
    Daniel A Starr
    Department of Molecular and Cellular Biology, University of California at Davis, CA 95616, USA
    Curr Biol 22:R678-80. 2012
    ..SUN proteins accelerate the pathological progression of laminopathies. Although the mechanisms remain to be elucidated, an intriguing possibility is that high levels of SUN proteins lead to a hyperactive DNA damage response...
  3. pmc Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges
    Daniel A Starr
    Department of Molecular and Cellular Biology, University of California, Davis, California 95616, USA
    Annu Rev Cell Dev Biol 26:421-44. 2010
    ..Knockouts of SUN or KASH proteins disrupt neurological and muscular development in mice. Defects in SUN and KASH proteins have been linked to human diseases including muscular dystrophy, ataxia, progeria, lissencephaly, and cancer...
  4. pmc A nuclear-envelope bridge positions nuclei and moves chromosomes
    Daniel A Starr
    Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
    J Cell Sci 122:577-86. 2009
    ....
  5. pmc Communication between the cytoskeleton and the nuclear envelope to position the nucleus
    Daniel A Starr
    Section of Molecular and Cellular Biology, University of California Davis, Davis, CA 95616, USA
    Mol Biosyst 3:583-9. 2007
    ..Nuclear migrations are a component of many cellular migration events and defects in nuclear positioning lead to human diseases, most notably lissencephaly...
  6. pmc UNC-83 IS a KASH protein required for nuclear migration and is recruited to the outer nuclear membrane by a physical interaction with the SUN protein UNC-84
    Matthew D McGee
    The Center for Genetics and Development and the Section of Molecular and Cellular Biology, University of California Davis, Davis, CA 95616, USA
    Mol Biol Cell 17:1790-801. 2006
    ..This mechanism seems conserved across eukaryotes and is the first proposed mechanism to target proteins specifically to the outer nuclear membrane...
  7. pmc UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration
    Heidi N Fridolfsson
    Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
    Dev Biol 338:237-50. 2010
    ..Kinesin-1 functions as the major force generator during nuclear migration, while dynein is involved in regulation of bidirectional transport of the nucleus...
  8. pmc UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration
    Marina Meyerzon
    Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
    Development 136:2725-33. 2009
    ....
  9. ncbi request reprint KASH 'n Karry: the KASH domain family of cargo-specific cytoskeletal adaptor proteins
    Daniel A Starr
    Section of Molecular and Cellular Biology, Center for Genetics and Development, University of California, Davis, CA, USA
    Bioessays 27:1136-46. 2005
    ....
  10. pmc KDP-1 is a nuclear envelope KASH protein required for cell-cycle progression
    Matthew D McGee
    Department of Molecular and Cellular Biology, University of California, Davis, CA, USA
    J Cell Sci 122:2895-905. 2009
    ..The data suggest that KDP-1 is a novel KASH protein that functions to ensure the timely progression of the cell cycle between the end of S phase and the entry into mitosis...
  11. ncbi request reprint A genetic approach to study the role of nuclear envelope components in nuclear positioning
    Daniel A Starr
    Center for Genetics and Development and Section of Molecular Biology, 313 Briggs Hall, University of California, Davis, CA 95616, USA
    Novartis Found Symp 264:208-19; discussion 219-230. 2005
    ..Together these proteins function to bridge the two membranes of the nuclear envelope, connecting the nuclear matrix to the cytoskeleton...
  12. pmc Centrosome attachment to the C. elegans male pronucleus is dependent on the surface area of the nuclear envelope
    Marina Meyerzon
    Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
    Dev Biol 327:433-46. 2009
    ..We propose that the limiting factor for centrosome attachment to the surface of abnormally small pronuclei is dynein...
  13. ncbi request reprint The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis
    Juehua Yu
    Institute of Developmental Biology and Molecular Medicine, Morgan Tan International Center for Life Sciences, School of Life Science, Fudan University, Shanghai, China
    Dev Biol 289:336-45. 2006
    ..These results indicate that maternal MSP-300 plays an important role in actin-dependent nuclear anchorage during cytoplasmic transport...
  14. ncbi request reprint Role of ANC-1 in tethering nuclei to the actin cytoskeleton
    Daniel A Starr
    Howard Hughes Medical Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Science 298:406-9. 2002
    ..Thus, ANC-1 may connect nuclei to the cytoskeleton by interacting with UNC-84 at the nuclear envelope and with actin in the cytoplasm...
  15. pmc Syne proteins anchor muscle nuclei at the neuromuscular junction
    R Mark Grady
    Department of Anatomy and Neurobiology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:4359-64. 2005
    ..We then exploited this phenotype to show that synaptic nuclear aggregates are dispensable for maturation of the NMJ...
  16. ncbi request reprint ANChors away: an actin based mechanism of nuclear positioning
    Daniel A Starr
    Howard Hughes Medical Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    J Cell Sci 116:211-6. 2003
    ..Syne/ANC-1 anchors nuclei by directly tethering the nuclear envelope to the actin cytoskeleton, and UNC-84/SUN functions at the nuclear envelope to recruit Syne/ANC-1...

Research Grants5

  1. Mechanisms of Nuclear Migration and Anchorage
    Daniel Starr; Fiscal Year: 2006
    ..elegans a powerful system for these studies. Together, these studies will provide mechanistic insight into the fundamental problem of how the nucleus positions itself in the cytoplasm. ..
  2. Mechanisms of Nuclear Migration and Anchorage
    Daniel Starr; Fiscal Year: 2007
    ..elegans a powerful system for these studies. Together, these studies will provide mechanistic insight into the fundamental problem of how the nucleus positions itself in the cytoplasm. ..
  3. Mechanisms of Nuclear Migration and Anchorage
    Daniel Starr; Fiscal Year: 2009
    ..Together, these studies will provide mechanistic insight into the fundamental problem of how the nucleus positions itself in the cytoplasm. ..
  4. Mechanisms of Nuclear Migration and Anchorage
    Daniel A Starr; Fiscal Year: 2010
    ..Together, these studies will provide mechanistic insight into the fundamental problem of how the nucleus positions itself in the cytoplasm. ..