Research Topics
Species | Robert M StarkeSummaryAffiliation: University of Virginia Country: USA Publications
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Publications
Role of fever in ventriculoperitoneal shunt placement after aneurysmal subarachnoid hemorrhageRobert M Starke
Department of Neurosurgery, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Neurosurgery 70:1361-8; discussion 1368. 2012..Central fever is common after aneurysmal subarachnoid hemorrhage (aSAH) and may delay ventriculoperitoneal shunt (VPS) placement...- Gamma knife surgery for skull base meningiomasRobert M Starke
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Neurosurg 116:588-97. 2012..In this study, the authors evaluate the outcomes of skull base meningiomas treated with Gamma Knife surgery (GKS) both as an adjunct to microsurgery and as a primary treatment modality... - Radiographic and clinical predictors of hemodynamic insufficiency in patients with athero-occlusive diseaseMatthew C Garrett
Department of Neurosurgery, Columbia University, New York, New York 10032, USA
J Stroke Cerebrovasc Dis 17:340-3. 2008..A better understanding of the clinical factors that identify patients with potential hemodynamic insufficiency would streamline screening and improve cost-efficiency... - Treatment guidelines for cerebral arteriovenous malformation microsurgeryRobert M Starke
Department of Neurosurgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA
Br J Neurosurg 23:376-86. 2009..In this paper, we review current guidelines for surgical planning, risk-benefit analysis, and prediction of outcome in AVM patients... - Endoscopic endonasal versus open transcranial resection of anterior midline skull base meningiomasRicardo J Komotar
Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
World Neurosurg 77:713-24. 2012.... - Endoscopic endonasal compared with microscopic transsphenoidal and open transcranial resection of craniopharyngiomasRicardo J Komotar
Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
World Neurosurg 77:329-41. 2012.... - Gamma Knife surgery for patients with nonfunctioning pituitary macroadenomas: predictors of tumor control, neurological deficits, and hypopituitarismRobert M Starke
Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
J Neurosurg 117:129-35. 2012..In this study, the authors evaluated outcomes following GKS of nonfunctioning pituitary macroadenomas and assessed predictors of tumor control, neurological deficits, and delayed hypopituitarism... 
Adjuvant embolization with N-butyl cyanoacrylate in the treatment of cerebral arteriovenous malformations: outcomes, complications, and predictors of neurologic deficitsRobert M Starke
Department of Neurosurgery, Columbia University, 710 West 168th Street, Room 428, Neurological Institute, New York, NY 10032, USA
Stroke 40:2783-90. 2009..The purpose of this study was to assess the frequency, severity, and predictors of neurological deficits after adjuvant embolization for cerebral arteriovenous malformations...- Systemic expression of matrix metalloproteinase-9 in patients with cerebral arteriovenous malformationsRobert M Starke
Department of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA
Neurosurgery 66:343-8; discussion 348. 2010..The objective of this study was to determine plasma levels of MMP-9 of patients with AVMs... 
The role of complement in stroke therapyRicardo J Komotar
Department of Neurological Surgery, Columbia University, New York, NY 10032, USA
Adv Exp Med Biol 632:23-33. 2008..In this paper, we review the role of the complement cascade in neuronal damage following ischemic injury and emphasize possible therapeutic targets...- Impact of a protocol for acute antifibrinolytic therapy on aneurysm rebleeding after subarachnoid hemorrhageRobert M Starke
Department of Neurosurgery, Columbia University, 710 West 168th St, Room 431, New York, NY 10032, USA
Stroke 39:2617-21. 2008..Although studies have found that a decrease in rebleeding with long-term antifibrinolytic therapy is offset by an increase in ischemic deficits, more recent studies have indicated that early, short-term therapy may be beneficial... - Monocyte chemoattractant protein-1 predicts outcome and vasospasm following aneurysmal subarachnoid hemorrhageGrace H Kim
Department of Neurological Surgery, Columbia University, New York, New York 10032, USA
J Neurosurg 109:38-43. 2008..The authors hypothesized that MCP-1 would be found in increased concentrations in the blood and cerebrospinal fluid (CSF) of patients with ASAH and would correlate with both outcome and the occurrence of vasospasm... - Gamma Knife surgery for parasellar meningiomas: long-term results including complications, predictive factors, and progression-free survivalBrian J Williams
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Neurosurg 114:1571-7. 2011..This is particularly true for patients with parasellar meningiomas. In this study, the authors evaluated the outcomes of Gamma Knife surgery (GKS) used to treat parasellar meningiomas... - Safety and efficacy of endovascular treatment of basilar tip aneurysms by coiling with and without stent assistance: a review of 235 casesNohra Chalouhi
Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
Neurosurgery 71:785-94. 2012..Endovascular therapy is now the preferred treatment option for basilar tip aneurysms (BTAs)... - Gamma Knife surgery of meningiomas located in the posterior fossa: factors predictive of outcome and remissionRobert M Starke
Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
J Neurosurg 114:1399-409. 2011..In this study, the authors evaluate the outcomes of posterior fossa meningiomas treated with Gamma Knife surgery (GKS). The authors also assess factors predictive of new postoperative neurological deficits and tumor progression... - Efficacy of lamina terminalis fenestration in reducing shunt-dependent hydrocephalus following aneurysmal subarachnoid hemorrhage: a systematic review. Clinical articleRicardo J Komotar
Department of Neurological Surgery, Columbia University, New York, NY 10032, USA
J Neurosurg 111:147-54. 2009.... - Endoscopic skull base surgery: a comprehensive comparison with open transcranial approachesRicardo J Komotar
Department of Neurological Surgery, University of Miami, Miami, FL, USA
Br J Neurosurg 26:637-48. 2012..In certain patients, the endonasal endoscopic approach may be a safe and effective alternative for the treatment of a wide variety of skull base pathology, particularly those with small midline tumours... - Synergistic neuroprotective effects of C3a and C5a receptor blockade following intracerebral hemorrhageMatthew C Garrett
Department of Neurological Surgery, Columbia University, 710 West 168th Street, New York, NY 10032, USA
Brain Res 1298:171-7. 2009..We investigated the role of C5a-receptor antagonist (C5aRA) solely and in combination with C3a-receptor antagonist (C3aRA) following ICH in mice... - A comprehensive review of radiosurgery for cerebral arteriovenous malformations: outcomes, predictive factors, and grading scalesRobert M Starke
Department of Neurological Surgery, Columbia University, New York, NY 10032, USA
Stereotact Funct Neurosurg 86:191-9. 2008..The purpose of this paper is to describe the most current predictive factors and grading systems for radiosurgical treatment of cerebral AVMs... - The role of polyamine metabolism in neuronal injury following cerebral ischemiaGrace H Kim
Department of Neurosurgery, Columbia University, 710 West 168th Street, Room 431, New York, New York 10032, USA
Can J Neurol Sci 36:14-9. 2009..Regulation of the polyamine metabolic pathway, therefore, may have the potential to limit injury following cerebral ischemia. To this end, we review this pathway in detail with an emphasis on clinical applicability... - Plasma levels of vascular endothelial growth factor after treatment for cerebral arteriovenous malformationsGrace H Kim
Department of Neurological Surgery, Columbia College of Physicians and Surgeons, Neurological Institute of New York, 630 W 168th St, Room 5 454, New York, NY 10032, USA
Stroke 39:2274-9. 2008..We sought to further investigate the role of VEGF in AVM pathophysiology by examining changes in plasma VEGF levels in patients undergoing treatment for AVMs... - A phase I clinical trial of tiopronin, a putative neuroprotective agent, in aneurysmal subarachnoid hemorrhageGrace H Kim
Department of Neurological Surgery, Columbia University Medical Center, New York, New York 10032, USA
Neurosurgery 67:182-5; discussion 186. 2010.... - The complement cascade: new avenues in stroke therapyRicardo J Komotar
Department of Neurological Surgery, Columbia University, New York, NY 10011, USA
Curr Vasc Pharmacol 7:287-92. 2009..We review the available literature and attempt to identify promising clinical therapeutic targets... - Clinical features, surgical treatment, and long-term outcome in adult patients with moyamoya disease. Clinical articleRobert M Starke
Department of Neurological Surgery, Columbia University, New York, New York 10032, USA
J Neurosurg 111:936-42. 2009..The object of this study was to report the clinical features, surgical treatment, and long-term outcomes in adults with moyamoya phenomenon treated at a single institution in the US... - In-stent stenosis after stent-assisted coiling: incidence, predictors and clinical outcomes of 435 casesNohra Chalouhi
Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
Neurosurgery 72:390-6. 2013..Neuroform and Enterprise are widely used self-expanding stents designed to treat wide-necked intracranial aneurysms... - Cigarette smoke and inflammation: role in cerebral aneurysm formation and ruptureNohra Chalouhi
Joseph and Marie Field Cerebrovascular Research Laboratory, Division of Neurovascular and Endovascular Surgery, Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
Mediators Inflamm 2012:271582. 2012..In this paper, we review the current body of knowledge implicating cigarette smoke-induced inflammation in cerebral aneurysm formation/rupture and attempt to highlight important avenues for future investigation... - Endoscopic endonasal compared with microscopic transsphenoidal and open transcranial resection of giant pituitary adenomasRicardo J Komotar
Department of Neurological Surgery, Miami University, Miami, FL, USA
Pituitary 15:150-9. 2012..CSF leak, which is a major limitation of the endonasal approach, may be avoided using meticulous multi-layer closure and vascularised nasoseptal flaps... - Safety and efficacy of intraoperative angiography in craniotomies for cerebral aneurysms and arteriovenous malformations: a review of 1093 consecutive casesNohra Chalouhi
Department of Neurosurgery, Thomas Jefferson University, and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
Neurosurgery 71:1162-9. 2012..In an era of indocyanine angiography, the routine use of intraoperative angiography (IOA) in the surgical treatment of aneurysms and vascular malformations is controversial... - Elevated troponin levels are predictive of mortality in surgical intracerebral hemorrhage patientsMatthew C Garrett
Department of Neurosurgery, Columbia University, Room 431, 710 West 168th Street, New York, NY 10032, USA
Neurocrit Care 12:199-203. 2010..To this end, we investigated whether troponin levels were an independent predictor of in-hospital mortality from all causes in surgically treated ICH patients... - Prophylactic antiepileptic drug therapy in patients undergoing supratentorial meningioma resection: a systematic analysis of efficacyRicardo J Komotar
Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
J Neurosurg 115:483-90. 2011.... - Endothelial nitric oxide synthase gene single-nucleotide polymorphism predicts cerebral vasospasm after aneurysmal subarachnoid hemorrhageRobert M Starke
Department of Neurological Surgery, Columbia University, New York, New York, USA
J Cereb Blood Flow Metab 28:1204-11. 2008..Presence of this genotype may allow the identification of individuals at high risk for post-aSAH vasospasm and lead to early treatment and improved outcome... - Impact of temozolomide chemotherapy on seizure frequency in patients with low-grade gliomasJonathan H Sherman
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
J Neurosurg 114:1617-21. 2011..The oral alkylating agent temozolomide has emerged as a potential initial treatment option for LGG. A few reports suggest an association between temozolomide and reduced seizure frequency in patients with intractable epilepsy... - Predictors of seizure onset after intracerebral hemorrhage and the role of long-term antiepileptic therapyMatthew C Garrett
Department of Neurosurgery, Columbia University, New York, NY 10032, USA
J Crit Care 24:335-9. 2009..We investigated predictors of early- and late-onset seizures after evacuation of intracerebral hemorrhage (ICH) in an attempt to guide antiepileptic drug management in this patient population... - Optimal surgical treatment for moyamoya disease in adults: direct versus indirect bypassRobert M Starke
Department of Neurosurgery, Columbia University, New York, New York 10032, USA
Neurosurg Focus 26:E8. 2009..In this article the authors review the literature concerning the optimal surgical treatment of adult patients with moyamoya disease... - Use of the histological pseudocapsule in surgery for Cushing disease: rapid postoperative cortisol decline predicting complete tumor resectionStephen J Monteith
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, VA, USA
J Neurosurg 116:721-7. 2012..Furthermore, the relevance of the rate of cortisol drop immediately after surgery has not been investigated... - The endoscope-assisted ventral approach compared with open microscope-assisted surgery for clival chordomasRicardo J Komotar
Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
World Neurosurg 76:318-27; discussion 259-62. 2011..We conducted a systematic review of case series and case reports in hope of furthering our understanding of the role of endoscopy in the management of these difficult cranial base lesions... - Gamma knife radiosurgery for intracranial hemangioblastomas--outcome at 3 yearsFaisal T Sayer
Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA
World Neurosurg 75:99-105; discussion 45-8. 2011..To define the role of Gamma Knife radiosurgery (GKRS) for the treatment of patients with hemangioblastomas... - The extracranial-intracranial bypass trial: implications for future investigationsMatthew C Garrett
Department of Neurosurgery, Columbia University, New York, New York 10032, USA
Neurosurg Focus 24:E4. 2008.... - Moyamoya disorder in the United StatesRobert M Starke
Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA
Neurosurgery 71:93-9. 2012..Studies have provided evidence that moyamoya disease in the United States may exhibit a different phenotype... - Antifibrinolytic therapy to prevent early rebleeding after subarachnoid hemorrhageMark Chwajol
Department of Neurosurgery, Albert Einstein College of Medicine, Bronx, NY, USA
Neurocrit Care 8:418-26. 2008..Additional randomized clinical trials are necessary to determine whether this management strategy is effective... - Resuscitation and critical care of poor-grade subarachnoid hemorrhageRicardo J Komotar
Department of Neurological Surgery, Columbia University, New York, New York 10032, USA
Neurosurgery 64:397-410; discussion 410-1. 2009.... - Endoscopic transsphenoidal surgery for cushing disease: techniques, outcomes, and predictors of remissionRobert M Starke
Department of Neurosurgery, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
Neurosurgery 72:240-7; discussion 247. 2013..The efficacy of endoscopic transsphenoidal surgery (ETS) for Cushing disease has not been clearly established... - Is packing density important in stent-assisted coiling?Nohra Chalouhi
Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
Neurosurgery 71:381-6; discussion 386-7. 2012.... - Radiation therapy and stereotactic radiosurgery for the treatment of Cushing's disease: an evidence-based reviewRobert M Starke
Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
Curr Opin Endocrinol Diabetes Obes 17:356-64. 2010..g. maximal dose, tumor margin dose), length of follow-up, tumor-control rate, complications, rate of hormone normalization, newly onset loss of pituitary function, and method used to assess endocrine remission... - Endoscopic transsphenoidal surgery for acromegaly: remission using modern criteria, complications, and predictors of outcomeJohn A Jane
Departments of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia 22908 0711, USA
J Clin Endocrinol Metab 96:2732-40. 2011..Despite the growing application of endoscopic transsphenoidal surgery (ETSS), outcomes for GH adenomas are not clearly defined... - Pupillary reactivity upon hospital admission predicts long-term outcome in poor grade aneurysmal subarachnoid hemorrhage patientsWilliam J Mack
Department of Neurosurgery, Columbia University, 710 West 168th Street, Room 431, New York, NY 10032, USA
Neurocrit Care 8:374-9. 2008..More accurate and predictive methods are needed to decide when aggressive therapy is warranted... - Brain magnetic resonance imaging scans for asymptomatic patients: role in medical screeningRicardo J Komotar
Department of Neurological Surgery, Columbia University, 710 W 168th St, Room 431, New York, NY 10032, USA
Mayo Clin Proc 83:563-5. 2008 - Gamma knife radiosurgery of meningiomas involving the foramen magnumRobert M Starke
Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA
J Craniovertebr Junction Spine 1:23-8. 2010..For some patients, stereotactic radiosurgery may be used as the primary treatment modality. We evaluatedthe long-term outcome of Gamma Knife radiosurgery (GKRS) for the treatment of patientswith a foramen magnum meningioma... - In-training factors predictive of choosing and sustaining a productive academic career path in neurological surgeryR Webster Crowley
Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
Neurosurgery 70:1024-32. 2012..Factors during neurosurgical residency that are predictive of an academic career path and promotion have not been defined... - A mouse model of intracerebral hemorrhage using autologous blood infusionMichal A Rynkowski
Department of Neurological Surgery, Columbia University, 710 West 168th Street, New York, New York 10032, USA
Nat Protoc 3:122-8. 2008..We believe that our model will serve as an ideal paradigm for investigating the complex pathophysiology of hemorrhagic stroke. The protocol for establishing this model takes about 2 h... - Standards for reporting randomized controlled trials in neurosurgeryErin N Kiehna
Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia, USA
J Neurosurg 114:280-5. 2011..The purpose of this study is to evaluate the quality and reporting of randomized controlled trials (RCTs) in neurosurgery and the factors that may affect the quality of reported trials... - MR imaging characteristics of oligodendroglial tumors with assessment of 1p/19q deletion statusJonathan H Sherman
Department of Neurological Surgery, University of Virginia, P O Box 800212, Health Sciences Center, Charlottesville, VA 22908, USA
Acta Neurochir (Wien) 152:1827-34. 2010..MR imaging can be used to help differentiate between low- and high-grade tumors. We hypothesize that certain MR imaging characteristics can be used to differentiate between patients with and without 1p and 19q deletion...