Robert M Starke

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. doi request reprint Role of fever in ventriculoperitoneal shunt placement after aneurysmal subarachnoid hemorrhage
    Robert M Starke
    Department of Neurosurgery, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Neurosurgery 70:1361-8; discussion 1368. 2012
  2. doi request reprint Gamma knife surgery for skull base meningiomas
    Robert M Starke
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Neurosurg 116:588-97. 2012
  3. doi request reprint Endovascular treatment of very small ruptured intracranial aneurysms: complications, occlusion rates and prediction of outcome
    Robert M Starke
    Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA
    J Neurointerv Surg 5:iii66-71. 2013
  4. doi request reprint The Pipeline Embolization Device: learning curve and predictors of complications and aneurysm obliteration
    Pascal Jabbour
    Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania, USA
    Neurosurgery 73:113-20; discussion 120. 2013
  5. pmc TNF-α induces phenotypic modulation in cerebral vascular smooth muscle cells: implications for cerebral aneurysm pathology
    Muhammad S Ali
    Joseph and Marie Field Cerebrovascular Research Laboratory, Division of Neurovascular and Endovascular Surgery, Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Cereb Blood Flow Metab 33:1564-73. 2013
  6. doi request reprint Radiographic and clinical predictors of hemodynamic insufficiency in patients with athero-occlusive disease
    Matthew C Garrett
    Department of Neurosurgery, Columbia University, New York, New York 10032, USA
    J Stroke Cerebrovasc Dis 17:340-3. 2008
  7. ncbi request reprint Treatment guidelines for cerebral arteriovenous malformation microsurgery
    Robert M Starke
    Department of Neurosurgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Br J Neurosurg 23:376-86. 2009
  8. doi request reprint Stent-assisted coiling of intracranial aneurysms: predictors of complications, recanalization, and outcome in 508 cases
    Nohra Chalouhi
    Department of Neurological Surgery, Division of Neurovascular Surgery and Endovascular Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Stroke 44:1348-53. 2013
  9. doi request reprint Endoscopic endonasal versus open transcranial resection of anterior midline skull base meningiomas
    Ricardo J Komotar
    Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    World Neurosurg 77:713-24. 2012
  10. doi request reprint Endoscopic endonasal compared with microscopic transsphenoidal and open transcranial resection of craniopharyngiomas
    Ricardo J Komotar
    Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    World Neurosurg 77:329-41. 2012

Detail Information

Publications86

  1. doi request reprint Role of fever in ventriculoperitoneal shunt placement after aneurysmal subarachnoid hemorrhage
    Robert M Starke
    Department of Neurosurgery, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Neurosurgery 70:1361-8; discussion 1368. 2012
    ..Central fever is common after aneurysmal subarachnoid hemorrhage (aSAH) and may delay ventriculoperitoneal shunt (VPS) placement...
  2. doi request reprint Gamma knife surgery for skull base meningiomas
    Robert M Starke
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Neurosurg 116:588-97. 2012
    ..In this study, the authors evaluate the outcomes of skull base meningiomas treated with Gamma Knife surgery (GKS) both as an adjunct to microsurgery and as a primary treatment modality...
  3. doi request reprint Endovascular treatment of very small ruptured intracranial aneurysms: complications, occlusion rates and prediction of outcome
    Robert M Starke
    Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA
    J Neurointerv Surg 5:iii66-71. 2013
    ..To assess predictors of outcome following endovascular treatment of small ruptured intracranial aneurysms (SRA)...
  4. doi request reprint The Pipeline Embolization Device: learning curve and predictors of complications and aneurysm obliteration
    Pascal Jabbour
    Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania, USA
    Neurosurgery 73:113-20; discussion 120. 2013
    ..The Pipeline Embolization Device (PED) has emerged as a promising treatment for intracranial aneurysms...
  5. pmc TNF-α induces phenotypic modulation in cerebral vascular smooth muscle cells: implications for cerebral aneurysm pathology
    Muhammad S Ali
    Joseph and Marie Field Cerebrovascular Research Laboratory, Division of Neurovascular and Endovascular Surgery, Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Cereb Blood Flow Metab 33:1564-73. 2013
    ..These results demonstrate a novel role for TNF-α in promoting a pro-inflammatory/matrix-remodeling phenotype, which has important implications for the mechanisms behind intracranial aneurysm formation. ..
  6. doi request reprint Radiographic and clinical predictors of hemodynamic insufficiency in patients with athero-occlusive disease
    Matthew C Garrett
    Department of Neurosurgery, Columbia University, New York, New York 10032, USA
    J Stroke Cerebrovasc Dis 17:340-3. 2008
    ..A better understanding of the clinical factors that identify patients with potential hemodynamic insufficiency would streamline screening and improve cost-efficiency...
  7. ncbi request reprint Treatment guidelines for cerebral arteriovenous malformation microsurgery
    Robert M Starke
    Department of Neurosurgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Br J Neurosurg 23:376-86. 2009
    ..In this paper, we review current guidelines for surgical planning, risk-benefit analysis, and prediction of outcome in AVM patients...
  8. doi request reprint Stent-assisted coiling of intracranial aneurysms: predictors of complications, recanalization, and outcome in 508 cases
    Nohra Chalouhi
    Department of Neurological Surgery, Division of Neurovascular Surgery and Endovascular Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Stroke 44:1348-53. 2013
    ..Self-expanding stents are increasingly used for treatment of complex intracranial aneurysms. We assess the safety and the efficacy of intracranial stenting and determine predictors of treatment outcomes...
  9. doi request reprint Endoscopic endonasal versus open transcranial resection of anterior midline skull base meningiomas
    Ricardo J Komotar
    Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    World Neurosurg 77:713-24. 2012
    ....
  10. doi request reprint Endoscopic endonasal compared with microscopic transsphenoidal and open transcranial resection of craniopharyngiomas
    Ricardo J Komotar
    Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    World Neurosurg 77:329-41. 2012
    ....
  11. ncbi request reprint In-stent stenosis after stent-assisted coiling: incidence, predictors and clinical outcomes of 435 cases
    Nohra Chalouhi
    Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
    Neurosurgery 72:390-6. 2013
    ..Neuroform and Enterprise are widely used self-expanding stents designed to treat wide-necked intracranial aneurysms...
  12. doi request reprint Gamma Knife surgery for patients with nonfunctioning pituitary macroadenomas: predictors of tumor control, neurological deficits, and hypopituitarism
    Robert M Starke
    Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosurg 117:129-35. 2012
    ..In this study, the authors evaluated outcomes following GKS of nonfunctioning pituitary macroadenomas and assessed predictors of tumor control, neurological deficits, and delayed hypopituitarism...
  13. ncbi request reprint Impact of a protocol for acute antifibrinolytic therapy on aneurysm rebleeding after subarachnoid hemorrhage
    Robert M Starke
    Department of Neurosurgery, Columbia University, 710 West 168th St, Room 431, New York, NY 10032, USA
    Stroke 39:2617-21. 2008
    ..Although studies have found that a decrease in rebleeding with long-term antifibrinolytic therapy is offset by an increase in ischemic deficits, more recent studies have indicated that early, short-term therapy may be beneficial...
  14. doi request reprint Gamma Knife surgery for parasellar meningiomas: long-term results including complications, predictive factors, and progression-free survival
    Brian J Williams
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Neurosurg 114:1571-7. 2011
    ..This is particularly true for patients with parasellar meningiomas. In this study, the authors evaluated the outcomes of Gamma Knife surgery (GKS) used to treat parasellar meningiomas...
  15. doi request reprint Systemic expression of matrix metalloproteinase-9 in patients with cerebral arteriovenous malformations
    Robert M Starke
    Department of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA
    Neurosurgery 66:343-8; discussion 348. 2010
    ..The objective of this study was to determine plasma levels of MMP-9 of patients with AVMs...
  16. doi request reprint Monocyte chemoattractant protein-1 predicts outcome and vasospasm following aneurysmal subarachnoid hemorrhage
    Grace H Kim
    Department of Neurological Surgery, Columbia University, New York, New York 10032, USA
    J Neurosurg 109:38-43. 2008
    ..The authors hypothesized that MCP-1 would be found in increased concentrations in the blood and cerebrospinal fluid (CSF) of patients with ASAH and would correlate with both outcome and the occurrence of vasospasm...
  17. pmc Adjuvant embolization with N-butyl cyanoacrylate in the treatment of cerebral arteriovenous malformations: outcomes, complications, and predictors of neurologic deficits
    Robert M Starke
    Department of Neurosurgery, Columbia University, 710 West 168th Street, Room 428, Neurological Institute, New York, NY 10032, USA
    Stroke 40:2783-90. 2009
    ..The purpose of this study was to assess the frequency, severity, and predictors of neurological deficits after adjuvant embolization for cerebral arteriovenous malformations...
  18. ncbi request reprint The role of complement in stroke therapy
    Ricardo J Komotar
    Department of Neurological Surgery, Columbia University, New York, NY 10032, USA
    Adv Exp Med Biol 632:23-33. 2008
    ..In this paper, we review the role of the complement cascade in neuronal damage following ischemic injury and emphasize possible therapeutic targets...
  19. pmc The role of oxidative stress in cerebral aneurysm formation and rupture
    Robert M Starke
    Joseph and Marie Field Cerebrovascular Research Laboratory, Division of Neurovascular and Endovascular Surgery, Department of Neurological Surgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
    Curr Neurovasc Res 10:247-55. 2013
    ..The goal of this review is to assess the role of oxidative stress in cerebral aneurysm pathogenesis. ..
  20. doi request reprint Treatment of ruptured intracranial aneurysms: comparison of stenting and balloon remodeling
    Rohan Chitale
    Department of Neurological Surgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
    Neurosurgery 72:953-9. 2013
    ..Most clinicians are reluctant to perform SAC in the setting of subarachnoid hemorrhage because of the need for dual antiplatelet therapy...
  21. doi request reprint Endoscopic endonasal compared with anterior craniofacial and combined cranionasal resection of esthesioneuroblastomas
    Ricardo J Komotar
    Department of Neurological Surgery, University of Miami, Miami, Florida, USA
    World Neurosurg 80:148-59. 2013
    ..We conducted a systematic review of case series and case reports to compare outcomes between these various surgical approaches...
  22. doi request reprint Endoscopic vs microsurgical transsphenoidal surgery for acromegaly: outcomes in a concurrent series of patients using modern criteria for remission
    Robert M Starke
    Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 98:3190-8. 2013
    ..It is unclear whether endoscopic transsphenoidal surgery (ETSS) or microsurgical transsphenoidal surgery (MTS) is a superior surgical approach for pituitary adenomas...
  23. doi request reprint Endovascular treatment of proximal and distal posterior inferior cerebellar artery aneurysms
    Nohra Chalouhi
    Department of Neurological Surgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
    J Neurosurg 118:991-9. 2013
    ..Experience with endovascular therapy has been limited to a few studies. The authors assess the feasibility, safety, and efficacy of endovascular therapy in the largest series of proximal and distal PICA aneurysms to date...
  24. ncbi request reprint A phase I clinical trial of tiopronin, a putative neuroprotective agent, in aneurysmal subarachnoid hemorrhage
    Grace H Kim
    Department of Neurological Surgery, Columbia University Medical Center, New York, New York 10032, USA
    Neurosurgery 67:182-5; discussion 186. 2010
    ....
  25. ncbi request reprint Safety and efficacy of endovascular treatment of basilar tip aneurysms by coiling with and without stent assistance: a review of 235 cases
    Nohra Chalouhi
    Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
    Neurosurgery 71:785-94. 2012
    ..Endovascular therapy is now the preferred treatment option for basilar tip aneurysms (BTAs)...
  26. doi request reprint Gamma Knife surgery of meningiomas located in the posterior fossa: factors predictive of outcome and remission
    Robert M Starke
    Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosurg 114:1399-409. 2011
    ..In this study, the authors evaluate the outcomes of posterior fossa meningiomas treated with Gamma Knife surgery (GKS). The authors also assess factors predictive of new postoperative neurological deficits and tumor progression...
  27. pmc Cigarette smoke modulates vascular smooth muscle phenotype: implications for carotid and cerebrovascular disease
    Robert M Starke
    Joseph and Marie Field Cerebrovascular Research Laboratory, Division of Neurovascular and Endovascular Surgery, Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 8:e71954. 2013
    ..Cigarette smoke is a major risk factor for atherosclerosis, but potential mechanisms are unclear, and its role in SMC phenotypic modulation has not been established...
  28. ncbi request reprint Perforator aneurysms of the posterior circulation: case series and review of the literature
    Dale Ding
    Department of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA
    J Neurointerv Surg 5:546-51. 2013
    ..Posterior circulation perforator artery aneurysms are sparsely reported in the literature. The natural history of these rare lesions remains unclear and their diagnosis and management are not well-defined...
  29. doi request reprint Carotid and vertebral artery sacrifice with a combination of Onyx and coils: technical note and case series
    Nohra Chalouhi
    Department of Neurological Surgery, Jefferson Hospital for Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA
    Neuroradiology 55:993-8. 2013
    ..The purpose of this study is to describe a new technique for carotid and vertebral artery sacrifice using a combination of Onyx and coils and to assess its feasibility, safety, and efficacy...
  30. doi request reprint Endoscopic endonasal versus open repair of anterior skull base CSF leak, meningocele, and encephalocele: a systematic review of outcomes
    Ricardo J Komotar
    Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Neurol Surg A Cent Eur Neurosurg 74:239-50. 2013
    ..The endoscopic endonasal approach represents a minimal access but equally aggressive alternative. We conducted a systematic review of case series and case reports to assess the role of endoscopy in the management of these lesions...
  31. doi request reprint Comparison of flow diversion and coiling in large unruptured intracranial saccular aneurysms
    Nohra Chalouhi
    Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, USA
    Stroke 44:2150-4. 2013
    ..The purpose of this study was to compare flow diversion and traditional embolization strategies in terms of safety, efficacy, and clinical outcomes in patients with unruptured, large saccular aneurysms (≥10 mm)...
  32. pmc Synergistic neuroprotective effects of C3a and C5a receptor blockade following intracerebral hemorrhage
    Matthew C Garrett
    Department of Neurological Surgery, Columbia University, 710 West 168th Street, New York, NY 10032, USA
    Brain Res 1298:171-7. 2009
    ..We investigated the role of C5a-receptor antagonist (C5aRA) solely and in combination with C3a-receptor antagonist (C3aRA) following ICH in mice...
  33. ncbi request reprint Efficacy of lamina terminalis fenestration in reducing shunt-dependent hydrocephalus following aneurysmal subarachnoid hemorrhage: a systematic review. Clinical article
    Ricardo J Komotar
    Department of Neurological Surgery, Columbia University, New York, NY 10032, USA
    J Neurosurg 111:147-54. 2009
    ....
  34. pmc Stereotactic radiosurgery with neoadjuvant embolization of larger arteriovenous malformations: an institutional experience
    Richard Dalyai
    Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, 901 Walnut Street, 3rd Floor, Philadelphia, PA 19107, USA
    Biomed Res Int 2014:306518. 2014
    ..This study investigates the safety and efficacy of a multimodality approach combining staged endovascular embolizations with subsequent SRS for the management of larger AVMs...
  35. ncbi request reprint Radiosurgery for primary motor and sensory cortex arteriovenous malformations: outcomes and the effect of eloquent location
    Dale Ding
    Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia
    Neurosurgery 73:816-24; discussio 824. 2013
    ..Eloquent intracranial arteriovenous malformations (AVMs) located in the primary motor or somatosensory cortex (PMSC) carry a high risk of microsurgical morbidity...
  36. ncbi request reprint Flow diversion versus traditional aneurysm embolization strategies: analysis of fluoroscopy and procedure times
    Nohra Chalouhi
    Department of Neurosurgery, Division of Neurovascular Surgery and Endovascular Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania, USA
    J Neurointerv Surg 6:291-5. 2014
    ..The purpose of this study was to compare the pipeline embolization device (PED) and traditional embolization strategies in terms of fluoroscopy and procedure time...
  37. doi request reprint Endoscopic transsphenoidal surgery for cushing disease: techniques, outcomes, and predictors of remission
    Robert M Starke
    Department of Neurosurgery, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    Neurosurgery 72:240-7; discussion 247. 2013
    ..The efficacy of endoscopic transsphenoidal surgery (ETS) for Cushing disease has not been clearly established...
  38. pmc Cigarette smoke and inflammation: role in cerebral aneurysm formation and rupture
    Nohra Chalouhi
    Joseph and Marie Field Cerebrovascular Research Laboratory, Division of Neurovascular and Endovascular Surgery, Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mediators Inflamm 2012:271582. 2012
    ..In this paper, we review the current body of knowledge implicating cigarette smoke-induced inflammation in cerebral aneurysm formation/rupture and attempt to highlight important avenues for future investigation...
  39. doi request reprint Radiosurgery for patients with unruptured intracranial arteriovenous malformations
    Dale Ding
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Neurosurg 118:958-66. 2013
    ..In the present study, the authors evaluate the radiographic and clinical outcomes of radiosurgery for a large cohort of patients with unruptured AVMs...
  40. ncbi request reprint Safety and efficacy of intraoperative angiography in craniotomies for cerebral aneurysms and arteriovenous malformations: a review of 1093 consecutive cases
    Nohra Chalouhi
    Department of Neurosurgery, Thomas Jefferson University, and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
    Neurosurgery 71:1162-9. 2012
    ..In an era of indocyanine angiography, the routine use of intraoperative angiography (IOA) in the surgical treatment of aneurysms and vascular malformations is controversial...
  41. ncbi request reprint Endoscopic skull base surgery: a comprehensive comparison with open transcranial approaches
    Ricardo J Komotar
    Department of Neurological Surgery, University of Miami, Miami, FL, USA
    Br J Neurosurg 26:637-48. 2012
    ..In certain patients, the endonasal endoscopic approach may be a safe and effective alternative for the treatment of a wide variety of skull base pathology, particularly those with small midline tumours...
  42. doi request reprint A comprehensive review of radiosurgery for cerebral arteriovenous malformations: outcomes, predictive factors, and grading scales
    Robert M Starke
    Department of Neurological Surgery, Columbia University, New York, NY 10032, USA
    Stereotact Funct Neurosurg 86:191-9. 2008
    ..The purpose of this paper is to describe the most current predictive factors and grading systems for radiosurgical treatment of cerebral AVMs...
  43. doi request reprint Plasma levels of vascular endothelial growth factor after treatment for cerebral arteriovenous malformations
    Grace H Kim
    Department of Neurological Surgery, Columbia College of Physicians and Surgeons, Neurological Institute of New York, 630 W 168th St, Room 5 454, New York, NY 10032, USA
    Stroke 39:2274-9. 2008
    ..We sought to further investigate the role of VEGF in AVM pathophysiology by examining changes in plasma VEGF levels in patients undergoing treatment for AVMs...
  44. ncbi request reprint The role of polyamine metabolism in neuronal injury following cerebral ischemia
    Grace H Kim
    Department of Neurosurgery, Columbia University, 710 West 168th Street, Room 431, New York, New York 10032, USA
    Can J Neurol Sci 36:14-9. 2009
    ..Regulation of the polyamine metabolic pathway, therefore, may have the potential to limit injury following cerebral ischemia. To this end, we review this pathway in detail with an emphasis on clinical applicability...
  45. pmc Endovascular treatment of cerebral mycotic aneurysm: a review of the literature and single center experience
    Mario Zanaty
    Department of Neurosurgery, Thomas Jefferson University, Jefferson Hospital for Neuroscience, Philadelphia, PA, USA
    Biomed Res Int 2013:151643. 2013
    ..This novel solution seems to provide additional benefits and long-term favorable outcomes. ..
  46. ncbi request reprint Radiosurgery for Spetzler-Martin Grade III arteriovenous malformations
    Dale Ding
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia
    J Neurosurg 120:959-69. 2014
    ..The authors report their experience with radiosurgery for the treatment of Grade III AVMs in a large cohort of patients...
  47. ncbi request reprint Programs selection criteria for neurological surgery applicants in the United States: a national survey for neurological surgery program directors
    Kenan Al Khalili
    Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania, USA
    World Neurosurg 81:473-477.e2. 2014
    ..To determine the criteria used by neurosurgery resident selection committees in different programs and to assess the process of selection...
  48. ncbi request reprint Vascular smooth muscle cells in cerebral aneurysm pathogenesis
    Robert M Starke
    Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA
    Transl Stroke Res 5:338-46. 2014
    ..This study reviews vascular SMC function and its contribution to cerebral aneurysm pathophysiology. ..
  49. pmc Critical role of TNF-α in cerebral aneurysm formation and progression to rupture
    Robert M Starke
    Joseph and Marie Field Cerebrovascular Research Laboratory, Division of Neurovascular and Endovascular Surgery, Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, PA, USA
    J Neuroinflammation 11:77. 2014
    ..Alterations in TNF-α expression have been associated with cerebral aneurysms, but a direct role in formation, progression, and rupture has not been established...
  50. doi request reprint Tumor necrosis factor-α modulates cerebral aneurysm formation and rupture
    Robert M Starke
    Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA
    Transl Stroke Res 5:269-77. 2014
    ..This review provides an update on the mechanisms underlying TNF-α-induced molecular modulation in cerebral aneurysms. ..
  51. ncbi request reprint Identification of knowledge gaps in neurosurgery through analysis of responses to the Self-Assessment in Neurological Surgery (SANS)
    Jason Sheehan
    Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA Electronic address
    World Neurosurg 81:229-33. 2014
    ..To examine the gaps in knowledge of neurosurgeons responding to the Self-Assessment in Neurological Surgery (SANS)...
  52. doi request reprint Treatment of posterior circulation aneurysms with the pipeline embolization device
    Nohra Chalouhi
    Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
    Neurosurgery 72:883-9. 2013
    ..Very few studies have assessed the safety and efficacy of PED treatment for posterior circulation aneurysms...
  53. doi request reprint Endovascular treatment of carotid cavernous aneurysms: complications, outcomes and comparison of interventional strategies
    Robert M Starke
    Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA Department of Neurological Surgery, Thomas Jefferson University, 901 Walnut Street, 3rd Floor, Philadelphia, PA 19107, USA
    J Clin Neurosci 21:40-6. 2014
    ..039). Endovascular therapy is a safe and effective therapy for CCA. When possible, stent assisted therapy may be the best option with fewer complications and low recanalization rates...
  54. ncbi request reprint Treatment of recurrent intracranial aneurysms with the Pipeline Embolization Device
    Nohra Chalouhi
    Department of Neurological Surgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania, USA
    J Neurointerv Surg 6:19-23. 2014
    ..The treatment of recurrent aneurysms after previous surgery or embolization is challenging. Little is known regarding the use of the Pipeline Embolization Device (PED) for recurrent aneurysms...
  55. doi request reprint A practical grading scale for predicting outcome after radiosurgery for arteriovenous malformations: analysis of 1012 treated patients
    Robert M Starke
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia
    J Neurosurg 119:981-7. 2013
    ..The authors performed a study to review outcomes following Gamma Knife radiosurgery for cerebral arteriovenous malformations (AVMs) and to create a practical scale to predict long-term outcome...
  56. ncbi request reprint Surgical treatment of ruptured anterior circulation aneurysms: comparison of pterional and supraorbital keyhole approaches
    Nohra Chalouhi
    Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
    Neurosurgery 72:437-41; discussion 441-2. 2013
    ..Recent advancements in microsurgical techniques and instrumentation have allowed the development of the keyhole approach in aneurysm surgery...
  57. pmc Clinical features, surgical treatment, and long-term outcome in adult patients with moyamoya disease. Clinical article
    Robert M Starke
    Department of Neurological Surgery, Columbia University, New York, New York 10032, USA
    J Neurosurg 111:936-42. 2009
    ..The object of this study was to report the clinical features, surgical treatment, and long-term outcomes in adults with moyamoya phenomenon treated at a single institution in the US...
  58. ncbi request reprint The complement cascade: new avenues in stroke therapy
    Ricardo J Komotar
    Department of Neurological Surgery, Columbia University, New York, NY 10011, USA
    Curr Vasc Pharmacol 7:287-92. 2009
    ..We review the available literature and attempt to identify promising clinical therapeutic targets...
  59. doi request reprint CT perfusion-guided versus time-guided mechanical recanalization in acute ischemic stroke patients
    Nohra Chalouhi
    Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, USA
    Clin Neurol Neurosurg 115:2471-5. 2013
    ..We compare the safety and efficacy of CT perfusion (CTP)-guided to time-guided mechanical recanalization in acute ischemic stroke (AIS) patients...
  60. doi request reprint Endoscopic endonasal compared with microscopic transsphenoidal and open transcranial resection of giant pituitary adenomas
    Ricardo J Komotar
    Department of Neurological Surgery, Miami University, Miami, FL, USA
    Pituitary 15:150-9. 2012
    ..CSF leak, which is a major limitation of the endonasal approach, may be avoided using meticulous multi-layer closure and vascularised nasoseptal flaps...
  61. doi request reprint Use of the histological pseudocapsule in surgery for Cushing disease: rapid postoperative cortisol decline predicting complete tumor resection
    Stephen J Monteith
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, VA, USA
    J Neurosurg 116:721-7. 2012
    ..Furthermore, the relevance of the rate of cortisol drop immediately after surgery has not been investigated...
  62. doi request reprint The endoscope-assisted ventral approach compared with open microscope-assisted surgery for clival chordomas
    Ricardo J Komotar
    Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    World Neurosurg 76:318-27; discussion 259-62. 2011
    ..We conducted a systematic review of case series and case reports in hope of furthering our understanding of the role of endoscopy in the management of these difficult cranial base lesions...
  63. doi request reprint Optimal surgical treatment for moyamoya disease in adults: direct versus indirect bypass
    Robert M Starke
    Department of Neurosurgery, Columbia University, New York, New York 10032, USA
    Neurosurg Focus 26:E8. 2009
    ..In this article the authors review the literature concerning the optimal surgical treatment of adult patients with moyamoya disease...
  64. doi request reprint Elevated troponin levels are predictive of mortality in surgical intracerebral hemorrhage patients
    Matthew C Garrett
    Department of Neurosurgery, Columbia University, Room 431, 710 West 168th Street, New York, NY 10032, USA
    Neurocrit Care 12:199-203. 2010
    ..To this end, we investigated whether troponin levels were an independent predictor of in-hospital mortality from all causes in surgically treated ICH patients...
  65. doi request reprint Predictors of seizure onset after intracerebral hemorrhage and the role of long-term antiepileptic therapy
    Matthew C Garrett
    Department of Neurosurgery, Columbia University, New York, NY 10032, USA
    J Crit Care 24:335-9. 2009
    ..We investigated predictors of early- and late-onset seizures after evacuation of intracerebral hemorrhage (ICH) in an attempt to guide antiepileptic drug management in this patient population...
  66. doi request reprint Impact of temozolomide chemotherapy on seizure frequency in patients with low-grade gliomas
    Jonathan H Sherman
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
    J Neurosurg 114:1617-21. 2011
    ..The oral alkylating agent temozolomide has emerged as a potential initial treatment option for LGG. A few reports suggest an association between temozolomide and reduced seizure frequency in patients with intractable epilepsy...
  67. doi request reprint Prophylactic antiepileptic drug therapy in patients undergoing supratentorial meningioma resection: a systematic analysis of efficacy
    Ricardo J Komotar
    Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Neurosurg 115:483-90. 2011
    ....
  68. pmc Endothelial nitric oxide synthase gene single-nucleotide polymorphism predicts cerebral vasospasm after aneurysmal subarachnoid hemorrhage
    Robert M Starke
    Department of Neurological Surgery, Columbia University, New York, New York, USA
    J Cereb Blood Flow Metab 28:1204-11. 2008
    ..Presence of this genotype may allow the identification of individuals at high risk for post-aSAH vasospasm and lead to early treatment and improved outcome...
  69. doi request reprint Gamma Knife radiosurgery for the management of nonfunctioning pituitary adenomas: a multicenter study
    Jason P Sheehan
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, VA, USA
    J Neurosurg 119:446-56. 2013
    ..Stereotactic radiosurgery has come to play an important role in the management of patients with nonfunctioning pituitary adenomas. This study examines the outcomes after radiosurgery in a large, multicenter patient population...
  70. doi request reprint The extracranial-intracranial bypass trial: implications for future investigations
    Matthew C Garrett
    Department of Neurosurgery, Columbia University, New York, New York 10032, USA
    Neurosurg Focus 24:E4. 2008
    ....
  71. doi request reprint Gamma knife radiosurgery for intracranial hemangioblastomas--outcome at 3 years
    Faisal T Sayer
    Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA
    World Neurosurg 75:99-105; discussion 45-8. 2011
    ..To define the role of Gamma Knife radiosurgery (GKRS) for the treatment of patients with hemangioblastomas...
  72. pmc Cerebral blood flow dynamics and head-of-bed changes in the setting of subarachnoid hemorrhage
    David K Kung
    Department of Neurosurgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, JCP 1616, Iowa City, IA 52242, USA
    Biomed Res Int 2013:640638. 2013
    ..Changing HOB position in the setting of SAH did not significantly affect cerebral or regional blood flow. These data suggest that early mobilization should be considered given the detrimental effects of prolonged bed rest...
  73. doi request reprint The role of radiosurgery in the management of WHO Grade II and III intracranial meningiomas
    Dale Ding
    Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia
    Neurosurg Focus 35:E16. 2013
    ..The timing and benefit of postoperative fractionated external beam radiation therapy and stereotactic radiosurgery remain controversial. The authors review the stereotactic radiosurgery outcomes for Grade II and III meningiomas...
  74. doi request reprint Moyamoya disorder in the United States
    Robert M Starke
    Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA
    Neurosurgery 71:93-9. 2012
    ..Studies have provided evidence that moyamoya disease in the United States may exhibit a different phenotype...
  75. ncbi request reprint Resuscitation and critical care of poor-grade subarachnoid hemorrhage
    Ricardo J Komotar
    Department of Neurological Surgery, Columbia University, New York, New York 10032, USA
    Neurosurgery 64:397-410; discussion 410-1. 2009
    ....
  76. doi request reprint Antifibrinolytic therapy to prevent early rebleeding after subarachnoid hemorrhage
    Mark Chwajol
    Department of Neurosurgery, Albert Einstein College of Medicine, Bronx, NY, USA
    Neurocrit Care 8:418-26. 2008
    ..Additional randomized clinical trials are necessary to determine whether this management strategy is effective...
  77. doi request reprint Is packing density important in stent-assisted coiling?
    Nohra Chalouhi
    Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania 19107, USA
    Neurosurgery 71:381-6; discussion 386-7. 2012
    ....
  78. doi request reprint Radiation therapy and stereotactic radiosurgery for the treatment of Cushing's disease: an evidence-based review
    Robert M Starke
    Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
    Curr Opin Endocrinol Diabetes Obes 17:356-64. 2010
    ..g. maximal dose, tumor margin dose), length of follow-up, tumor-control rate, complications, rate of hormone normalization, newly onset loss of pituitary function, and method used to assess endocrine remission...
  79. doi request reprint Endoscopic transsphenoidal surgery for acromegaly: remission using modern criteria, complications, and predictors of outcome
    John A Jane
    Departments of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia 22908 0711, USA
    J Clin Endocrinol Metab 96:2732-40. 2011
    ..Despite the growing application of endoscopic transsphenoidal surgery (ETSS), outcomes for GH adenomas are not clearly defined...
  80. ncbi request reprint Pupillary reactivity upon hospital admission predicts long-term outcome in poor grade aneurysmal subarachnoid hemorrhage patients
    William J Mack
    Department of Neurosurgery, Columbia University, 710 West 168th Street, Room 431, New York, NY 10032, USA
    Neurocrit Care 8:374-9. 2008
    ..More accurate and predictive methods are needed to decide when aggressive therapy is warranted...
  81. pmc Gamma knife radiosurgery of meningiomas involving the foramen magnum
    Robert M Starke
    Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA
    J Craniovertebr Junction Spine 1:23-8. 2010
    ..For some patients, stereotactic radiosurgery may be used as the primary treatment modality. We evaluatedthe long-term outcome of Gamma Knife radiosurgery (GKRS) for the treatment of patientswith a foramen magnum meningioma...
  82. doi request reprint Brain magnetic resonance imaging scans for asymptomatic patients: role in medical screening
    Ricardo J Komotar
    Department of Neurological Surgery, Columbia University, 710 W 168th St, Room 431, New York, NY 10032, USA
    Mayo Clin Proc 83:563-5. 2008
  83. doi request reprint In-training factors predictive of choosing and sustaining a productive academic career path in neurological surgery
    R Webster Crowley
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
    Neurosurgery 70:1024-32. 2012
    ..Factors during neurosurgical residency that are predictive of an academic career path and promotion have not been defined...
  84. doi request reprint Standards for reporting randomized controlled trials in neurosurgery
    Erin N Kiehna
    Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia, USA
    J Neurosurg 114:280-5. 2011
    ..The purpose of this study is to evaluate the quality and reporting of randomized controlled trials (RCTs) in neurosurgery and the factors that may affect the quality of reported trials...
  85. doi request reprint MR imaging characteristics of oligodendroglial tumors with assessment of 1p/19q deletion status
    Jonathan H Sherman
    Department of Neurological Surgery, University of Virginia, P O Box 800212, Health Sciences Center, Charlottesville, VA 22908, USA
    Acta Neurochir (Wien) 152:1827-34. 2010
    ..MR imaging can be used to help differentiate between low- and high-grade tumors. We hypothesize that certain MR imaging characteristics can be used to differentiate between patients with and without 1p and 19q deletion...
  86. doi request reprint A mouse model of intracerebral hemorrhage using autologous blood infusion
    Michal A Rynkowski
    Department of Neurological Surgery, Columbia University, 710 West 168th Street, New York, New York 10032, USA
    Nat Protoc 3:122-8. 2008
    ..We believe that our model will serve as an ideal paradigm for investigating the complex pathophysiology of hemorrhagic stroke. The protocol for establishing this model takes about 2 h...