Kimber L Stanhope

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Adverse metabolic effects of dietary fructose: results from the recent epidemiological, clinical, and mechanistic studies
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California 95616, USA
    Curr Opin Lipidol 24:198-206. 2013
  2. doi request reprint Role of fructose-containing sugars in the epidemics of obesity and metabolic syndrome
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA
    Annu Rev Med 63:329-43. 2012
  3. pmc Metabolic responses to prolonged consumption of glucose- and fructose-sweetened beverages are not associated with postprandial or 24-h glucose and insulin excursions
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, School of Medicine, University of California, Davis, CA 95616, USA
    Am J Clin Nutr 94:112-9. 2011
  4. pmc Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    J Clin Endocrinol Metab 96:E1596-605. 2011
  5. pmc Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
    Kimber L Stanhope
    Department of Molecular Biosciences, UCD, Davis, California 95616, USA
    J Clin Invest 119:1322-34. 2009
  6. pmc Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, Davis, CA 95616 8669, USA
    Am J Clin Nutr 87:1194-203. 2008
  7. pmc Dietary fructose accelerates the development of diabetes in UCD-T2DM rats: amelioration by the antioxidant, alpha-lipoic acid
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, One Shields Ave, Davis, CA 95616, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1343-50. 2010
  8. pmc Circulating concentrations of monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, and soluble leukocyte adhesion molecule-1 in overweight/obese men and women consuming fructose- or glucose-sweetened beverages for 10 weeks
    Chad L Cox
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    J Clin Endocrinol Metab 96:E2034-8. 2011
  9. pmc Chronic administration of the glucagon-like peptide-1 analog, liraglutide, delays the onset of diabetes and lowers triglycerides in UCD-T2DM rats
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, USA
    Diabetes 59:2653-61. 2010
  10. pmc Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women
    Michael M Swarbrick
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Br J Nutr 100:947-52. 2008

Collaborators

Detail Information

Publications30

  1. doi request reprint Adverse metabolic effects of dietary fructose: results from the recent epidemiological, clinical, and mechanistic studies
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California 95616, USA
    Curr Opin Lipidol 24:198-206. 2013
    ..The effects of dietary sugar on risk factors and the processes associated with metabolic disease remain a controversial topic, with recent reviews of the available evidence arriving at widely discrepant conclusions...
  2. doi request reprint Role of fructose-containing sugars in the epidemics of obesity and metabolic syndrome
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA
    Annu Rev Med 63:329-43. 2012
    ....
  3. pmc Metabolic responses to prolonged consumption of glucose- and fructose-sweetened beverages are not associated with postprandial or 24-h glucose and insulin excursions
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, School of Medicine, University of California, Davis, CA 95616, USA
    Am J Clin Nutr 94:112-9. 2011
    ..It has been proposed that adverse metabolic effects of chronic consumption of sugar-sweetened beverages are a consequence of increased circulating glucose and insulin excursions, ie, dietary glycemic index (GI)...
  4. pmc Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    J Clin Endocrinol Metab 96:E1596-605. 2011
    ....
  5. pmc Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
    Kimber L Stanhope
    Department of Molecular Biosciences, UCD, Davis, California 95616, USA
    J Clin Invest 119:1322-34. 2009
    ..These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults...
  6. pmc Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, Davis, CA 95616 8669, USA
    Am J Clin Nutr 87:1194-203. 2008
    ..However, pure fructose and glucose are not commonly used as sweeteners. High-fructose corn syrup (HFCS) has replaced sucrose as the predominant sweetener in beverages in the United States...
  7. pmc Dietary fructose accelerates the development of diabetes in UCD-T2DM rats: amelioration by the antioxidant, alpha-lipoic acid
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, One Shields Ave, Davis, CA 95616, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1343-50. 2010
    ..In conclusion, dietary fructose accelerates the onset of T2DM in UCD-T2DM rats, and LA ameliorates the effects of fructose by improving glucose homeostasis, possibly by preserving beta-cell function...
  8. pmc Circulating concentrations of monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, and soluble leukocyte adhesion molecule-1 in overweight/obese men and women consuming fructose- or glucose-sweetened beverages for 10 weeks
    Chad L Cox
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    J Clin Endocrinol Metab 96:E2034-8. 2011
    ..Data describing the effects of fructose consumption on circulating levels of proinflammatory and prothrombotic markers in humans are unavailable...
  9. pmc Chronic administration of the glucagon-like peptide-1 analog, liraglutide, delays the onset of diabetes and lowers triglycerides in UCD-T2DM rats
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, USA
    Diabetes 59:2653-61. 2010
    ..The efficacy of liraglutide, a human glucagon-like peptide-1 (GLP-1) analog, to prevent or delay diabetes in UCD-T2DM rats, a model of polygenic obese type 2 diabetes, was investigated...
  10. pmc Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women
    Michael M Swarbrick
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Br J Nutr 100:947-52. 2008
    ....
  11. pmc Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Dis Model Mech 6:443-56. 2013
    ..These results suggest that postoperative increases in circulating cholic acid concentration contribute to improvements in glucose homeostasis after IT surgery by ameliorating ER stress...
  12. pmc Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high-fructose corn syrup
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Am J Clin Nutr 88:1733S-1737S. 2008
    ....
  13. pmc Fructose consumption: considerations for future research on its effects on adipose distribution, lipid metabolism, and insulin sensitivity in humans
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Nutr 139:1236S-1241S. 2009
    ....
  14. pmc Development and characterization of a novel rat model of type 2 diabetes mellitus: the UC Davis type 2 diabetes mellitus UCD-T2DM rat
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Ave, Davis, CA 95616, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1782-93. 2008
    ..Thus diabetes in the UC Davis-T2DM rat is more similar to clinical T2DM in humans than in other existing rat models and provides a useful model for future studies of the pathophysiology, treatment, and prevention of T2DM...
  15. pmc Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys
    Michael M Swarbrick
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Endocrinology 150:1670-9. 2009
    ....
  16. pmc Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans
    Chad L Cox
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA
    Nutr Metab (Lond) 9:68. 2012
    ..abstract:..
  17. pmc Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 108:14670-5. 2011
    ....
  18. pmc Vertical sleeve gastrectomy improves glucose and lipid metabolism and delays diabetes onset in UCD-T2DM rats
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    Endocrinology 153:3620-32. 2012
    ..This is potentially mediated by increases of circulating bile acids, adiponectin, and nutrient-stimulated GLP-1 secretion and decreased circulating ghrelin concentrations...
  19. pmc Glucose sensing by gut endocrine cells and activation of the vagal afferent pathway is impaired in a rodent model of type 2 diabetes mellitus
    Jennifer Lee
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Am J Physiol Regul Integr Comp Physiol 302:R657-66. 2012
    ..01, P < 0.001, respectively) in RD and 3MD. These data suggest that glucose sensing in enteroendocrine and enterochromaffin cells and activation of neural pathways is markedly impaired in UCD-T2DM rats...
  20. pmc Ileal interposition surgery improves glucose and lipid metabolism and delays diabetes onset in the UCD-T2DM rat
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California 95616, USA
    Gastroenterology 138:2437-46, 2446.e1. 2010
    ..In this study we investigated effects of IT surgery on glucose tolerance and diabetes onset in UCD-T2DM (University of California at Davis type 2 diabetes mellitus) rats, a polygenic obese animal model of type 2 diabetes...
  21. doi request reprint Supplementation with EPA or fish oil for 11 months lowers circulating lipids, but does not delay the onset of diabetes in UC Davis-type 2 diabetes mellitus rats
    Bethany P Cummings
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Br J Nutr 104:1628-34. 2010
    ..01). In conclusion, EPA and fish oil supplementation lowers circulating lipid concentrations, but does not delay the onset of T2DM in UCD-T2DM rats...
  22. ncbi request reprint Fructose consumption and moderate zinc deficiency influence growth and adipocyte metabolism in young rats prone to adult-onset obesity
    Erin L Streiff
    Department of Nutrition, University of California at Davis, One Shields Avenue, Davis, CA, USA
    Biol Trace Elem Res 118:53-64. 2007
    ..The mesenteric adipocytes from the animals in the LZF group utilized more glucose. Thus, the addition of fructose to a LZ diet reduced energy intake and growth and altered adipocyte fuel metabolism in young growing rats...
  23. pmc Metabolic and endocrine profiles in response to systemic infusion of fructose and glucose in rhesus macaques
    Sean H Adams
    US Department of Agriculture Agricultural Research Service Western Human Nutrition Research Center, University of California, Davis, Davis, California 95616, USA
    Endocrinology 149:3002-8. 2008
    ..e. limited post-fructose insulin excursions and/or hexose-specific differences in adipocyte metabolism) are likely to underlie disparate effects of fructose and glucose to increase circulating leptin concentrations...
  24. ncbi request reprint Effects of inhibiting transcription and protein synthesis on basal and insulin-stimulated leptin gene expression and leptin secretion in cultured rat adipocytes
    Maria J Moreno-Aliaga
    Department of Nutrition, University of California, Davis, One Shields Ave, Davis, CA 95616, USA
    Biochem Biophys Res Commun 307:907-14. 2003
    ..01) during the first 4 h of treatment and at all later time points, which indicate that de novo protein synthesis is required for insulin-mediated glucose metabolism to increase leptin secretion...
  25. ncbi request reprint Administration of Lispro insulin with meals improves glycemic control, increases circulating leptin, and suppresses ghrelin, compared with regular/NPH insulin in female patients with type 1 diabetes
    Steven C Griffen
    Medical Center, Patient Support and Services Building Suite G 400, University of California Davis, 4150 V Street, Sacramento, CA 95817, USA
    J Clin Endocrinol Metab 91:485-91. 2006
    ..Exogenous insulin administration often poorly reproduces normal insulin patterns and may less effectively regulate leptin and ghrelin, two hormones involved in the control of appetite and adiposity...
  26. pmc Fructose consumption: recent results and their potential implications
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Ann N Y Acad Sci 1190:15-24. 2010
    ....
  27. ncbi request reprint Evidence that tumor necrosis factor-alpha-induced hyperinsulinemia prevents decreases of circulating leptin during fasting in rats
    Edward A Medina
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis 95616, USA
    Metabolism 51:1104-10. 2002
    ..Elevated leptin levels may in turn contribute to the effect of TNF-alpha to decrease food intake...
  28. doi request reprint Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Curr Opin Lipidol 19:16-24. 2008
    ..From these results and a review of the current literature, we present two potential sequences of events by which fructose consumption may contribute to metabolic syndrome...
  29. pmc On-chip phenotypic analysis of inflammatory monocytes in atherogenesis and myocardial infarction
    Greg A Foster
    Departments of Biomedical Engineering and Nutrition, and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616
    Proc Natl Acad Sci U S A 110:13944-9. 2013
    ..These experiments reveal that CD11c/CD18 is an inducible integrin whose expression correlates with a monocyte inflammatory state in subjects at risk for atherogenesis and in patients with myocardial infarction. ..
  30. pmc Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases
    Christine Beeton
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 103:17414-9. 2006
    ..Repeated dosing with Kv1.3 inhibitors in rats has not revealed systemic toxicity. Further development of Kv1.3 blockers for autoimmune disease therapy is warranted...