Research Topics
| Kimber L StanhopeSummaryAffiliation: University of California Country: USA Publications
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Publications
Role of fructose-containing sugars in the epidemics of obesity and metabolic syndromeKimber L Stanhope
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA
Annu Rev Med 63:329-43. 2012....
Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and womenKimber L Stanhope
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
J Clin Endocrinol Metab 96:E1596-605. 2011....- Metabolic responses to prolonged consumption of glucose- and fructose-sweetened beverages are not associated with postprandial or 24-h glucose and insulin excursionsKimber L Stanhope
Department of Molecular Biosciences, School of Veterinary Medicine, School of Medicine, University of California, Davis, CA 95616, USA
Am J Clin Nutr 94:112-9. 2011..It has been proposed that adverse metabolic effects of chronic consumption of sugar-sweetened beverages are a consequence of increased circulating glucose and insulin excursions, ie, dietary glycemic index (GI)... - Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humansKimber L Stanhope
Department of Molecular Biosciences, UCD, Davis, California 95616, USA
J Clin Invest 119:1322-34. 2009..These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults... - Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with mealsKimber L Stanhope
Department of Molecular Biosciences, School of Veterinary Medicine, Davis, CA 95616 8669, USA
Am J Clin Nutr 87:1194-203. 2008..However, pure fructose and glucose are not commonly used as sweeteners. High-fructose corn syrup (HFCS) has replaced sucrose as the predominant sweetener in beverages in the United States... - Dietary fructose accelerates the development of diabetes in UCD-T2DM rats: amelioration by the antioxidant, alpha-lipoic acidBethany P Cummings
Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, One Shields Ave, Davis, CA 95616, USA
Am J Physiol Regul Integr Comp Physiol 298:R1343-50. 2010..In conclusion, dietary fructose accelerates the onset of T2DM in UCD-T2DM rats, and LA ameliorates the effects of fructose by improving glucose homeostasis, possibly by preserving beta-cell function... - Circulating concentrations of monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, and soluble leukocyte adhesion molecule-1 in overweight/obese men and women consuming fructose- or glucose-sweetened beverages for 10 weeksChad L Cox
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
J Clin Endocrinol Metab 96:E2034-8. 2011..Data describing the effects of fructose consumption on circulating levels of proinflammatory and prothrombotic markers in humans are unavailable... - Chronic administration of the glucagon-like peptide-1 analog, liraglutide, delays the onset of diabetes and lowers triglycerides in UCD-T2DM ratsBethany P Cummings
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California, USA
Diabetes 59:2653-61. 2010..The efficacy of liraglutide, a human glucagon-like peptide-1 (GLP-1) analog, to prevent or delay diabetes in UCD-T2DM rats, a model of polygenic obese type 2 diabetes, was investigated... - Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese womenMichael M Swarbrick
Department of Nutrition, University of California, Davis, CA 95616, USA
Br J Nutr 100:947-52. 2008.... - Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high-fructose corn syrupKimber L Stanhope
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Am J Clin Nutr 88:1733S-1737S. 2008.... - Fructose consumption: considerations for future research on its effects on adipose distribution, lipid metabolism, and insulin sensitivity in humansKimber L Stanhope
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
J Nutr 139:1236S-1241S. 2009.... - Development and characterization of a novel rat model of type 2 diabetes mellitus: the UC Davis type 2 diabetes mellitus UCD-T2DM ratBethany P Cummings
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Ave, Davis, CA 95616, USA
Am J Physiol Regul Integr Comp Physiol 295:R1782-93. 2008..Thus diabetes in the UC Davis-T2DM rat is more similar to clinical T2DM in humans than in other existing rat models and provides a useful model for future studies of the pathophysiology, treatment, and prevention of T2DM... - Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeysMichael M Swarbrick
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
Endocrinology 150:1670-9. 2009.... - Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humansChad L Cox
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA
Nutr Metab (Lond) 9:68. 2012..abstract:.. - Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM ratsBethany P Cummings
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 108:14670-5. 2011.... - Vertical sleeve gastrectomy improves glucose and lipid metabolism and delays diabetes onset in UCD-T2DM ratsBethany P Cummings
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
Endocrinology 153:3620-32. 2012..This is potentially mediated by increases of circulating bile acids, adiponectin, and nutrient-stimulated GLP-1 secretion and decreased circulating ghrelin concentrations... - Glucose sensing by gut endocrine cells and activation of the vagal afferent pathway is impaired in a rodent model of type 2 diabetes mellitusJennifer Lee
Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
Am J Physiol Regul Integr Comp Physiol 302:R657-66. 2012..01, P < 0.001, respectively) in RD and 3MD. These data suggest that glucose sensing in enteroendocrine and enterochromaffin cells and activation of neural pathways is markedly impaired in UCD-T2DM rats... - Ileal interposition surgery improves glucose and lipid metabolism and delays diabetes onset in the UCD-T2DM ratBethany P Cummings
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, California 95616, USA
Gastroenterology 138:2437-46, 2446.e1. 2010..In this study we investigated effects of IT surgery on glucose tolerance and diabetes onset in UCD-T2DM (University of California at Davis type 2 diabetes mellitus) rats, a polygenic obese animal model of type 2 diabetes... - Supplementation with EPA or fish oil for 11 months lowers circulating lipids, but does not delay the onset of diabetes in UC Davis-type 2 diabetes mellitus ratsBethany P Cummings
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Br J Nutr 104:1628-34. 2010..01). In conclusion, EPA and fish oil supplementation lowers circulating lipid concentrations, but does not delay the onset of T2DM in UCD-T2DM rats... 
Fructose consumption and moderate zinc deficiency influence growth and adipocyte metabolism in young rats prone to adult-onset obesityErin L Streiff
Department of Nutrition, University of California at Davis, One Shields Avenue, Davis, CA, USA
Biol Trace Elem Res 118:53-64. 2007..The mesenteric adipocytes from the animals in the LZF group utilized more glucose. Thus, the addition of fructose to a LZ diet reduced energy intake and growth and altered adipocyte fuel metabolism in young growing rats...- Metabolic and endocrine profiles in response to systemic infusion of fructose and glucose in rhesus macaquesSean H Adams
US Department of Agriculture Agricultural Research Service Western Human Nutrition Research Center, University of California, Davis, Davis, California 95616, USA
Endocrinology 149:3002-8. 2008..e. limited post-fructose insulin excursions and/or hexose-specific differences in adipocyte metabolism) are likely to underlie disparate effects of fructose and glucose to increase circulating leptin concentrations... - Effects of inhibiting transcription and protein synthesis on basal and insulin-stimulated leptin gene expression and leptin secretion in cultured rat adipocytesMaria J Moreno-Aliaga
Department of Nutrition, University of California, Davis, One Shields Ave, Davis, CA 95616, USA
Biochem Biophys Res Commun 307:907-14. 2003..01) during the first 4 h of treatment and at all later time points, which indicate that de novo protein synthesis is required for insulin-mediated glucose metabolism to increase leptin secretion... - Administration of Lispro insulin with meals improves glycemic control, increases circulating leptin, and suppresses ghrelin, compared with regular/NPH insulin in female patients with type 1 diabetesSteven C Griffen
Medical Center, Patient Support and Services Building Suite G 400, University of California Davis, 4150 V Street, Sacramento, CA 95817, USA
J Clin Endocrinol Metab 91:485-91. 2006..Exogenous insulin administration often poorly reproduces normal insulin patterns and may less effectively regulate leptin and ghrelin, two hormones involved in the control of appetite and adiposity... - Fructose consumption: recent results and their potential implicationsKimber L Stanhope
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
Ann N Y Acad Sci 1190:15-24. 2010.... - Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistanceKimber L Stanhope
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
Curr Opin Lipidol 19:16-24. 2008..From these results and a review of the current literature, we present two potential sequences of events by which fructose consumption may contribute to metabolic syndrome... - Evidence that tumor necrosis factor-alpha-induced hyperinsulinemia prevents decreases of circulating leptin during fasting in ratsEdward A Medina
Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis 95616, USA
Metabolism 51:1104-10. 2002..Elevated leptin levels may in turn contribute to the effect of TNF-alpha to decrease food intake... - Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseasesChristine Beeton
Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 103:17414-9. 2006..Repeated dosing with Kv1.3 inhibitors in rats has not revealed systemic toxicity. Further development of Kv1.3 blockers for autoimmune disease therapy is warranted...