Ben Z Stanger

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Platelets and tumor cells: a new form of border control
    Ben Z Stanger
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer Cell 24:9-11. 2013
  2. pmc Control of cell identity in pancreas development and regeneration
    Ben Z Stanger
    Division of Gastroenterology, Department of Medicine, Department of Cell and Developmental Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Gastroenterology 144:1170-9. 2013
  3. pmc Quit your YAPing: a new target for cancer therapy
    Ben Z Stanger
    Gastroenterology Division, Department of Medicine, Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 26:1263-7. 2012
  4. pmc Robust cellular reprogramming occurs spontaneously during liver regeneration
    Kilangsungla Yanger
    Department of Medicine, Gastroenterology Division
    Genes Dev 27:719-24. 2013
  5. doi request reprint Molecular mechanisms of liver and bile duct development
    Yiwei Zong
    Department of Medicine and Cell and Developmental Biology, Abramson Family Cancer Research Institute, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Wiley Interdiscip Rev Dev Biol 1:643-55. 2012
  6. pmc The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis
    Maximilian Reichert
    Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genes Dev 27:288-300. 2013
  7. pmc Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer
    Lauren J Bayne
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cancer Cell 21:822-35. 2012
  8. pmc LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7
    Blair B Madison
    Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 27:2233-45. 2013
  9. ncbi request reprint Hippo pathway activity influences liver cell fate
    Dean Yimlamai
    The Stem Cell Program, Boston Children s Hospital, Boston, MA 02115, USA Division of Gastroenterology and Nutrition, Department of Medicine, Boston Children s Hospital, Boston, MA 02115, USA
    Cell 157:1324-38. 2014
  10. pmc An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression
    Jungsun Kim
    Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 5157, USA
    Cell Rep 3:2088-99. 2013

Collaborators

Detail Information

Publications27

  1. pmc Platelets and tumor cells: a new form of border control
    Ben Z Stanger
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer Cell 24:9-11. 2013
    ..In this issue of Cancer Cell, Schumacher and colleagues suggest that ATP released from tumor-associated platelets in the blood facilitates tumor metastasis by relaxing endothelial barrier function. ..
  2. pmc Control of cell identity in pancreas development and regeneration
    Ben Z Stanger
    Division of Gastroenterology, Department of Medicine, Department of Cell and Developmental Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Gastroenterology 144:1170-9. 2013
    ..We review different aspects of cell identity in the pancreas, discussing how cells achieve their identity during embryonic development and maturation, and how this identity remains plastic, even in the adult pancreas...
  3. pmc Quit your YAPing: a new target for cancer therapy
    Ben Z Stanger
    Gastroenterology Division, Department of Medicine, Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 26:1263-7. 2012
    ..As this intervention impedes tumorigenesis in the liver with no apparent effect on normal liver homeostasis, the work paves the way for the development of new strategies to target this pervasive oncogenic pathway...
  4. pmc Robust cellular reprogramming occurs spontaneously during liver regeneration
    Kilangsungla Yanger
    Department of Medicine, Gastroenterology Division
    Genes Dev 27:719-24. 2013
    ..These results provide direct evidence that mammalian regeneration prompts extensive and dramatic changes in cellular identity under injury conditions...
  5. doi request reprint Molecular mechanisms of liver and bile duct development
    Yiwei Zong
    Department of Medicine and Cell and Developmental Biology, Abramson Family Cancer Research Institute, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Wiley Interdiscip Rev Dev Biol 1:643-55. 2012
    ..This review highlights some of the best understood steps of liver development, summarizing progress in our understanding of the molecular mechanisms that underlie differentiation, morphogenesis, and functional integration of the liver...
  6. pmc The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis
    Maximilian Reichert
    Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genes Dev 27:288-300. 2013
    ..Furthermore, our data provide a possible explanation of why pancreatic cancer is skewed toward a ductal fate...
  7. pmc Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer
    Lauren J Bayne
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cancer Cell 21:822-35. 2012
    ..In humans, PDA tumor cells prominently expressed GM-CSF in vivo. Thus, tumor-derived GM-CSF is an important regulator of inflammation and immune suppression within the tumor microenvironment...
  8. pmc LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7
    Blair B Madison
    Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 27:2233-45. 2013
    ..Let-7-dependent effects of LIN28B may supersede Let-7-independent effects on intestinal tissue growth. In summary, LIN28B can definitively act as an oncogene in the absence of canonical genetic alterations. ..
  9. ncbi request reprint Hippo pathway activity influences liver cell fate
    Dean Yimlamai
    The Stem Cell Program, Boston Children s Hospital, Boston, MA 02115, USA Division of Gastroenterology and Nutrition, Department of Medicine, Boston Children s Hospital, Boston, MA 02115, USA
    Cell 157:1324-38. 2014
    ....
  10. pmc An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression
    Jungsun Kim
    Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 5157, USA
    Cell Rep 3:2088-99. 2013
    ..Thus, rare events allow iPSC technology to provide a live human cell model of early pancreatic cancer and insights into disease progression. ..
  11. ncbi request reprint Detection of circulating pancreas epithelial cells in patients with pancreatic cystic lesions
    Andrew D Rhim
    Division of Gastroenterology, Department of Internal Medicine, Pancreatic Cancer Center, University of Michigan Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan Gastroenterology Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
    Gastroenterology 146:647-51. 2014
    ..These findings indicate that cancer cells are present in the circulation of patients before tumors are detected, which might be used in risk assessment. ..
  12. pmc Molecular mechanisms of bile duct development
    Yiwei Zong
    Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA
    Int J Biochem Cell Biol 43:257-64. 2011
    ..Insights gained from studies of the molecular mechanisms of bile duct development have the potential to reveal novel mechanisms of differentiation and morphogenesis in addition to potential targets for therapy of bile duct disorders...
  13. pmc Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance
    Yaqing Zhang
    Authors Affiliations Departments of Surgery, Pathology, and Cell and Developmental Biology, Department of Internal Medicine Gastroenterology, Michigan Center for Translational Pathology, Program in Cellular and Molecular Biology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan Vascular Biology Program, Department of Surgery, Karp Family Research Laboratories, Children s Hospital, Boston, Massachusetts Gastroenterology Division, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Department of Pharmacology, and University of Malaya Cancer Research Institute, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Cancer Res 73:6359-74. 2013
    ..Thus, IL-6 emerges as a key player at all stages of pancreatic carcinogenesis and a potential therapeutic target...
  14. pmc Pdx1 maintains β cell identity and function by repressing an α cell program
    Tao Gao
    Gastroenterology Division, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA 19104, USA Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Metab 19:259-71. 2014
    ..We discuss the significance of these findings in the context of the emerging notion that loss of β cell identity contributes to the pathogenesis of type 2 diabetes. ..
  15. pmc EMT and dissemination precede pancreatic tumor formation
    Andrew D Rhim
    Gastroenterology Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell 148:349-61. 2012
    ..These results provide insight into the earliest events of cellular invasion in situ and suggest that inflammation enhances cancer progression in part by facilitating EMT and entry into the circulation...
  16. pmc Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis
    Andrew S Chu
    Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Hepatology 53:1685-95. 2011
    ..In no case did we find evidence of colocalization of YFP with the mesenchymal markers S100A4, vimentin, α-SMA, or procollagen 1α2, although these proteins were abundant in the peribiliary regions...
  17. pmc Antiviral autophagy restrictsRift Valley fever virus infection and is conserved from flies to mammals
    Ryan H Moy
    Department of Microbiology, Penn Genome Frontiers Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 40:51-65. 2014
    ..Thus, autophagy modulation might be an effective strategy for treating RVFV infection, which lacks approved vaccines and therapeutics. ..
  18. pmc Hippo signaling regulates differentiation and maintenance in the exocrine pancreas
    Tao Gao
    Gastroenterology Division, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 144:1543-53, 1553.e1. 2013
    ..In this study, we investigated the role of the core Hippo kinases-Mst1 and Mst2-in pancreatic development and homeostasis...
  19. pmc Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma
    Linda Hanlon
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, 3601Spruce Street, Philadelphia, PA 19104, USA
    Cancer Res 70:4280-6. 2010
    ..Unexpectedly, the loss of Notch1 in this model resulted in increased tumor incidence and progression, implying that Notch1 can function as a tumor suppressor gene in PDAC...
  20. ncbi request reprint Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
    Andrew D Rhim
    Division of Gastroenterology, Department of Internal Medicine and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA Gastroenterology Division, Department of Medicine and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer Cell 25:735-47. 2014
    ..Together, these data demonstrate that some components of the tumor stroma can act to restrain tumor growth...
  21. pmc Cytokinesis defines a spatial landmark for hepatocyte polarization and apical lumen formation
    Ting Wang
    Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Sci 127:2483-92. 2014
    ..These findings define a novel mechanism for cytokinesis-linked polarization and tube formation, which appears to be broadly conserved in diverse cell types. ..
  22. ncbi request reprint De novo formation of insulin-producing "neo-β cell islets" from intestinal crypts
    Yi Ju Chen
    Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Rep 6:1046-58. 2014
    ..Our results thus demonstrate that the intestine is an accessible and abundant source of functional insulin-producing cells. ..
  23. pmc Function of GATA factors in the adult mouse liver
    Rena Zheng
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America Division of Hematology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e83723. 2013
    ..This points to the presence of an unusually robust transcriptional network in adult hepatocytes that ensures the maintenance of liver function. ..
  24. ncbi request reprint Organ size determination and the limits of regulation
    Ben Z Stanger
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cell Cycle 7:318-24. 2008
    ..This review outlines our current understanding of the field and highlights several important outstanding questions...
  25. pmc Notch signaling controls liver development by regulating biliary differentiation
    Yiwei Zong
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 136:1727-39. 2009
    ..These results reconcile previous conflicting reports about the role of Notch during liver development and suggest that Notch acts by coordinating biliary differentiation and morphogenesis...
  26. pmc Molecular biology of pancreatic ductal adenocarcinoma progression: aberrant activation of developmental pathways
    Andrew D Rhim
    Gastroenterology Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Prog Mol Biol Transl Sci 97:41-78. 2010
    ....
  27. ncbi request reprint The fringe molecules induce endocrine differentiation in embryonic endoderm by activating cMyt1/cMyt3
    Yanwen Xu
    Vanderbilt University, Department of Cell and Developmental Biology, Nashville, TN 37232, USA
    Dev Biol 297:340-9. 2006
    ..These results suggest that Mfng-mediated repression of Notch signaling could serve as a trigger for endocrine islet differentiation...