Nicholas M Stamatos

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Polysialylated neuropilin-2 is expressed on the surface of human dendritic cells and modulates dendritic cell-T lymphocyte interactions
    Sabrina Curreli
    Institute of Human Virology, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 282:30346-56. 2007
  2. ncbi request reprint Desialylation of glycoconjugates on the surface of monocytes activates the extracellular signal-related kinases ERK 1/2 and results in enhanced production of specific cytokines
    Nicholas M Stamatos
    Institute of Human Virology, Department of Medicine, University of Maryland Medical Center, University of Maryland, Baltimore, MD 21201, USA
    J Leukoc Biol 75:307-13. 2004
  3. ncbi request reprint Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages
    Nicholas M Stamatos
    Institute of Human Virology, University of Maryland, Baltimore, MD 21201, USA
    FEBS J 272:2545-56. 2005
  4. pmc LPS-induced cytokine production in human dendritic cells is regulated by sialidase activity
    Nicholas M Stamatos
    University of Maryland Medical Center, 725 West Lombard St, Baltimore, MD 21201, USA
    J Leukoc Biol 88:1227-39. 2010
  5. ncbi request reprint Sialidase expression in activated human T lymphocytes influences production of IFN-gamma
    Xinli Nan
    Institute of Human Biology, and Department of Medicine, University of Maryland Medical Center, 725 West Lombard Street, Baltimore, MD 21201, USA
    J Leukoc Biol 81:284-96. 2007
  6. pmc Expression of sialyltransferase activity on intact human neutrophils
    Salahaldin Rifat
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Leukoc Biol 84:1075-81. 2008
  7. ncbi request reprint Mobilization of neutrophil sialidase activity desialylates the pulmonary vascular endothelial surface and increases resting neutrophil adhesion to and migration across the endothelium
    Serhan Sakarya
    Department of Medicine, Division of Infectious Diseases, University of Maryland School of Medicine Baltimore, MD 21201, USA
    Glycobiology 14:481-94. 2004
  8. ncbi request reprint Toward a carbohydrate-based HIV-1 vaccine: synthesis and immunological studies of oligomannose-containing glycoconjugates
    Jiahong Ni
    Institute of Human Virology, University of Maryland Biotechnology Institute, University of Maryland, Baltimore, Maryland 21201, USA
    Bioconjug Chem 17:493-500. 2006
  9. ncbi request reprint Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments
    Feng Liang
    Sainte Justine Hospital and the Department of Pediatrics, University of Montreal, Montreal, Quebec H3T 1C5, Canada
    J Biol Chem 281:27526-38. 2006

Research Grants

  1. Role of Cellular Sialidase in Pathogenesis of HIV-1
    Nicholas Stamatos; Fiscal Year: 2004

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Polysialylated neuropilin-2 is expressed on the surface of human dendritic cells and modulates dendritic cell-T lymphocyte interactions
    Sabrina Curreli
    Institute of Human Virology, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 282:30346-56. 2007
    ..Thus, this newly recognized polysialylated protein on the surface of dendritic cells influences dendritic cell-T lymphocyte interactions through one or more of its distinct extracellular domains...
  2. ncbi request reprint Desialylation of glycoconjugates on the surface of monocytes activates the extracellular signal-related kinases ERK 1/2 and results in enhanced production of specific cytokines
    Nicholas M Stamatos
    Institute of Human Virology, Department of Medicine, University of Maryland Medical Center, University of Maryland, Baltimore, MD 21201, USA
    J Leukoc Biol 75:307-13. 2004
    ..These results suggest that changes in the sialic acid content of surface glycoconjugates influence the activation of monocytes...
  3. ncbi request reprint Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages
    Nicholas M Stamatos
    Institute of Human Virology, University of Maryland, Baltimore, MD 21201, USA
    FEBS J 272:2545-56. 2005
    ..Thus, the differentiation of monocytes into macrophages is associated with regulation of the expression of at least three distinct cellular sialidases, with specific up-regulation of the enzyme activity of only Neu1...
  4. pmc LPS-induced cytokine production in human dendritic cells is regulated by sialidase activity
    Nicholas M Stamatos
    University of Maryland Medical Center, 725 West Lombard St, Baltimore, MD 21201, USA
    J Leukoc Biol 88:1227-39. 2010
    ..We conclude that sialidase-mediated change in sialic acid content of specific cell surface glycoconjugates in DCs regulates LPS-induced cytokine production, thereby contributing to development of adaptive immune responses...
  5. ncbi request reprint Sialidase expression in activated human T lymphocytes influences production of IFN-gamma
    Xinli Nan
    Institute of Human Biology, and Department of Medicine, University of Maryland Medical Center, 725 West Lombard Street, Baltimore, MD 21201, USA
    J Leukoc Biol 81:284-96. 2007
    ..The down-regulation of IFN-gamma occurred at the transcriptional level. Thus, sialidase activity in activated T lymphocytes contributes to the hyposialylation of specific cell surface glycoconjugates and to the production of IFN-gamma...
  6. pmc Expression of sialyltransferase activity on intact human neutrophils
    Salahaldin Rifat
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Leukoc Biol 84:1075-81. 2008
    ..We conclude that intact PMNs express sialidase and ST activities that permit rapid modulation of their surface sialylation and their ability to adhere to and migrate across the endothelium...
  7. ncbi request reprint Mobilization of neutrophil sialidase activity desialylates the pulmonary vascular endothelial surface and increases resting neutrophil adhesion to and migration across the endothelium
    Serhan Sakarya
    Department of Medicine, Division of Infectious Diseases, University of Maryland School of Medicine Baltimore, MD 21201, USA
    Glycobiology 14:481-94. 2004
    ..The ability of activated PMNs, through endogenous sialidase activity, to render the EC surface hyperadherent for unstimulated PMNs may provide for rapid amplification of the PMN-mediated host response...
  8. ncbi request reprint Toward a carbohydrate-based HIV-1 vaccine: synthesis and immunological studies of oligomannose-containing glycoconjugates
    Jiahong Ni
    Institute of Human Virology, University of Maryland Biotechnology Institute, University of Maryland, Baltimore, Maryland 21201, USA
    Bioconjug Chem 17:493-500. 2006
    ..The anti-sera showed weak cross-reactivity to HIV-1 gp120...
  9. ncbi request reprint Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments
    Feng Liang
    Sainte Justine Hospital and the Department of Pediatrics, University of Montreal, Montreal, Quebec H3T 1C5, Canada
    J Biol Chem 281:27526-38. 2006
    ..Altogether our data suggest that the upregulation of the Neu1 expression is important for the primary function of macrophages and establish the link between Neu1 and the cellular immune response...

Research Grants1

  1. Role of Cellular Sialidase in Pathogenesis of HIV-1
    Nicholas Stamatos; Fiscal Year: 2004
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