Research Topics
Genomes and GenesSpecies | Michael StallingsSummaryAffiliation: University of Colorado Country: USA Publications
Research Grants
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Detail Information
Publications
The familial aggregation of depressive symptoms, antisocial behavior, and alcohol abuseM C Stallings
Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
Am J Med Genet 74:183-91. 1997..More important, correlations among the transmissible family factors for these psychiatric syndromes ranged from .58 to .73, suggesting substantial overlap among the underlying familial antecedents for these disorders...- A genome-wide search for quantitative trait Loci that influence antisocial drug dependence in adolescenceMichael C Stallings
Institute for Behavioral Genetics and Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, 80309 0444, USA
Arch Gen Psychiatry 62:1042-51. 2005..Previously we reported 2 chromosomal regions (3q24-3q25 and 9q34) likely to contain genes that influence substance dependence vulnerability (DV) in adolescence... - A genome-wide search for quantitative trait loci influencing substance dependence vulnerability in adolescenceMichael C Stallings
Institute for Behavioral Genetics, University of Colorado, Campus Box 447, Boulder, CO 80309 0447, USA
Drug Alcohol Depend 70:295-307. 2003..2. Multipoint mapping corroborated two locations and provided preliminary evidence for linkage to regions on chromosome 3q24-25 (near markers D3S1279 and D3S1614) and chromosome 9q34 (near markers D9S1826 and D9S1838)... - Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: failure to confirm in adolescent patientsSusan E Young
Institute for Behavioral Genetics, UCB 447, University of Colorado, Boulder, CO 80301, USA
Am J Psychiatry 163:1019-25. 2006.... - Relationships between personality and preferred substance and motivations for use among adolescent substance abusersJustin B Adams
Department of Psychology, University of Colorado, Boulder, Colorado 80309-0447, USA
Am J Drug Alcohol Abuse 29:691-712. 2003.... - Examining the heritability of a laboratory-based smoking endophenotype: initial results from an experimental twin studyLara A Ray
Department of Psychology and Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, United States of America
Twin Res Hum Genet 10:546-53. 2007..To the best of our knowledge, this is the first study to examine the genetic basis of a laboratory smoking endophenotype, in this case tension reduction after smoking. Implications for genetic association studies are discussed... - Common and specific genetic influences on aggressive and nonaggressive conduct disorder domainsHeather Gelhorn
Institute for Behavioral Genetics, University of Colorado, Boulder, 80309, USA
J Am Acad Child Adolesc Psychiatry 45:570-7. 2006..To explore the genetic and environmental influences on DSM-IV conduct disorder (CD) aggressive and nonaggressive subscales, taking into account age and sex differences... 
Item response theory analysis of DSM-IV cannabis abuse and dependence criteria in adolescentsChristie A Hartman
School of Medicine at the University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
J Am Acad Child Adolesc Psychiatry 47:165-73. 2008..different levels of severity of substance involvement, to what degree do each of the 11 abuse and dependence criteria assess adolescent cannabis problems, and do the DSM-IV items function similarly across different adolescent populations?..- Subjective effects to marijuana associated with marijuana use in community and clinical subjectsJoanna S Zeiger
Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, United States
Drug Alcohol Depend 109:161-6. 2010..e. subjective effects). We have examined subjective effects in adolescent, young adult community, and clinical populations to determine how patterns of use may be predicted by an individual's subjective experiences with the drug... - Ethnicity, body mass, and genome-wide dataJason D Boardman
Institute of Behavioral Science and University of Colorado Population Center, University of Colorado, Boulder, Colorado 80309 0483, USA
Biodemography Soc Biol 56:123-36. 2010..In this case, adjusting for genetic background has no bearing on the influence of self-identified ethnicity... - Bivariate analysis of disordered eating characteristics in adolescence and young adulthoodMelissa A Munn
Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado, USA
Int J Eat Disord 43:751-61. 2010..We examined the etiology of two disordered eating characteristics... - The family transmission of adolescent alcohol abuse and dependenceChristie A Hartman
University of Colorado Health Sciences Center, Division of Substance Dependence, 4200 East 9th Avenue, Box C 268 35, Denver, Colorado 80262, USA
J Stud Alcohol 67:657-64. 2006..This study examines the familial transmission of alcohol abuse and dependence to adolescents... - The role of conduct disorder in explaining the comorbidity between alcohol and illicit drug dependence in adolescenceTanya M M Button
Institute for Behavioral Genetics, Campus Box 447, University of Colorado, Boulder, CO 80309, USA
Drug Alcohol Depend 87:46-53. 2007..This paper describes the result of an investigation of the extent to which comorbid alcohol and illicit drug dependence in adolescents are explained by etiological factors in common with conduct disorder... - Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotineMarissa A Ehringer
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
Am J Med Genet B Neuropsychiatr Genet 144:596-604. 2007..This study provides the first evidence for association between the CHRNB2 gene and nicotine- and alcohol-related phenotypes, and suggests that polymorphisms in CHRNB2 may be important in mediating early responses to nicotine and alcohol... - Between- and within-family association test of the dopamine receptor D2 TaqIA polymorphism and alcohol abuse and dependence in a general population sample of adultsBrett C Haberstick
Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309 0447, USA
J Stud Alcohol Drugs 68:362-70. 2007..The mixed results of association between the DRD2 TaqIA polymorphism and alcohol-use disorders may be the result of differences in sample size, phenotype definition, heterogeneity of the samples, and genetic admixture... - The human protein kinase C gamma gene (PRKCG) as a susceptibility locus for behavioral disinhibitionIsabel R Schlaepfer
Institute for Behavioral Genetics, University of Colorado, Boulder, USA, and Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
Addict Biol 12:200-9. 2007..This study provides the first exploration of the PRKCG gene and its association with behavioral disinhibition and warrants further study in other larger population samples... - Delinquent peer affiliation and conduct problems: A twin studyTanya M M Button
Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
J Abnorm Psychol 116:554-64. 2007..The magnitude of the genetic variance of conduct problems was contextually dependent on levels of delinquent peer affiliation and was greater at higher levels of delinquent peer affiliation... - Common and drug-specific genetic influences on subjective effects to alcohol, tobacco and marijuana useBrett C Haberstick
Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA
Addiction 106:215-24. 2011..To examine variation in positive and negative subjective effects to alcohol, tobacco and marijuana and covariation between these three drugs and each effect... - The etiology of stability and change in religious values and religious attendanceTanya M M Button
Institute for Behavioral Genetics, University of Colorado at Boulder, 1480 30th Street, Boulder, CO 80309 0447, USA
Behav Genet 41:201-10. 2011.... 
DeFries-Fulker and Pearson-Aitken model-fitting analyses of reading performance data from selected and unselected twin pairsJesse L Hawke
Institute for Behavioral Genetics, University of Colorado, Boulder, 447 UCB, Boulder, CO 80309 0447, US
Behav Genet 38:101-7. 2008..However, the PA selection formula may be more readily generalized to the multivariate case...- Association of candidate genes with antisocial drug dependence in adolescentsRobin P Corley
Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
Drug Alcohol Depend 96:90-8. 2008..The custom-designed SNP chip served as an effective and flexible platform for rapid interrogation of a large number of plausible candidate genes... - Perceived peer delinquency and the genetic predisposition for substance dependence vulnerabilityTanya M M Button
Institute for Behavioral Genetics, Campus Box 447, University of Colorado, Boulder, CO 80309, United States
Drug Alcohol Depend 100:1-8. 2009..The magnitudes of both shared and non-shared environmental influences were negligible among those who perceived their peers to be least delinquent and were greater among those with higher levels of perceived peers' delinquency... - The moderating effect of religiosity on the genetic variance of problem alcohol useTanya M M Button
Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado 80309 0447, USA
Alcohol Clin Exp Res 34:1619-24. 2010..g., urbanicity, marital status, and religiosity). The aim of the current study was to identify whether religiosity moderated the genetic variance of problem alcohol use in men and women at two time points: adolescence and early adulthood... - Genetic and environmental vulnerabilities underlying adolescent substance use and problem use: general or specific?Susan E Young
Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80303, USA
Behav Genet 36:603-15. 2006..Our results suggest that tobacco, alcohol, and marijuana problem use are mediated by common genetic influences, but shared environmental influences may be more substance-specific for problem use... - Factor structure and concurrent validity of the Drug Use Screening Inventory in a community adolescent sampleElizabeth A Siewert
Institute of Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
Addict Behav 29:627-38. 2004..The resulting set of six subscales shows adequate internal consistency and provides an easily interpretable research tool for investigating etiological relationships between substance use problems and other risk behaviors... - The validity of the Neale and Kendler model-fitting approach in examining the etiology of comorbiditySoo Hyun Rhee
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
Behav Genet 34:251-65. 2004..As suggested by Neale and Kendler, the model-fitting approach can be applied to both unselected and selected data and to both twin and family data... - Genetic and environmental influences on substance initiation, use, and problem use in adolescentsSoo Hyun Rhee
Department of Psychology and the Institute for Behavioral Genetics, University of Colorado at Boulder, 90309, USA
Arch Gen Psychiatry 60:1256-64. 2003..We conducted a sibling/twin/adoption study of substance initiation, use, and problem use, estimating the relative contribution of genetic and environmental influences on these phenotypes in adolescents... - Investigating age differences in the genetic and environmental structure of the tridimensional personality questionnaire in later adulthoodNoa Heiman
Institute for Behavioral Genetics, University of Colorado, Boulder, USA
Behav Genet 33:171-80. 2003..For HA, RD, and PS there were no significant age-related differences in total variance. However, for NS we observed a decline in total phenotypic variance across age cohorts... - Sibling-based association analyses of the serotonin transporter polymorphism and internalizing behavior problems in childrenSusan E Young
Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA
J Child Psychol Psychiatry 44:961-7. 2003..However, the specific genetic mechanisms responsible for this risk have not yet been identified... - Genetic and environmental analysis of behavioral risk factors for adolescent drug use in a community twin sampleElizabeth A Siewert
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309-0447, USA
Twin Res 6:490-6. 2003.... - The validity of analyses testing the etiology of comorbidity between two disorders: comparisons of disorder prevalences in familiesSoo Hyun Rhee
Department of Psychology, Institute for Behavioral Genetics, Campus Box 447, University of Colorado, Boulder, Colorado 80309, USA
Behav Genet 33:257-69. 2003.... - The validity of analyses testing the etiology of comorbidity between two disorders: a review of family studiesSoo Hyun Rhee
Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA
J Child Psychol Psychiatry 44:612-36. 2003..Unfortunately, the conclusions of family studies using these two methods have been conflicting. In the present study, we examined the validity of family prevalence analyses in testing alternative comorbidity models... - Investigating the genetic and environmental structure of Cloninger's personality dimensions in adolescenceNoa Heiman
Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado 80309, USA
Twin Res 7:462-70. 2004..We found moderate heritability estimates for NS, HA and RD ranging from .28 to .36--with no evidence for sex-limitation in those influences... - Genetic influences on vulnerability to, and protective factors for, adolescent drinkingElizabeth A Siewert
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309-0447, USA
Twin Res 7:617-25. 2004..We propose that adolescent alcohol consumption needs to be understood in the context of these genetically influenced externalizing and internalizing propensities... - Examination of the causes of covariation between conduct disorder symptoms and vulnerability to drug dependenceTanya M M Button
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309 0447, USA
Twin Res Hum Genet 9:38-45. 2006..Therefore, there appears to be pleiotropic genetic influence on CD symptoms and dependence vulnerability... - Comorbidity between alcohol dependence and illicit drug dependence in adolescents with antisocial behavior and matched controlsSoo Hyun Rhee
Institute for Behavioral Genetics, Campus Box 447, University of Colorado, Boulder, CO 80309, USA
Drug Alcohol Depend 84:85-92. 2006..Discrepancies in results may reflect different analytical approaches or differences in the samples. Here, we examine the causes of comorbidity between alcohol dependence and illicit drug dependence in adolescents... - Genetic and environmental influences on conduct disorder: symptom, domain and full-scale analysesHeather L Gelhorn
Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
J Child Psychol Psychiatry 46:580-91. 2005.... - Childhood maltreatment, subsequent antisocial behavior, and the role of monoamine oxidase A genotypeDavid Huizinga
Institute of Behavioral Science, University of Colorado, Boulder, 80303, USA
Biol Psychiatry 60:677-83. 2006..Despite wide interest in this hypothesis, results remain mixed from the few attempts at replication... - Population stratification in the candidate gene study: fatal threat or red herring?Kent E Hutchison
Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
Psychol Bull 130:66-79. 2004..In this respect, behavioral scientists are well suited to investigating genetic factors that influence psychological mechanisms... - Genetic analysis of low-dose ethanol-induced activation (LDA) in inbred long sleep (ILS) and inbred short sleep (ISS) miceJeremy C Owens
Institute for Behavioral Genetics and the Department of Psychology, University of Colorado, Boulder 80309-0447, USA
Behav Genet 32:163-71. 2002..We conclude that LDA is a polygenic trait, specified by two to six loci, which have not been affected by inbreeding or genetic drift in the ILS and ISS populations... - Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene clusterSarah H Stephens
Department of Integrative Physiology, University of Colorado Boulder, CO 80309, USA
Behav Genet 42:402-14. 2012..These results expand on previous work focused mainly on drug behaviors, and support the hypothesis that variation in the CHRNA5/CHRNA3/CHRNB4 locus is associated with early externalizing behaviors... - Family transmission of marijuana use, abuse, and dependenceChristian J Hopfer
University of Colorado Health Sciences Center, Denver 80262, USA
J Am Acad Child Adolesc Psychiatry 42:834-41. 2003..To examine the familial aggregation of marijuana use, abuse, and dependence... - Challenges in genetic studies of the etiology of substance use and substance use disorders: introduction to the special issueCarol A Prescott
Department of Psychology, University of Southern California, SGM 501, Los Angeles, CA, 90036, USA
Behav Genet 36:473-82. 2006.... - Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescentsChristian J Hopfer
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Med Genet B Neuropsychiatr Genet 141:895-901. 2006..Our findings provide evidence suggesting that a common CNR1 haplotype is associated with developing fewer cannabis dependence symptoms among adolescents who have experimented with cannabis... - Case-control and within-family tests for an association between conduct disorder and 5HTTLPRJoseph T Sakai
Division of Substance Dependence, Department of Psychiatry, University of Colorado School of Medicine, Denver, CO, USA
Am J Med Genet B Neuropsychiatr Genet 141:825-32. 2006..61; P = 0.20). These data suggest that the s-allele may confer some risk for aggressive behavior or may be in linkage disequilibrium with such an allele... - Psychological masculinity-femininity via the gender diagnosticity approach: heritability and consistency across ages and populationsJohn C Loehlin
University of Texas at Austin, Psychology Department, 78712, USA
J Pers 73:1295-319. 2005..Cross-age continuity appeared mainly to reflect the influence of the genes... - Test of association between TaqIA A1 allele and alcohol use disorder phenotypes in a sample of adolescent patients with serious substance and behavioral problemsJoseph T Sakai
Department of Psychiatry, Division of Substance Dependence, University of Colorado School of Medicine, Denver, CO 80262, USA
Drug Alcohol Depend 88:130-7. 2007.... - A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9Christian J Hopfer
Division of Substance Dependence, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, CO 80262, USA
Drug Alcohol Depend 89:34-41. 2007..Genetic risk factors account for part of the variation in the development of cannabis dependence symptoms; however, no linkage studies have been performed for cannabis dependence symptoms. This study aimed to identify such loci... - The androgen receptor gene and psychological traits: are results consistent in Sweden and Australia?John C Loehlin
Department of Psychology, University of Texas, Austin, USA
Twin Res 6:201-8. 2003..It was concluded that if the number of CAG repeats on this gene is related to psychological traits at all, the relationship is a weak one...
Research Grants
- BIOMETRICAL ANALYSIS OF PERSONALITY IN ADULTHOODMichael Stallings; Fiscal Year: 2002..e., predictive) validity of the existing and derived personality scales. The overarching goal of our multivariate investigations is to improve the measurement of personality concepts for gerontologically-relevant research. ..
- NATURE & NURTURE IN SOCIAL DEMOGRAPHY: AN ADOPTION STUDYMichael Stallings; Fiscal Year: 2007..This study promises to advance our understanding of how family factors influence adult outcomes, and to enrich socialization theories and models of life-course development. ..