Research Topics
Genomes and Genes | Didier Y R StainierSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryoBrian R Keegan
Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY, USA
Development 129:1623-32. 2002..This study provides the first genetic evidence for parallel functions of Spt6 and Spt5 in metazoans and establishes a system for the future analysis of transcription elongation during development...- Fgf10 regulates hepatopancreatic ductal system patterning and differentiationP Duc Si Dong
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and the Diabetes Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94158, USA
Nat Genet 39:397-402. 2007..These data shed light onto how the multipotent cells of the foregut endoderm, and subsequently those of the hepatopancreatic duct, are directed toward different organ fates... 
Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafishChunyue Yin
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Cardiovascular Research Institute, Liver Center, University of California, San Francisco, San Francisco, CA 94158, USA
Dev Cell 18:973-84. 2010..Our study reveals an unexpected role for Hand2, a key regulator of cell specification and differentiation, in modulating ECM remodeling during organogenesis...- Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreasP Duc Si Dong
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
Genes Dev 22:1445-50. 2008..We propose that low levels of Ptf1a promote endocrine fate, whereas high levels repress endocrine fate and promote exocrine fate... - Multiple roles for Med12 in vertebrate endoderm developmentChong Hyun Shin
Department of Biochemistry and Biophysics, Liver Center, University of California, San Francisco, CA 94158, USA
Dev Biol 317:467-79. 2008.... - Tbx5 and Bmp signaling are essential for proepicardium specification in zebrafishJiandong Liu
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Cardiovascular Research Institute, and Liver Center, University of California, San Francisco, CA 94158, USA
Circ Res 106:1818-28. 2010..Despite the importance of these cells in cardiac development, function and regeneration, the signals required for the specification of the PE remain largely unexplored... - The g protein-coupled receptor agtrl1b regulates early development of myocardial progenitorsIan C Scott
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
Dev Cell 12:403-13. 2007..These results support a model in which agtrl1b regulates the migration of cells fated to form myocardial progenitors... - Restriction of hepatic competence by Fgf signalingDonghun Shin
Department of Biochemistry and Biophysics, Liver Center, Institute for Regeneration Medicine, University of California, San Francisco, CA 94158, USA
Development 138:1339-48. 2011..These data provide in vivo evidence that endodermal cells outside the liver-forming region retain hepatic competence and show that an extrinsic signal, Fgf10a, negatively regulates hepatic competence... - Cardiac conduction is required to preserve cardiac chamber morphologyNeil C Chi
Departments of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 107:14662-7. 2010..Overall, these in vivo studies indicate that cardiac electrical forces are required to preserve cardiac chamber morphology and may act as a key epigenetic factor in cardiac remodeling... - A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryosSuk Won Jin
Department of Biochemistry and Biophysics, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California San Francisco, CA 94158, USA
Dev Biol 307:29-42. 2007..The analysis of the newly defined loci should lead to a greater understanding of vascular development and possibly provide new drug targets to treat the numerous pathologies associated with dysregulated blood vessel growth... - The yolk syncytial layer regulates myocardial migration by influencing extracellular matrix assembly in zebrafishTakuya Sakaguchi
Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics and Human Genetics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143 2711, USA
Development 133:4063-72. 2006..Based on these data, we propose that the extra-embryonic YSL regulates myocardial migration, at least in part by influencing fibronectin expression and subsequent assembly of the extracellular matrix in embryonic tissues... - Conditional targeted cell ablation in zebrafish: a new tool for regeneration studiesSilvia Curado
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94158 2324, USA
Dev Dyn 236:1025-35. 2007.... - Intra-endodermal interactions are required for pancreatic beta cell inductionWon Suk Chung
Department of Biochemistry and Biophysics, and the Diabetes Center, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
Dev Cell 14:582-93. 2008.... - Chromatin remodelling complex dosage modulates transcription factor function in heart developmentJun K Takeuchi
Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
Nat Commun 2:187. 2011.... - Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formationShane P Herbert
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
Science 326:294-8. 2009..Thus, directional control of progenitor migration drives arterial-venous segregation and generation of separate parallel vessels from a single precursor vessel, a process essential for vascular development... - microRNA-138 modulates cardiac patterning during embryonic developmentSarah U Morton
Gladstone Institute of Cardiovascular Disease, Department of Pediatrics, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 105:17830-5. 2008.... - Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regenerationRyan M Anderson
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Diabetes Center, and Liver Center, University of California, San Francisco, San Francisco, CA 94158 2324, USA
Dev Biol 334:213-23. 2009..In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors or the reprogramming of cells toward the pancreatic beta cell fate... - Genetic and cellular analyses of zebrafish atrioventricular cushion and valve developmentDimitris Beis
Department of Biochemistry and Biophysics and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
Development 132:4193-204. 2005..This collection of mutants provides a unique set of tools to further our understanding of the genetic basis of cell behavior and differentiation during AV valve development... - The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signalingPia Aanstad
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Cardiovascular Research Institute, Diabetes Center, University of California, San Francisco, CA 94158, USA
Curr Biol 19:1034-9. 2009..These data indicate that the ECD, previously thought to be dispensable for vertebrate Smo function, both regulates Smo ciliary localization and is essential for high-level Hh signaling... - Haematopoietic stem cells derive directly from aortic endothelium during developmentJulien Y Bertrand
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0380, USA
Nature 464:108-11. 2010..Finally, using a permanent lineage tracing strategy, we demonstrate that the HSCs generated from haemogenic endothelium are the lineal founders of the adult haematopoietic system... - Foxn4 directly regulates tbx2b expression and atrioventricular canal formationNeil C Chi
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, California 94158, USA
Genes Dev 22:734-9. 2008..sli/foxn4 is expressed in the AV canal, and its encoded product binds to a highly conserved tbx2 enhancer domain that contains Foxn4- and T-box-binding sites, both necessary to regulate tbx2b expression in the AV canal... - A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafishJason E Fish
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Development 138:1409-19. 2011..These findings suggest a new paradigm for microRNA-based control of ligand-receptor interactions and provide evidence for a novel signaling pathway regulating vertebrate heart tube assembly... - Cellular and molecular analyses of vascular tube and lumen formation in zebrafishSuk Won Jin
Department of Biochemistry and Biophysics and Cardiovascular Research Institute, Program in Developmental Biology, University of California San Francisco, 1550 Fourth Street, San Francisco, CA 94143, USA
Development 132:5199-209. 2005..These studies provide the tools and a cellular framework for the investigation of mutations affecting vasculogenesis in zebrafish... - The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration modelSilvia Curado
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California San Francisco, 1550 Fourth Street, San Francisco, CA 94158 2324, USA
Dis Model Mech 3:486-95. 2010..We used this regeneration model to analyze the signaling commonalities between hepatocyte development and regeneration... - Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like bIsla D Cheung
Department of Biochemistry and Biophysics, Program in Developmental and Stem Cell Biology, and Institute for Regeneration Medicine, University of California, San Francisco, CA 94158, USA
Dev Biol 361:68-78. 2012..Thus, cldn15lb mutants provide a novel in vivo model to study the role of tight junction proteins in the remodeling of the biliary network and hereditary cholestasis... - Hand2 regulates epithelial formation during myocardial diferentiationLe A Trinh
Department of Biochemistry and Biophysics Programs in Developmental Biology, Genetics, and Human Genetics, University of California, San Francisco, San Francisco, California 94143, USA
Curr Biol 15:441-6. 2005..Furthermore, these results demonstrate that two independent processes, the polarizaton of myocardial precursors and the allocation of proper cell number, contribute to myocardial development... - Cardiac developmentLe A Trinh
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, University of California, San Francisco, California 94143-0448, USA
Methods Cell Biol 76:455-73. 2004 - Fibronectin regulates epithelial organization during myocardial migration in zebrafishL A Trinh
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA
Dev Cell 6:371-82. 2004..These data suggest that myocardial migration is dependent on epithelial integrity... - A mutation in zebrafish hmgcr1b reveals a role for isoprenoids in vertebrate heart-tube formationLeonard D'Amico
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94158, USA
Curr Biol 17:252-9. 2007..We conclude that protein prenylation, acting downstream of Hmgcr1b and possibly through Ras and, or, Rho signaling, is required for the morphogenesis of the myocardial sheets for formation of the primitive heart tube... - Mesodermal Wnt2b signalling positively regulates liver specificationElke A Ober
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and the Liver Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94143, USA
Nature 442:688-91. 2006..Taken together, these data reveal an unexpected positive role for Wnt signalling in liver specification, and indicate a possible common theme for the localized formation of endodermal organs along the gut tube... - Bmp and Fgf signaling are essential for liver specification in zebrafishDonghun Shin
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
Development 134:2041-50. 2007.... - The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafishNick Osborne
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Cardiovascular Research Institute, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94143, USA
Curr Biol 18:1882-8. 2008..Through gain- and loss-of-function analyses, we show that toh is required for signaling by S1P(2). Further evidence indicates that Toh is involved in the trafficking or cellular release of S1P... - Early myocardial function affects endocardial cushion development in zebrafishThomas Bartman
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, USA
PLoS Biol 2:E129. 2004.... - MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signalingDavid Hassel
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Circ Res 111:1421-33. 2012..Various signaling pathways control the behavior of endothelial cells, but their posttranscriptional dose titration by microRNAs is poorly understood... - Intrinsic and extrinsic modifiers of the regulative capacity of the developing liverDonghun Shin
Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics and Human Genetics, Institute for Regeneration Medicine, Diabetes Center and Liver Center, University of California, San Francisco, CA 94158, USA
Mech Dev 128:525-35. 2012..Altogether, these studies reveal that there is more than one way to form a liver, and provide molecular insights into the phenomenon of tissue plasticity... - Regulation of neurocoel morphogenesis by Pard6 gamma bChantilly Munson
Department of Biochemistry and Biophysics, Genetics and Human Genetics, University of California, San Francisco, CA 94158, USA
Dev Biol 324:41-54. 2008..Altogether, these data indicate a previously unappreciated functional diversity and complexity within the vertebrate pard6 gene family... - Suppression of Alk8-mediated Bmp signaling cell-autonomously induces pancreatic beta-cells in zebrafishWon Suk Chung
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, The Liver Center, Institute for Regeneration Medicine and Diabetes Center, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 107:1142-7. 2010..These results provide important unique insight into the intercellular signaling environment necessary for in vivo and in vitro generation of beta-cells... - Endothelial signals modulate hepatocyte apicobasal polarization in zebrafishTakuya F Sakaguchi
Department of Biochemistry and Biophysics, Program in Developmental Biology, University of California, San Francisco, California 94158, USA
Curr Biol 18:1565-71. 2008.... 
Optogenetic control of cardiac functionAristides B Arrenberg
Department of Physiology, University of California, San Francisco, CA 94158, USA
Science 330:971-4. 2010..Our studies combine optogenetics and light-sheet microscopy to reveal the emergence of organ function during development...- The basic helix-loop-helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: analysis of stellate cell entry into the developing liverChunyue Yin
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA
Hepatology 56:1958-70. 2012..The Tg(hand2:EGFP) line represents a unique tool for in vivo analysis and molecular dissection of HSC behavior... - Bmp2 signaling regulates the hepatic versus pancreatic fate decisionWon Suk Chung
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
Dev Cell 15:738-48. 2008..These data provide in vivo evidence for the existence of bipotential hepatopancreatic progenitors and indicate that their fate is regulated by the medio-lateral patterning of the endodermal sheet, a process controlled by Bmp2b... - Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular developmentWiebke Herzog
Department of Biochemistry and Biophysics and The Cardiovascular Research Institute, Programs in Developmental Biology, Genetics, and Human Genetics, University of California, San Francisco, San Francisco, CA 94158, USA
Circ Res 104:1260-6. 2009..These analyses of zebrafish and human endothelial cells reveal a new noncanonical function of Sars in endothelial development... - miR-126 regulates angiogenic signaling and vascular integrityJason E Fish
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Dev Cell 15:272-84. 2008..These findings illustrate that a single miRNA can regulate vascular integrity and angiogenesis, providing a new target for modulating vascular formation and function... - Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje networkShan Shan Zhang
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 108:13576-81. 2011..Irx3 directly represses Cx43 transcription and indirectly activates Cx40 transcription. Our results reveal a critical role for Irx3 in the precise regulation of intercellular gap junction coupling and impulse propagation in the heart... - A cellular framework for gut-looping morphogenesis in zebrafishSally Horne-Badovinac
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, University of California, San Francisco, CA 94143, USA
Science 302:662-5. 2003..Finally, reducing left-sided Nodal activity randomizes the pattern of LPM migration and gut looping. These results reveal a cellular framework for the regulation of organ laterality by asymmetrically expressed genes... - A dual role for ErbB2 signaling in cardiac trabeculationJiandong Liu
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA
Development 137:3867-75. 2010.... - Formation of the digestive system in zebrafish. II. Pancreas morphogenesisHolly A Field
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
Dev Biol 261:197-208. 2003.... - Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1Stephanie Woo
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
J Cell Biol 198:941-52. 2012..Together, our results reveal a novel role for Nodal signaling in regulating actin dynamics and migration behavior, which are crucial for endodermal morphogenesis and cell fate decisions... - Adenosine signaling promotes regeneration of pancreatic β cells in vivoOlov Andersson
Department of Biochemistry and Biophysics, Program in Developmental and Stem Cell Biology and Program in Genetics and Human Genetics, Diabetes Center, Institute for Regeneration Medicine and Liver Center, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA
Cell Metab 15:885-94. 2012..With this whole-organism screen, we identified components of the adenosine pathway that could be therapeutically targeted for the treatment of diabetes... - Distinct populations of quiescent and proliferative pancreatic beta-cells identified by HOTcre mediated labelingDaniel Hesselson
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Institute for Regeneration Medicine, Liver Center and Diabetes Center, University of California, 1550 Fourth Street, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 106:14896-901. 2009..g., diabetes mellitus). Our data reveal the existence of distinct populations of beta-cells in vivo and should help develop better strategies to regulate beta-cell differentiation and proliferation... - High-speed imaging of developing heart valves reveals interplay of morphogenesis and functionPaul J Scherz
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA
Development 135:1179-87. 2008..Thus, different signaling pathways regulate distinct aspects of the behavior of individual cells during valve morphogenesis, thereby influencing specific facets of valve function... - No organ left behind: tales of gut development and evolutionDidier Y R Stainier
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, CA 94143 2711, USA
Science 307:1902-4. 2005..The patterning of the gut along its longitudinal, dorsoventral, left-right, and radial axes is one of the fascinating issues that pertain to the development, function, and homeostasis of this understudied organ... - The HeArt of regenerationSilvia Curado
Department of Biochemistry and Biophysics and The Cardiovascular Research Institute, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94158, USA
Cell 127:462-4. 2006..analyze regeneration in the zebrafish heart. Their work indicates that new cardiomyocytes originate from undifferentiated progenitor cells and reveals a critical role for the epicardium, the cellular layer that covers the heart... - Genetic control of single lumen formation in the zebrafish gutMichel Bagnat
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94158 2324, USA
Nat Cell Biol 9:954-60. 2007..This work shows that single lumen formation is genetically controlled and appears to be driven by the accumulation of fluid... - Vegfc is required for vascular development and endoderm morphogenesis in zebrafishElke A Ober
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, California 94143 0448, USA
EMBO Rep 5:78-84. 2004.... - Nitroreductase-mediated cell/tissue ablation in zebrafish: a spatially and temporally controlled ablation method with applications in developmental and regeneration studiesSilvia Curado
Department of Biochemistry and Biophysics, Program in Developmental Biology, Liver Center, Diabetes Center and the Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158 2324, USA
Nat Protoc 3:948-54. 2008..Using this protocol, cell ablation can be achieved in 12-72 h, depending on the transgenic line used, and recovery initiates within the following 24 h... - Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasisMassimo M Santoro
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94158, USA
Nat Genet 39:1397-402. 2007.... - Different levels of Notch signaling regulate quiescence, renewal and differentiation in pancreatic endocrine progenitorsNikolay Ninov
Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics and Human Genetics, Diabetes Center, and Liver Center, University of California, San Francisco, San Francisco, CA 94158, USA
Development 139:1557-67. 2012..These data show that different levels of Notch signaling drive distinct behaviors in a progenitor population... - Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardiumJames W Smyth
Cardiovascular Research Institute, Department of Medicine, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
J Clin Invest 120:266-79. 2010..We anticipate that protecting the microtubule-based forward delivery apparatus of connexons could improve cell-cell coupling and reduce ischemia-related cardiac arrhythmias... - A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrulaKevin M Vogeli
Department of Biochemistry and Biophysics, University of California, San Francisco, 1550 Fourth Street, San Francisco, California 94158-2324, USA
Nature 443:337-9. 2006..Our results provide in vivo evidence supporting the existence of the haemangioblast and reveal distinct features of this cell population... - Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factorsSarah De Val
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158 2517, USA
Cell 135:1053-64. 2008..Finally, we show that FOX:ETS motifs are present in many known endothelial-specific enhancers and that this motif is an efficient predictor of endothelial enhancers in the human genome... - Suppression of Ptf1a activity induces acinar-to-endocrine conversionDaniel Hesselson
Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics, and Human Genetics, Institute for Regeneration Medicine, Liver Center, and Diabetes Center, University of California, San Francisco, 1550 Fourth Street, San Francisco, CA 94158, USA
Curr Biol 21:712-7. 2011..These data indicate that targeted postembryonic disruption of the acinar cell fate can restore the developmental plasticity that is lost during development... - Zebrafish model for human long QT syndromeRima Arnaout
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Cardiovascular Research Institute, University of California, 1550 Fourth Street, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 104:11316-21. 2007..Our findings provide insight into the pathogenesis of homozygous kcnh2 mutations and expand the use of zebrafish mutants as a model system to study human arrhythmias... - Selective plane illumination microscopy techniques in developmental biologyJan Huisken
Department of Biochemistry and Biophysics, and Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
Development 136:1963-75. 2009.... - Molecular control of endothelial cell behaviour during blood vessel morphogenesisShane P Herbert
Department of Biochemistry and Biophysics, Program in Developmental Biology, Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
Nat Rev Mol Cell Biol 12:551-64. 2011..These emerging frameworks controlling angiogenesis provide unique insights into fundamental biological processes common to other systems, such as tissue branching morphogenesis, mechanotransduction and tubulogenesis... - Formation of the digestive system in zebrafish. I. Liver morphogenesisHolly A Field
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA
Dev Biol 253:279-90. 2003.... - In vivo cell biology: following the zebrafish trendDimitris Beis
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 2711, USA
Trends Cell Biol 16:105-12. 2006..Although this model system has been predominantly appreciated for its amenability to forward genetics, current advances in imaging technology and an increasing number of transgenic lines are bringing it closer to its full potential... - deLiver'in regeneration: injury response and developmentSilvia Curado
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, Diabetes Center and the Cardiovascular Research Institute, University of California, San Francisco, CA 94158 2324, USA
Semin Liver Dis 30:288-95. 2010..Also, as our understanding of liver development is becoming more detailed, it is important to evaluate the commonalities and differences between organ development and regeneration... - Vertebrate Smoothened functions at the primary ciliumKevin C Corbit
Developmental and Stem Cell Biology Program, University of California, San Francisco, California 94143, USA
Nature 437:1018-21. 2005..Thus, Hh-dependent translocation to cilia is essential for Smo activity, suggesting that Smo acts at the primary cilium... - Even fluorescence excitation by multidirectional selective plane illumination microscopy (mSPIM)Jan Huisken
Department of Biochemistry and Biophysics, University of California San Francisco, 1550 Fourth Street, San Francisco, California 94158 2324, USA
Opt Lett 32:2608-10. 2007..The multidirectional illumination proves essential in biological specimens such as millimeter-sized embryos. The performance of mSPIM is demonstrated by the imaging of live zebrafish embryos... - Lipid receptors in cardiovascular developmentNick Osborne
Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 0448, USA
Annu Rev Physiol 65:23-43. 2003.... - A glimpse into the molecular entrails of endoderm formationDidier Y R Stainier
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, University of California, San Francisco, San Francisco, California 94143-0448, USA
Genes Dev 16:893-907. 2002 - Pattern formation: swimming in retinoic acidDeborah Yelon
Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Curr Biol 12:R707-9. 2002..Recent studies in zebrafish extend this model by demonstrating the influence of retinoic acid on endoderm regionalization... - Cardiac troponin T is essential in sarcomere assembly and cardiac contractilityAmy J Sehnert
Department of Biochemistry and Biophysics, University of California at San Francisco, 513 Parnassus Avenue, Box 0448, San Francisco, California 94143 0448, USA
Nat Genet 31:106-10. 2002.... - In vivo regulation of the chicken cardiac troponin T gene promoter in zebrafish embryosWilliam E Tidyman
Department of Anatomy and Cardiovascular Research Institute, University of California San Francisco, 94143, USA
Dev Dyn 227:484-96. 2003..Thus, the PARP-I transcriptional regulatory mechanism that governs muscle specificity of the chicken cTnT promoter is conserved across several chordate classes spanning at least 350 million years of evolution... - The guts of endoderm formationRachel M Warga
Department of Biology, University of Rochester, Rochester, New York 14627, USA
Results Probl Cell Differ 40:28-47. 2002..In addition, we refer to the cells that contribute to the endoderm as progenitors prior to their involution and precursors after their involution... - A window to the heart: can zebrafish mutants help us understand heart disease in humans?Amy J Sehnert
Departmentt of Pediatrics, Pediatric Cardiology Division, University of California, San Fransisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Trends Genet 18:491-4. 2002..Today, studies of zebrafish mutants with defective heart function are providing insight into the genes required to generate a normal heartbeat... - Development. Fishing out a new heartIan C Scott
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
Science 298:2141-2. 2002 - nanor, a novel zygotic gene, is expressed initially at the midblastula transition in zebrafishRonan T Bree
Department of Biochemistry, National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland
Biochem Biophys Res Commun 333:722-8. 2005..It is initially expressed after the MBT at the sphere stage and during epiboly it is expressed in the forerunner cells. At 24 h post-fertilization, expression is solely anterior... - Lessons from "lower" organisms: what worms, flies, and zebrafish can teach us about human energy metabolismAmnon Schlegel
Department of Biochemistry and Biophysics, Division of Endocrinology at the University of California San Francisco, San Francisco, California, United States of America
PLoS Genet 3:e199. 2007..We summarize findings in these organisms that shed light on highly conserved pathways of energy homeostasis... - Microsomal triglyceride transfer protein is required for yolk lipid utilization and absorption of dietary lipids in zebrafish larvaeAmnon Schlegel
Department of Biochemistry and Biophysics, University of California, MC 2711, 1550 Fourth Street, Room 381, San Francisco, California 94143, USA
Biochemistry 45:15179-87. 2006..Importantly, the vasculature appeared unaffected in Mtp MO-injected larvae. These studies indicate that zebrafish larvae are suitable for genetic studies of lipid transport and metabolism... - Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genesFeng Qian
Laboratory of Molecular and Developmental Immunology, Institute of Molecular and Cell Biology, Proteos, Singapore
Dev Dyn 233:1163-72. 2005..Our study provides valuable information for studying hematopoiesis and vessel formation. The method described here offers a powerful tool for gene expression profiling of zebrafish mutants in general... - Genetic and physiologic dissection of the vertebrate cardiac conduction systemNeil C Chi
Department of Biochemistry and Biophysics and Programs in Developmental Biology, Genetics, and Human Genetics, University of California San Francisco, San Francisco, California, United States of America
PLoS Biol 6:e109. 2008.... - The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formationLeon H Parker
Molecular Biology Department, Genentech Inc, South San Francisco, California 94080, USA
Nature 428:754-8. 2004..This process fails to take place in Egfl7 knockdown embryos, leading to the failure of vascular tube formation. Our study defines a regulator that controls a specific and important step in vasculogenesis... - Notch signaling can regulate endoderm formation in zebrafishYutaka Kikuchi
Division of Biological Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya, Japan
Dev Dyn 229:756-62. 2004..Altogether, these results suggest that Notch signaling plays a role in the formation of the endoderm, possibly in its segregation from the mesoderm... - Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafishEli Berdougo
Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Development 130:6121-9. 2003..These findings are relevant to our understanding of congenital defects in cardiac chamber morphogenesis... - Developmental biology: twisting the body into shapeIan C Scott
Nature 425:461-3. 2003 - The Mix family homeodomain gene bonnie and clyde functions with other components of the Nodal signaling pathway to regulate neural patterning in zebrafishL A Trinh
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, San Francisco, CA 94143 0448, USA
Development 130:4989-98. 2003.... - Entrails, heart, brain, limbs, and lymphatics- a recipe for success?Didier Y R Stainier
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
Dev Cell 5:193-6. 2003..Discussions extended into the late hours of the night as the meeting participants indulged in tasting some of their favorite organs, in the form of Spanish delicacies... - Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw jointCraig T Miller
Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
Development 130:1353-65. 2003..Together our results reveal two critical edn1 effectors that pattern the vertebrate jaw: hand2 specifies ventral pharyngeal cartilage of the lower jaw and bapx1 specifies the jaw joint... - From endoderm formation to liver and pancreas development in zebrafishElke A Ober
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, University of California, San Francisco, CA 94143-0448, USA
Mech Dev 120:5-18. 2003..The generation of transgenic lines expressing GFP in these organs promises to be particularly helpful in such studies... - Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesisAnnie N Y Ng
Colon Molecular and Cell Biology Laboratory, Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
Dev Biol 286:114-35. 2005..At 126 hpf, the posterior intestine remains an unfolded monolayer of simple columnar epithelium...