C E Stafstrom

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Epilepsy comorbidities: how can animal models help?
    Carl E Stafstrom
    Departments of Neurology and Pediatrics, University of Wisconsin, Centennial Building 7176, 1685 Highland Avenue, Madison, WI, 53705, USA
    Adv Exp Med Biol 813:273-81. 2014
  2. pmc Update on the management of Lennox-Gastaut syndrome with a focus on rufinamide
    Carl E Stafstrom
    Section of Pediatric Neurology, Departments of Neurology and Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Neuropsychiatr Dis Treat 5:547-51. 2009
  3. doi request reprint Art therapy focus groups for children and adolescents with epilepsy
    Carl E Stafstrom
    Department of Neurology, University of Wisconsin, Madison, WI 53705, USA
    Epilepsy Behav 24:227-33. 2012
  4. ncbi request reprint NMDA-induced seizures in developing rats cause long-term learning impairment and increased seizure susceptibility
    Carl E Stafstrom
    Department of Neurology, Neuroscience Training Program, H6 528, University of Wisconsin, 600 Highland Avenue, 53792, Madison, WI, USA
    Epilepsy Res 53:129-37. 2003
  5. ncbi request reprint Seizure drawings: insight into the self-image of children with epilepsy
    Carl E Stafstrom
    Departments of Neurology and Pediatrics, University of Wisconsin, Wisconsin Madison, 53792, USA
    Epilepsy Behav 4:43-56. 2003
  6. ncbi request reprint Seizure suppression via glycolysis inhibition with 2-deoxy-D-glucose (2DG)
    Carl E Stafstrom
    Department of Neurology, University of Wisconsin, Madison, Wisconsin 53792, USA
    Epilepsia 49:97-100. 2008
  7. ncbi request reprint Assessing the behavioral and cognitive effects of seizures on the developing brain
    Carl E Stafstrom
    Departments of Neurology and Pediatrics, University of Wisconsin, Madison, 600 Highland Avenue, Madison, WI 53792, USA
    Prog Brain Res 135:377-90. 2002
  8. ncbi request reprint Counseling youth about military service options and Selective Service registration: an integral part of anticipatory guidance of adolescents
    Carl E Stafstrom
    Department of Neurology, H6 528, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792, USA
    Pediatrics 119:1199-203. 2007
  9. ncbi request reprint Epilepsy: a review of selected clinical syndromes and advances in basic science
    Carl E Stafstrom
    Department of Neurology, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Cereb Blood Flow Metab 26:983-1004. 2006
  10. ncbi request reprint Serial headache drawings by children with migraine: correlation with clinical headache status
    Carl E Stafstrom
    Department of Neurology, University of Wisconsin, 600 Highland Avenue, Madison, 53792, USA
    J Child Neurol 20:809-13. 2005

Detail Information

Publications41

  1. ncbi request reprint Epilepsy comorbidities: how can animal models help?
    Carl E Stafstrom
    Departments of Neurology and Pediatrics, University of Wisconsin, Centennial Building 7176, 1685 Highland Avenue, Madison, WI, 53705, USA
    Adv Exp Med Biol 813:273-81. 2014
    ..In this chapter, depression is used as an example of how animal models can inform translational questions about epilepsy comorbidities. ..
  2. pmc Update on the management of Lennox-Gastaut syndrome with a focus on rufinamide
    Carl E Stafstrom
    Section of Pediatric Neurology, Departments of Neurology and Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Neuropsychiatr Dis Treat 5:547-51. 2009
    ..In particular, the review focuses on rufinamide, a recently released anticonvulsant medication with reported effectiveness in this epilepsy syndrome...
  3. doi request reprint Art therapy focus groups for children and adolescents with epilepsy
    Carl E Stafstrom
    Department of Neurology, University of Wisconsin, Madison, WI 53705, USA
    Epilepsy Behav 24:227-33. 2012
    ..However, subjects and parents were uniformly positive about their group experiences, suggesting a qualitative benefit from participation in art therapy focus groups...
  4. ncbi request reprint NMDA-induced seizures in developing rats cause long-term learning impairment and increased seizure susceptibility
    Carl E Stafstrom
    Department of Neurology, Neuroscience Training Program, H6 528, University of Wisconsin, 600 Highland Avenue, 53792, Madison, WI, USA
    Epilepsy Res 53:129-37. 2003
    ..This study provides additional evidence for long-term alterations of neuronal excitability and cognitive capacity associated with seizures during development...
  5. ncbi request reprint Seizure drawings: insight into the self-image of children with epilepsy
    Carl E Stafstrom
    Departments of Neurology and Pediatrics, University of Wisconsin, Wisconsin Madison, 53792, USA
    Epilepsy Behav 4:43-56. 2003
    ..In conclusion, drawings are a powerful method to examine the self-concept of children with epilepsy and gain insight into their feelings about themselves and their world...
  6. ncbi request reprint Seizure suppression via glycolysis inhibition with 2-deoxy-D-glucose (2DG)
    Carl E Stafstrom
    Department of Neurology, University of Wisconsin, Madison, Wisconsin 53792, USA
    Epilepsia 49:97-100. 2008
    ..Finally, 2DG has a favorable preliminary toxicity profile. These factors support the possibility that 2DG or other modifiers of glycolysis can be used as novel treatments for epilepsy...
  7. ncbi request reprint Assessing the behavioral and cognitive effects of seizures on the developing brain
    Carl E Stafstrom
    Departments of Neurology and Pediatrics, University of Wisconsin, Madison, 600 Highland Avenue, Madison, WI 53792, USA
    Prog Brain Res 135:377-90. 2002
    ..Seizure-induced behavioral and cognitive deficits, which may not become obvious until long after the onset of the epilepsy, might be equally or more detrimental to a child's overall function than the seizures themselves...
  8. ncbi request reprint Counseling youth about military service options and Selective Service registration: an integral part of anticipatory guidance of adolescents
    Carl E Stafstrom
    Department of Neurology, H6 528, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792, USA
    Pediatrics 119:1199-203. 2007
  9. ncbi request reprint Epilepsy: a review of selected clinical syndromes and advances in basic science
    Carl E Stafstrom
    Department of Neurology, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Cereb Blood Flow Metab 26:983-1004. 2006
    ..Despite this diversity of clinical phenotype and mechanism, these syndromes are informative as to how pathophysiological processes converge to produce brain hyperexcitability and seizures...
  10. ncbi request reprint Serial headache drawings by children with migraine: correlation with clinical headache status
    Carl E Stafstrom
    Department of Neurology, University of Wisconsin, 600 Highland Avenue, Madison, 53792, USA
    J Child Neurol 20:809-13. 2005
    ..The technique is simple, inexpensive, and enjoyable for children and can be applied in a variety of clinical settings...
  11. pmc Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models
    Carl E Stafstrom
    Department of Neurology, University of Wisconsin, Madison, WI 53792, USA
    Ann Neurol 65:435-47. 2009
    ....
  12. doi request reprint Severe epilepsy syndromes of early childhood: the link between genetics and pathophysiology with a focus on SCN1A mutations
    Carl E Stafstrom
    University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    J Child Neurol 24:15S-23S. 2009
    ..Eventually, such information might enable clinicians to select an appropriate therapeutic regimen for patients with specific epilepsy gene mutations...
  13. doi request reprint Mechanisms of action of antiepileptic drugs: the search for synergy
    Carl E Stafstrom
    Pediatric Neurology Section, Department of Neurology, University of Wisconsin, Madison, Wisconsin, USA
    Curr Opin Neurol 23:157-63. 2010
    ....
  14. doi request reprint Treatment of infantile spasms: emerging insights from clinical and basic science perspectives
    Carl E Stafstrom
    University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    J Child Neurol 26:1411-21. 2011
    ..This summary derives from a meeting of specialists in infantile spasms clinical care and research held in New York City on June 14, 2010...
  15. doi request reprint Ezogabine (retigabine)
    Carl E Stafstrom
    University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    Nat Rev Drug Discov 10:729-30. 2011
    ..D.A.) for the adjunctive treatment of partial-onset seizures in adult patients. The same drug was granted marketing authorization for this indication in the European Union in March 2011, where it is known as retigabine (Trobalt)...
  16. ncbi request reprint The usefulness of children's drawings in the diagnosis of headache
    Carl E Stafstrom
    Departments of Pediatrics and Neurology, Division of Pediatric Neurology, Floating Hospital for Children, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Pediatrics 109:460-72. 2002
    ..To determine whether drawings can aid in the differential diagnosis of headaches in children...
  17. ncbi request reprint Epilepsy genes: the link between molecular dysfunction and pathophysiology
    C E Stafstrom
    Departments of Neurology and Pediatrics, University of Wisconsin, Madison, Wisconsin 53792, USA
    Ment Retard Dev Disabil Res Rev 6:281-92. 2000
    ..Gene defects can lead to epilepsy by altering multiple and diverse aspects of neuronal function...
  18. ncbi request reprint Animal models of the ketogenic diet: what have we learned, what can we learn?
    C E Stafstrom
    Department of Neurology, University of Wisconsin, Madison 53792, USA
    Epilepsy Res 37:241-59. 1999
    ....
  19. ncbi request reprint Seizures in a 7-month-old child after exposure to the essential plant oil thuja
    Carl E Stafstrom
    Section of Pediatric Neurology, Departments of Neurology and Pediatrics, University of Wisconsin, Madison, WI 53792, USA
    Pediatr Neurol 37:446-8. 2007
    ..The epileptogenic potential of plant-derived essential oils and other herbal remedies should be recognized by practitioners providing neurologic care to children...
  20. ncbi request reprint Models of epilepsy in the developing and adult brain: implications for neuroprotection
    Carl E Stafstrom
    Department of Neurology, University of Wisconsin, Madison, WI 53792, USA
    Epilepsy Behav 7:S18-24. 2005
    ..The concept of seizure-induced brain damage must be expanded to include behavioral and cognitive deficits, as well as structural neuronal damage and increased predisposition to seizures...
  21. ncbi request reprint Recurrent seizures in immature rats: effect on auditory and visual discrimination
    J C Neill
    Department of Neurology, Harvard Medical School, Children s Hospital, Boston, MA 02115, USA
    Brain Res Dev Brain Res 95:283-92. 1996
    ..Histological examination showed no gross cell loss in the hippocampus. This study demonstrates that serial seizures in the developing brain cause detrimental effects on visual and auditory spatial learning...
  22. ncbi request reprint Electrophysiological observations in hippocampal slices from rats treated with the ketogenic diet
    C E Stafstrom
    Department of Neurology, Children s Hospital, Harvard Medical School, Boston, MA, USA
    Dev Neurosci 21:393-9. 1999
    ..Therefore, at least part of the KD mechanism of action may involve long-term changes in network excitability...
  23. ncbi request reprint Downregulation of kainate receptors in the hippocampus following repeated seizures in immature rats
    Pushpa Tandon
    Department of Neurology, Harvard Medical School, Center for Research in Pediatric Epilepsy, Children s Hospital, Boston, MA 02115, USA
    Brain Res Dev Brain Res 136:145-50. 2002
    ....
  24. ncbi request reprint Intractable pediatric epilepsy: vagal nerve stimulation and the ketogenic diet
    Raj D Sheth
    Department of Neurology, University of Wisconsin at Madison, H6 574 CSC, 600 Highland Avenue, Madison, WI 53792 5132, USA
    Neurol Clin 20:1183-94. 2002
    ..With better understanding of the scientific principles underlying brain ketosis, we should be able to optimize the KD to achieve even better results...
  25. ncbi request reprint Nonpharmacological treatment options for epilepsy
    Raj D Sheth
    Department of Neurology, University of Wisconsin, Madison, Madison, WI 53792 5132, USA
    Semin Pediatr Neurol 12:106-13. 2005
    ..In addition, pyridoxine-dependent seizures are discussed as an example of an etiology of refractory seizures that responds well to replacement therapy...
  26. ncbi request reprint Hemiplegic migraine: hyperperfusion and abortive therapy with intravenous verapamil
    David A Hsu
    Department of Neurology H6 526, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
    Brain Dev 30:86-90. 2008
    ..The beneficial effect of verapamil on headache but not hemiplegia suggests a distinct mechanism for pain and neuronal dysfunction in hemiplegic migraine, with the beneficial effect on pain not due to vasodilation...
  27. ncbi request reprint Seizures in the developing brain cause adverse long-term effects on spatial learning and anxiety
    Umit Sayin
    Department of Neurology, University of Wisconsin, Madison, Wisconsin 53792, USA
    Epilepsia 45:1539-48. 2004
    ..Here we extend those findings by using a set of behavioral paradigms that are sensitive to additional aspects of learning and behavior...
  28. ncbi request reprint Anticonvulsant action and long-term effects of gabapentin in the immature brain
    M R Cilio
    Department of Neurology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuropharmacology 40:139-47. 2001
    ....
  29. ncbi request reprint Effects of uncontrolled seizures. Neural changes in animal models
    Carl E Stafstrom
    Division of Clinical Neurophysiology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Adv Exp Med Biol 497:171-94. 2002
    ..Doctors Stafstrom and Holmes have spent several years studying the brain damage and behavioral deficits caused by repeated seizures or status epilepticus. They discuss possible mechanisms and the effects of age...
  30. ncbi request reprint The ketogenic diet for the treatment of epilepsy: a challenge for nutritional neuroscientists
    Carl E Stafstrom
    Department of Neurology and the Neuroscience Training Program, University of Wisconsin, Madison, WI 53792, USA
    Nutr Neurosci 6:67-79. 2003
    ..We encourage scientists with a primary interest in nutritional neuroscience to join with those of us in the epilepsy research community to address these urgent questions, for the benefit of children ravaged by intractable seizures...
  31. ncbi request reprint Infantile spasms: criteria for an animal model
    Carl E Stafstrom
    Departments of Neurology and Pediatrics, University of Wisconsin, Madison, Wisconsin 53792, USA
    Int Rev Neurobiol 49:391-411. 2002
    ..Neither of these models conforms exactly to the human analog, but each possesses intriguing similarities that provide testable hypotheses for future investigations...
  32. ncbi request reprint Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus
    Gregory L Holmes
    Department of Neurology, Center for Research in Pediatric Epilepsy, Harvard Medical School, Children s Hospital, Hunnewell 2, 300 Longwood Avenue, Boston, MA 02115, USA
    Epilepsy Res 48:3-13. 2002
    ..This study demonstrates that choline supplementation prior to or following KA-induced status epilepticus can protect rats from memory deficits induced by status epilepticus...
  33. ncbi request reprint Can preventative antiepileptic therapy alter outcome in infants with tuberous sclerosis complex?
    Carl E Stafstrom
    Department of Neurology, University of Wisconsin, Madison, Wisconsin 53792, USA
    Epilepsia 48:1632-4. 2007
  34. ncbi request reprint Models of pediatric epilepsies: strategies and opportunities
    Carl E Stafstrom
    University of Wisconsin, USA
    Epilepsia 47:1407-14. 2006
  35. ncbi request reprint Neurobiological mechanisms of developmental epilepsy: translating experimental findings into clinical application
    Carl E Stafstrom
    Department of Neurology, Section of Pediatric Neurology, University of Wisconsin, Madison 53792, USA
    Semin Pediatr Neurol 14:164-72. 2007
    ..These topics are relevant to the pediatric neurologist when evaluating and treating a young child with seizures...
  36. ncbi request reprint Burst suppression electroencephalogram pattern in the newborn: predicting the outcome
    Laurie M Douglass
    Division of Pediatric Neurology, The Floating Hospital for Children at New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    J Child Neurol 17:403-8. 2002
    ..Infants with reactive burst suppression EEGs during the acute phase of illness appear to have the best prognosis...
  37. ncbi request reprint Effects of nimodipine on the behavioral sequalae of experimental status epilepticus in prepubescent rats
    Mohamad A Mikati
    Department of Pediatrics, and Adult and Pediatric Epilepsy Program, Faculty of Medicine, American University of Beirut, Lebanon
    Epilepsy Behav 5:168-74. 2004
    ..The goal of this study was to investigate the potential protective effects of nimodipine (ND), a calcium channel blocker, on the acute manifestations and long-term behavioral sequalae of experimental status epilepticus (SE)...
  38. ncbi request reprint Detrimental effects of the ketogenic diet on cognitive function in rats
    Qian Zhao
    Section of Neurology, Neuroscience Center at Dartmouth, Dartmouth Hitchcock Medical Center, One Medical Center Lebanon, NH 03756, USA
    Pediatr Res 55:498-506. 2004
    ..This study raises concerns about the long-term effects of the KD on brain development...
  39. ncbi request reprint Tuberous sclerosis complex and epilepsy: recent developments and future challenges
    Gregory L Holmes
    Neuroscience Center at Dartmouth, Section of Neurology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Epilepsia 48:617-30. 2007
    ..Finally, we provide an updated literature review and a consensus statement from the Tuberous Sclerosis Complex Working Group for future research into the mechanisms of epilepsy in TSC...
  40. ncbi request reprint Using artwork to better understand patients with neurologic disorders
    Carl E Stafstrom
    Epilepsy Behav 6:113-4. 2005
  41. ncbi request reprint It's time to eliminate the term seizure disorder from our lexicon
    Carl E Stafstrom
    Epilepsia 46:456. 2005