Research Topics
| C E StafstromSummaryAffiliation: University of Wisconsin Country: USA Publications
| Collaborators
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Detail Information
Publications
Art therapy focus groups for children and adolescents with epilepsyCarl E Stafstrom
Department of Neurology, University of Wisconsin, Madison, WI 53705, USA
Epilepsy Behav 24:227-33. 2012..However, subjects and parents were uniformly positive about their group experiences, suggesting a qualitative benefit from participation in art therapy focus groups...
Models of epilepsy in the developing and adult brain: implications for neuroprotectionCarl E Stafstrom
Department of Neurology, University of Wisconsin, Madison, WI 53792, USA
Epilepsy Behav 7:S18-24. 2005..The concept of seizure-induced brain damage must be expanded to include behavioral and cognitive deficits, as well as structural neuronal damage and increased predisposition to seizures...- Serial headache drawings by children with migraine: correlation with clinical headache statusCarl E Stafstrom
Department of Neurology, University of Wisconsin, 600 Highland Avenue, Madison, 53792, USA
J Child Neurol 20:809-13. 2005..The technique is simple, inexpensive, and enjoyable for children and can be applied in a variety of clinical settings... - Epilepsy: a review of selected clinical syndromes and advances in basic scienceCarl E Stafstrom
Department of Neurology, University of Wisconsin, Madison, Wisconsin 53792, USA
J Cereb Blood Flow Metab 26:983-1004. 2006..Despite this diversity of clinical phenotype and mechanism, these syndromes are informative as to how pathophysiological processes converge to produce brain hyperexcitability and seizures... - Counseling youth about military service options and Selective Service registration: an integral part of anticipatory guidance of adolescentsCarl E Stafstrom
Department of Neurology, H6-528, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792, USA
Pediatrics 119:1199-203. 2007 - Seizure drawings: insight into the self-image of children with epilepsyCarl E Stafstrom
Departments of Neurology and Pediatrics, University of Wisconsin, Wisconsin Madison, 53792, USA
Epilepsy Behav 4:43-56. 2003..In conclusion, drawings are a powerful method to examine the self-concept of children with epilepsy and gain insight into their feelings about themselves and their world... - NMDA-induced seizures in developing rats cause long-term learning impairment and increased seizure susceptibilityCarl E Stafstrom
Department of Neurology, Neuroscience Training Program, H6 528, University of Wisconsin, 600 Highland Avenue, 53792, Madison, WI, USA
Epilepsy Res 53:129-37. 2003..This study provides additional evidence for long-term alterations of neuronal excitability and cognitive capacity associated with seizures during development... - Seizures in a 7-month-old child after exposure to the essential plant oil thujaCarl E Stafstrom
Section of Pediatric Neurology, Departments of Neurology and Pediatrics, University of Wisconsin, Madison, WI 53792, USA
Pediatr Neurol 37:446-8. 2007..The epileptogenic potential of plant-derived essential oils and other herbal remedies should be recognized by practitioners providing neurologic care to children... - Assessing the behavioral and cognitive effects of seizures on the developing brainCarl E Stafstrom
Departments of Neurology and Pediatrics, University of Wisconsin, Madison, 600 Highland Avenue, Madison, WI 53792, USA
Prog Brain Res 135:377-90. 2002..Seizure-induced behavioral and cognitive deficits, which may not become obvious until long after the onset of the epilepsy, might be equally or more detrimental to a child's overall function than the seizures themselves... - Seizure suppression via glycolysis inhibition with 2-deoxy-D-glucose (2DG)Carl E Stafstrom
Department of Neurology, University of Wisconsin, Madison, Wisconsin 53792, USA
Epilepsia 49:97-100. 2008..Finally, 2DG has a favorable preliminary toxicity profile. These factors support the possibility that 2DG or other modifiers of glycolysis can be used as novel treatments for epilepsy... 
Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy modelsCarl E Stafstrom
Department of Neurology, University of Wisconsin, Madison, WI 53792, USA
Ann Neurol 65:435-47. 2009....- Severe epilepsy syndromes of early childhood: the link between genetics and pathophysiology with a focus on SCN1A mutationsCarl E Stafstrom
University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
J Child Neurol 24:15S-23S. 2009..Eventually, such information might enable clinicians to select an appropriate therapeutic regimen for patients with specific epilepsy gene mutations... - The usefulness of children's drawings in the diagnosis of headacheCarl E Stafstrom
Departments of Pediatrics and Neurology, Division of Pediatric Neurology, Floating Hospital for Children, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
Pediatrics 109:460-72. 2002..To determine whether drawings can aid in the differential diagnosis of headaches in children... - Mechanisms of action of antiepileptic drugs: the search for synergyCarl E Stafstrom
Pediatric Neurology Section, Department of Neurology, University of Wisconsin, Madison, Wisconsin, USA
Curr Opin Neurol 23:157-63. 2010.... - Epilepsy genes: the link between molecular dysfunction and pathophysiologyC E Stafstrom
Departments of Neurology and Pediatrics, University of Wisconsin, Madison, Wisconsin 53792, USA
Ment Retard Dev Disabil Res Rev 6:281-92. 2000..Gene defects can lead to epilepsy by altering multiple and diverse aspects of neuronal function... - Treatment of infantile spasms: emerging insights from clinical and basic science perspectivesCarl E Stafstrom
University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
J Child Neurol 26:1411-21. 2011..This summary derives from a meeting of specialists in infantile spasms clinical care and research held in New York City on June 14, 2010... - Animal models of the ketogenic diet: what have we learned, what can we learn?C E Stafstrom
Department of Neurology, University of Wisconsin, Madison 53792, USA
Epilepsy Res 37:241-59. 1999.... - Ezogabine (retigabine)Carl E Stafstrom
University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
Nat Rev Drug Discov 10:729-30. 2011..D.A.) for the adjunctive treatment of partial-onset seizures in adult patients. The same drug was granted marketing authorization for this indication in the European Union in March 2011, where it is known as retigabine (Trobalt)... - Recurrent seizures in immature rats: effect on auditory and visual discriminationJ C Neill
Department of Neurology, Harvard Medical School, Children s Hospital, Boston, MA 02115, USA
Brain Res Dev Brain Res 95:283-92. 1996..Histological examination showed no gross cell loss in the hippocampus. This study demonstrates that serial seizures in the developing brain cause detrimental effects on visual and auditory spatial learning... - Electrophysiological observations in hippocampal slices from rats treated with the ketogenic dietC E Stafstrom
Department of Neurology, Children s Hospital, Harvard Medical School, Boston, MA, USA
Dev Neurosci 21:393-9. 1999..Therefore, at least part of the KD mechanism of action may involve long-term changes in network excitability... - Seizures in the developing brain cause adverse long-term effects on spatial learning and anxietyUmit Sayin
Department of Neurology, University of Wisconsin, Madison, Wisconsin 53792, USA
Epilepsia 45:1539-48. 2004..These results may have clinical implications, favoring early and aggressive control of seizures during development... - Hemiplegic migraine: hyperperfusion and abortive therapy with intravenous verapamilDavid A Hsu
Department of Neurology H6 526, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
Brain Dev 30:86-90. 2008..The beneficial effect of verapamil on headache but not hemiplegia suggests a distinct mechanism for pain and neuronal dysfunction in hemiplegic migraine, with the beneficial effect on pain not due to vasodilation... - Intractable pediatric epilepsy: vagal nerve stimulation and the ketogenic dietRaj D Sheth
Department of Neurology, University of Wisconsin at Madison, H6 574 CSC, 600 Highland Avenue, Madison, WI 53792 5132, USA
Neurol Clin 20:1183-94. 2002..With better understanding of the scientific principles underlying brain ketosis, we should be able to optimize the KD to achieve even better results... - Downregulation of kainate receptors in the hippocampus following repeated seizures in immature ratsPushpa Tandon
Department of Neurology, Harvard Medical School, Center for Research in Pediatric Epilepsy, Children's Hospital, Boston, MA 02115, USA
Brain Res Dev Brain Res 136:145-50. 2002.... - Nonpharmacological treatment options for epilepsyRaj D Sheth
Department of Neurology, University of Wisconsin, Madison, Madison, WI 53792 5132, USA
Semin Pediatr Neurol 12:106-13. 2005..In addition, pyridoxine-dependent seizures are discussed as an example of an etiology of refractory seizures that responds well to replacement therapy... - Anticonvulsant action and long-term effects of gabapentin in the immature brainM R Cilio
Department of Neurology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Neuropharmacology 40:139-47. 2001.... - Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticusGregory L Holmes
Department of Neurology, Center for Research in Pediatric Epilepsy, Harvard Medical School, Children s Hospital, Hunnewell 2, 300 Longwood Avenue, Boston, MA 02115, USA
Epilepsy Res 48:3-13. 2002..This study demonstrates that choline supplementation prior to or following KA-induced status epilepticus can protect rats from memory deficits induced by status epilepticus... - Effects of uncontrolled seizures. Neural changes in animal modelsCarl E Stafstrom
Division of Clinical Neurophysiology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
Adv Exp Med Biol 497:171-94. 2002..Doctors Stafstrom and Holmes have spent several years studying the brain damage and behavioral deficits caused by repeated seizures or status epilepticus. They discuss possible mechanisms and the effects of age... - Infantile spasms: criteria for an animal modelCarl E Stafstrom
Departments of Neurology and Pediatrics, University of Wisconsin, Madison, Wisconsin 53792, USA
Int Rev Neurobiol 49:391-411. 2002..Neither of these models conforms exactly to the human analog, but each possesses intriguing similarities that provide testable hypotheses for future investigations... - The ketogenic diet for the treatment of epilepsy: a challenge for nutritional neuroscientistsCarl E Stafstrom
Department of Neurology and the Neuroscience Training Program, University of Wisconsin, Madison, WI 53792, USA
Nutr Neurosci 6:67-79. 2003..We encourage scientists with a primary interest in nutritional neuroscience to join with those of us in the epilepsy research community to address these urgent questions, for the benefit of children ravaged by intractable seizures... - Can preventative antiepileptic therapy alter outcome in infants with tuberous sclerosis complex?Carl E Stafstrom
Department of Neurology, University of Wisconsin, Madison, Wisconsin 53792, USA
Epilepsia 48:1632-4. 2007 - Models of pediatric epilepsies: strategies and opportunitiesCarl E Stafstrom
University of Wisconsin, USA
Epilepsia 47:1407-14. 2006 - Burst suppression electroencephalogram pattern in the newborn: predicting the outcomeLaurie M Douglass
Division of Pediatric Neurology, The Floating Hospital for Children at New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
J Child Neurol 17:403-8. 2002..Infants with reactive burst suppression EEGs during the acute phase of illness appear to have the best prognosis... - Neurobiological mechanisms of developmental epilepsy: translating experimental findings into clinical applicationCarl E Stafstrom
Department of Neurology, Section of Pediatric Neurology, University of Wisconsin, Madison 53792, USA
Semin Pediatr Neurol 14:164-72. 2007..These topics are relevant to the pediatric neurologist when evaluating and treating a young child with seizures... - Tuberous sclerosis complex and epilepsy: recent developments and future challengesGregory L Holmes
Neuroscience Center at Dartmouth, Section of Neurology, Dartmouth Medical School, Hanover, New Hampshire, USA
Epilepsia 48:617-30. 2007..Finally, we provide an updated literature review and a consensus statement from the Tuberous Sclerosis Complex Working Group for future research into the mechanisms of epilepsy in TSC... - Detrimental effects of the ketogenic diet on cognitive function in ratsQian Zhao
Section of Neurology, Neuroscience Center at Dartmouth, Dartmouth-Hitchcock Medical Center, One Medical Center Lebanon, NH 03756, USA
Pediatr Res 55:498-506. 2004..This study raises concerns about the long-term effects of the KD on brain development... - Effects of nimodipine on the behavioral sequalae of experimental status epilepticus in prepubescent ratsMohamad A Mikati
Department of Pediatrics, and Adult and Pediatric Epilepsy Program, Faculty of Medicine, American University of Beirut, Lebanon
Epilepsy Behav 5:168-74. 2004..The goal of this study was to investigate the potential protective effects of nimodipine (ND), a calcium channel blocker, on the acute manifestations and long-term behavioral sequalae of experimental status epilepticus (SE)... - It's time to eliminate the term seizure disorder from our lexiconCarl E Stafstrom
Epilepsia 46:456. 2005 - Using artwork to better understand patients with neurologic disordersCarl E Stafstrom
Epilepsy Behav 6:113-4. 2005