Hinrich Staecker

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. doi request reprint Developments in delivery of medications for inner ear disease
    Hinrich Staecker
    University of Kansas School of Medicine, Department of Otolaryngology Head and Neck Surgery, MS 3010, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Expert Opin Drug Deliv 10:639-50. 2013
  2. pmc Development of gene therapy for inner ear disease: Using bilateral vestibular hypofunction as a vehicle for translational research
    Hinrich Staecker
    Dept Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, MS 3010, 3901 Rainbow Blvd, Kansas City, KS 66209, USA
    Hear Res 276:44-51. 2011
  3. ncbi request reprint Vestibular hair cell regeneration and restoration of balance function induced by math1 gene transfer
    Hinrich Staecker
    Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
    Otol Neurotol 28:223-31. 2007
  4. ncbi request reprint Vector-mediated delivery of bcl-2 prevents degeneration of auditory hair cells and neurons after injury
    Hinrich Staecker
    Department of Otolaryngology, University of Kansas, Kansas City, Kans 66160, USA
    ORL J Otorhinolaryngol Relat Spec 69:43-50. 2007
  5. doi request reprint Neurotrophin therapy and cochlear implantation: translating animal models to human therapy
    Hinrich Staecker
    Department of Otolaryngology Head and Neck Surgery, University of Kansas, Kansas City, KS 66160, USA
    Exp Neurol 226:1-5. 2010
  6. ncbi request reprint Arrest of apoptosis in auditory neurons: implications for sensorineural preservation in cochlear implantation
    Ulysses Scarpidis
    Department of Otolaryngology, Albert Einstein College of Medicine, Bronx, New York, USA
    Otol Neurotol 24:409-17. 2003
  7. doi request reprint Bcl-2 gene therapy prevents aminoglycoside-induced degeneration of auditory and vestibular hair cells
    Susanna C Pfannenstiel
    Department of Otolaryngology Head and Neck Surgery, University of Kansas, School of Medicine, Kansas City, Kans 66160, USA
    Audiol Neurootol 14:254-66. 2009
  8. doi request reprint Cochlear implantation: an opportunity for drug development
    Hinrich Staecker
    Department of Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    Drug Discov Today 15:314-21. 2010
  9. doi request reprint Canalostomy as a surgical approach for cochlear gene therapy in the rat
    Davina Gassner
    Department of Otolaryngology, Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas, USA
    Anat Rec (Hoboken) 295:1830-6. 2012
  10. doi request reprint Adenovector-mediated gene delivery to human umbilical cord mesenchymal stromal cells induces inner ear cell phenotype
    Keerthana Devarajan
    Bioengineering Program, University of Kansas, Lawrence, 66045, USA
    Cell Reprogram 15:43-54. 2013

Collaborators

Detail Information

Publications21

  1. doi request reprint Developments in delivery of medications for inner ear disease
    Hinrich Staecker
    University of Kansas School of Medicine, Department of Otolaryngology Head and Neck Surgery, MS 3010, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Expert Opin Drug Deliv 10:639-50. 2013
    ..Despite the high incidence of inner ear disease in the general population, there are currently no dedicated pharmacologic interventions available to treat these problems...
  2. pmc Development of gene therapy for inner ear disease: Using bilateral vestibular hypofunction as a vehicle for translational research
    Hinrich Staecker
    Dept Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, MS 3010, 3901 Rainbow Blvd, Kansas City, KS 66209, USA
    Hear Res 276:44-51. 2011
    ..This approach is particularly suited for the development of molecular therapies targeted at the vestibular system given that no device based therapeutic such a cochlear implant available for vestibular loss...
  3. ncbi request reprint Vestibular hair cell regeneration and restoration of balance function induced by math1 gene transfer
    Hinrich Staecker
    Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
    Otol Neurotol 28:223-31. 2007
    ..Delivery of math1 using an adenovector (Admath1.11D) results in vestibular hair cell regeneration and recovery of balance function in ototoxin-treated adult mice...
  4. ncbi request reprint Vector-mediated delivery of bcl-2 prevents degeneration of auditory hair cells and neurons after injury
    Hinrich Staecker
    Department of Otolaryngology, University of Kansas, Kansas City, Kans 66160, USA
    ORL J Otorhinolaryngol Relat Spec 69:43-50. 2007
    ..To test the hypothesis that bcl-2 prevents oxidative stress-induced apoptosis of auditory sensory cells in explants of the organ of Corti and dissociated cell cultures of the spiral ganglion...
  5. doi request reprint Neurotrophin therapy and cochlear implantation: translating animal models to human therapy
    Hinrich Staecker
    Department of Otolaryngology Head and Neck Surgery, University of Kansas, Kansas City, KS 66160, USA
    Exp Neurol 226:1-5. 2010
    ....
  6. ncbi request reprint Arrest of apoptosis in auditory neurons: implications for sensorineural preservation in cochlear implantation
    Ulysses Scarpidis
    Department of Otolaryngology, Albert Einstein College of Medicine, Bronx, New York, USA
    Otol Neurotol 24:409-17. 2003
    ..The JNK/c-Jun cell death pathway is a major pathway responsible for the loss of oxidative stress-damaged auditory neurons...
  7. doi request reprint Bcl-2 gene therapy prevents aminoglycoside-induced degeneration of auditory and vestibular hair cells
    Susanna C Pfannenstiel
    Department of Otolaryngology Head and Neck Surgery, University of Kansas, School of Medicine, Kansas City, Kans 66160, USA
    Audiol Neurootol 14:254-66. 2009
    ..Pretreatment with Ad.11D.bcl-2 resulted in morphologic protection of hair cells and preservation of hearing thresholds measured by ABR...
  8. doi request reprint Cochlear implantation: an opportunity for drug development
    Hinrich Staecker
    Department of Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, KS 66160, USA
    Drug Discov Today 15:314-21. 2010
    ..The evolution of cochlear implantation thus presents us with an opportunity to develop a range of local pharmacologic interventions to prevent hearing degeneration...
  9. doi request reprint Canalostomy as a surgical approach for cochlear gene therapy in the rat
    Davina Gassner
    Department of Otolaryngology, Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas, USA
    Anat Rec (Hoboken) 295:1830-6. 2012
    ..Immunohistochemical assessment after delivery of a green fluorescent protein expressing vector showed significant GFP expression in the cochlea...
  10. doi request reprint Adenovector-mediated gene delivery to human umbilical cord mesenchymal stromal cells induces inner ear cell phenotype
    Keerthana Devarajan
    Bioengineering Program, University of Kansas, Lawrence, 66045, USA
    Cell Reprogram 15:43-54. 2013
    ..The results demonstrated for the first time that hUCMSCs can differentiate into hair cell-like cells, thus introducing a new potential tissue engineering and cell transplantation approach for the treatment of hearing loss...
  11. pmc Atoh1 induces auditory hair cell recovery in mice after ototoxic injury
    Shannon Kraft
    Department of Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
    Laryngoscope 123:992-9. 2013
    ..To evaluate the ability of the Ad28.gfap.atoh1 to promote hair cell regeneration and hearing recovery in cochlea injured with kanamycin and furosemide...
  12. doi request reprint Low dose oxidative stress induces mitochondrial damage in hair cells
    Kim Baker
    Department of Otolaryngology, Children s Mercy Medical Center, Kansas City, Missouri, USA
    Anat Rec (Hoboken) 295:1868-76. 2012
    ....
  13. ncbi request reprint Advances in inner ear gene therapy: exploring cochlear protection and regeneration
    Carrie R Maiorana
    Department of Otolaryngology, University of Kansas, Kansas City, KS 66160, USA
    Curr Opin Otolaryngol Head Neck Surg 13:308-12. 2005
    ..To review the application of gene therapy in the inner ear. Gene delivery to the inner ear was first reported in 1996. Since then the field has progressed on multiple fronts...
  14. doi request reprint Partial deafness cochlear implantation at the University of Kansas: techniques and outcomes
    Sandra Prentiss
    Department of Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, USA
    J Am Acad Audiol 21:197-203. 2010
    ..Conclusion: Hearing preservation was achievable even with deep implant insertion. Patients performed well in combined acoustic and electric conditions...
  15. ncbi request reprint The effect of diabetes on sensorineural hearing loss
    Venkata Kakarlapudi
    Department of Otolaryngology, Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Otol Neurotol 24:382-6. 2003
    ..To identify whether patients with diabetes have a higher incidence of sensorineural hearing loss than the general population and examine whether control of diabetes is related to severity of hearing loss...
  16. ncbi request reprint Transsynaptic delivery of nanoparticles to the central auditory nervous system
    Mark Praetorius
    Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg Medical Center, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Acta Otolaryngol 127:486-90. 2007
    ..Silica nanoparticles may serve as a nonviral delivery system to the sensory hair cells, spiral ganglion cells within the cochlea, and the vestibular organ, as well as the cochlear nucleus...
  17. ncbi request reprint Pharmacodynamics of adenovector distribution within the inner ear tissues of the mouse
    Mark Praetorius
    Department of Otolaryngology, University of Heidelberg Medical Center, Heidelberg, Germany
    Hear Res 227:53-8. 2007
    ..Understanding these basic distribution patterns and parameters for delivery are important for the design of gene delivery vectors and vital for modeling dose responses to achieve safe efficacious delivery of a therapeutic agent...
  18. ncbi request reprint Hearing preservation after inner ear gene therapy: the effect of vector and surgical approach
    Mark Praetorius
    Department of Otolaryngology, University Hospital of the Saarland, Homburg Saar, Germany
    ORL J Otorhinolaryngol Relat Spec 65:211-4. 2003
    ..Injection of comparable doses of vector into a basal turn cochleostomy resulted in high-frequency hearing loss. Addition of a pancaspase inhibitor protected hearing when larger volumes of fluid were administered to the inner ear...
  19. ncbi request reprint Drug delivery to the inner ear using gene therapy
    Hinrich Staecker
    Division of Otolaryngology, University of Maryland School of Medicine, 16 S Eutaw Street, Suite 500, Baltimore, MD 21201, USA
    Otolaryngol Clin North Am 37:1091-108. 2004
    ..As the understanding of gene therapy improves, investigators will be able to move toward targeted single-gene replacement to treat disorders such as connexin mutations and applying gene therapy to sensory cell replacement...
  20. ncbi request reprint Mechanisms of cell death in the injured auditory system: otoprotective strategies
    Philippe P Lefebvre
    Department of Otolaryngology, University of Liege, Belgium
    Audiol Neurootol 7:165-70. 2002
    ..These mechanisms have several different points at which inhibitors could be targeted to protect cells from programmed cell death, including the prevention of oxidative stress-induced apoptosis and the activation of caspases and calpains...
  21. ncbi request reprint Vertigo and abacavir
    Lori E Fantry
    University of Maryland Medical School Institute of Human Virology, Baltimore, Maryland, USA
    AIDS Patient Care STDS 16:5-7. 2002
    ..The mechanism by which abacavir appeared to be associated with vertigo in this patient is unknown...

Research Grants5

  1. Development of atonal therapy for bilateral vestibular hypofunction
    Hinrich Staecker; Fiscal Year: 2009
    ..The gene controlling development of hearing and balance sensory cells will be tested for its ability to restore balance function in models that prepare moving this molecular therapeutic into clinical studies. ..
  2. Development of atonal therapy for bilateral vestibular hypofunction
    Hinrich Staecker; Fiscal Year: 2010
    ..The gene controlling development of hearing and balance sensory cells will be tested for its ability to restore balance function in models that prepare moving this molecular therapeutic into clinical studies. ..