Hinrich Staecker

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Oxidative stress in aging in the C57B16/J mouse cochlea
    H Staecker
    Division of Otolaryngology, University of Maryland Medical School, Baltimore, Maryland 21201 1619, USA
    Acta Otolaryngol 121:666-72. 2001
  2. ncbi request reprint Broadening the spectrum of treatment options for SNHL
    Hinrich Staecker
    Department of Otolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore 21201, USA
    Arch Otolaryngol Head Neck Surg 131:734. 2005
  3. doi request reprint Neurotrophin therapy and cochlear implantation: translating animal models to human therapy
    Hinrich Staecker
    Department of Otolaryngology Head and Neck Surgery, University of Kansas, Kansas City, KS 66160, USA
    Exp Neurol 226:1-5. 2010
  4. doi request reprint Bcl-2 gene therapy prevents aminoglycoside-induced degeneration of auditory and vestibular hair cells
    Susanna C Pfannenstiel
    Department of Otolaryngology Head and Neck Surgery, University of Kansas, School of Medicine, Kansas City, Kans 66160, USA
    Audiol Neurootol 14:254-66. 2009
  5. pmc Atoh1 induces auditory hair cell recovery in mice after ototoxic injury
    Shannon Kraft
    Department of Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
    Laryngoscope 123:992-9. 2013
  6. ncbi request reprint Vertigo and abacavir
    Lori E Fantry
    University of Maryland Medical School Institute of Human Virology, Baltimore, Maryland, USA
    AIDS Patient Care STDS 16:5-7. 2002
  7. ncbi request reprint Drug delivery to the inner ear using gene therapy
    Hinrich Staecker
    Division of Otolaryngology, University of Maryland School of Medicine, 16 S Eutaw Street, Suite 500, Baltimore, MD 21201, USA
    Otolaryngol Clin North Am 37:1091-108. 2004
  8. ncbi request reprint Steroid perfusion of the inner ear for sudden sensorineural hearing loss after failure of conventional therapy: a pilot study
    Philippe P Lefebvre
    Department of Otorhinolaryngology, University of Liege, Liege, Belgium
    Acta Otolaryngol 122:698-702. 2002
  9. ncbi request reprint Topical steroid therapy using the Silverstein Microwick in sudden sensorineural hearing loss after failure of conventional treatment
    France Van Wijck
    Department of Otorhinolaryngology, University of Liege, Liege, Belgium
    Acta Otolaryngol 127:1012-7. 2007
  10. ncbi request reprint Vestibular hair cell regeneration and restoration of balance function induced by math1 gene transfer
    Hinrich Staecker
    Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
    Otol Neurotol 28:223-31. 2007

Collaborators

  • M Praetorius
  • Lori E Fantry
  • Thomas Balkany
  • W Liu
  • Christoph Klingmann
  • Bernhard Schick
  • Philippe P Lefebvre
  • Shannon Kraft
  • Douglas E Brough
  • Susanna C Pfannenstiel
  • France Van Wijck
  • Carrie R Maiorana
  • Ulysses Scarpidis
  • Venkata Kakarlapudi
  • Brigitte Malgrange
  • Chi Hsu
  • Peter K Plinkert
  • Thomas R Van De Water
  • Adrien A Eshraghi
  • Craig H Fletcher
  • Ken Kojima
  • Cynthia Shoemaker
  • Dilip Madnani
  • Phillipe Lefebvre
  • Robert Sawyer
  • Gustave Moonen
  • Thomas Van De Water

Detail Information

Publications18

  1. pmc Oxidative stress in aging in the C57B16/J mouse cochlea
    H Staecker
    Division of Otolaryngology, University of Maryland Medical School, Baltimore, Maryland 21201 1619, USA
    Acta Otolaryngol 121:666-72. 2001
    ....
  2. ncbi request reprint Broadening the spectrum of treatment options for SNHL
    Hinrich Staecker
    Department of Otolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore 21201, USA
    Arch Otolaryngol Head Neck Surg 131:734. 2005
  3. doi request reprint Neurotrophin therapy and cochlear implantation: translating animal models to human therapy
    Hinrich Staecker
    Department of Otolaryngology Head and Neck Surgery, University of Kansas, Kansas City, KS 66160, USA
    Exp Neurol 226:1-5. 2010
    ....
  4. doi request reprint Bcl-2 gene therapy prevents aminoglycoside-induced degeneration of auditory and vestibular hair cells
    Susanna C Pfannenstiel
    Department of Otolaryngology Head and Neck Surgery, University of Kansas, School of Medicine, Kansas City, Kans 66160, USA
    Audiol Neurootol 14:254-66. 2009
    ..Pretreatment with Ad.11D.bcl-2 resulted in morphologic protection of hair cells and preservation of hearing thresholds measured by ABR...
  5. pmc Atoh1 induces auditory hair cell recovery in mice after ototoxic injury
    Shannon Kraft
    Department of Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
    Laryngoscope 123:992-9. 2013
    ..To evaluate the ability of the Ad28.gfap.atoh1 to promote hair cell regeneration and hearing recovery in cochlea injured with kanamycin and furosemide...
  6. ncbi request reprint Vertigo and abacavir
    Lori E Fantry
    University of Maryland Medical School Institute of Human Virology, Baltimore, Maryland, USA
    AIDS Patient Care STDS 16:5-7. 2002
    ..The mechanism by which abacavir appeared to be associated with vertigo in this patient is unknown...
  7. ncbi request reprint Drug delivery to the inner ear using gene therapy
    Hinrich Staecker
    Division of Otolaryngology, University of Maryland School of Medicine, 16 S Eutaw Street, Suite 500, Baltimore, MD 21201, USA
    Otolaryngol Clin North Am 37:1091-108. 2004
    ..As the understanding of gene therapy improves, investigators will be able to move toward targeted single-gene replacement to treat disorders such as connexin mutations and applying gene therapy to sensory cell replacement...
  8. ncbi request reprint Steroid perfusion of the inner ear for sudden sensorineural hearing loss after failure of conventional therapy: a pilot study
    Philippe P Lefebvre
    Department of Otorhinolaryngology, University of Liege, Liege, Belgium
    Acta Otolaryngol 122:698-702. 2002
    ..In conclusion, methylprednisolone perfused at the level of the round window membrane resulted in significant recovery of hearing function after the failure of standard treatment of SSHL...
  9. ncbi request reprint Topical steroid therapy using the Silverstein Microwick in sudden sensorineural hearing loss after failure of conventional treatment
    France Van Wijck
    Department of Otorhinolaryngology, University of Liege, Liege, Belgium
    Acta Otolaryngol 127:1012-7. 2007
    ..Local administration of steroids to the inner ear through the round window route improves hearing in patients after failure of conventional therapy...
  10. ncbi request reprint Vestibular hair cell regeneration and restoration of balance function induced by math1 gene transfer
    Hinrich Staecker
    Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
    Otol Neurotol 28:223-31. 2007
    ..Delivery of math1 using an adenovector (Admath1.11D) results in vestibular hair cell regeneration and recovery of balance function in ototoxin-treated adult mice...
  11. ncbi request reprint Arrest of apoptosis in auditory neurons: implications for sensorineural preservation in cochlear implantation
    Ulysses Scarpidis
    Department of Otolaryngology, Albert Einstein College of Medicine, Bronx, New York, USA
    Otol Neurotol 24:409-17. 2003
    ..The JNK/c-Jun cell death pathway is a major pathway responsible for the loss of oxidative stress-damaged auditory neurons...
  12. ncbi request reprint Transsynaptic delivery of nanoparticles to the central auditory nervous system
    Mark Praetorius
    Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg Medical Center, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Acta Otolaryngol 127:486-90. 2007
    ..Silica nanoparticles may serve as a nonviral delivery system to the sensory hair cells, spiral ganglion cells within the cochlea, and the vestibular organ, as well as the cochlear nucleus...
  13. ncbi request reprint Vector-mediated delivery of bcl-2 prevents degeneration of auditory hair cells and neurons after injury
    Hinrich Staecker
    Department of Otolaryngology, University of Kansas, Kansas City, Kans 66160, USA
    ORL J Otorhinolaryngol Relat Spec 69:43-50. 2007
    ..To test the hypothesis that bcl-2 prevents oxidative stress-induced apoptosis of auditory sensory cells in explants of the organ of Corti and dissociated cell cultures of the spiral ganglion...
  14. ncbi request reprint Pharmacodynamics of adenovector distribution within the inner ear tissues of the mouse
    Mark Praetorius
    Department of Otolaryngology, University of Heidelberg Medical Center, Heidelberg, Germany
    Hear Res 227:53-8. 2007
    ..Understanding these basic distribution patterns and parameters for delivery are important for the design of gene delivery vectors and vital for modeling dose responses to achieve safe efficacious delivery of a therapeutic agent...
  15. ncbi request reprint Microperfusion of the inner ear
    Philippe P Lefebvre
    Dept of Otorhinolaryngology, University of Liege, Belgium
    Acta Otorhinolaryngol Belg 56:365-8. 2002
  16. ncbi request reprint The effect of diabetes on sensorineural hearing loss
    Venkata Kakarlapudi
    Department of Otolaryngology, Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Otol Neurotol 24:382-6. 2003
    ..To identify whether patients with diabetes have a higher incidence of sensorineural hearing loss than the general population and examine whether control of diabetes is related to severity of hearing loss...
  17. ncbi request reprint Hearing preservation after inner ear gene therapy: the effect of vector and surgical approach
    Mark Praetorius
    Department of Otolaryngology, University Hospital of the Saarland, Homburg Saar, Germany
    ORL J Otorhinolaryngol Relat Spec 65:211-4. 2003
    ..Injection of comparable doses of vector into a basal turn cochleostomy resulted in high-frequency hearing loss. Addition of a pancaspase inhibitor protected hearing when larger volumes of fluid were administered to the inner ear...
  18. ncbi request reprint Advances in inner ear gene therapy: exploring cochlear protection and regeneration
    Carrie R Maiorana
    Department of Otolaryngology, University of Kansas, Kansas City, KS 66160, USA
    Curr Opin Otolaryngol Head Neck Surg 13:308-12. 2005
    ..To review the application of gene therapy in the inner ear. Gene delivery to the inner ear was first reported in 1996. Since then the field has progressed on multiple fronts...