S P Stabler

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women
    S P Stabler
    Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Am J Clin Nutr 70:911-9. 1999
  2. ncbi request reprint Vitamin B12 deficiency as a worldwide problem
    Sally P Stabler
    Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Annu Rev Nutr 24:299-326. 2004
  3. pmc Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle
    Randy J Chandler
    Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Med Genet 8:64. 2007
  4. ncbi request reprint Effects of parenteral cysteine and glutathione feeding in a baboon model of severe prematurity
    S P Stabler
    Departments of Medicine and Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80220, USA
    Am J Clin Nutr 72:1548-57. 2000
  5. ncbi request reprint Elevated serum S-adenosylhomocysteine in cobalamin-deficient elderly and response to treatment
    Sally P Stabler
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Am J Clin Nutr 84:1422-9. 2006
  6. ncbi request reprint Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry
    Sally P Stabler
    Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin Chem 50:365-72. 2004
  7. ncbi request reprint Vitamin B-12 deficiency in the elderly: current dilemmas
    S P Stabler
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80220, USA
    Am J Clin Nutr 66:741-9. 1997
  8. ncbi request reprint Etiology and diagnostic evaluation of macrocytosis
    D G Savage
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Am J Med Sci 319:343-52. 2000
  9. pmc Identification and quantitation of cobalamin and cobalamin analogues in human feces
    Robert H Allen
    Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Clin Nutr 87:1324-35. 2008
  10. ncbi request reprint Low ratio of S-adenosylmethionine to S-adenosylhomocysteine is associated with vitamin deficiency in Brazilian pregnant women and newborns
    Elvira M Guerra-Shinohara
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciências Farmacêuticas da Universidade de São Paulo, Sao Paulo, Brazil
    Am J Clin Nutr 80:1312-21. 2004

Research Grants

  1. PREVALENCE AND SPECTRUM OF B12 DEFICIENCY IN THE AGED
    Sally Stabler; Fiscal Year: 2001
  2. PREVALENCE AND SPECTRUM OF B12 DEFICIENCY IN THE AGED
    Sally Stabler; Fiscal Year: 1993
  3. B12 Nutrition in the Aged
    Sally Stabler; Fiscal Year: 2007

Collaborators

  • Robert H Allen
  • B W Penninx
  • M Pahor
  • L P Fried
  • D G Savage
  • Mary Ann Johnson
  • S J Kittner
  • S Harvey Mudd
  • Conrad Wagner
  • S A Beresford
  • Hieronim Jakubowski
  • Steven Zeisel
  • Clinton B Wright
  • J T Brosnan
  • V Vasiliou
  • J David Spence
  • R L Sacco
  • Elvira M Guerra-Shinohara
  • Mihalis I Panayiotidis
  • Suparna Rajan
  • Patricia R Barbosa
  • Randy J Chandler
  • Kevin A Strauss
  • Sohyun Park
  • Olga E Morita
  • Regina A Pagliusi
  • Julie Robertson
  • Aftab Ahmad
  • Carl W White
  • Monica S Lewis
  • Suhong Xiao
  • S Harvey Mudd
  • Jeffrey I Wallace
  • E M Cottington
  • Kenneth N Maclean
  • Clet Niyikiza
  • Kayla I Brodkin
  • Felipe R Carvalho
  • Andre D Luchessi
  • Rosario D C Hirata
  • Renata Trentin
  • Mario H Hirata
  • Mihai D Niculescu
  • Donna L Robinson
  • Matthew Tsai
  • D Holmes Morton
  • Jennifer Sloan
  • Christine Hendrickson
  • Grazyna Chwatko
  • Vera L Blaia-d'Avila
  • Erik G Puffenberger
  • Klaus H Kaestner
  • Charles P Venditti
  • Hong Fu
  • Haig H Kazazian
  • B Kelly Schneider
  • Daniel Hernandez-Saavedra
  • Leighton H Legros
  • Joe M McCord
  • Albert R De Chicchis
  • Kelly Shea-Miller
  • Malak Kotb
  • Aglaia Pappa
  • Asok C Antony
  • Ying Sheng Tang
  • Hiremagalur N Jayaram
  • Rehana A Khan
  • Francesco Iemolo
  • Deborah K Hansen
  • L Stephen Miller
  • Elizabeth T M Horsley
  • Evelyn B Dolce
  • Vânia D'Almeida
  • Sabrina Peres
  • Silvia P Irazusta
  • Luiz F Sampaio Neto
  • Shawn E McCandless
  • Jonathan Kronick
  • Cheryl Garganta
  • Martin Pomper
  • Nancy Braverman
  • Parul Jayakar
  • Kamer Tezcan
  • Mary G Ampola
  • Marlene W Borschel
  • Harvey L Levy
  • Hobart Wiltse
  • Albert Tangerman
  • David E Seitz
  • Vladimir Kery

Detail Information

Publications29

  1. ncbi request reprint Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women
    S P Stabler
    Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Am J Clin Nutr 70:911-9. 1999
    ..Many previous investigations of cobalamin and folate status were performed in white populations...
  2. ncbi request reprint Vitamin B12 deficiency as a worldwide problem
    Sally P Stabler
    Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Annu Rev Nutr 24:299-326. 2004
    ..Areas for research include intermittent vitamin B12 supplement dosing and better measurements of the bioavailability of B12 in fermented vegetarian foods and algae...
  3. pmc Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle
    Randy J Chandler
    Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Med Genet 8:64. 2007
    ..Current treatment regimens rely on dietary management and, in severely affected patients, liver or combined liver-kidney transplantation. For undetermined reasons, transplantation does not correct the biochemical phenotype...
  4. ncbi request reprint Effects of parenteral cysteine and glutathione feeding in a baboon model of severe prematurity
    S P Stabler
    Departments of Medicine and Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80220, USA
    Am J Clin Nutr 72:1548-57. 2000
    ..The availability of cysteine for glutathione synthesis is low in premature infants with respiratory distress...
  5. ncbi request reprint Elevated serum S-adenosylhomocysteine in cobalamin-deficient elderly and response to treatment
    Sally P Stabler
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Am J Clin Nutr 84:1422-9. 2006
    ..S-Adenosylmethionine (SAM)-dependent methylation reactions produce S-adenosylhomocysteine (SAH), the precursor of homocysteine, which has been associated with adverse events when it is elevated...
  6. ncbi request reprint Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry
    Sally P Stabler
    Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin Chem 50:365-72. 2004
    ....
  7. ncbi request reprint Vitamin B-12 deficiency in the elderly: current dilemmas
    S P Stabler
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80220, USA
    Am J Clin Nutr 66:741-9. 1997
    ..Research efforts should be directed toward determining practical methods for diagnosing and treating vitamin B-12 deficiency in the millions of elderly subjects with undiagnosed deficiency...
  8. ncbi request reprint Etiology and diagnostic evaluation of macrocytosis
    D G Savage
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Am J Med Sci 319:343-52. 2000
    ..Elevation of mean cell volume (MCV) is a common clinical problem, but the etiologic spectrum and optimal diagnostic evaluation of macrocytosis are not well defined...
  9. pmc Identification and quantitation of cobalamin and cobalamin analogues in human feces
    Robert H Allen
    Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Clin Nutr 87:1324-35. 2008
    ..Cobalamin (vitamin B-12) and cobalamin analogues are present in human feces, but a complete identification has not been established, and the amounts present have not been determined...
  10. ncbi request reprint Low ratio of S-adenosylmethionine to S-adenosylhomocysteine is associated with vitamin deficiency in Brazilian pregnant women and newborns
    Elvira M Guerra-Shinohara
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciências Farmacêuticas da Universidade de São Paulo, Sao Paulo, Brazil
    Am J Clin Nutr 80:1312-21. 2004
    ..The effect of low maternal cobalamin concentrations on transmethylation metabolism in pregnant women and their newborns is unknown...
  11. ncbi request reprint Methyl balance and transmethylation fluxes in humans
    S Harvey Mudd
    Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, MD 20892, USA
    Am J Clin Nutr 85:19-25. 2007
    ....
  12. pmc Elevated serum S-adenosylhomocysteine in cobalamin-deficient megaloblastic anemia
    Elvira M Guerra-Shinohara
    Department of Clinical and Toxicological Analysis, Pharmaceutical School, University of Sao Paulo, Sao Paulo 05508 900, Brazil
    Metabolism 56:339-47. 2007
    ..In conclusion, serum SAH is elevated in cobalamin-deficient subjects with megaloblastic anemia and corrects with parenteral cobalamin therapy...
  13. ncbi request reprint Evaluation of nutritional and genetic determinants of total homocysteine, methylmalonic acid and S-adenosylmethionine/S-adenosylhomocysteine values in Brazilian childbearing-age women
    Patricia R Barbosa
    Department of Clinical Chemistry and Toxicology, School of Pharmaceutical Sciences, University of Sao Paulo, Brazil
    Clin Chim Acta 388:139-47. 2008
    ..We investigated the nutritional and genetic determinants for total homocysteine (tHcy), methylmalonic acid (MMA) and SAM/SAH in healthy Brazilian childbearing-age women...
  14. ncbi request reprint Hyperhomocysteinemia and vitamin B-12 deficiency in elderly using Title IIIc nutrition services
    Mary Ann Johnson
    Department of Foods and Nutrition, University of Georgia, Athens, USA
    Am J Clin Nutr 77:211-20. 2003
    ..The effect of the folate food fortification program on the prevalence of hyperhomocysteinemia in the older population with coexisting vitamin B-12 deficiency is not known...
  15. ncbi request reprint Age-related hearing loss, methylmalonic acid, and vitamin B12 status in older adults
    Sohyun Park
    Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA
    J Nutr Elder 25:105-20. 2006
    ..Thus, elevated MMA concentration may be associated with hearing loss in older adults. However, short-term B12 supplementation was unrelated to improvements in hearing status in B12-deficient individuals...
  16. ncbi request reprint Prevention of brain disease from severe 5,10-methylenetetrahydrofolate reductase deficiency
    Kevin A Strauss
    Clinic for Special Children, Strasburg, PA 17579, USA
    Mol Genet Metab 91:165-75. 2007
    ..To effectively support the metabolic requirements of rapid brain growth, a large dose of betaine should be started early in life...
  17. ncbi request reprint Screening for cobalamin deficiency in geriatric outpatients: prevalence and influence of synthetic cobalamin intake
    Suparna Rajan
    Seattle Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA
    J Am Geriatr Soc 50:624-30. 2002
    ..To describe the prevalence of cobalamin (Cbl) deficiency in older adult outpatients and to determine whether regular intake of a synthetic source of cobalamin confers protection against Cbl deficiency...
  18. ncbi request reprint Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia
    Mihalis I Panayiotidis
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Free Radic Biol Med 40:348-58. 2006
    ..These results indicate activation of MAT 2A and the transmethylation pathway in the metabolic response to hyperoxia in lung epithelium...
  19. pmc Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products
    Julie Robertson
    Department of Family Medicine, McMaster University, Hamilton, Ont
    CMAJ 172:1569-73. 2005
    ....
  20. ncbi request reprint Elevated methylmalonic acid is related to cognitive impairement in older adults enrolled in an elderly nutrition program
    Monica S Lewis
    Department of Psychology, The University of Georgia, Athens, GA 30602, USA
    J Nutr Elder 24:47-65. 2005
    ..Monitoring and reducing serum MMA concentrations by increasing the intake of vitamin B12 may provide protection against cognitive decline in this and other older populations...
  21. ncbi request reprint Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy
    Clet Niyikiza
    Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    Mol Cancer Ther 1:545-52. 2002
    ..Most importantly, decreasing homocysteine levels via vitamin supplementation leads to a better safety profile of pemetrexed and possibly to an improved efficacy...
  22. ncbi request reprint Infantile hypermethioninemia and hyperhomocysteinemia due to high methionine intake: a diagnostic trap
    S Harvey Mudd
    NIMH DIRP LMB, Laboratory of Molecular Biology, National Institute of Mental Health, Building 36, Room 1B 08, 36 Convent Drive, MSC 4034, Bethesda, MD 20892 4034, USA
    Mol Genet Metab 79:6-16. 2003
    ....
  23. ncbi request reprint Vitamins, homocysteine, and cognition
    Sally P Stabler
    Am J Clin Nutr 78:359-60. 2003
  24. ncbi request reprint Adverse event associated with methionine loading test: a case report
    E M Cottington
    Case Western Reserve University, Cleveland, Ohio, USA
    Arterioscler Thromb Vasc Biol 22:1046-50. 2002
    ....
  25. ncbi request reprint Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cells
    Mihalis I Panayiotidis
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Chem Biol Interact 147:87-97. 2004
    ..The transsulfuration pathway was likely activated by CSE since cystathionine increased, potentially contributing to the increased total intracellular GSH content...
  26. ncbi request reprint High homocysteine and thrombosis without connective tissue disorders are associated with a novel class of cystathionine beta-synthase (CBS) mutations
    Kenneth N Maclean
    Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
    Hum Mutat 19:641-55. 2002
    ....
  27. ncbi request reprint Maternal folate deficiency results in selective upregulation of folate receptors and heterogeneous nuclear ribonucleoprotein-E1 associated with multiple subtle aberrations in fetal tissues
    Suhong Xiao
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5254, USA
    Birth Defects Res A Clin Mol Teratol 73:6-28. 2005
    ..Accordingly, we tested the hypothesis that sustained murine maternal folate deficiency would negatively impact pregnancy outcomes, upregulate FR, and selectively reduce fetal cell proliferation...
  28. pmc Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study
    Clinton B Wright
    Department of Neurology, Columbia University College of Physicians and Surgeons and the Mailman School of Public Health, New York, NY, USA
    Stroke 36:1207-11. 2005
    ..White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations...
  29. ncbi request reprint Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults
    Suparna Rajan
    Seattle Veteran Affairs Puget Sound Health Care System, Seattle, Washington, USA
    J Am Geriatr Soc 50:1789-95. 2002
    ....

Research Grants15

  1. PREVALENCE AND SPECTRUM OF B12 DEFICIENCY IN THE AGED
    Sally Stabler; Fiscal Year: 2001
    ..This proposal seeks to investigate the clinical consequences of cobalamin deficiency in the elderly in order to improve diagnosis and replacement therapy for these individuals. ..
  2. PREVALENCE AND SPECTRUM OF B12 DEFICIENCY IN THE AGED
    Sally Stabler; Fiscal Year: 1993
    ..In addition, in two subsets of patients, the pattern of neurobehavioral abnormalities will be defined using sensitive multifaceted methodology, and the nature and extent of response to cobalamin therapy will be determined...
  3. B12 Nutrition in the Aged
    Sally Stabler; Fiscal Year: 2007
    ..abstract_text> ..