Research Topics
| S P StablerSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly womenS P Stabler
Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
Am J Clin Nutr 70:911-9. 1999..Many previous investigations of cobalamin and folate status were performed in white populations...- Vitamin B12 deficiency as a worldwide problemSally P Stabler
Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Annu Rev Nutr 24:299-326. 2004..Areas for research include intermittent vitamin B12 supplement dosing and better measurements of the bioavailability of B12 in fermented vegetarian foods and algae... 
Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscleRandy J Chandler
Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
BMC Med Genet 8:64. 2007..Current treatment regimens rely on dietary management and, in severely affected patients, liver or combined liver-kidney transplantation. For undetermined reasons, transplantation does not correct the biochemical phenotype...- Effects of parenteral cysteine and glutathione feeding in a baboon model of severe prematurityS P Stabler
Departments of Medicine and Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80220, USA
Am J Clin Nutr 72:1548-57. 2000..The availability of cysteine for glutathione synthesis is low in premature infants with respiratory distress... - Elevated serum S-adenosylhomocysteine in cobalamin-deficient elderly and response to treatmentSally P Stabler
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
Am J Clin Nutr 84:1422-9. 2006..S-Adenosylmethionine (SAM)-dependent methylation reactions produce S-adenosylhomocysteine (SAH), the precursor of homocysteine, which has been associated with adverse events when it is elevated... - Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometrySally P Stabler
Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Clin Chem 50:365-72. 2004.... - Vitamin B-12 deficiency in the elderly: current dilemmasS P Stabler
Department of Medicine, University of Colorado Health Sciences Center, Denver 80220, USA
Am J Clin Nutr 66:741-9. 1997..Research efforts should be directed toward determining practical methods for diagnosing and treating vitamin B-12 deficiency in the millions of elderly subjects with undiagnosed deficiency... - Etiology and diagnostic evaluation of macrocytosisD G Savage
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
Am J Med Sci 319:343-52. 2000..Elevation of mean cell volume (MCV) is a common clinical problem, but the etiologic spectrum and optimal diagnostic evaluation of macrocytosis are not well defined... - Identification and quantitation of cobalamin and cobalamin analogues in human fecesRobert H Allen
Division of Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Am J Clin Nutr 87:1324-35. 2008..Cobalamin (vitamin B-12) and cobalamin analogues are present in human feces, but a complete identification has not been established, and the amounts present have not been determined... - Low ratio of S-adenosylmethionine to S-adenosylhomocysteine is associated with vitamin deficiency in Brazilian pregnant women and newbornsElvira M Guerra-Shinohara
Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciências Farmacêuticas da Universidade de São Paulo, Sao Paulo, Brazil
Am J Clin Nutr 80:1312-21. 2004..The effect of low maternal cobalamin concentrations on transmethylation metabolism in pregnant women and their newborns is unknown... - Methyl balance and transmethylation fluxes in humansS Harvey Mudd
Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, MD 20892, USA
Am J Clin Nutr 85:19-25. 2007.... - Elevated serum S-adenosylhomocysteine in cobalamin-deficient megaloblastic anemiaElvira M Guerra Shinohara
Department of Clinical and Toxicological Analysis, Pharmaceutical School, University of Sao Paulo, Sao Paulo 05508 900, Brazil
Metabolism 56:339-47. 2007..In conclusion, serum SAH is elevated in cobalamin-deficient subjects with megaloblastic anemia and corrects with parenteral cobalamin therapy... - Evaluation of nutritional and genetic determinants of total homocysteine, methylmalonic acid and S-adenosylmethionine/S-adenosylhomocysteine values in Brazilian childbearing-age womenPatricia R Barbosa
Department of Clinical Chemistry and Toxicology, School of Pharmaceutical Sciences, University of Sao Paulo, Brazil
Clin Chim Acta 388:139-47. 2008..We investigated the nutritional and genetic determinants for total homocysteine (tHcy), methylmalonic acid (MMA) and SAM/SAH in healthy Brazilian childbearing-age women... - Hyperhomocysteinemia and vitamin B-12 deficiency in elderly using Title IIIc nutrition servicesMary Ann Johnson
Department of Foods and Nutrition, University of Georgia, Athens, USA
Am J Clin Nutr 77:211-20. 2003..042). High-dose oral B-12 therapy lowered mean MMA and tHcy by 49% and 32%, respectively. CONCLUSION: Vitamin B-12 deficiency was prevalent and was associated with poor cognition, anemia, and hyperhomocysteinemia... - Age-related hearing loss, methylmalonic acid, and vitamin B12 status in older adultsSohyun Park
Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA
J Nutr Elder 25:105-20. 2006..Thus, elevated MMA concentration may be associated with hearing loss in older adults. However, short-term B12 supplementation was unrelated to improvements in hearing status in B12-deficient individuals... - Prevention of brain disease from severe 5,10-methylenetetrahydrofolate reductase deficiencyKevin A Strauss
Clinic for Special Children, Strasburg, PA 17579, USA
Mol Genet Metab 91:165-75. 2007..To effectively support the metabolic requirements of rapid brain growth, a large dose of betaine should be started early in life... - Screening for cobalamin deficiency in geriatric outpatients: prevalence and influence of synthetic cobalamin intakeSuparna Rajan
Seattle Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA
J Am Geriatr Soc 50:624-30. 2002..Appropriate screening intervals and the optimal dose of supplemental Cbl to prevent Cbl deficiency remains to be determined... - Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxiaMihalis I Panayiotidis
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Free Radic Biol Med 40:348-58. 2006..These results indicate activation of MAT 2A and the transmethylation pathway in the metabolic response to hyperoxia in lung epithelium... - Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain productsJulie Robertson
Department of Family Medicine, McMaster University, Hamilton, Ont
CMAJ 172:1569-73. 2005.... - Elevated methylmalonic acid is related to cognitive impairement in older adults enrolled in an elderly nutrition programMonica S Lewis
Department of Psychology, The University of Georgia, Athens, GA 30602, USA
J Nutr Elder 24:47-65. 2005..Monitoring and reducing serum MMA concentrations by increasing the intake of vitamin B12 may provide protection against cognitive decline in this and other older populations... - Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapyClet Niyikiza
Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
Mol Cancer Ther 1:545-52. 2002..Most importantly, decreasing homocysteine levels via vitamin supplementation leads to a better safety profile of pemetrexed and possibly to an improved efficacy... - Infantile hypermethioninemia and hyperhomocysteinemia due to high methionine intake: a diagnostic trapS Harvey Mudd
NIMH DIRP LMB, Laboratory of Molecular Biology, National Institute of Mental Health, Building 36, Room 1B 08, 36 Convent Drive, MSC 4034, Bethesda, MD 20892 4034, USA
Mol Genet Metab 79:6-16. 2003.... - Vitamins, homocysteine, and cognitionSally P Stabler
Am J Clin Nutr 78:359-60. 2003 - Adverse event associated with methionine loading test: a case reportE M Cottington
Case Western Reserve University, Cleveland, Ohio, USA
Arterioscler Thromb Vasc Biol 22:1046-50. 2002.... - Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cellsMihalis I Panayiotidis
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Chem Biol Interact 147:87-97. 2004..The transsulfuration pathway was likely activated by CSE since cystathionine increased, potentially contributing to the increased total intracellular GSH content... - High homocysteine and thrombosis without connective tissue disorders are associated with a novel class of cystathionine beta-synthase (CBS) mutationsKenneth N Maclean
Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
Hum Mutat 19:641-55. 2002.... - Maternal folate deficiency results in selective upregulation of folate receptors and heterogeneous nuclear ribonucleoprotein-E1 associated with multiple subtle aberrations in fetal tissuesSuhong Xiao
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202-5254, USA
Birth Defects Res A Clin Mol Teratol 73:6-28. 2005..The potential significance of these findings to explain the wide spectrum of folate-responsive birth defects in humans is discussed... - Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan StudyClinton B Wright
Department of Neurology, Columbia University College of Physicians and Surgeons and the Mailman School of Public Health, New York, NY, USA
Stroke 36:1207-11. 2005..White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations... - Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adultsSuparna Rajan
Seattle Veteran Affairs Puget Sound Health Care System, Seattle, Washington, USA
J Am Geriatr Soc 50:1789-95. 2002..CONCLUSIONS: Most Cbl-deficient older people require more than 100 microg of oral Cbl to normalize serum MMA, which is a larger dose than is available in most standard multivitamins and Cbl supplements...
Research Grants
- PREVALENCE AND SPECTRUM OF B12 DEFICIENCY IN THE AGEDSally Stabler; Fiscal Year: 2001..This proposal seeks to investigate the clinical consequences of cobalamin deficiency in the elderly in order to improve diagnosis and replacement therapy for these individuals. ..
- PREVALENCE AND SPECTRUM OF B12 DEFICIENCY IN THE AGEDSally Stabler; Fiscal Year: 1993..In addition, in two subsets of patients, the pattern of neurobehavioral abnormalities will be defined using sensitive multifaceted methodology, and the nature and extent of response to cobalamin therapy will be determined...
- B12 Nutrition in the AgedSally Stabler; Fiscal Year: 2007..abstract_text> ..