Research Topics
| Martin St John SuttonSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Detail Information
Publications
Cardiac resynchronization induces major structural and functional reverse remodeling in patients with New York Heart Association class I/II heart failureMartin St John Sutton
University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Circulation 120:1858-65. 2009..It is not known whether patients with New York Heart Association class I/II systolic heart failure exhibit left ventricular (LV) reverse remodeling with CRT or whether reverse remodeling is modified by the cause of heart failure...
Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failureMartin G St John Sutton
Division of Cardiology, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
Circulation 107:1985-90. 2003..The purpose of the present study was to determine whether improvements in left ventricular (LV) size and function were associated with CRT...- Left ventricular remodeling and ventricular arrhythmias after myocardial infarctionMartin St John Sutton
Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Circulation 107:2577-82. 2003.... - Familial occurrence of peripartum cardiomyopathy presages a genetic rather than an environmental causeMartin St John Sutton
Division of Cardiovascular Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
Curr Heart Fail Rep 7:153-5. 2010.... 
Reverse remodelling in heart failure with cardiac resynchronisation therapyM St John Sutton
Division of Cardiology, Department of Medicine, University of Pennsylvania Medical Center, Room 9017, Gates Pavilion, 3400, Spruce Street, Philadelphia, PA 19104, USA
Heart 93:167-71. 2007..Cardiac resynchronisation therapy is a novel and effective treatment for systolic heart failure, and is associated with reverse remodelling of the LV...- Sustained reverse left ventricular structural remodeling with cardiac resynchronization at one year is a function of etiology: quantitative Doppler echocardiographic evidence from the Multicenter InSync Randomized Clinical Evaluation (MIRACLE)Martin G St John Sutton
University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Circulation 113:266-72. 2006..The purpose of this study was to determine whether reverse left ventricular (LV) remodeling and symptomatic benefit from CRT were sustained at 12 months, and if so, in what proportion of patients this occurred... - Risk assessment in patients with depressed left ventricular function after myocardial infarction using the myocardial performance index--Survival and Ventricular Enlargement (SAVE) experienceNagesh S Anavekar
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Am Soc Echocardiogr 19:28-33. 2006..The prognostic significance of MPI is less clear for cardiovascular (CV) events after myocardial infarction (MI) among individuals at high risk with depressed left ventricular (LV) systolic function... - Left ventricular remodeling in human heart failure: quantitative echocardiographic assessment of 1,794 patientsBonnie Ky
Division of Cardiovascular Medicine Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Echocardiography 29:758-65. 2012..We sought to define the adaptive remodeling that occurs in chronic human HF through the detailed analyses of a large quantitative echocardiography database... - Ventricular remodeling does not accompany the development of heart failure in diabetic patients after myocardial infarctionScott D Solomon
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
Circulation 106:1251-5. 2002..We used data from the Survival and Ventricular Enlargement (SAVE) echocardiographic substudy to test the hypothesis that diabetes was associated with increased LV enlargement after MI... - Early and late systolic wall stress differentially relate to myocardial contraction and relaxation in middle-aged adults: the asklepios studyJulio A Chirinos
3800 Woodland Ave Rm 8B111, Philadelphia, PA 19104
Hypertension 61:296-303. 2013..A loading sequence characterized by prominent late systolic wall stress was associated with lower longitudinal systolic function and diastolic relaxation... - Prognostic use of echocardiography 1 year after a myocardial infarctionHicham Skali
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Am Heart J 150:743-9. 2005..4, 95% CI 8.2-46.0) in follow-up. CONCLUSIONS: In a stable population of survivors of MI, impaired LV and RV function at 1 year after MI are independently and additively predictive of increased risk of HF or death... - Heart failure with normal ejection fraction: consideration of mechanisms other than diastolic dysfunctionTravis Bench
Division of Cardiology, Columbia University, 177 Fort Washington Avenue, New York, NY 10032, USA
Curr Heart Fail Rep 6:57-64. 2009..In this article, we review the current understanding of nondiastolic mechanisms that may contribute to the HF with normal EF syndrome to highlight potential pathways for research that may lead to new targets for therapy... - Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure: results from the Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) studyMichael R Gold
Division of Cardiology, Medical University of South Carolina, 25 Courtenay Dr, ART 7031, Charleston, SC 29425 5920, USA
Circulation 126:822-9. 2012..We aimed to assess the impact of baseline QRS duration and morphology and the change in QRS duration with pacing on CRT outcomes in mild heart failure... - Predictors of remodeling in the CRT era: influence of mitral regurgitation, BNP, and genderThomas P Cappola
Division of Cardiovascular Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
J Card Fail 12:182-8. 2006..Future studies should take these clinical factors into account when determining the influence of genetic factors and novel therapies on ventricular remodeling in chronic heart failure... - Gender differences in cardiac remodeling and clinical outcomes in chronic stable angina pectoris (from the ACTION Trial)Bonnie Ky
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Am J Cardiol 105:943-7. 2010..These findings may reflect inherent gender-based differences in ischemic heart disease and cardiac remodeling and might help to identify women at high risk... - Mitral valve tenting index for assessment of subvalvular remodelingLiam P Ryan
Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Ann Thorac Surg 84:1243-9. 2007..An effective technique for determining the extent of subvalvular remodeling could improve surgical results by identifying patients who are unlikely to benefit from annuloplasty alone... - Time-varying myocardial stress and systolic pressure-stress relationship: role in myocardial-arterial coupling in hypertensionJulio A Chirinos
University of Pennsylvania, Philadelphia, USA
Circulation 119:2798-807. 2009..We assessed the relationship between instantaneous ejection-phase pressure and myocardial stress and the effect of arterial wave reflections on myocardial stress in hypertensive and normotensive adults... - The utility of prescreening transesophageal echocardiograms: a prospective studyJeffrey Ogbara
Department of Medicine, Cardiovascular Division, Echocardiography Laboratory University of Pennsylvania, Philadelphia, Pennsylvania, USA
Echocardiography 28:767-73. 2011..However, the intersection of the AUC with the safety and clinical use of transesophageal echocardiography (TEE) is not well established... - Right ventricular dysfunction and risk of heart failure and mortality after myocardial infarctionLeonardo A M Zornoff
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 39:1450-5. 2002..3% to 29.2%; p = 0.006). CONCLUSIONS: Right ventricular function is an independent predictor of death and the development of HF in patients with LV dysfunction after MI... - Clinical utility of automated assessment of left ventricular ejection fraction using artificial intelligence-assisted border detectionHind W Rahmouni
Department of Medicine, Cardiovascular Division, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA
Am Heart J 155:562-70. 2008..We tested Siemens AutoEF software (Siemens Medical Solutions, Erlangen, Germany) to determine whether it correlated with visual estimates of EF, manual planimetry, and cardiac magnetic resonance (CMR)... - Cardiopulmonary exercise variables in diastolic versus systolic heart failureMary Jane Farr
Division of Cardiology, Columbia University, New York, New York, USA
Am J Cardiol 102:203-6. 2008..3, diastolic HF vs systolic HF). In conclusion, the CPX response in patients with diastolic HF and systolic HF is markedly abnormal and indistinguishable with regard to peak VO(2) and ventilation despite marked differences in the LV EF... - Images in cardiovascular medicine. Pulmonary venous aneurysms in hereditary hemorrhagic telangiectasia detected by 3-dimensional magnetic resonance angiographyVictor A Ferrari
Adult Congenital Heart Disease Program, Division of Cardiovascular Medicine, Department of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce St, 9014 E Gates Pavilion, Philadelphia, PA 19104, USA
Circulation 108:e122-3. 2003 - Left ventricular mass: allometric scaling, normative values, effect of obesity, and prognostic performanceJulio A Chirinos
University of Pennsylvania Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
Hypertension 56:91-8. 2010..We provide more appropriate normalization methods, normative data by 2D echocardiography and gradient-echo cardiac MRI, and cutoffs for defining LVH, along with prognostic validation data... - Chronic kidney disease and cardiac remodelling in patients with mild heart failure: results from the REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction (REVERSE) studyJehu Mathew
Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA, USA
Eur J Heart Fail 14:1420-8. 2012..Chronic kidney disease (CKD) is a risk factor for left ventricular hypertrophy (LVH) and heart failure. We evaluated the effect of CKD on left ventricular (LV) remodelling among patients with mild heart failure... - Importance of blood pressure control in left ventricular mass regressionAlan B Miller
Division of Cardiology, Department of Medicine, University of Florida, Jacksonville, Florida 32209, USA
J Am Soc Hypertens 4:302-10. 2010..3; atenolol/lisinopril: -6.7; lisinopril: -7.9 g/m(2)). Achievement of targeted BP control is more important than treatment regimen in achieving LV mass reduction... - Transition from chronic compensated to acute decompensated heart failure: pathophysiological insights obtained from continuous monitoring of intracardiac pressuresMichael R Zile
Department of Medicine, Division of Cardiology, Medical University of South Carolina, Charleston, SC 29425, USA
Circulation 118:1433-41. 2008..The purpose of this study was to use echocardiographic and implantable hemodynamic monitor data to examine the pathophysiology of chronic compensated and acute decompensated HF in SHF versus DHF patients... - Expectations of surgeons from an imagerHind Rahmouni
University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Heart Fail Clin 3:121-37. 2007..These rapid developments are challenging for the imager and the surgeon and mandate a close collaboration between the two disciplines to minimize surgical risk and improve the outcome of patients who have heart failure... - Hypertrophic cardiomyopathy. Pathophysiology, diagnosis, and treatmentEric D Popjes
Department of Medicine, Division of Cardiology, Penn State Milton S. Hershey Medical Center, Hershey, Penn, USA
Geriatrics 58:41-6; quiz 47. 2003..Identification of those at risk for sudden death may require consideration of prophylactic defibrillator placement... - A comparison of the effects of rosiglitazone and glyburide on cardiovascular function and glycemic control in patients with type 2 diabetesMartin St John Sutton
University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Diabetes Care 25:2058-64. 2002..This open-label, active-controlled study investigated the cardiac safety and antihyperglycemic effect of rosiglitazone (RSG) in patients with type 2 diabetes... - Assessment of ventricular remodeling in heart failure clinical trialsJames N Kirkpatrick
Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Curr Heart Fail Rep 9:328-36. 2012..To date, trials have demonstrated a linkage between indices of remodeling and clinical outcomes measures. Indices of remodeling have facilitated identification of targets for novel pharmaceutical agents and new device therapies... - The influence of annuloplasty ring geometry on mitral leaflet curvatureLiam P Ryan
The Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
Ann Thorac Surg 86:749-60; discussion 749-60. 2008..We describe an echocardiographically based methodology for quantifying mitral valve geometry and its application to the characterization of ovine mitral valve geometry before and after implantation of an annuloplasty ring...