Research Topics
Species | SATISH SRIVASTAVASummaryAffiliation: University of Texas Medical Branch Country: USA Publications
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Detail Information
Publications
Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthmaUmesh C S Yadav
Department of Biochemistry, 301 University Blvd, The University of Texas Medical Branch, Galveston, TX 77555, USA
Respir Res 12:145. 2011....
Structural and kinetic determinants of aldehyde reduction by aldose reductaseS Srivastava
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77555, USA
Biochemistry 38:42-54. 1999....- Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disordersSatish K Srivastava
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
Chem Biol Interact 191:330-8. 2011..Our results thus offer a novel therapeutic approach to treat a wide array of inflammatory diseases... - Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic optionsSatish K Srivastava
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555, USA
Endocr Rev 26:380-92. 2005.... - Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibitionKota V Ramana
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
Circulation 114:1838-46. 2006..Postreceptor signaling events that lead to stress responses and cytokine production are sensitive to redox changes and products of lipid peroxidation... - Inhibition of aldose reductase attenuates TNF-alpha-induced expression of adhesion molecules in endothelial cellsKota V Ramana
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555, USA
FASEB J 18:1209-18. 2004.... - Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF-alpha in human lens epithelial cellsKota V Ramana
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555-0647, USA
FASEB J 17:315-7. 2003..These observations could provide new insights into the pathophysiology of diabetes and the role of aberrant glucose metabolism in apoptotic cell death... - Inhibition of aldose reductase attenuates endotoxin signals in human non-pigmented ciliary epithelial cellsUmesh C S Yadav
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 6 644 Basic Science Building, 301 University Blvd, Galveston, TX 77555 0647, USA
Exp Eye Res 90:555-63. 2010..Taken together, our results suggest that AR plays an important role in the LPS-induced inflammatory changes in hNPECs and that inhibition of AR could be a novel therapeutic approach for ocular inflammation... - Inhibition of aldose reductase prevents lipopolysaccharide-induced inflammatory response in human lens epithelial cellsAgnieszka Pladzyk
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555-0647, USA
Invest Ophthalmol Vis Sci 47:5395-403. 2006..Thus, inhibition of AR could be a therapeutic target for Gram-negative bacterial infection-induced visual complications... - Aldose reductase prevents aldehyde toxicity in cultured human lens epithelial cellsAgnieszka Pladzyk
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Blvd, 6.644 Basic Science Bldg, Galveston, TX 77555-0647, USA
Exp Eye Res 83:408-16. 2006..The results indicate that the lipid aldehydes generated under oxidative stress are cytotoxic to HLEC leading to apoptosis and that the reduction of lipid aldehydes by AR would prevent it... - Aldose reductase inhibition prevents endotoxin-induced uveitis in ratsUmesh C S Yadav
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
Invest Ophthalmol Vis Sci 48:4634-42. 2007..The purpose of the present study was to elucidate the role of the polyol pathway enzyme aldose reductase (AR) in the mediation of ocular inflammation in a rat model of endotoxin-induced uveitis (EIU)... - Inhibition of aldose reductase prevents experimental allergic airway inflammation in miceUmesh C S Yadav
Department of Biochemistry and Molecular Biology, Immunology, University of Texas Medical Branch, Galveston, Texas, United States
PLoS ONE 4:e6535. 2009..Hence, we investigated the efficacy of AR inhibition in the prevention of allergic responses to a common natural airborne allergen, ragweed pollen that leads to airway inflammation and hyper-responsiveness in a murine model of asthma... - Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cellsRavinder Tammali
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
Cancer Res 66:9705-13. 2006.... - Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cellsRavinder Tammali
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Blvd 6 644 Basic Science Bldg, Galveston, TX 77555 0647, USA
Cancer Lett 252:299-306. 2007..These results suggest that inhibition of AR could be a novel chemopreventive approach to colon cancer... - Aldose reductase mediates the mitogenic signals of cytokinesKota V Ramana
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 619 Basic Science Building, Galveston, TX 77555, USA
Chem Biol Interact 143:587-96. 2003..These observations suggest a possible therapeutic use of AR inhibitors in these pathological conditions... - Aldose reductase regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycleRavinder Tammali
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
Endocrinology 151:2140-50. 2010..Thus, inhibition of AR may be a useful therapeutic approach in preventing vascular complications... - Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cellsKota V Ramana
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 619 Basic Science Building, Galveston, TX 77555, USA
FEBS Lett 570:189-94. 2004..These observations suggest that AR is a critical regulator of TNF-alpha-induced apoptotic signaling in endothelial cells... - Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-alpha via protein kinase C-delta and TNF-alpha converting enzyme in vascular smooth muscle cellsAramati B M Reddy
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555 0647, USA
Endocrinology 150:63-74. 2009..Therefore, inhibition of TACE by TNF-alpha protease inhibitor-1, or pharmacological inhibition of PKC-delta or AR may represent useful strategies for treating vascular inflammation associated with diabetes... - Prevention of posterior capsular opacification through aldose reductase inhibitionUmesh C S Yadav
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
Invest Ophthalmol Vis Sci 50:752-9. 2009..The purpose of this study was to evaluate the effect of aldose reductase (AR) inhibition on posterior capsular opacification (PCO) with the use of a pig eye capsular bag model... - Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophagesKota V Ramana
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
Free Radic Biol Med 42:1290-302. 2007..7 cells. Inhibition or ablation of AR activity may be a potential therapeutic target in endotoximia and other inflammatory diseases... - Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophagesKota V Ramana
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Boulevard 6 638 Basic Science Building, Galveston, TX 77555 0647, USA
Cytokine 36:115-22. 2006..These results suggest the therapeutic use of AR inhibitors as anti-inflammatory drugs... - Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsisAramati B M Reddy
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
Cytokine 48:170-6. 2009..Our aim is to investigate the effect of AR inhibitors on the prevention of inflammatory cytokines in the cecum ligation and puncture (CLP) model of polymicrobial sepsis which closely mimics the sepsis syndrome in humans... - Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophagesKota V Ramana
Department of Biochemistry, University of Texas Medical Branch, Galveston, Texas 77555, USA
J Biol Chem 281:33019-29. 2006..Collectively, these data provide evidence that inhibition of AR may be a significant therapeutic approach in preventing bacterial endotoxin-induced sepsis and tissue damage... - Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growthKota V Ramana
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
J Biol Chem 281:17652-60. 2006..These results raise the possibility that the glutathione conjugates of lipid peroxidation products are novel mediators of cell signaling and growth... - Aldose reductase inhibition prevents lipopolysaccharide-induced glucose uptake and glucose transporter 3 expression in RAW264.7 macrophagesAramati B M Reddy
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, United States
Int J Biochem Cell Biol 42:1039-45. 2010..These results indicate that AR mediates LPS-induced glucose uptake and expression of glucose transporter-3 via cAMP/PKA/CREB pathway and thus represents a novel mechanism by which AR regulates LPS-induced inflammation... - Aldose reductase: a novel therapeutic target for inflammatory pathologiesKota V Ramana
6 638 BSB, Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
Int J Biochem Cell Biol 42:17-20. 2010..Therefore the future use of AR inhibitors in down-regulating major inflammatory pathologies such as cancer and cardiovascular diseases could relieve some of the major health concerns of worldwide... - Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cellsKota V Ramana
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0647, USA
Mol Cancer Ther 9:813-24. 2010..Mol Cancer Ther; 9(4); 813-24. (c)2010 AACR... - Activation of nuclear factor-kappaB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductaseKota V Ramana
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555, USA
Diabetes 53:2910-20. 2004..Collectively, these results suggest that inhibition of aldose reductase, which prevents PKC-dependent nonosmotic NF-kappaB activation, may be a useful approach for treating vascular inflammation caused by diabetes... - Aldose reductase mediates mitogenic signaling in vascular smooth muscle cellsKota V Ramana
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555, USA
J Biol Chem 277:32063-70. 2002..Collectively, these data suggest that inhibition of NF-kappa B may be a significant cause of the antimitogenic effects of AR inhibition and that this may be related to disruption of PKC-associated signaling in the AR-inhibited cells... - Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cellsKota V Ramana
Department of Human Biological Chemistry and Genetics, 6.644 Basic Science Building, University of Texas Medical Branch, Galveston, Texas 77555-0647, USA
Diabetes 54:818-29. 2005.... 
Aldose reductase inhibition suppresses the expression of Th2 cytokines and airway inflammation in ovalbumin-induced asthma in miceUmesh C S Yadav
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
J Immunol 183:4723-32. 2009..Our results indicate that AR inhibitors may offer a novel therapeutic approach to treat inflammatory airway diseases such as asthma...- Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formationRavinder Tammali
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
Carcinogenesis 30:799-807. 2009..Our results suggest that AR mediates the formation of ACF in AOM-treated mice and thereby inhibition of AR could provide an effective chemopreventive approach for the treatment of colon cancer... - Cadmium-induced apoptotic death of human retinal pigment epithelial cells is mediated by MAPK pathwayNilesh M Kalariya
Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA
Exp Eye Res 89:494-502. 2009..The toxic effects of Cd on ARPE-19 cells indicate that environmental heavy metals such as Cd could be important potential factors in RPE cells death associated retinal diseases particularly related to smoking... - Glutathione level regulates HNE-induced genotoxicity in human erythroleukemia cellsUmesh C S Yadav
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
Toxicol Appl Pharmacol 227:257-64. 2008..These results suggest that the genotoxicity of HNE is highly dependent on cellular GSH/GST/AR levels and favorable modulation of the aldehyde detoxification system may help in controlling the oxidative stress-induced complications... - Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cellsNilesh M Kalariya
Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Room 2 100, 700 University Boulevard, Galveston, TX 77555 1106, USA
Exp Eye Res 86:70-80. 2008..This would suggest that high carotenoid supplementation for treatment of AMD should be used cautiously... - Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetesDeepak Chandra
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, USA
Diabetes 51:3095-101. 2002..Thus, increasing NO availability may be a useful strategy for inhibiting the polyol pathway and preventing the development of diabetes complications... - Metabolism of lipid derived aldehyde, 4-hydroxynonenal in human lens epithelial cells and rat lensSanjeev Choudhary
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555-0647, USA
Invest Ophthalmol Vis Sci 44:2675-82. 2003..Thus, under normal physiological conditions, the lens has multiple routes to detoxify HNE. However, oxidative stress may overwhelm the metabolic capacity of the lens to detoxify HNE and lead to formation of cataract... - Regulation of lens aldose reductase activity by nitric oxideSeema Srivastava
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555-0647, USA
Exp Eye Res 81:664-72. 2005..Exogenous delivery of NO may represent a potentially useful strategy for preventing or delaying diabetic cataractogenesis and the development of other diabetic complications... - Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophagesUmesh C S Yadav
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
Free Radic Biol Med 48:1423-34. 2010..Benfotiamine suppresses oxidative stress-induced NF-kappaB activation and prevents bacterial endotoxin-induced inflammation, indicating that vitamin B1 supplementation could be beneficial in the treatment of inflammatory diseases... - Nitric oxide regulates the polyol pathway of glucose metabolism in vascular smooth muscle cellsKota V Ramana
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555-0647, USA
FASEB J 17:417-25. 2003.... - Molecular cloning and oxidative modification of human lens ALDH1A1: implication in impaired detoxification of lipid aldehydesTianlin Xiao
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
J Toxicol Environ Health A 72:577-84. 2009.... - Role of aldose reductase in TNF-alpha-induced apoptosis of vascular endothelial cellsDeepak Chandra
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555, USA
Chem Biol Interact 143:605-12. 2003..These observations could form the basis of future investigations into the therapeutic utility of AR inhibitors in preserving endothelial function and integrity during atherosclerosis and diabetes... - Aldose reductase-regulated tumor necrosis factor-alpha production is essential for high glucose-induced vascular smooth muscle cell growthKota V Ramana
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
Endocrinology 148:4371-84. 2007..Interruption of the autocrine effects of TNF-alpha may be a useful strategy for treating diabetic vasculopathies... - Oxidative stress-induced up-regulation of the chloride channel and Na+/Ca2+ exchanger during cataractogenesis in diabetic ratsKota V Ramana
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 6-644 Basic Science Building, Galveston, TX 77555-0647, USA
J Diabetes Complications 18:177-82. 2004.... - Regulation of aldose reductase and the polyol pathway activity by nitric oxideSatish K Srivastava
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 619 Basic Science Building, Galveston, TX 77555, USA
Chem Biol Interact 143:333-40. 2003.... - Genotoxic effects of carotenoid breakdown products in human retinal pigment epithelial cellsNilesh M Kalariya
AMD Center, Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, Texas 77555 1106, USA
Curr Eye Res 34:737-47. 2009..To investigate the genotoxic effects of lutein (LBP) and beta -carotene breakdown products (beta -apo-8-carotenal, BA8C) and the preventive role of GSH in human retinal pigment epithelial cells (ARPE-19)... - Structure of a glutathione conjugate bound to the active site of aldose reductaseRanvir Singh
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston 77555-0647, USA
Proteins 64:101-10. 2006..The current structure identifies major interactions of glutathione conjugates with the AR active-site residues... - Inhibition of fiber cell globulization and hyperglycemia-induced lens opacification by aminopeptidase inhibitor bestatinDeepak Chandra
Department of Human Biological Chemistry, University of Texas Medical Branch, Galveston, TX 77555-0647, USA
Invest Ophthalmol Vis Sci 43:2285-92. 2002..Inhibition of FCGAP by bestatin attenuates Ca(2+)-induced globulization of the isolated fiber cells in vitro and hyperglycemia-induced opacification of cultured rat lens... - Current prospective of aldose reductase inhibition in the therapy of allergic airway inflammation in asthmaK V Ramana
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
Curr Mol Med 11:599-608. 2011.... - Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cellsSanjay Srivastava
Division of Cardiology, Department of Medicine, Delia Baxter Building, 580 S Preston St, Room 421B, University of Louisville, Louisville, KY 40202, USA
Diabetes 55:901-10. 2006..Even though inhibition of aldose reductase increases vascular oxidative stress, this approach may be useful in preventing abnormal SMC growth in vessels of diabetic patients... - L-Arginine prevents metabolic effects of high glucose in diabetic miceMatthew B West
Institute of Molecular Cardiology and Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40202, United States
FEBS Lett 582:2609-14. 2008..These data suggest that increasing NO bioavailability by L-arginine corrects the major biochemical abnormalities of diabetes... - Aldose reductase catalyzes reduction of the lipid peroxidation product 4-oxonon-2-enalJonathan A Doorn
Department of Pharmaceutical Sciences, School of Pharmacy, The University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Chem Res Toxicol 16:1418-23. 2003..Results of the present study are the first to demonstrate that AR may represent a pathway for metabolism of 4ONE and GS-4ONE... - Relevance of renal-specific oxidoreductase in tubulogenesis during mammalian nephron developmentYashpal S Kanwar
Department of Pathology, Northwestern University, Chicago, Illinois 60611, USA
Am J Physiol Renal Physiol 282:F752-62. 2002..Immunoprecipitation also indicated a selective translational blockade of RSOR. These findings suggest that RSOR is developmentally regulated, exhibits a distinct spatiotemporal distribution, and probably plays a role in tubulogenesis... - Gene regulation of aldose-, aldehyde- and a renal specific oxido reductase (RSOR) in the pathobiology of diabetes mellitusFarhad R Danesh
Departments of Pathology and Medicine, Northwestern University Medical School, Chicago, Illinois, USA
Curr Med Chem 10:1399-406. 2003....
Research Grants
- Chemoprevention of Colorectal Cancer by Aldose Reductase InhibitionSatish K Srivastava; Fiscal Year: 2011..Completion of these studies should identify the molecular mechanisms of AR- reduced LDAs in mediating carcinogenic signals, and lead to use of AR inhibitors as excellent chemopreventive drugs for CRC. ..
- METABOLIC STUDIES IN NORMAL AND CATARACTOUS LENSESSATISH SRIVASTAVA; Fiscal Year: 2001....
- ALDOSE REDUCTASE AND DIABETIC COMPLICATIONSSATISH SRIVASTAVA; Fiscal Year: 2002..The PI results should show whether inclusions of antioxidants as part of ARI therapy in diabetes would be useful to counteract and decrease in cellular antioxidant defense due to inhibition of AR. ..
- Chemoprevention of Colorectal Cancer by Aldose Reductase InhibitionSatish K Srivastava; Fiscal Year: 2010..Our project will determine the mechanisms of colon carcinogenesis, and ultimately lead to the development of new chemopreventive approaches to prevent death from colon cancer. ..
- Role of Aldose Reductase in Diabetic ComplicationsSATISH SRIVASTAVA; Fiscal Year: 2007..Our investigations will also help in evaluating the long-term risks or benefits of anti-AR therapy. ..
- METABOLIC STUDIES IN NORMAL AND CATARACTOUS LENSESSATISH SRIVASTAVA; Fiscal Year: 2006....
- METABOLIC STUDIES IN NORMAL AND CATARACTOUS LENSESSATISH SRIVASTAVA; Fiscal Year: 1980..Similar studies using rat and mice lens will reinvestigate the mechanism of lithium transport in this tissue. ..
- METABOLIC STUDIES IN NORMAL AND CATARACTOUS LENSESSATISH SRIVASTAVA; Fiscal Year: 1993....
- METABOLIC STUDIES IN NORMAL AND CATARACTOUS LENSESSATISH SRIVASTAVA; Fiscal Year: 1999..abstract_text> ..
- ALDOSE REDUCTASE AND DIABETIC COMPLICATIONSSATISH SRIVASTAVA; Fiscal Year: 1993..Our studies will help in understanding the role of AR in the etiology of diabetic complications, and will provide a logical approach to treating or preventing the development of such complications. ..
- ALDOSE REDUCTASE AND DIABETIC COMPLICATIONSSATISH SRIVASTAVA; Fiscal Year: 1990..These studies will help in understanding the role of aldose reductase in the pathophysiology of diabetic complications and should eventually aid the investigators in devising specific inhibitors of aldose reductase...