SATISH SRIVASTAVA

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. ncbi request reprint Prevention of allergic rhinitis by aldose reductase inhibition in a murine model
    Umesh C S Yadav
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
    Inflamm Allergy Drug Targets 12:178-86. 2013
  2. pmc Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma
    Umesh C S Yadav
    Department of Biochemistry, 301 University Blvd, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Respir Res 12:145. 2011
  3. ncbi request reprint Structural and kinetic determinants of aldehyde reduction by aldose reductase
    S Srivastava
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77555, USA
    Biochemistry 38:42-54. 1999
  4. pmc Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders
    Satish K Srivastava
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Chem Biol Interact 191:330-8. 2011
  5. ncbi request reprint Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options
    Satish K Srivastava
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Endocr Rev 26:380-92. 2005
  6. ncbi request reprint Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition
    Kota V Ramana
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Circulation 114:1838-46. 2006
  7. ncbi request reprint Inhibition of aldose reductase attenuates TNF-alpha-induced expression of adhesion molecules in endothelial cells
    Kota V Ramana
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    FASEB J 18:1209-18. 2004
  8. ncbi request reprint Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF-alpha in human lens epithelial cells
    Kota V Ramana
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
    FASEB J 17:315-7. 2003
  9. pmc Inhibition of aldose reductase attenuates endotoxin signals in human non-pigmented ciliary epithelial cells
    Umesh C S Yadav
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 6 644 Basic Science Building, 301 University Blvd, Galveston, TX 77555 0647, USA
    Exp Eye Res 90:555-63. 2010
  10. ncbi request reprint Inhibition of aldose reductase prevents lipopolysaccharide-induced inflammatory response in human lens epithelial cells
    Agnieszka Pladzyk
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
    Invest Ophthalmol Vis Sci 47:5395-403. 2006

Research Grants

  1. Chemoprevention of Colorectal Cancer by Aldose Reductase Inhibition
    Satish K Srivastava; Fiscal Year: 2011
  2. METABOLIC STUDIES IN NORMAL AND CATARACTOUS LENSES
    SATISH SRIVASTAVA; Fiscal Year: 2001
  3. ALDOSE REDUCTASE AND DIABETIC COMPLICATIONS
    SATISH SRIVASTAVA; Fiscal Year: 2002
  4. Chemoprevention of Colorectal Cancer by Aldose Reductase Inhibition
    Satish K Srivastava; Fiscal Year: 2010
  5. Role of Aldose Reductase in Diabetic Complications
    SATISH SRIVASTAVA; Fiscal Year: 2007
  6. METABOLIC STUDIES IN NORMAL AND CATARACTOUS LENSES
    SATISH SRIVASTAVA; Fiscal Year: 2006
  7. METABOLIC STUDIES IN NORMAL AND CATARACTOUS LENSES
    SATISH SRIVASTAVA; Fiscal Year: 1980
  8. METABOLIC STUDIES IN NORMAL AND CATARACTOUS LENSES
    SATISH SRIVASTAVA; Fiscal Year: 1993
  9. METABOLIC STUDIES IN NORMAL AND CATARACTOUS LENSES
    SATISH SRIVASTAVA; Fiscal Year: 1999
  10. ALDOSE REDUCTASE AND DIABETIC COMPLICATIONS
    SATISH SRIVASTAVA; Fiscal Year: 1993

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Prevention of allergic rhinitis by aldose reductase inhibition in a murine model
    Umesh C S Yadav
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
    Inflamm Allergy Drug Targets 12:178-86. 2013
    ..We have investigated the role of AR in mediating pathological symptoms associated with allergic rhinitis in mice...
  2. pmc Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma
    Umesh C S Yadav
    Department of Biochemistry, 301 University Blvd, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Respir Res 12:145. 2011
    ....
  3. ncbi request reprint Structural and kinetic determinants of aldehyde reduction by aldose reductase
    S Srivastava
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77555, USA
    Biochemistry 38:42-54. 1999
    ....
  4. pmc Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders
    Satish K Srivastava
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Chem Biol Interact 191:330-8. 2011
    ..Our results thus offer a novel therapeutic approach to treat a wide array of inflammatory diseases...
  5. ncbi request reprint Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options
    Satish K Srivastava
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Endocr Rev 26:380-92. 2005
    ....
  6. ncbi request reprint Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition
    Kota V Ramana
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Circulation 114:1838-46. 2006
    ..Postreceptor signaling events that lead to stress responses and cytokine production are sensitive to redox changes and products of lipid peroxidation...
  7. ncbi request reprint Inhibition of aldose reductase attenuates TNF-alpha-induced expression of adhesion molecules in endothelial cells
    Kota V Ramana
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    FASEB J 18:1209-18. 2004
    ....
  8. ncbi request reprint Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF-alpha in human lens epithelial cells
    Kota V Ramana
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
    FASEB J 17:315-7. 2003
    ..These observations could provide new insights into the pathophysiology of diabetes and the role of aberrant glucose metabolism in apoptotic cell death...
  9. pmc Inhibition of aldose reductase attenuates endotoxin signals in human non-pigmented ciliary epithelial cells
    Umesh C S Yadav
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 6 644 Basic Science Building, 301 University Blvd, Galveston, TX 77555 0647, USA
    Exp Eye Res 90:555-63. 2010
    ..Taken together, our results suggest that AR plays an important role in the LPS-induced inflammatory changes in hNPECs and that inhibition of AR could be a novel therapeutic approach for ocular inflammation...
  10. ncbi request reprint Inhibition of aldose reductase prevents lipopolysaccharide-induced inflammatory response in human lens epithelial cells
    Agnieszka Pladzyk
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
    Invest Ophthalmol Vis Sci 47:5395-403. 2006
    ....
  11. ncbi request reprint Aldose reductase prevents aldehyde toxicity in cultured human lens epithelial cells
    Agnieszka Pladzyk
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Blvd, 6 644 Basic Science Bldg, Galveston, TX 77555 0647, USA
    Exp Eye Res 83:408-16. 2006
    ..The results indicate that the lipid aldehydes generated under oxidative stress are cytotoxic to HLEC leading to apoptosis and that the reduction of lipid aldehydes by AR would prevent it...
  12. pmc Aldose reductase inhibition prevents endotoxin-induced uveitis in rats
    Umesh C S Yadav
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
    Invest Ophthalmol Vis Sci 48:4634-42. 2007
    ..The purpose of the present study was to elucidate the role of the polyol pathway enzyme aldose reductase (AR) in the mediation of ocular inflammation in a rat model of endotoxin-induced uveitis (EIU)...
  13. pmc Inhibition of aldose reductase prevents experimental allergic airway inflammation in mice
    Umesh C S Yadav
    Department of Biochemistry and Molecular Biology, Immunology, University of Texas Medical Branch, Galveston, Texas, United States
    PLoS ONE 4:e6535. 2009
    ..Hence, we investigated the efficacy of AR inhibition in the prevention of allergic responses to a common natural airborne allergen, ragweed pollen that leads to airway inflammation and hyper-responsiveness in a murine model of asthma...
  14. pmc Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells
    Ravinder Tammali
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Blvd 6 644 Basic Science Bldg, Galveston, TX 77555 0647, USA
    Cancer Lett 252:299-306. 2007
    ..These results suggest that inhibition of AR could be a novel chemopreventive approach to colon cancer...
  15. ncbi request reprint Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells
    Ravinder Tammali
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
    Cancer Res 66:9705-13. 2006
    ....
  16. pmc Aldose reductase regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycle
    Ravinder Tammali
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
    Endocrinology 151:2140-50. 2010
    ..Thus, inhibition of AR may be a useful therapeutic approach in preventing vascular complications...
  17. ncbi request reprint Aldose reductase mediates the mitogenic signals of cytokines
    Kota V Ramana
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 619 Basic Science Building, Galveston, TX 77555, USA
    Chem Biol Interact 143:587-96. 2003
    ..These observations suggest a possible therapeutic use of AR inhibitors in these pathological conditions...
  18. pmc Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages
    Kota V Ramana
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Free Radic Biol Med 42:1290-302. 2007
    ..7 cells. Inhibition or ablation of AR activity may be a potential therapeutic target in endotoximia and other inflammatory diseases...
  19. pmc Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis
    Aramati B M Reddy
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Cytokine 48:170-6. 2009
    ..Our aim is to investigate the effect of AR inhibitors on the prevention of inflammatory cytokines in the cecum ligation and puncture (CLP) model of polymicrobial sepsis which closely mimics the sepsis syndrome in humans...
  20. pmc Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-alpha via protein kinase C-delta and TNF-alpha converting enzyme in vascular smooth muscle cells
    Aramati B M Reddy
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555 0647, USA
    Endocrinology 150:63-74. 2009
    ..Therefore, inhibition of TACE by TNF-alpha protease inhibitor-1, or pharmacological inhibition of PKC-delta or AR may represent useful strategies for treating vascular inflammation associated with diabetes...
  21. pmc Prevention of posterior capsular opacification through aldose reductase inhibition
    Umesh C S Yadav
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
    Invest Ophthalmol Vis Sci 50:752-9. 2009
    ..The purpose of this study was to evaluate the effect of aldose reductase (AR) inhibition on posterior capsular opacification (PCO) with the use of a pig eye capsular bag model...
  22. ncbi request reprint Activation of nuclear factor-kappaB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase
    Kota V Ramana
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555, USA
    Diabetes 53:2910-20. 2004
    ..Collectively, these results suggest that inhibition of aldose reductase, which prevents PKC-dependent nonosmotic NF-kappaB activation, may be a useful approach for treating vascular inflammation caused by diabetes...
  23. pmc Aldose reductase: a novel therapeutic target for inflammatory pathologies
    Kota V Ramana
    6 638 BSB, Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Int J Biochem Cell Biol 42:17-20. 2010
    ..Therefore the future use of AR inhibitors in down-regulating major inflammatory pathologies such as cancer and cardiovascular diseases could relieve some of the major health concerns of worldwide...
  24. pmc Aldose reductase inhibition prevents lipopolysaccharide-induced glucose uptake and glucose transporter 3 expression in RAW264.7 macrophages
    Aramati B M Reddy
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, United States
    Int J Biochem Cell Biol 42:1039-45. 2010
    ..These results indicate that AR mediates LPS-induced glucose uptake and expression of glucose transporter-3 via cAMP/PKA/CREB pathway and thus represents a novel mechanism by which AR regulates LPS-induced inflammation...
  25. pmc Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells
    Kota V Ramana
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0647, USA
    Mol Cancer Ther 9:813-24. 2010
    ..Mol Cancer Ther; 9(4); 813-24. (c)2010 AACR...
  26. ncbi request reprint Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells
    Kota V Ramana
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 277:32063-70. 2002
    ..Collectively, these data suggest that inhibition of NF-kappa B may be a significant cause of the antimitogenic effects of AR inhibition and that this may be related to disruption of PKC-associated signaling in the AR-inhibited cells...
  27. pmc Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages
    Kota V Ramana
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Boulevard 6 638 Basic Science Building, Galveston, TX 77555 0647, USA
    Cytokine 36:115-22. 2006
    ..These results suggest the therapeutic use of AR inhibitors as anti-inflammatory drugs...
  28. ncbi request reprint Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth
    Kota V Ramana
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Biol Chem 281:17652-60. 2006
    ..These results raise the possibility that the glutathione conjugates of lipid peroxidation products are novel mediators of cell signaling and growth...
  29. ncbi request reprint Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells
    Kota V Ramana
    Department of Human Biological Chemistry and Genetics, 6 644 Basic Science Building, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
    Diabetes 54:818-29. 2005
    ....
  30. ncbi request reprint Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cells
    Kota V Ramana
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 619 Basic Science Building, Galveston, TX 77555, USA
    FEBS Lett 570:189-94. 2004
    ..These observations suggest that AR is a critical regulator of TNF-alpha-induced apoptotic signaling in endothelial cells...
  31. ncbi request reprint Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages
    Kota V Ramana
    Department of Biochemistry, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 281:33019-29. 2006
    ..Collectively, these data provide evidence that inhibition of AR may be a significant therapeutic approach in preventing bacterial endotoxin-induced sepsis and tissue damage...
  32. doi request reprint Aldose reductase inhibition suppresses the expression of Th2 cytokines and airway inflammation in ovalbumin-induced asthma in mice
    Umesh C S Yadav
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Immunol 183:4723-32. 2009
    ..Our results indicate that AR inhibitors may offer a novel therapeutic approach to treat inflammatory airway diseases such as asthma...
  33. ncbi request reprint Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes
    Deepak Chandra
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, USA
    Diabetes 51:3095-101. 2002
    ..Thus, increasing NO availability may be a useful strategy for inhibiting the polyol pathway and preventing the development of diabetes complications...
  34. doi request reprint Cadmium-induced apoptotic death of human retinal pigment epithelial cells is mediated by MAPK pathway
    Nilesh M Kalariya
    Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA
    Exp Eye Res 89:494-502. 2009
    ..The toxic effects of Cd on ARPE-19 cells indicate that environmental heavy metals such as Cd could be important potential factors in RPE cells death associated retinal diseases particularly related to smoking...
  35. pmc Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation
    Ravinder Tammali
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
    Carcinogenesis 30:799-807. 2009
    ..Our results suggest that AR mediates the formation of ACF in AOM-treated mice and thereby inhibition of AR could provide an effective chemopreventive approach for the treatment of colon cancer...
  36. ncbi request reprint Metabolism of lipid derived aldehyde, 4-hydroxynonenal in human lens epithelial cells and rat lens
    Sanjeev Choudhary
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
    Invest Ophthalmol Vis Sci 44:2675-82. 2003
    ..To determine how HNE is detoxified in ocular tissues, its metabolism in cultured human lens epithelial cells (HLECs) as well as rat lens was investigated...
  37. pmc Glutathione level regulates HNE-induced genotoxicity in human erythroleukemia cells
    Umesh C S Yadav
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
    Toxicol Appl Pharmacol 227:257-64. 2008
    ..These results suggest that the genotoxicity of HNE is highly dependent on cellular GSH/GST/AR levels and favorable modulation of the aldehyde detoxification system may help in controlling the oxidative stress-induced complications...
  38. pmc Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cells
    Nilesh M Kalariya
    Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Room 2 100, 700 University Boulevard, Galveston, TX 77555 1106, USA
    Exp Eye Res 86:70-80. 2008
    ..This would suggest that high carotenoid supplementation for treatment of AMD should be used cautiously...
  39. ncbi request reprint Regulation of lens aldose reductase activity by nitric oxide
    Seema Srivastava
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
    Exp Eye Res 81:664-72. 2005
    ..Exogenous delivery of NO may represent a potentially useful strategy for preventing or delaying diabetic cataractogenesis and the development of other diabetic complications...
  40. doi request reprint Molecular cloning and oxidative modification of human lens ALDH1A1: implication in impaired detoxification of lipid aldehydes
    Tianlin Xiao
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
    J Toxicol Environ Health A 72:577-84. 2009
    ....
  41. ncbi request reprint Role of aldose reductase in TNF-alpha-induced apoptosis of vascular endothelial cells
    Deepak Chandra
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555, USA
    Chem Biol Interact 143:605-12. 2003
    ..These observations could form the basis of future investigations into the therapeutic utility of AR inhibitors in preserving endothelial function and integrity during atherosclerosis and diabetes...
  42. pmc Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages
    Umesh C S Yadav
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Free Radic Biol Med 48:1423-34. 2010
    ..Benfotiamine suppresses oxidative stress-induced NF-kappaB activation and prevents bacterial endotoxin-induced inflammation, indicating that vitamin B1 supplementation could be beneficial in the treatment of inflammatory diseases...
  43. ncbi request reprint Aldose reductase-regulated tumor necrosis factor-alpha production is essential for high glucose-induced vascular smooth muscle cell growth
    Kota V Ramana
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
    Endocrinology 148:4371-84. 2007
    ..Interruption of the autocrine effects of TNF-alpha may be a useful strategy for treating diabetic vasculopathies...
  44. ncbi request reprint Nitric oxide regulates the polyol pathway of glucose metabolism in vascular smooth muscle cells
    Kota V Ramana
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
    FASEB J 17:417-25. 2003
    ....
  45. ncbi request reprint Regulation of aldose reductase and the polyol pathway activity by nitric oxide
    Satish K Srivastava
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 619 Basic Science Building, Galveston, TX 77555, USA
    Chem Biol Interact 143:333-40. 2003
    ....
  46. ncbi request reprint Inhibition of fiber cell globulization and hyperglycemia-induced lens opacification by aminopeptidase inhibitor bestatin
    Deepak Chandra
    Department of Human Biological Chemistry, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
    Invest Ophthalmol Vis Sci 43:2285-92. 2002
    ..To examine the role of calcium-dependent and -independent proteolytic activity in the globulization of isolated fiber cells and glucose-induced lens opacification...
  47. pmc Genotoxic effects of carotenoid breakdown products in human retinal pigment epithelial cells
    Nilesh M Kalariya
    AMD Center, Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, Texas 77555 1106, USA
    Curr Eye Res 34:737-47. 2009
    ..To investigate the genotoxic effects of lutein (LBP) and beta -carotene breakdown products (beta -apo-8-carotenal, BA8C) and the preventive role of GSH in human retinal pigment epithelial cells (ARPE-19)...
  48. ncbi request reprint Oxidative stress-induced up-regulation of the chloride channel and Na+/Ca2+ exchanger during cataractogenesis in diabetic rats
    Kota V Ramana
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 6 644 Basic Science Building, Galveston, TX 77555 0647, USA
    J Diabetes Complications 18:177-82. 2004
    ....
  49. ncbi request reprint Structure of a glutathione conjugate bound to the active site of aldose reductase
    Ranvir Singh
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston 77555 0647, USA
    Proteins 64:101-10. 2006
    ..The current structure identifies major interactions of glutathione conjugates with the AR active-site residues...
  50. ncbi request reprint Current prospective of aldose reductase inhibition in the therapy of allergic airway inflammation in asthma
    K V Ramana
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
    Curr Mol Med 11:599-608. 2011
    ....
  51. pmc Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells
    Sanjay Srivastava
    Division of Cardiology, Department of Medicine, Delia Baxter Building, 580 S Preston St, Room 421B, University of Louisville, Louisville, KY 40202, USA
    Diabetes 55:901-10. 2006
    ..Even though inhibition of aldose reductase increases vascular oxidative stress, this approach may be useful in preventing abnormal SMC growth in vessels of diabetic patients...
  52. ncbi request reprint Aldose reductase catalyzes reduction of the lipid peroxidation product 4-oxonon-2-enal
    Jonathan A Doorn
    Department of Pharmaceutical Sciences, School of Pharmacy, The University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Chem Res Toxicol 16:1418-23. 2003
    ..Results of the present study are the first to demonstrate that AR may represent a pathway for metabolism of 4ONE and GS-4ONE...
  53. pmc L-Arginine prevents metabolic effects of high glucose in diabetic mice
    Matthew B West
    Institute of Molecular Cardiology and Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40202, United States
    FEBS Lett 582:2609-14. 2008
    ..These data suggest that increasing NO bioavailability by L-arginine corrects the major biochemical abnormalities of diabetes...
  54. ncbi request reprint Gene regulation of aldose-, aldehyde- and a renal specific oxido reductase (RSOR) in the pathobiology of diabetes mellitus
    Farhad R Danesh
    Departments of Pathology and Medicine, Northwestern University Medical School, Chicago, Illinois, USA
    Curr Med Chem 10:1399-406. 2003
    ....
  55. ncbi request reprint Relevance of renal-specific oxidoreductase in tubulogenesis during mammalian nephron development
    Yashpal S Kanwar
    Department of Pathology, Northwestern University, Chicago, Illinois 60611, USA
    Am J Physiol Renal Physiol 282:F752-62. 2002
    ..Immunoprecipitation also indicated a selective translational blockade of RSOR. These findings suggest that RSOR is developmentally regulated, exhibits a distinct spatiotemporal distribution, and probably plays a role in tubulogenesis...

Research Grants47

  1. Chemoprevention of Colorectal Cancer by Aldose Reductase Inhibition
    Satish K Srivastava; Fiscal Year: 2011
    ..Completion of these studies should identify the molecular mechanisms of AR- reduced LDAs in mediating carcinogenic signals, and lead to use of AR inhibitors as excellent chemopreventive drugs for CRC. ..
  2. METABOLIC STUDIES IN NORMAL AND CATARACTOUS LENSES
    SATISH SRIVASTAVA; Fiscal Year: 2001
    ....
  3. ALDOSE REDUCTASE AND DIABETIC COMPLICATIONS
    SATISH SRIVASTAVA; Fiscal Year: 2002
    ..The PI results should show whether inclusions of antioxidants as part of ARI therapy in diabetes would be useful to counteract and decrease in cellular antioxidant defense due to inhibition of AR. ..
  4. Chemoprevention of Colorectal Cancer by Aldose Reductase Inhibition
    Satish K Srivastava; Fiscal Year: 2010
    ..Our project will determine the mechanisms of colon carcinogenesis, and ultimately lead to the development of new chemopreventive approaches to prevent death from colon cancer. ..
  5. Role of Aldose Reductase in Diabetic Complications
    SATISH SRIVASTAVA; Fiscal Year: 2007
    ..Our investigations will also help in evaluating the long-term risks or benefits of anti-AR therapy. ..
  6. METABOLIC STUDIES IN NORMAL AND CATARACTOUS LENSES
    SATISH SRIVASTAVA; Fiscal Year: 2006
    ....
  7. METABOLIC STUDIES IN NORMAL AND CATARACTOUS LENSES
    SATISH SRIVASTAVA; Fiscal Year: 1980
    ..Similar studies using rat and mice lens will reinvestigate the mechanism of lithium transport in this tissue. ..
  8. METABOLIC STUDIES IN NORMAL AND CATARACTOUS LENSES
    SATISH SRIVASTAVA; Fiscal Year: 1993
    ....
  9. METABOLIC STUDIES IN NORMAL AND CATARACTOUS LENSES
    SATISH SRIVASTAVA; Fiscal Year: 1999
    ..abstract_text> ..
  10. ALDOSE REDUCTASE AND DIABETIC COMPLICATIONS
    SATISH SRIVASTAVA; Fiscal Year: 1993
    ..Our studies will help in understanding the role of AR in the etiology of diabetic complications, and will provide a logical approach to treating or preventing the development of such complications. ..
  11. ALDOSE REDUCTASE AND DIABETIC COMPLICATIONS
    SATISH SRIVASTAVA; Fiscal Year: 1990
    ..These studies will help in understanding the role of aldose reductase in the pathophysiology of diabetic complications and should eventually aid the investigators in devising specific inhibitors of aldose reductase...