OM PRAKASH SRIVASTAVA

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Existence of deamidated alphaB-crystallin fragments in normal and cataractous human lenses
    Om P Srivastava
    Department of Physiological Optics, School of Optometry, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Vis 9:110-8. 2003
  2. ncbi request reprint Characterization of covalent multimers of crystallins in aging human lenses
    Om P Srivastava
    Department of Physiological Optics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 279:10901-9. 2004
  3. ncbi request reprint Molecular changes in selected epithelial proteins in human keratoconus corneas compared to normal corneas
    Om P Srivastava
    Department of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Vis 12:1615-25. 2006
  4. doi request reprint Structural and functional roles of deamidation and/or truncation of N- or C-termini in human alpha A-crystallin
    Jose M Chaves
    Department of Vision Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Biochemistry 47:10069-83. 2008
  5. pmc High-resolution mass spectrometry analysis of protein oxidations and resultant loss of function
    Stephen Barnes
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochem Soc Trans 36:1037-44. 2008
  6. pmc Structural and functional roles of deamidation of N146 and/or truncation of NH2- or COOH-termini in human αB-crystallin
    C O Asomugha
    Department of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
    Mol Vis 17:2407-20. 2011
  7. pmc Identification of crystallin modifications in the human lens cortex and nucleus using laser capture microdissection and CyDye labeling
    C O Asomugha
    Department of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 4390, USA
    Mol Vis 16:476-94. 2010
  8. pmc A serine-type protease activity of human lens βA3-crystallin is responsible for its autodegradation
    R Gupta
    Department of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Vis 16:2242-52. 2010
  9. pmc Structural and functional properties of NH(2)-terminal domain, core domain, and COOH-terminal extension of αA- and αB-crystallins
    C O Asomugha
    Department of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 4390, USA
    Mol Vis 17:2356-67. 2011
  10. ncbi request reprint Crosslinking of human lens 9 kDa gammaD-crystallin fragment in vitro and in vivo
    Om P Srivastava
    Department of Physiological Optics, School of Optometry, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Vis 9:644-56. 2003

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Existence of deamidated alphaB-crystallin fragments in normal and cataractous human lenses
    Om P Srivastava
    Department of Physiological Optics, School of Optometry, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Vis 9:110-8. 2003
    ....
  2. ncbi request reprint Characterization of covalent multimers of crystallins in aging human lenses
    Om P Srivastava
    Department of Physiological Optics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 279:10901-9. 2004
    ..Together, the results suggested that covalent multimers appeared early in life (i.e. 25 years of age) and increased in number with aging, and the two beaded filament proteins form covalent complexes with crystallin fragments in vivo...
  3. ncbi request reprint Molecular changes in selected epithelial proteins in human keratoconus corneas compared to normal corneas
    Om P Srivastava
    Department of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Vis 12:1615-25. 2006
    ..The purpose of the study was to determine molecular changes in selected epithelial proteins in human keratoconus (KC) corneas compared to normal corneas...
  4. doi request reprint Structural and functional roles of deamidation and/or truncation of N- or C-termini in human alpha A-crystallin
    Jose M Chaves
    Department of Vision Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Biochemistry 47:10069-83. 2008
    ....
  5. pmc High-resolution mass spectrometry analysis of protein oxidations and resultant loss of function
    Stephen Barnes
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochem Soc Trans 36:1037-44. 2008
    ..These results suggest that future in vivo studies should carefully assess the critical sites that are modified rather than using antibodies that do not distinguish between different modified sites...
  6. pmc Structural and functional roles of deamidation of N146 and/or truncation of NH2- or COOH-termini in human αB-crystallin
    C O Asomugha
    Department of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
    Mol Vis 17:2407-20. 2011
    ..The purpose of the study was to determine the relative effects of deamidation and/or truncation on the structural and functional properties of αB-crystallin...
  7. pmc Identification of crystallin modifications in the human lens cortex and nucleus using laser capture microdissection and CyDye labeling
    C O Asomugha
    Department of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 4390, USA
    Mol Vis 16:476-94. 2010
    ....
  8. pmc A serine-type protease activity of human lens βA3-crystallin is responsible for its autodegradation
    R Gupta
    Department of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Vis 16:2242-52. 2010
    ..The purpose of the study was to determine whether the autodegradation of human βA3-crystallin is due to its intrinsic protease activity...
  9. pmc Structural and functional properties of NH(2)-terminal domain, core domain, and COOH-terminal extension of αA- and αB-crystallins
    C O Asomugha
    Department of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 4390, USA
    Mol Vis 17:2356-67. 2011
    ....
  10. ncbi request reprint Crosslinking of human lens 9 kDa gammaD-crystallin fragment in vitro and in vivo
    Om P Srivastava
    Department of Physiological Optics, School of Optometry, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Vis 9:644-56. 2003
    ....
  11. pmc Isolation and characterization of betaA3-crystallin associated proteinase from alpha-crystallin fraction of human lenses
    O P Srivastava
    Department of Vision Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Vis 14:1872-85. 2008
    ..The purpose was to characterize the properties of a proteinase activity associated with betaA3-crystallin, which was isolated from the alpha-crystallin fraction of human lenses...
  12. ncbi request reprint Deamidation affects structural and functional properties of human alphaA-crystallin and its oligomerization with alphaB-crystallin
    Ratna Gupta
    Department of Physiological Optics, University of Alabama at Birmingham, Birmingham, Alabama 35294 4390, USA
    J Biol Chem 279:44258-69. 2004
    ....
  13. pmc Identification of interaction sites between human betaA3- and alphaA/alphaB-crystallins by mammalian two-hybrid and fluorescence resonance energy transfer acceptor photobleaching methods
    Ratna Gupta
    Department of Vision Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294 4390, USA
    J Biol Chem 284:18481-92. 2009
    ..The results showed that the motifs III and IV of betaA3-crystallin were interactive with alphaA-crystallin, and motifs II and III of betaA3-crystallin primarily interacted with alphaB-crystallin...
  14. ncbi request reprint Crystallins in water soluble-high molecular weight protein fractions and water insoluble protein fractions in aging and cataractous human lenses
    Veronica Harrington
    Department of Physiological Optics, School of Optometry, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Vis 10:476-89. 2004
    ..Because these changes were cataract specific and not aging specific, the results were expected to provide information regarding potential mechanisms of age related cataract development...
  15. ncbi request reprint Effect of deamidation of asparagine 146 on functional and structural properties of human lens alphaB-crystallin
    Ratna Gupta
    Department of Physiological Optics, University of Alabama at Birmingham, Birmingham, Alabama 35294 4390, USA
    Invest Ophthalmol Vis Sci 45:206-14. 2004
    ..To elucidate the effect of deamidation on the structural and functional properties of human alphaB-crystallin...

Research Grants18

  1. Project title Proteinase Inhibitors & Crystallin Fragments in Cataract
    OM SRIVASTAVA; Fiscal Year: 2009
    ..phs ..
  2. Proteinase Inhbitors & Crystallin Fragments in Cataract
    OM SRIVASTAVA; Fiscal Year: 2007
    ..abstract_text> ..
  3. Proteinase Inhbitors & Crystallin Fragments in Cataract
    OM SRIVASTAVA; Fiscal Year: 2006
    ..abstract_text> ..
  4. Proteinase Inhbitors & Crystallin Fragments in Cataract
    OM SRIVASTAVA; Fiscal Year: 2007
    ..abstract_text> ..
  5. Proteinase Inhbitors & Crystallin Fragments in Cataract
    OM SRIVASTAVA; Fiscal Year: 2005
    ....
  6. Proteinase Inhbitors & Crystallin Fragments in Cataract
    OM SRIVASTAVA; Fiscal Year: 2006
    ..abstract_text> ..
  7. PROTEINASE INHIBITORS & CRYSTALLIN FRAGMENTS IN CATARACT
    OM SRIVASTAVA; Fiscal Year: 2004
    ..Since all of the proposed studies will be carried out in human lenses, the results will be directly relevant to the human senile cataract problem. ..
  8. Proteinase Inhbitors & Crystallin Fragments in Cataract
    OM SRIVASTAVA; Fiscal Year: 2005
    ..abstract_text> ..
  9. PROTEINASE INHIBITORS & CRYSTALLIN FRAGMENTS IN CATARACT
    OM SRIVASTAVA; Fiscal Year: 2004
    ..Since all of the proposed studies will be carried out in human lenses, the results will be directly relevant to the human senile cataract problem. ..
  10. PROTEINASE INHIBITORS & CRYSTALLIN FRAGMENTS IN CATARACT
    OM SRIVASTAVA; Fiscal Year: 2003
    ..Since all of the proposed studies will be carried out in human lenses, the results will be directly relevant to the human senile cataract problem. ..
  11. PROTEINASE INHIBITORS & CRYSTALLIN FRAGMENTS IN CATARACT
    OM SRIVASTAVA; Fiscal Year: 2002
    ..Since all of the proposed studies will be carried out in human lenses, the results will be directly relevant to the human senile cataract problem. ..
  12. PROTEINASE INHIBITORS & CRYSTALLIN FRAGMENTS IN CATARACT
    OM SRIVASTAVA; Fiscal Year: 2001
    ..Since all of the proposed studies will be carried out in human lenses, the results will be directly relevant to the human senile cataract problem. ..
  13. PROTEINASE INHIBITORS & CRYSTALLIN FRAGMENTS IN CATARACT
    OM SRIVASTAVA; Fiscal Year: 2000
    ..Since all of the proposed studies will be carried out in human lenses, the results will be directly relevant to the human senile cataract problem. ..
  14. Project title Proteinase Inhibitors & Crystallin Fragments in Cataract
    OM PRAKASH SRIVASTAVA; Fiscal Year: 2010
    ..phs ..