Research Topics
Genomes and Genes
| Deepak SrivastavaSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Cardiac repair with thymosin β4 and cardiac reprogramming factorsDeepak Srivastava
Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
Ann N Y Acad Sci 1270:66-72. 2012..These findings suggest that thymosin β4 and cardiac reprogramming technology may synergistically limit damage to the heart and promote cardiac regeneration through the stimulation of endogenous cells within the heart...
Making or breaking the heart: from lineage determination to morphogenesisDeepak Srivastava
Gladstone Institute of Cardiovascular Disease and Department of Pediatrics and Biochemistry, University of California, San Francisco, CA 94158, USA
Cell 126:1037-48. 2006....- Potential of stem-cell-based therapies for heart diseaseDeepak Srivastava
Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California San Francisco, 1650 Owens Street, San Francisco, California 94158, USA
Nature 441:1097-9. 2006..The exciting discoveries in basic science will require rigorous testing in animal models to determine those most worthy of future clinical trials... - Thymosin beta4 is cardioprotective after myocardial infarctionDeepak Srivastava
Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
Ann N Y Acad Sci 1112:161-70. 2007..These findings suggest that thymosin beta4 promotes cardiomyocyte and endothelial migration, survival, and repair and may be a novel therapeutic target in the setting of acute myocardial damage... - Genetic regulation of cardiogenesis and congenital heart diseaseDeepak Srivastava
Gladstone Institute of Cardiovascular Disease, Department of Pediatrics, University of California, San Francisco, California 94158, USA
Annu Rev Pathol 1:199-213. 2006..The lessons learned from examining the early steps of heart formation are essential for informing the prevention of malformations and their long-term consequences, as well as for approaches to guide stem cells into cardiac lineages... 
A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fateChulan Kwon
Gladstone Institute of Cardiovascular Disease and Departments of Pediatrics and Biochemistry and Biophysics, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
Nat Cell Biol 11:951-7. 2009..These findings reveal a regulatory network controlling CPC expansion and cell fate that involves unanticipated functions of beta-catenin, Notch1 and Isl1 that may be leveraged for regenerative approaches involving CPCs...- The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal archNeil T Sheehy
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Development 137:4307-16. 2010..These results suggest that post-transcriptional regulation by miRNAs is required for differentiation of NCC-derived tissues and that miR-452 is involved in epithelial-mesenchymal signaling in the pharyngeal arch... - Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac developmentMeenakshi Maitra
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Dev Biol 326:368-77. 2009..These findings highlight the unique genetic interactions of Gata4 and Gata6 with Tbx5 for normal cardiac morphogenesis in vivo... - skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regenerationChong Yon Park
Department of Pediatrics, Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 107:20750-5. 2010..Our results indicate that skNAC plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration in mice... - Notch post-translationally regulates β-catenin protein in stem and progenitor cellsChulan Kwon
Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, San Francisco, 1650 Owens Street, San Francisco, California 94158, USA
Nat Cell Biol 13:1244-51. 2011..It did, however, require the endocytic adaptor protein Numb and lysosomal activity. This study reveals a previously unrecognized function of Notch in negatively titrating active β-catenin protein levels in stem and progenitor cells... - Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factorsTonghuan Hu
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
Development 131:5491-502. 2004.... - Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factorsMasaki Ieda
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, CA 94158, USA
Cell 142:375-86. 2010..Reprogramming of endogenous or explanted fibroblasts might provide a source of cardiomyocytes for regenerative approaches... - In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytesLi Qian
1Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
Nature 485:593-8. 2012..These findings demonstrate that cardiac fibroblasts can be reprogrammed into cardiomyocyte-like cells in their native environment for potential regenerative purposes... - Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression varianceLinda W Van Laake
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 94158, USA
Circ Res 107:340-7. 2010.... - miR-145 and miR-143 regulate smooth muscle cell fate and plasticityKimberly R Cordes
Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
Nature 460:705-10. 2009..These findings demonstrate that miR-145 can direct the smooth muscle fate and that miR-145 and miR-143 function to regulate the quiescent versus proliferative phenotype of smooth muscle cells... - Hand2 function in second heart field progenitors is essential for cardiogenesisTakatoshi Tsuchihashi
Gladstone Institute of Cardiovascular Disease, University of California San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
Dev Biol 351:62-9. 2011..These findings demonstrate that Hand2 is essential for survival of second heart field progenitors and that the graded loss of Hand2 function in this cardiac progenitor pool can cause a spectrum of congenital heart malformation... - Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signalingMasaki Ieda
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 94158, USA
Dev Cell 16:233-44. 2009..These findings reveal a previously unrecognized paracrine function of embryonic cardiac fibroblasts in regulating cardiomyocyte proliferation... - Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repairIldiko Bock-Marquette
Department of Pediatrics, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, Texas 75390 9148, USA
Nature 432:466-72. 2004..These findings suggest that thymosin beta4 promotes cardiomyocyte migration, survival and repair and the pathway it regulates may be a new therapeutic target in the setting of acute myocardial damage... - Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2Yong Zhao
Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
Cell 129:303-17. 2007..These findings indicate that subtle alteration of miRNA dosage can have profound consequences in mammals and demonstrate the utility of mammalian loss-of-function models in revealing physiologic miRNA targets... - A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafishJason E Fish
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Development 138:1409-19. 2011..These findings suggest a new paradigm for microRNA-based control of ligand-receptor interactions and provide evidence for a novel signaling pathway regulating vertebrate heart tube assembly... - microRNA-138 modulates cardiac patterning during embryonic developmentSarah U Morton
Gladstone Institute of Cardiovascular Disease, Department of Pediatrics, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 105:17830-5. 2008.... - miR-126 regulates angiogenic signaling and vascular integrityJason E Fish
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Dev Cell 15:272-84. 2008..These findings illustrate that a single miRNA can regulate vascular integrity and angiogenesis, providing a new target for modulating vascular formation and function... - MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signalingDavid Hassel
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Circ Res 111:1421-33. 2012..Various signaling pathways control the behavior of endothelial cells, but their posttranscriptional dose titration by microRNAs is poorly understood... - Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarctionAnkur Saxena
Gladstone Institute of Cardiovascular Disease, 1650 Owens St, San Francisco, CA 94158, USA
Circulation 117:2224-31. 2008..One possible cell-independent alternative is the direct administration of small proteins to damaged myocardium... - MicroRNA regulation of cell lineages in mouse and human embryonic stem cellsKathryn N Ivey
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
Cell Stem Cell 2:219-29. 2008..Our findings indicate that muscle-specific miRNAs reinforce the silencing of nonmuscle genes during cell lineage commitment and suggest that miRNAs may have general utility in regulating cell-fate decisions from pluripotent ES cells... - A rare human sequence variant reveals myocardin autoinhibitionJoshua F Ransom
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA
J Biol Chem 283:35845-52. 2008..These findings identify a novel mechanism that regulates levels of MYOCD-dependent activation of the SRF genetic program differentially in cardiac and smooth muscle... - Mutations in NOTCH1 cause aortic valve diseaseVidu Garg
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
Nature 437:270-4. 2005..These results suggest that NOTCH1 mutations cause an early developmental defect in the aortic valve and a later de-repression of calcium deposition that causes progressive aortic valve disease... - miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytesLi Qian
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 208:549-60. 2011..This antiapoptotic effect on cardiomyocytes in vivo was partially mediated by Bim. Our results suggest that manipulating miRNA levels during stress-induced apoptosis may be a novel therapeutic strategy for cardiac disease... - Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valvesVishal Nigam
Department of Pediatrics Cardiology, University of California, San Francisco, USA
J Heart Valve Dis 19:459-65. 2010..In-vitro experiments were also carried out to determine if these miRNAs could modulate calcification-related genes... - Loss of Apaf-1 leads to partial rescue of the HAND2-null phenotypeAparna R Aiyer
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Room NA8 124, Dallas, TX 75390 9148, USA
Dev Biol 278:155-62. 2005.... - A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarityIsabelle N King
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Dev Cell 20:497-510. 2011..These findings illustrate the power of Drosophila-based screens to find points of intersection between miRNAs and conserved pathways in mammals... - Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterningVasanth Vedantham
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94158, USA
Dev Biol 373:149-62. 2013..These findings reveal mechanisms that control the distribution of automaticity among cardiomyocytes during development and in response to stress... - MicroRNA regulation of cardiovascular developmentKimberly R Cordes
Gladstone Institute of Cardiovascular Disease, 1650 Owens St, San Francisco, CA 94158, USA
Circ Res 104:724-32. 2009..Further analysis of miRNA function during cardiovascular development will allow us to determine the potential for novel miRNA-based therapeutic strategies... - Notch1 represses osteogenic pathways in aortic valve cellsVishal Nigam
Gladstone Institute of Cardiovascular Disease and Departments of Pediatrics, University of California, San Francisco, CA 94158, USA
J Mol Cell Cardiol 47:828-34. 2009..siRNA-mediated knockdown of Bmp2 blocked the calcification induced by Notch inhibition in AVICs. These findings suggest that Notch1 signaling in aortic valve cells represses osteoblast-like calcification pathways mediated by Bmp2... - MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signalingChulan Kwon
Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, 1650 Owens Street, San Francisco, CA 94158
Proc Natl Acad Sci U S A 102:18986-91. 2005.... - Transcriptional regulation during development of the ductus arteriosusKathryn N Ivey
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA
Circ Res 103:388-95. 2008.... - The chemokine receptor CXCR7 functions to regulate cardiac valve remodelingSangho Yu
Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
Dev Dyn 240:384-93. 2011..Thus, CXCR7 is involved in semilunar valve development, possibly by regulating BMP signaling, and may contribute to aortic and pulmonary valve stenosis... - Monkeying around with cardiac progenitors: hope for the futureLi Qian
Gladstone Institute of Cardiovascular Disease, Department of Pediatrics, University of California, San Francisco, California 94158, USA
J Clin Invest 120:1034-6. 2010..These findings move the field another step closer to clinical use of ES or iPS cell-derived cardiovascular progenitors in cardiac repair... - MicroRNAs in cardiac developmentKimberly R Cordes
Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, San Francisco, CA 94158, USA
Pediatr Cardiol 31:349-56. 2010..Further analysis of miRNA function during cardiovascular development will allow us to determine the potential for novel miRNA-based therapeutic strategies... - Identification of GATA6 sequence variants in patients with congenital heart defectsMeenakshi Maitra
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Pediatr Res 68:281-5. 2010..These data suggest that nonsynonymous GATA6 sequence variants are infrequently found in individuals with CHD... - Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitorsChulan Kwon
Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, 1650 Owens Street, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 104:10894-9. 2007..Together, these data provide in vivo and in vitro evidence that canonical Wnt signaling promotes the expansion of cardiac progenitors and differentiation of cardiomyocytes... - Hrt and Hes negatively regulate Notch signaling through interactions with RBP-JkappaIsabelle N King
Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9063, USA
Biochem Biophys Res Commun 345:446-52. 2006..These findings suggest a novel mechanism for negative feedback on Notch signaling that requires RBP-Jkappa to interact physically with Hrt and Hes... - Elevated miR-499 levels blunt the cardiac stress responseJoseph T C Shieh
Gladstone Institute of Cardiovascular Disease, San Francisco, California, United States of America
PLoS ONE 6:e19481. 2011..Here we investigate miR-499, a microRNA embedded within a ventricular-specific myosin heavy chain gene, which is expressed in heart and skeletal muscle... - Building a heart: implications for congenital heart diseaseDeepak Srivastava
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Tex 75390-9148, USA
J Nucl Cardiol 10:63-70. 2003 - MicroRNAs as regulators of differentiation and cell fate decisionsKathryn N Ivey
Department of Pediatrics, Gladstone Institute of Cardiovascular Disease, University of California San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
Cell Stem Cell 7:36-41. 2010..We discuss this emerging topic, in part using muscle differentiation as a paradigm, and highlight common themes and unique modalities by which microRNAs exert their lineage-promoting or differentiation effects on multiple tissues... - Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart diseaseMarie K Schluterman
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
Am J Med Genet A 143:817-23. 2007.... - Stem cell therapy for cardiac diseaseHarold S Bernstein
Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA
Pediatr Res 71:491-9. 2012..Finally, we will review progress being made in assessing functional improvement in animals and humans after cellular transplant... - Wnt/beta-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesisChulan Kwon
Gladstone Institute of Cardiovascular Disease, San Francisco, San Francisco, California 94158, USA
Cell Cycle 7:3815-8. 2008..Here we discuss the required roles of Wnt/beta-catenin signaling at the different stages of heart development... - A resource for the conditional ablation of microRNAs in the mouseChong Yon Park
UCSF Diabetes Center, UCSF, San Francisco, CA 94143, USA
Cell Rep 1:385-91. 2012..These data and collection of resources will be of value for the in vivo dissection of miRNA functions in mouse models... - Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cellsMark P White
Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
Stem Cells 31:92-103. 2013.... - MicroRNAs: opening a new vein in angiogenesis researchJason E Fish
Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
Sci Signal 2:pe1. 2009..Additional microRNAs have been implicated in the regulation of various aspects of angiogenesis. Thus, targeting the expression of microRNAs may be a novel therapeutic approach for diseases involving excess or insufficient vasculature... - A developmental view of microRNA functionYong Zhao
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
Trends Biochem Sci 32:189-97. 2007..Future discoveries in this area are likely to reveal developmental-regulation and disease mechanisms related to miRNAs... - Stretching to meet needs: integrin-linked kinase and the cardiac pumpDeepak Srivastava
Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California at San Francisco, San Francisco, California 94158, USA
Genes Dev 20:2327-31. 2006 - Functional attenuation of UFD1l, a 22q11.2 deletion syndrome candidate gene, leads to cardiac outflow septation defects in chicken embryosChihiro Yamagishi
Department of Pediatrics, University of Texas, Southwestern Medical Center at Dallas, Dallas 75390-9148, USA
Pediatr Res 53:546-53. 2003..These data suggest that Ufd1l may play a role in cardiac NCC during conotruncal septation... - GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5Vidu Garg
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Rm NA8 124, Dallas, Texas 75390 9148, USA
Nature 424:443-7. 2003..These results implicate GATA4 as a genetic cause of human cardiac septal defects, perhaps through its interaction with TBX5... - Derivation conditions impact X-inactivation status in female human induced pluripotent stem cellsKiichiro Tomoda
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, San Francisco, CA 94158, USA
Cell Stem Cell 11:91-9. 2012..Thus, feeders are a significant factor affecting X-inactivation status. The efficient production of Xa/Xa hiPSC lines provides unprecedented opportunities to understand human X-reactivation and -inactivation... - The genetics of cardiac birth defectsJoshua Ransom
Gladstone Institute of Cardiovascular Disease and the Department of Pediatrics, University of California at San Francisco, 1650 Owens Street, San Francisco, CA 94158, United States
Semin Cell Dev Biol 18:132-9. 2007..Here, we review the known genetic causes of cardiac malformations and discuss future approaches for addressing sporadic congenital heart disease as a complex trait... - The paradoxical patent ductus arteriosusKathryn N Ivey
Gladstone Institute of Cardiovascular Disease, University of California San Francisco, San Francisco, California 94158, USA
J Clin Invest 116:2863-5. 2006.... - Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancerHiroyuki Yamagishi
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
Genes Dev 17:269-81. 2003..We propose that Tbx1 is a direct transcriptional target of Fox proteins and that Fox proteins may serve an intermediary role in Shh regulation of Tbx1... - Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchymeKathryn Ivey
Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9104, USA
Dev Biol 255:230-7. 2003..We conclude that the Galpha(q) and Galpha(11) proteins serve as the intracellular mediators of ET-1 signaling in the pharyngeal arch mesenchyme... - Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanismIrfan S Kathiriya
Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
J Biol Chem 279:54937-43. 2004..These results suggest that HRT proteins may regulate specific sets of cardiac genes by modulating the function of GATA proteins and other cardiac transcriptional activators in a signal-dependent manner... - Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesisPaul D Gottlieb
Section of Molecular Genetics and Microbiology and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA
Nat Genet 31:25-32. 2002..These results indicate that m-Bop is essential for cardiomyocyte differentiation and cardiac morphogenesis... - The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent mannerDavid G McFadden
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
Development 132:189-201. 2005..These findings demonstrate that Hand factors play pivotal and partially redundant roles in cardiac morphogenesis, cardiomyocyte differentiation and cardiac-specific transcription... - Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesisYong Zhao
Department of Pediatrics Cardiology, University of Texas Southwestern Medical Center and Children s Medical Center Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
Nature 436:214-20. 2005..This work suggests that miR-1 genes titrate the effects of critical cardiac regulatory proteins to control the balance between differentiation and proliferation during cardiogenesis... - Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibitionKota V Ramana
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
Circulation 114:1838-46. 2006..Postreceptor signaling events that lead to stress responses and cytokine production are sensitive to redox changes and products of lipid peroxidation... - Tooth-type specific expression of dHAND/Hand2: possible involvement in murine lower incisor morphogenesisMakoto Abe
Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry, 1 8, Yamadaoka, Suita, Osaka 565 0871, Japan
Cell Tissue Res 310:201-12. 2002..The present results suggest that the dHAND gene plays important roles in type-specific development of lower incisors, and that basic fibroblast growth factor is involved downstream of the dHAND pathway in tooth germ cells... - Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heartKazuko Koshiba-Takeuchi
Programs in Cardiovascular Research, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Nat Genet 38:175-83. 2006..Thus, a positive and negative feed-forward circuit between Tbx5 and Sall4 ensures precise patterning of embryonic limb and heart and provides a unifying mechanism for heart/hand syndromes... - Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac functionMei Xin
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 104:7975-80. 2007..These findings reveal a ventricular myocardial cell-autonomous function for Hrt2 in the suppression of atrial cell identity and the maintenance of postnatal cardiac function... - Genetic and comparative mapping of genes dysregulated in mouse hearts lacking the Hand2 transcription factor geneMelissa P Villanueva
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Genomics 80:593-600. 2002..Nebulette was shown to be deleted in DiGeorge Syndrome 2 patients with the proximal deletion of human 10p13-p14 that is associated with cardiac and craniofacial abnormalities... - Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5Haibo Jia
Department of Medicine and Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 104:14008-13. 2007..Hence, our studies suggest that Grl regulates embryonic heart growth via opposing Gata5, at least in part through their protein interactions in modulating gene expression... - Spectrum of heart disease associated with murine and human GATA4 mutationSatish K Rajagopal
Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
J Mol Cell Cardiol 43:677-85. 2007..Additional studies will be required to determine the degree to which GATA4 mutation contributes to human CHD characterized by ECD or RV hypoplasia... - Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of PediatricsMary Ella Pierpont
Children s Hospital of Minnesota and University of Minnesota, USA
Circulation 115:3015-38. 2007.... - The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradientDanny L Costantini
Program in Cardiovascular Research, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Cell 123:347-58. 2005..Thus, an Irx5 repressor gradient negatively regulates potassium-channel-gene expression in the heart, forming an inverse I(to,f) gradient that ensures coordinated cardiac repolarization while also preventing arrhythmias... - Heart disease: an ongoing genetic battle?Deepak Srivastava
Nature 429:819-22. 2004 - Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expressionTerence D Capellini
Department of Cell and Developmental Biology, Cornell University Weill Medical School, New York, NY 10021, USA
Development 133:2263-73. 2006.... - Tbx1 is regulated by forkhead proteins in the secondary heart fieldJun Maeda
Department of Pediatrics, Division of Pediatric Cardiology, Keio University School of Medicine, Tokyo, Japan
Dev Dyn 235:701-10. 2006.... - Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular developmentChad A Cowan
Center for Developmental Biology and Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
Dev Biol 271:263-71. 2004....
Research Grants
- Cardiogenesis: Molecular MechanismsDeepak Srivastava; Fiscal Year: 2010..This work promises to uncover a new area of molecular regulation in the heart and may provide mechanisms to finely regulate dosages of critical proteins in the prenatal or postnatal heart. ..
- Isolated and Syndromic Cardiac Outflow Tract DefectsDeepak Srivastava; Fiscal Year: 2006..These studies will reveal the upstream and downstream mechanisms through which Tbx1 functions and are essential to understanding the pathogenesis of syndromic types of pharyngeal arch and cardiac outflow tract defects. ..
- CARDIOGENESIS-- MOLECULAR MECHANISMSDeepak Srivastava; Fiscal Year: 2005..These studies will provide insights into the mechanisms of segmented gene regulation during cardiac morphogenesis that may ultimately allow for preventive interventions for CHD. ..
- Cardiogenesis: Molecular MechanismsDeepak Srivastava; Fiscal Year: 2007..This work promises to uncover a new area of molecular regulation in the heart and may provide mechanisms to finely regulate dosages of critical proteins in the prenatal or postnatal heart. ..
- Cardiac Defects/Cross-species analysis/Human MutationsDeepak Srivastava; Fiscal Year: 2009..Such studies will not only provide insight into the relevance of the human mutations, but will also reveal important structure-function aspects regarding the biology through which the cardiac regulatory proteins operate. ..
- Cardiogenesis: Molecular MechanismsDeepak Srivastava; Fiscal Year: 2009..This work promises to uncover a new area of molecular regulation in the heart and may provide mechanisms to finely regulate dosages of critical proteins in the prenatal or postnatal heart. ..
- CARDIOGENESIS--MOLECULAR MECHANISMSDeepak Srivastava; Fiscal Year: 2000..The third and final aim will define the cis-acting sequences that regulate the expression of the HAND genes in tissue culture cells and transgenic mice. ..
- SYNDROMIC CARDIAC OUTFLOW TRACT DEFECTSDeepak Srivastava; Fiscal Year: 2002..In this fashion, we intend to approach the molecular basis for certain congenital heart defects, particularly those affecting the cardiac outflow tract and aortic arch in isolation and in CATCH-22 syndrome. ..
- Cardiac Development and Cogenital Heart DiseaseDeepak Srivastava; Fiscal Year: 2004..The exposure of graduate students and post-doctoral fellows to the exciting opportunities in this field is essential for future progress and for the career development of the trainees. ..