Research Topics
Genomes and Genes
Species | D SrivastavaSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
| Collaborators
|
Detail Information
Publications
HAND proteins: molecular mediators of cardiac development and congenital heart diseaseD Srivastava
Department of Pediatric Cardiology, University of Texas Southwestern Medical Center, Dallas 75235 9148, USA
Trends Cardiovasc Med 9:11-8. 1999..Congenital heart disease is considered as a defect in segmental development of the heart and the role of dHAND and eHAND in regulating such developmental pathways in normal and abnormal cardiogenesis is examined...- Developmental and genetic aspects of congenital heart diseaseD Srivastava
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9148, USA
Curr Opin Cardiol 14:263-8. 1999..A systematic dissection of molecular pathways involved in cardiogenesis should allow for further identification of genes responsible for CHD... - Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHANDD Srivastava
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9148, USA
Nat Genet 16:154-60. 1997.... - A genetic blueprint for cardiac developmentD Srivastava
Department of Molecular Biology, University of Texas, Southwestern Medical Center at Dallas, 75390 9148, USA
Nature 407:221-6. 2000.... - Genetic assembly of the heart: implications for congenital heart diseaseD Srivastava
Department of Pediatrics and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
Annu Rev Physiol 63:451-69. 2001..In this review, genetic pathways regulating cardiogenesis revealed by cross-species studies are reviewed and correlated with human CHD... - The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formationH Yamagishi
Department of Pediatrics, Division of Cardiology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
Dev Biol 239:190-203. 2001..5 and dHAND. These studies provide the first demonstration of gene mutations that result in ablation of the entire ventricular segment of the mammalian heart, and reveal essential transcriptional pathways for ventricular formation... - Molecular mechanisms of ventricular hypoplasiaD Srivastava
Departments of Pediatrics and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
Cold Spring Harb Symp Quant Biol 67:121-5. 2002.... - A common cis-acting sequence in the DiGeorge critical region regulates bi-directional transcription of UFD1L and CDC45LA Kunte
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Rm NA8 124, Dallas, TX 75390 9148, USA
Mech Dev 108:81-92. 2001..These results reveal the presence of a conserved regulatory region in the 22q11 deletion locus that can direct simultaneous transcription of genes involved in ubiquitin mediated protein processing (UFD1L) and cell cycle control (CDC45L)... - A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heartD G McFadden
Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 75390 9148, USA
Development 127:5331-41. 2000..Since GATA factors are not chamber-restricted, these findings suggest the existence of positive and/or negative coregulators that cooperate with GATA factors to control right ventricular-specific gene expression in the developing heart... - A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchymeT Thomas
Department of Pediatrics, Division of Cardiology and Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9148, USA edu
Development 125:3005-14. 1998..Complete disruption of this molecular pathway results in growth failure of the branchial arches from apoptosis, while partial disruption leads to defects of branchial arch derivatives, similar to those seen in CATCH-22 syndrome... - Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch developmentV Garg
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Rm NA8 124, Dallas, Texas 75390 9148, USA
Dev Biol 235:62-73. 2001..Furthermore, Shh was sufficient to induce Tbx1 expression when misexpressed in selected regions of chick embryos. These studies reveal a Shh-mediated pathway that regulates Tbx1 during pharyngeal arch development... - Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1A B Firulli
Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 75235 9148, USA
Nat Genet 18:266-70. 1998..Heart development was also perturbed and did not progress beyond the cardiac-looping stage. Our results demonstrate important roles for Hand1 in extraembryonic mesodermal and heart development... - A molecular pathway revealing a genetic basis for human cardiac and craniofacial defectsH Yamagishi
Department of Pediatrics, Division of Cardiology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Room NA8 124, Dallas, TX 75235 9148, USA
Science 283:1158-61. 1999..These data suggest that UFD1L haploinsufficiency contributes to the congenital heart and craniofacial defects seen in 22q11 deletion... - The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidednessT Thomas
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235 9148, USA
Dev Biol 196:228-36. 1998.... 
Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signalingO Nakagawa
Departments of Molecular Biology and Pediatrics, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
Proc Natl Acad Sci U S A 97:13655-60. 2000..These findings identify HRT genes as downstream targets for Notch signaling and reveal a negative autoregulatory loop whereby HRT proteins repress their own expression through interference with Notch signaling...- CHAMP, a novel cardiac-specific helicase regulated by MEF2CZ P Liu
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9148, USA
Dev Biol 234:497-509. 2001..These findings suggest that CHAMP acts downstream of MEF2C in a cardiac-specific regulatory pathway for RNA processing and/or transcriptional control... - Conservation of sequence and expression of Xenopus and zebrafish dHAND during cardiac, branchial arch and lateral mesoderm developmentS Angelo
Department of Pediatrics, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75235 9148, USA
Mech Dev 95:231-7. 2000..Within the branchial arches, XdHAND was expressed in a broader domain than XeHAND, similar to their mouse counterparts. Together, these data demonstrate conservation of HAND structure and expression across species... - Human eHAND, but not dHAND, is down-regulated in cardiomyopathiesA Natarajan
Division of Intensive Care, Department of Pediatrics, University of Texas Southwestern Medical Center, University of Texas Southwestern Medical Center, One Baylor Plaza, Dallas, Texas 75390-9148, USA
J Mol Cell Cardiol 33:1607-14. 2001..Downregulation of eHAND in ischemic and dilated cardiomyopathy suggests a correlation between eHAND dysregulation and the evolution of a subset of cardiomyopathies... - HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segmentsO Nakagawa
Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas, 75235 9148, USA
Dev Biol 216:72-84. 1999..The unique and complementary expression patterns of this novel subfamily of bHLH proteins suggest a previously unrecognized role for Hairy-related pathways in segmental patterning of the heart and pharyngeal arches, among other organs... - The basic helix-loop-helix transcription factor, dHAND, is required for vascular developmentH Yamagishi
Department of Pediatrics, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
J Clin Invest 105:261-70. 2000..These results suggest that dHAND is required for vascular development and regulates angiogenesis, possibly through a VEGF signaling pathway... - Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathwayM Fernandez-Teran
Departamento de Anatomia y Biologia Celular, Universidad de Cantabria, Spain
Development 127:2133-42. 2000..Our results indicate a role for dHAND in the establishment of anterior-posterior polarization of the limb bud... - A transcriptional pathway for cardiac developmentQ Lin
Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas 75235-9148, USA
Cold Spring Harb Symp Quant Biol 62:405-11. 1997 - A subclass of bHLH proteins required for cardiac morphogenesisD Srivastava
Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
Science 270:1995-9. 1995..Thus, dHAND and eHAND may play redundant roles in the regulation of the morphogenetic events of vertebrate heart development...