Supriya Srinivasan

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo
    Supriya Srinivasan
    Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e668. 2007
  2. pmc Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans
    Supriya Srinivasan
    Gladstone Institute of Cardiovascular Disease, UCSF, San Francisco, California 94143 0540, USA
    J Clin Invest 114:1158-64. 2004
  3. pmc AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans
    Katherine A Cunningham
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94158 2517, USA
    Cell Metab 16:113-21. 2012
  4. pmc Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of C. elegans Bardet-Biedl syndrome mutants
    Brian H Lee
    Department of Physiology and The UCSF Diabetes Center, University of California, San Francisco, San Francisco, California, United States of America
    PLoS Biol 9:e1001219. 2011
  5. pmc Engineering GPCR signaling pathways with RASSLs
    Bruce R Conklin
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, California 94158, USA
    Nat Methods 5:673-8. 2008
  6. ncbi request reprint Engineering the melanocortin-4 receptor to control G(s) signaling in vivo
    Supriya Srinivasan
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141, USA
    Ann N Y Acad Sci 994:225-32. 2003
  7. pmc Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms
    Supriya Srinivasan
    Department of Physiology and UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA 94158 2517, USA
    Cell Metab 7:533-44. 2008

Collaborators

Detail Information

Publications7

  1. pmc Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo
    Supriya Srinivasan
    Gladstone Institute of Cardiovascular Disease, University of California at San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e668. 2007
    ..Our study also demonstrates the use of human genetic variation for protein engineering...
  2. pmc Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans
    Supriya Srinivasan
    Gladstone Institute of Cardiovascular Disease, UCSF, San Francisco, California 94143 0540, USA
    J Clin Invest 114:1158-64. 2004
    ..Our results also suggest that the tonic satiety signal provided by the constitutive activity of MC4R may be required for maintaining long-term energy homeostasis in humans...
  3. pmc AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans
    Katherine A Cunningham
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94158 2517, USA
    Cell Metab 16:113-21. 2012
    ..We show that AMPK-mediated regulation of glutamatergic release is conserved in rat hippocampal neurons. These findings reveal cellular and molecular mediators of serotonergic signaling...
  4. pmc Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of C. elegans Bardet-Biedl syndrome mutants
    Brian H Lee
    Department of Physiology and The UCSF Diabetes Center, University of California, San Francisco, San Francisco, California, United States of America
    PLoS Biol 9:e1001219. 2011
    ..These findings expand the role of BBS proteins to the regulation of dense-core-vesicle exocytosis and suggest that some features of Bardet-Biedl Syndrome may be caused by excessive neuroendocrine secretion...
  5. pmc Engineering GPCR signaling pathways with RASSLs
    Bruce R Conklin
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, California 94158, USA
    Nat Methods 5:673-8. 2008
    ..Currently, RASSLs exist for the three major GPCR signaling pathways (G(s), G(i) and G(q)). We review these advances here to facilitate the use of these powerful and diverse tools...
  6. ncbi request reprint Engineering the melanocortin-4 receptor to control G(s) signaling in vivo
    Supriya Srinivasan
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141, USA
    Ann N Y Acad Sci 994:225-32. 2003
    ..The MC4R G(s) RASSL could be used to control many physiological responses associated with G(s) signaling such as heart rate, energy homeostasis, and cell proliferation...
  7. pmc Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms
    Supriya Srinivasan
    Department of Physiology and UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA 94158 2517, USA
    Cell Metab 7:533-44. 2008
    ..Moreover, obesity and thinness are not solely determined by feeding behavior. Rather, feeding behavior and fat metabolism are coordinated but independent responses of the nervous system to the perception of nutrient availability...