Research Topics
| Sundar SrinivasanSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
Bone mechanotransduction may require augmentation in order to strengthen the senescent skeletonSundar Srinivasan
Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA 98104 4240, USA
Ageing Res Rev 11:353-60. 2012..If the safety and efficacy of this strategy were to be confirmed for human use, it would enable the utilization of exercise as a viable countermeasure against skeletal fragility at senescence...
Enabling bone formation in the aged skeleton via rest-inserted mechanical loadingSundar Srinivasan
Orthopaedic Science Laboratories, Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA 98104, USA
Bone 33:946-55. 2003....- Rest-inserted loading rapidly amplifies the response of bone to small increases in strain and load cyclesSundar Srinivasan
Dept of Orthopaedics, University of Washington, Seattle, WA 98104 2499, USA
J Appl Physiol 102:1945-52. 2007..In sum, the data of this study indicate that inserting a 10-s rest interval between each load cycle amplifies bone's response to mechanical loading, even within a peri-threshold range of strain magnitudes and cycle numbers... - Why rest stimulates bone formation: a hypothesis based on complex adaptive phenomenonTed S Gross
Orthopaedic Science Laboratories, Department of Orthopaedics and Sports Medicine, University of Washington, Seattle 98107, USA
Exerc Sport Sci Rev 32:9-13. 2004..They hypothesize that the osteogenic nature of rest-inserted loading arises by enabling osteocytes to communicate as a small world network... - Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycleSundar Srinivasan
Department of Orthopedics and Sports Medicine, University of Washington, Seattle 98104-2499, USA
J Bone Miner Res 17:1613-20. 2002..We conclude that 10 s of rest between each load cycle of a low-magnitude loading protocol greatly enhances the osteogenic potential of the regimen... - Cortical bone resorption following muscle paralysis is spatially heterogeneousBrandon J Ausk
Orthopaedics and Sports Medicine, University of Washington, Seattle, WA 98104 2420, USA
Bone 50:14-22. 2012..Clarifying this relation holds potential to yield unique insight into how the removal of factors critical for bone homeostasis acutely precipitates local modulation of cellular responses within bone... - Botox induced muscle paralysis rapidly degrades boneSarah E Warner
Department of Orthopaedics and Sports Medicine, University of Washington, 325 Ninth Ave, Box 359798, Seattle, WA 98104-2499, USA
Bone 38:257-64. 2006..Given the rapidly expanding use of neuromuscular inhibitors for indications such as pain reduction, these data also raise the critical need to monitor bone loss in these patients... - An agent based model for real-time signaling induced in osteocytic networks by mechanical stimuliBrandon J Ausk
Orthopaedic Science Laboratories, Department of Orthopaedic Surgery and Sports Medicine, University of Washington, Box 359798, 325 Ninth Ave, Seattle, WA 98104-2499, USA
J Biomech 39:2638-46. 2006..Importantly, this emergence based approach suggested mechanisms potentially underlying the benefit of rest-inserted stimuli and provides a unique framework for a broader exploration of mechanotransduction function within bone... - 32 wk old C3H/HeJ mice actively respond to mechanical loadingSandra L Poliachik
Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA, 98104, USA
Bone 42:653-9. 2008..However, when basal surface osteoblast activity is equivalent to that of 16 wk C57 mice, C3H mice demonstrate a clear ability to respond to either rest-inserted or cyclic loading... - Upregulation of osteopontin by osteocytes deprived of mechanical loading or oxygenTed S Gross
Orthopaedic Science Laboratories, Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA 98104 2499, USA
J Bone Miner Res 20:250-6. 2005..Within the context of OPN's role in osteoclast migration and attachment, hypoxia-induced osteocyte OPN expression may serve to mediate disuse-induced bone resorption... - Mice lacking thrombospondin 2 show an atypical pattern of endocortical and periosteal bone formation in response to mechanical loadingKurt D Hankenson
Department of Orthopaedic Surgery, and Unit for Laboratory Animal Medicine, University of Michigan, G161 400 N Ingalls Bldg, Ann Arbor, MI 48109, USA
Bone 38:310-6. 2006.... - Noninvasive loading of the murine tibia: an in vivo model for the study of mechanotransductionTed S Gross
Department of Orthopedic Surgery, University of Cincinnati, Ohio, USA
J Bone Miner Res 17:493-501. 2002....
Research Grants
- Predicting bone formation induced by mechanical loading using agent based modelsSundar Srinivasan; Fiscal Year: 2007..Success of this application will therefore represent a crucial first step towards our long-term goal of developing tools for the optimized design of mechanical loading protocols to augment bone mass and strength. ..
- Aging-related degradation in bone mechanotransductionSundar Srinivasan; Fiscal Year: 2009..Clinically, success of this project would provide the rationale for examination of this concept to augment bone mass in the elderly. ..
- Aging-related degradation in bone mechanotransductionSundar Srinivasan; Fiscal Year: 2010..Clinically, success of this project would provide the rationale for examination of this concept to augment bone mass in the elderly. ..
- Aging-related degradation in bone mechanotransductionSundar Srinivasan; Fiscal Year: 2010..Clinically, success of this project would provide the rationale for examination of this concept to augment bone mass in the aged population. ..