Sundar Srinivasan

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Bone mechanotransduction may require augmentation in order to strengthen the senescent skeleton
    Sundar Srinivasan
    Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA 98104 4240, USA
    Ageing Res Rev 11:353-60. 2012
  2. ncbi request reprint Rest-inserted loading rapidly amplifies the response of bone to small increases in strain and load cycles
    Sundar Srinivasan
    Dept of Orthopaedics, University of Washington, Seattle, WA 98104 2499, USA
    J Appl Physiol (1985) 102:1945-52. 2007
  3. ncbi request reprint Enabling bone formation in the aged skeleton via rest-inserted mechanical loading
    Sundar Srinivasan
    Orthopaedic Science Laboratories, Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA 98104, USA
    Bone 33:946-55. 2003
  4. pmc Metaphyseal and diaphyseal bone loss in the tibia following transient muscle paralysis are spatiotemporally distinct resorption events
    Brandon J Ausk
    Orthopaedics and Sports Medicine, University of Washington, Seattle, WA, USA Electronic address
    Bone 57:413-22. 2013
  5. pmc Why rest stimulates bone formation: a hypothesis based on complex adaptive phenomenon
    Ted S Gross
    Orthopaedic Science Laboratories, Department of Orthopaedics and Sports Medicine, University of Washington, Seattle 98107, USA
    Exerc Sport Sci Rev 32:9-13. 2004
  6. pmc Distinct cyclosporin a doses are required to enhance bone formation induced by cyclic and rest-inserted loading in the senescent skeleton
    Sundar Srinivasan
    Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 9:e84868. 2014
  7. pmc Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle
    Sundar Srinivasan
    Department of Orthopedics and Sports Medicine, University of Washington, Seattle 98104 2499, USA
    J Bone Miner Res 17:1613-20. 2002
  8. pmc Cortical bone resorption following muscle paralysis is spatially heterogeneous
    Brandon J Ausk
    Orthopaedics and Sports Medicine, University of Washington, Seattle, WA 98104 2420, USA
    Bone 50:14-22. 2012
  9. pmc Botox induced muscle paralysis rapidly degrades bone
    Sarah E Warner
    Department of Orthopaedics and Sports Medicine, University of Washington, 325 Ninth Ave, Box 359798, Seattle, WA 98104 2499, USA
    Bone 38:257-64. 2006
  10. pmc Systems-based identification of temporal processing pathways during bone cell mechanotransduction
    Leah E Worton
    Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e74205. 2013

Collaborators

Detail Information

Publications16

  1. pmc Bone mechanotransduction may require augmentation in order to strengthen the senescent skeleton
    Sundar Srinivasan
    Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA 98104 4240, USA
    Ageing Res Rev 11:353-60. 2012
    ..If the safety and efficacy of this strategy were to be confirmed for human use, it would enable the utilization of exercise as a viable countermeasure against skeletal fragility at senescence...
  2. ncbi request reprint Rest-inserted loading rapidly amplifies the response of bone to small increases in strain and load cycles
    Sundar Srinivasan
    Dept of Orthopaedics, University of Washington, Seattle, WA 98104 2499, USA
    J Appl Physiol (1985) 102:1945-52. 2007
    ..In sum, the data of this study indicate that inserting a 10-s rest interval between each load cycle amplifies bone's response to mechanical loading, even within a peri-threshold range of strain magnitudes and cycle numbers...
  3. ncbi request reprint Enabling bone formation in the aged skeleton via rest-inserted mechanical loading
    Sundar Srinivasan
    Orthopaedic Science Laboratories, Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA 98104, USA
    Bone 33:946-55. 2003
    ....
  4. pmc Metaphyseal and diaphyseal bone loss in the tibia following transient muscle paralysis are spatiotemporally distinct resorption events
    Brandon J Ausk
    Orthopaedics and Sports Medicine, University of Washington, Seattle, WA, USA Electronic address
    Bone 57:413-22. 2013
    ..In a broader context, these findings are an essential first step toward clarifying the timing and origins of multiple resorptive events that would require targeting to fully inhibit bone loss following neuromuscular trauma. ..
  5. pmc Why rest stimulates bone formation: a hypothesis based on complex adaptive phenomenon
    Ted S Gross
    Orthopaedic Science Laboratories, Department of Orthopaedics and Sports Medicine, University of Washington, Seattle 98107, USA
    Exerc Sport Sci Rev 32:9-13. 2004
    ..They hypothesize that the osteogenic nature of rest-inserted loading arises by enabling osteocytes to communicate as a small world network...
  6. pmc Distinct cyclosporin a doses are required to enhance bone formation induced by cyclic and rest-inserted loading in the senescent skeleton
    Sundar Srinivasan
    Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 9:e84868. 2014
    ....
  7. pmc Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle
    Sundar Srinivasan
    Department of Orthopedics and Sports Medicine, University of Washington, Seattle 98104 2499, USA
    J Bone Miner Res 17:1613-20. 2002
    ..We conclude that 10 s of rest between each load cycle of a low-magnitude loading protocol greatly enhances the osteogenic potential of the regimen...
  8. pmc Cortical bone resorption following muscle paralysis is spatially heterogeneous
    Brandon J Ausk
    Orthopaedics and Sports Medicine, University of Washington, Seattle, WA 98104 2420, USA
    Bone 50:14-22. 2012
    ..Clarifying this relation holds potential to yield unique insight into how the removal of factors critical for bone homeostasis acutely precipitates local modulation of cellular responses within bone...
  9. pmc Botox induced muscle paralysis rapidly degrades bone
    Sarah E Warner
    Department of Orthopaedics and Sports Medicine, University of Washington, 325 Ninth Ave, Box 359798, Seattle, WA 98104 2499, USA
    Bone 38:257-64. 2006
    ..Given the rapidly expanding use of neuromuscular inhibitors for indications such as pain reduction, these data also raise the critical need to monitor bone loss in these patients...
  10. pmc Systems-based identification of temporal processing pathways during bone cell mechanotransduction
    Leah E Worton
    Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e74205. 2013
    ....
  11. ncbi request reprint An agent based model for real-time signaling induced in osteocytic networks by mechanical stimuli
    Brandon J Ausk
    Orthopaedic Science Laboratories, Department of Orthopaedic Surgery and Sports Medicine, University of Washington, Box 359798, 325 Ninth Ave, Seattle, WA 98104 2499, USA
    J Biomech 39:2638-46. 2006
    ..Importantly, this emergence based approach suggested mechanisms potentially underlying the benefit of rest-inserted stimuli and provides a unique framework for a broader exploration of mechanotransduction function within bone...
  12. pmc 32 wk old C3H/HeJ mice actively respond to mechanical loading
    Sandra L Poliachik
    Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA, 98104, USA
    Bone 42:653-9. 2008
    ..However, when basal surface osteoblast activity is equivalent to that of 16 wk C57 mice, C3H mice demonstrate a clear ability to respond to either rest-inserted or cyclic loading...
  13. pmc Upregulation of osteopontin by osteocytes deprived of mechanical loading or oxygen
    Ted S Gross
    Orthopaedic Science Laboratories, Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA 98104 2499, USA
    J Bone Miner Res 20:250-6. 2005
    ..Within the context of OPN's role in osteoclast migration and attachment, hypoxia-induced osteocyte OPN expression may serve to mediate disuse-induced bone resorption...
  14. ncbi request reprint Mice lacking thrombospondin 2 show an atypical pattern of endocortical and periosteal bone formation in response to mechanical loading
    Kurt D Hankenson
    Department of Orthopaedic Surgery, and Unit for Laboratory Animal Medicine, University of Michigan, G161 400 N Ingalls Bldg, Ann Arbor, MI 48109, USA
    Bone 38:310-6. 2006
    ....
  15. pmc Noninvasive loading of the murine tibia: an in vivo model for the study of mechanotransduction
    Ted S Gross
    Department of Orthopedic Surgery, University of Cincinnati, Ohio, USA
    J Bone Miner Res 17:493-501. 2002
    ....

Research Grants5

  1. Predicting bone formation induced by mechanical loading using agent based models
    Sundar Srinivasan; Fiscal Year: 2007
    ..Success of this application will therefore represent a crucial first step towards our long-term goal of developing tools for the optimized design of mechanical loading protocols to augment bone mass and strength. ..
  2. Aging-related degradation in bone mechanotransduction
    Sundar Srinivasan; Fiscal Year: 2009
    ..Clinically, success of this project would provide the rationale for examination of this concept to augment bone mass in the elderly. ..
  3. Aging-related degradation in bone mechanotransduction
    Sundar Srinivasan; Fiscal Year: 2010
    ..Clinically, success of this project would provide the rationale for examination of this concept to augment bone mass in the elderly. ..
  4. Aging-related degradation in bone mechanotransduction
    Sundar Srinivasan; Fiscal Year: 2010
    ..Clinically, success of this project would provide the rationale for examination of this concept to augment bone mass in the aged population. ..