Genomes and Genes
Affiliation: University of California
- Ex vivo MR spectroscopic measure differentiates tumor from treatment effects in GBMRadhika Srinivasan
Department of Radiology and Biomedical Imaging, 1700 4th Street, Byers Hall, Suite 301, San Francisco, CA 94143 2532, USA
Neuro Oncol 12:1152-61. 2010..Low levels of MCI for tumor were associated with a reduced apparent diffusion coefficient and elevated choline-N-acetyl-aspartate index derived from in vivo MR images...
- MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an application to multiple sclerosisRadhika Srinivasan
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94107 1739, USA
Magn Reson Imaging 28:163-70. 2010..Reduced GSH was also observed in a MS WM lesion. This preliminary investigation demonstrates the potential of this marker to probe oxidative state in MS...
- TE-averaged two-dimensional proton spectroscopic imaging of glutamate at 3 TRadhika Srinivasan
Center for Molecular and Functional Imaging, University of California San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107 1739, USA
Neuroimage 30:1171-8. 2006....
- Comparison of T(1) and T(2) metabolite relaxation times in glioma and normal brain at 3TYan Li
University of California, San Francisco University of California, Berkeley UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, California 94143 2532, USA
J Magn Reson Imaging 28:342-50. 2008..To measure T(1) and T(2) relaxation times of metabolites in glioma patients at 3T and to investigate how these values influence the observed metabolite levels...
- Identifying malignant transformations in recurrent low grade gliomas using high resolution magic angle spinning spectroscopyAlexandra Constantin
Electrical Engineering and Computer Science, Sutardja Dai Hall, University of California, Berkeley, Berkeley, CA 94709, USA
Artif Intell Med 55:61-70. 2012..This was achieved by exploring the use of multivariate pattern recognition methods to generate statistical models of the metabolic characteristics of recurrent LGGs that correlate with aggressive biology and poor clinical outcome...
- Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 TRadhika Srinivasan
Center for Molecular and Functional Imaging, Department of Radiology, University of California San Francisco, 185 Berry Street, 350, San Francisco, CA 94107 1739, USA
Brain 128:1016-25. 2005..001) myo-inositol levels in acute lesions compared with control white matter. These in vivo results support the hypothesis that altered glutamate metabolism is present in brains of multiple sclerosis patients...
- Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomasAdam Elkhaled
Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94158, USA
Sci Transl Med 4:116ra5. 2012..Such information may augment the ability of clinicians to monitor therapeutic response and provide criteria for stratifying patients to specific treatment regimens...
- Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosisSergio E Baranzini
Department of Neurology, School of Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0435, USA
Brain 133:2603-11. 2010..Spectroscopy-based imaging provides a novel quantitative endophenotype for genetic association studies directed towards identifying new factors that contribute to the heterogeneity of clinical expression of multiple sclerosis...
- High-resolution phased-array MRI of the human brain at 7 tesla: initial experience in multiple sclerosis patientsMeredith Metcalf
UCSF UC Berkeley Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA 94017, USA
J Neuroimaging 20:141-7. 2010..Clear involvement of the GM was observed with improved morphological detail in comparison to imaging at lower-field strength...
- Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to ironKathryn E Hammond
University of California San Francisco Berkeley Joint Graduate Group in Bioengineering, University of California San Francisco, San Francisco, CA, USA
Ann Neurol 64:707-13. 2008..The purpose of this study was to quantify local field shifts in MS and to investigate their relation to disease duration and disability status...
- A comparative study of myo-inositol quantification using LCmodel at 1.5 T and 3.0 T with 3 D 1H proton spectroscopic imaging of the human brainRadhika Srinivasan
Magnetic Resonance Science Center, University of California, AC109, Box 1290, San Francisco, CA 94143, USA
Magn Reson Imaging 22:523-8. 2004..Using data from normal controls and the LCmodel quantification procedure, we found that the quantification precision, reproducibility and detection sensitivity of myo-inositol is significantly better at 3 T relative to 1.5 T...
- Standardized, reproducible, high resolution global measurements of T1 relaxation metrics in cases of multiple sclerosisRadhika Srinivasan
Magnetic Resonance Science Center, The Department of Radiology, University of California, San Francisco, 94143, USA
AJNR Am J Neuroradiol 24:58-67. 2003..The reproducibility of the T1 metrics derived from these maps and their sensitivity to distinguish between control participants and patients with multiple sclerosis are evaluated...