David W Sretavan

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Microscale surgery on single axons
    David W Sretavan
    Department of Ophthalmology, University of California, San Francisco, California 94143, USA
    Neurosurgery 57:635-46; discussion 635-46. 2005
  2. ncbi Upregulation of EphB2 and ephrin-B2 at the optic nerve head of DBA/2J glaucomatous mice coincides with axon loss
    Juan Du
    Department of Ophthalmology, University of California San Francisco, CA 94143, USA
    Invest Ophthalmol Vis Sci 48:5567-81. 2007
  3. ncbi In vivo use of a nanoknife for axon microsurgery
    Wesley C Chang
    Department of Ophthalmology, University of California, San Francisco, California 94143, USA
    Neurosurgery 61:683-91; discussion 691-2. 2007
  4. ncbi Axon repair: surgical application at a subcellular scale
    Wesley C Chang
    Neuroscience and Bioengineering Programs, Department of Ophthalmology, University of California, San Francisco, CA 94143, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 2:151-61. 2010
  5. ncbi Microtechnology and nanotechnology in nerve repair
    Wesley C Chang
    Department of Ophthalmology, University of California, San Francisco, CA 94143, USA
    Neurol Res 30:1053-62. 2008
  6. ncbi Isolation of neuronal substructures and precise neural microdissection using a nanocutting device
    Wesley C Chang
    Department of Ophthalmology, Program in Neuroscience, Bioengineering Graduate Program, University of California, 10 Koret Way, K110, Box 0730, San Francisco, CA 94143, USA
    J Neurosci Methods 152:83-90. 2006
  7. ncbi Single cell and neural process experimentation using laterally applied electrical fields between pairs of closely apposed microelectrodes with vertical sidewalls
    Wesley C Chang
    Department of Ophthalmology, University of California, K110, Box 0730, UC San Francisco, 10 Koret Way, K 110, San Francisco, CA 94143, USA
    Biosens Bioelectron 24:3600-7. 2009
  8. ncbi Novel high-resolution micropatterning for neuron culture using polylysine adsorption on a cell repellant, plasma-polymerized background
    Wesley C Chang
    Department of Ophthalmology and Phsiology, Neuroscience and Bioengineering Programs, University of California, San Francisco, CA, USA
    Langmuir 24:13048-57. 2008
  9. ncbi L1/Laminin modulation of growth cone response to EphB triggers growth pauses and regulates the microtubule destabilizing protein SCG10
    Leejee H Suh
    Department of Ophthalmology, University of California San Francisco, San Francisco, California 94143, USA
    J Neurosci 24:1976-86. 2004
  10. ncbi Microtechnology in medicine: the emergence of surgical microdevices
    Wesley C Chang
    Department of Ophtalmology, University of California, San Francisco, San Franciso, California, USA
    Clin Neurosurg 54:137-47. 2007

Research Grants

  1. Microscale Axon Repair As A Novel Paradigm For Nerve Injuries
    David W Sretavan; Fiscal Year: 2010
  2. Guidance Molecules in Retinal Axon Disease
    David W Sretavan; Fiscal Year: 2010
  3. Guidance Molecules in Retinal Axon Regeneration
    David Sretavan; Fiscal Year: 2007
  4. MOLECULAR DEVELOPMENT OF CENTRAL RETINAL PATHWAYS
    David Sretavan; Fiscal Year: 2002
  5. Microscale Axon Repair As A Novel Paradigm For Nerve Injuries
    David Sretavan; Fiscal Year: 2009

Collaborators

Detail Information

Publications15

  1. ncbi Microscale surgery on single axons
    David W Sretavan
    Department of Ophthalmology, University of California, San Francisco, California 94143, USA
    Neurosurgery 57:635-46; discussion 635-46. 2005
    ....
  2. ncbi Upregulation of EphB2 and ephrin-B2 at the optic nerve head of DBA/2J glaucomatous mice coincides with axon loss
    Juan Du
    Department of Ophthalmology, University of California San Francisco, CA 94143, USA
    Invest Ophthalmol Vis Sci 48:5567-81. 2007
    ..To further demonstrate that the proteins encoded by these genes bind to RGC axons and influence fundamental axon physiology...
  3. ncbi In vivo use of a nanoknife for axon microsurgery
    Wesley C Chang
    Department of Ophthalmology, University of California, San Francisco, California 94143, USA
    Neurosurgery 61:683-91; discussion 691-2. 2007
    ..In this study, we examined the in vivo use of 10 to 100 microm-long nanoknives with cutting edges of 20 nm in radius of curvature during peripheral nerve surgery...
  4. ncbi Axon repair: surgical application at a subcellular scale
    Wesley C Chang
    Neuroscience and Bioengineering Programs, Department of Ophthalmology, University of California, San Francisco, CA 94143, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 2:151-61. 2010
    ..We discuss results generated by these two approaches and hurdles confronting both strategies...
  5. ncbi Microtechnology and nanotechnology in nerve repair
    Wesley C Chang
    Department of Ophthalmology, University of California, San Francisco, CA 94143, USA
    Neurol Res 30:1053-62. 2008
    ..This review will describe the novel contributions to the field of nerve repair from the emerging disciplines of microtechnology and nanotechnology...
  6. ncbi Isolation of neuronal substructures and precise neural microdissection using a nanocutting device
    Wesley C Chang
    Department of Ophthalmology, Program in Neuroscience, Bioengineering Graduate Program, University of California, 10 Koret Way, K110, Box 0730, San Francisco, CA 94143, USA
    J Neurosci Methods 152:83-90. 2006
    ..Its ease of use and possibility for batch fabrication makes this a highly effective and versatile tool for tissue microdissection and the microanalysis of neuronal function...
  7. ncbi Single cell and neural process experimentation using laterally applied electrical fields between pairs of closely apposed microelectrodes with vertical sidewalls
    Wesley C Chang
    Department of Ophthalmology, University of California, K110, Box 0730, UC San Francisco, 10 Koret Way, K 110, San Francisco, CA 94143, USA
    Biosens Bioelectron 24:3600-7. 2009
    ....
  8. ncbi Novel high-resolution micropatterning for neuron culture using polylysine adsorption on a cell repellant, plasma-polymerized background
    Wesley C Chang
    Department of Ophthalmology and Phsiology, Neuroscience and Bioengineering Programs, University of California, San Francisco, CA, USA
    Langmuir 24:13048-57. 2008
    ..Using this "piggybacking" of laminin on polylysine, we were also able to culture and micropattern retinal ganglion cells (RGC)...
  9. ncbi L1/Laminin modulation of growth cone response to EphB triggers growth pauses and regulates the microtubule destabilizing protein SCG10
    Leejee H Suh
    Department of Ophthalmology, University of California San Francisco, San Francisco, California 94143, USA
    J Neurosci 24:1976-86. 2004
    ..Furthermore, the results are consistent with EphB-mediated axon guidance mechanisms that involve the SCG10-mediated regulation of the growth cone microtubule cytoskeleton...
  10. ncbi Microtechnology in medicine: the emergence of surgical microdevices
    Wesley C Chang
    Department of Ophtalmology, University of California, San Francisco, San Franciso, California, USA
    Clin Neurosurg 54:137-47. 2007
    ....
  11. ncbi Invariant Sema5A inhibition serves an ensheathing function during optic nerve development
    Stephen F Oster
    Department of Ophthalmology, Medical Scientist Training Program, University of California San Francisco, CA 94143, USA
    Development 130:775-84. 2003
    ..Furthermore, this function is accomplished using molecules such as Sema5A that exhibit conserved inhibitory responses in the presence of co-impinging signals from multiple families of guidance molecules...
  12. ncbi Rabbit models for continuous curvilinear capsulorhexis instruction
    Jason Ruggiero
    Department of Ophthalmology, University of California San Francisco, San Francisco, California 94143, USA
    J Cataract Refract Surg 38:1266-70. 2012
    ..To develop a rabbit model for continuous curvilinear capsulorhexis (CCC) instruction...
  13. ncbi EphB3: an endogenous mediator of adult axonal plasticity and regrowth after CNS injury
    Xiao Liu
    Program in Neuroscience, Department of Ophthalmology, University of California, San Francisco, California 94143, USA
    J Neurosci 26:3087-101. 2006
    ..Of note, the loss of EphB3 did not affect the ability of injured RGC axons to elaborate complex terminal branching, suggesting that additional EphB3-independent mechanisms governed adult axon branching triggered by CNS damage...
  14. ncbi An oligodendrocyte lineage-specific semaphorin, Sema5A, inhibits axon growth by retinal ganglion cells
    Jeffrey L Goldberg
    Stanford University School of Medicine, Department of Neurobiology, Stanford, California 94305 5125, USA
    J Neurosci 24:4989-99. 2004
    ..These data support the hypothesis that sema5A expression by oligodendrocyte lineage cells contributes to the glial cues that inhibit CNS regeneration...
  15. ncbi Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans
    David B Kantor
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Neuron 44:961-75. 2004
    ..Thus, neuronal responses to Sema5A are proteoglycan dependent and interpreted according to the biological context in which this membrane bound guidance cue is presented...

Research Grants18

  1. Microscale Axon Repair As A Novel Paradigm For Nerve Injuries
    David W Sretavan; Fiscal Year: 2010
    ..Since medicine today offers no specific therapy that can reconstitute function after injuries to neural pathways, this project has direct relevance to an area of clinical need. ..
  2. Guidance Molecules in Retinal Axon Disease
    David W Sretavan; Fiscal Year: 2010
    ..abstract_text> ..
  3. Guidance Molecules in Retinal Axon Regeneration
    David Sretavan; Fiscal Year: 2007
    ..Together, these studies will help establish a foundation for developing strategies to promote retinal axon regeneration and functional recovery after injury and disease. ..
  4. MOLECULAR DEVELOPMENT OF CENTRAL RETINAL PATHWAYS
    David Sretavan; Fiscal Year: 2002
    ..The results may also provide insight into the etiology of the developmental disorders such as optic nerve hypoplasia and assist in attempts to promote functional recovery in the visual system after injury or disease. ..
  5. Microscale Axon Repair As A Novel Paradigm For Nerve Injuries
    David Sretavan; Fiscal Year: 2009
    ..Since medicine today offers no specific therapy that can reconstitute function after injuries to neural pathways, this project has direct relevance to an area of clinical need. ..