Robert H Squires
Affiliation: University of Pittsburgh
- Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: a placebo-controlled clinical trialRobert H Squires
Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
Hepatology 57:1542-9. 2013..0493). There were no significant differences between treatment arms for hospital or ICU length of stay, organ systems failing, or highest recorded grade of HE...
- Natural history of pediatric intestinal failure: initial report from the Pediatric Intestinal Failure ConsortiumRobert H Squires
Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
J Pediatr 161:723-8.e2. 2012..To characterize the natural history of intestinal failure (IF) among 14 pediatric centers during the intestinal transplantation era...
- Acute liver failure in childrenRobert H Squires
University of Pittsburgh, Pittsburgh, PA 15213, USA
Semin Liver Dis 28:153-66. 2008..Overall, short-term outcomes are better in children than adults but are dependent upon the degree of encephalopathy and diagnosis...
- Munchausen syndrome by proxy: ongoing clinical challengesJanet E Squires
Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA
J Pediatr Gastroenterol Nutr 51:248-53. 2010..In addition, we believe contemporary developments within the modern health care system likely facilitate this condition...
- Evaluation of the liver injury unit scoring system to predict survival in a multinational study of pediatric acute liver failureBrandy R Lu
Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA
J Pediatr 162:1010-6.e1-4. 2013....
- Pattern of diagnostic evaluation for the causes of pediatric acute liver failure: an opportunity for quality improvementMichael R Narkewicz
Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado Denver School of Medicine and the Pediatric Liver Center, The Children s Hospital, Aurora, CO, USA
J Pediatr 155:801-806.e1. 2009..To describe the frequency of diagnostic testing for the 4 most common causes of pediatric acute liver failure (PALF) (drugs, metabolic disease, autoimmune process, and infections) in indeterminate PALF within the PALF Study Group Database...
- Characterization and outcomes of young infants with acute liver failureShikha S Sundaram
Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, The Children s Hospital, University of Colorado School of Medicine, Aurora, CO, USA
J Pediatr 159:813-818.e1. 2011..To characterize infants aged ≤ 90 days enrolled in an international, multicenter, prospective registry of children aged < 18 years with acute liver failure (ALF)...
- Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study groupRobert H Squires
University of Pittsburgh, Children s Hospital of Pittsburgh, PA 15213, USA
J Pediatr 148:652-658. 2006..To determine short-term outcome for children with acute liver failure (ALF) as it relates to cause, clinical status, and patient demographics and to determine prognostic factors...
- King's College Hospital Criteria for non-acetaminophen induced acute liver failure in an international cohort of childrenVinay Sundaram
Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
J Pediatr 162:319-23.e1. 2013..To validate King's College Hospital criteria (KCHC) in children with non-acetaminophen induced pediatric acute liver failure (PALF) and to determine whether re-optimizing the KCHC would improve predictive accuracy...
- Prognostic scoring indices in Wilson disease: a case series and cautionary taleRyan T Fischer
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA 15238, USA
J Pediatr Gastroenterol Nutr 52:466-9. 2011..The Wilson Index is a prognostic index used to determine the risk of death without transplant in WD. We sought to determine the accuracy of this system in our own patient population...
- Translational systems approaches to the biology of inflammation and healingYoram Vodovotz
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Immunopharmacol Immunotoxicol 32:181-95. 2010..This plethora of computational and intertwined experimental/engineering approaches is the cornerstone of Translational Systems Biology approaches for inflammatory diseases...
- Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failureNabil Azhar
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 8:e78202. 2013..We hypothesized that specific, dynamic, and measurable patterns of immune/inflammatory dysregulation will correlate with outcomes in PALF...
- Current perspectives on pediatric intestinal transplantationGeorge V Mazariegos
Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
Curr Gastroenterol Rep 11:226-33. 2009..Experience at centers of excellence demonstrates 1- and 5-year patient survival rates of 95% and 77%, respectively, with ongoing investigations focusing on lowering long-term causes of graft loss such as chronic rejection...
- Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate causeLaura P James
Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas, USA
Pediatrics 118:e676-81. 2006..The objective of this study was to use a new assay for the detection of acetaminophen cysteine protein adducts in children with acute liver failure to determine the role of acetaminophen toxicity in acute liver failure of unknown cause...
- Portal hypertension in children: expert pediatric opinion on the report of the Baveno v Consensus Workshop on Methodology of Diagnosis and Therapy in Portal HypertensionBenjamin L Shneider
Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
Pediatr Transplant 16:426-37. 2012..The opinions of that expert panel are reported...
- Acute liver failure: Summary of a workshopWilliam M Lee
Division of Digestive and Liver Diseases, University of Texas Southwestern Medical School, Dallas, TX 75390 8887, USA
Hepatology 47:1401-15. 2008..Advances in stem cell research may allow provision of cells for bioartificial liver support. ALF presents many challenging opportunities in both clinical and basic research...
- Growth failure and outcomes in infants with biliary atresia: a report from the Biliary Atresia Research ConsortiumPatricia A DeRusso
Johns Hopkins School of Medicine and The Johns Hopkins Children s Center, Baltimore, Maryland, USA
Hepatology 46:1632-8. 2007..The combination of intermediate bilirubin concentrations and poor mean weight z-scores 3 months after HPE was also associated with poor clinical outcome...
- Screening for Wilson disease in acute liver failure: a comparison of currently available diagnostic testsJessica D Korman
Montefiore Medical Center, Bronx, NY, USA
Hepatology 48:1167-74. 2008..In addition, an AST:ALT ratio >2.2 yielded a sensitivity of 94%, a specificity of 86%, and a likelihood ratio of 7 for diagnosing fulminant WD. Combining the tests provided a diagnostic sensitivity and specificity of 100%...
- Isolated liver transplantation in infants with short gut syndrome: is less better?George V Mazariegos
Liver Transpl 12:1040-1. 2006
- Acute liver failure in childrenJohn Bucuvalas
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Clin Liver Dis 10:149-68, vii. 2006..This article examines current knowledge of the epidemiology, pathobiology, and treatment of ALF in children and identifies potential gaps in this knowledge for future study...
- Liver transplantation for cholestasis associated with cystic fibrosis in the pediatric populationErnesto P Molmenti
Baylor University Medical Center, Dallas, TX, USA
Pediatr Transplant 7:93-7. 2003..The presence of Aspergillus in the sputum does not constitute a contraindication for OLTX...
- Liver disease caused by failure to racemize trihydroxycholestanoic acid: gene mutation and effect of bile acid therapyKenneth D R Setchell
Division of Clinical Mass Spectrometry, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Gastroenterology 124:217-32. 2003....
- Treatment of unresectable hepatoblastoma with liver transplantation in the pediatric populationErnesto P Molmenti
Baylor University Medical Center, Transplantation Services, Dallas, TX 75246, USA
Am J Transplant 2:535-8. 2002..Early diagnosis and treatment were found to be associated with better results. Response to chemotherapy may be an important factor influencing survival. Rising AFP levels after transplantation are associated with recurrence...