Robert H Squires

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: a placebo-controlled clinical trial
    Robert H Squires
    Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
    Hepatology 57:1542-9. 2013
  2. pmc Natural history of pediatric intestinal failure: initial report from the Pediatric Intestinal Failure Consortium
    Robert H Squires
    Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
    J Pediatr 161:723-8.e2. 2012
  3. doi Munchausen syndrome by proxy: ongoing clinical challenges
    Janet E Squires
    Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA
    J Pediatr Gastroenterol Nutr 51:248-53. 2010
  4. doi Acute liver failure in children
    Robert H Squires
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    Semin Liver Dis 28:153-66. 2008
  5. pmc Evaluation of the liver injury unit scoring system to predict survival in a multinational study of pediatric acute liver failure
    Brandy R Lu
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA
    J Pediatr 162:1010-6.e1-4. 2013
  6. pmc Pattern of diagnostic evaluation for the causes of pediatric acute liver failure: an opportunity for quality improvement
    Michael R Narkewicz
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado Denver School of Medicine and the Pediatric Liver Center, The Children s Hospital, Aurora, CO, USA
    J Pediatr 155:801-806.e1. 2009
  7. pmc Characterization and outcomes of young infants with acute liver failure
    Shikha S Sundaram
    Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, The Children s Hospital, University of Colorado School of Medicine, Aurora, CO, USA
    J Pediatr 159:813-818.e1. 2011
  8. pmc Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group
    Robert H Squires
    University of Pittsburgh, Children s Hospital of Pittsburgh, PA 15213, USA
    J Pediatr 148:652-658. 2006
  9. pmc King's College Hospital Criteria for non-acetaminophen induced acute liver failure in an international cohort of children
    Vinay Sundaram
    Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Pediatr 162:319-23.e1. 2013
  10. pmc Race affects outcome among infants with intestinal failure
    Robert H Squires
    Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA Nationwide Children s Hospital, Columbus, OH Seattle Children s Hospital, Seattle, WA The Hospital for Sick Children, Toronto, Ontario, Canada Children s Hospital Colorado Medical Center, Denver Boston Children s Hospital, Boston, MA Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA
    J Pediatr Gastroenterol Nutr 59:537-43. 2014

Collaborators

Detail Information

Publications26

  1. pmc Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: a placebo-controlled clinical trial
    Robert H Squires
    Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
    Hepatology 57:1542-9. 2013
    ..0493). There were no significant differences between treatment arms for hospital or ICU length of stay, organ systems failing, or highest recorded grade of HE...
  2. pmc Natural history of pediatric intestinal failure: initial report from the Pediatric Intestinal Failure Consortium
    Robert H Squires
    Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
    J Pediatr 161:723-8.e2. 2012
    ..To characterize the natural history of intestinal failure (IF) among 14 pediatric centers during the intestinal transplantation era...
  3. doi Munchausen syndrome by proxy: ongoing clinical challenges
    Janet E Squires
    Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA
    J Pediatr Gastroenterol Nutr 51:248-53. 2010
    ..In addition, we believe contemporary developments within the modern health care system likely facilitate this condition...
  4. doi Acute liver failure in children
    Robert H Squires
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    Semin Liver Dis 28:153-66. 2008
    ..Overall, short-term outcomes are better in children than adults but are dependent upon the degree of encephalopathy and diagnosis...
  5. pmc Evaluation of the liver injury unit scoring system to predict survival in a multinational study of pediatric acute liver failure
    Brandy R Lu
    Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA
    J Pediatr 162:1010-6.e1-4. 2013
    ....
  6. pmc Pattern of diagnostic evaluation for the causes of pediatric acute liver failure: an opportunity for quality improvement
    Michael R Narkewicz
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado Denver School of Medicine and the Pediatric Liver Center, The Children s Hospital, Aurora, CO, USA
    J Pediatr 155:801-806.e1. 2009
    ..To describe the frequency of diagnostic testing for the 4 most common causes of pediatric acute liver failure (PALF) (drugs, metabolic disease, autoimmune process, and infections) in indeterminate PALF within the PALF Study Group Database...
  7. pmc Characterization and outcomes of young infants with acute liver failure
    Shikha S Sundaram
    Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, The Children s Hospital, University of Colorado School of Medicine, Aurora, CO, USA
    J Pediatr 159:813-818.e1. 2011
    ..To characterize infants aged ≤ 90 days enrolled in an international, multicenter, prospective registry of children aged < 18 years with acute liver failure (ALF)...
  8. pmc Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group
    Robert H Squires
    University of Pittsburgh, Children s Hospital of Pittsburgh, PA 15213, USA
    J Pediatr 148:652-658. 2006
    ..To determine short-term outcome for children with acute liver failure (ALF) as it relates to cause, clinical status, and patient demographics and to determine prognostic factors...
  9. pmc King's College Hospital Criteria for non-acetaminophen induced acute liver failure in an international cohort of children
    Vinay Sundaram
    Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Pediatr 162:319-23.e1. 2013
    ..To validate King's College Hospital criteria (KCHC) in children with non-acetaminophen induced pediatric acute liver failure (PALF) and to determine whether re-optimizing the KCHC would improve predictive accuracy...
  10. pmc Race affects outcome among infants with intestinal failure
    Robert H Squires
    Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA Nationwide Children s Hospital, Columbus, OH Seattle Children s Hospital, Seattle, WA The Hospital for Sick Children, Toronto, Ontario, Canada Children s Hospital Colorado Medical Center, Denver Boston Children s Hospital, Boston, MA Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA
    J Pediatr Gastroenterol Nutr 59:537-43. 2014
    ..We sought to determine whether ethnic and racial differences were associated with patient survival and likelihood of receiving an intestinal transplant in a contemporary cohort of children with IF...
  11. doi Analysis of viral testing in nonacetaminophen pediatric acute liver failure
    Kathleen B Schwarz
    Department of Pediatrics, Johns Hopkins University School of Medicine, Division of Gastroenterology and Nutrition, Charlotte R Bloomberg Johns Hopkins Children s Center, Baltimore, MD Liver Unit, Birmingham Children s Hospital, Birmingham, UK Department of Pediatrics, Columbia University School of Medicine, Division of Gastroenterology, New York, NY Department of Pediatrics and Communicable Diseases, University of Michigan School of Medicine, Division of Pediatric Gastroenterology, Ann Arbor Department of Pediatrics, University of Texas Southwestern Medical Center, Division of Gastroenterology, Dallas Department of Pediatrics, University of Cincinnati College of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH Department of Epidemiology Department of Pediatrics, University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA
    J Pediatr Gastroenterol Nutr 59:616-23. 2014
    ..Viral infections are often suspected to cause pediatric acute liver failure (PALF), but large-scale studies have not been performed. We analyzed the results of viral testing among nonacetaminophen PALF study participants...
  12. doi Prognostic scoring indices in Wilson disease: a case series and cautionary tale
    Ryan T Fischer
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA 15238, USA
    J Pediatr Gastroenterol Nutr 52:466-9. 2011
    ..The Wilson Index is a prognostic index used to determine the risk of death without transplant in WD. We sought to determine the accuracy of this system in our own patient population...
  13. pmc Translational systems approaches to the biology of inflammation and healing
    Yoram Vodovotz
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Immunopharmacol Immunotoxicol 32:181-95. 2010
    ..This plethora of computational and intertwined experimental/engineering approaches is the cornerstone of Translational Systems Biology approaches for inflammatory diseases...
  14. pmc Neuropsychological functioning and health-related quality of life: pediatric acute liver failure study group results
    Lisa G Sorensen
    Department of Child and Adolescent Psychiatry Department of Pediatrics, Ann and Robert H Lurie Children s Hospital of Chicago, Chicago, IL Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA Department of Psychology and Neuroscience, Baylor University, Waco, TX Department of Pediatrics, Texas A and M University, College Station Department of Paediatrics, Hospital for Sick Children, Toronto, ON, Canada Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA
    J Pediatr Gastroenterol Nutr 60:75-83. 2015
    ..The goal was to determine the prevalence of reduced neuropsychological functioning and health-related quality of life (HRQOL) following PALF...
  15. pmc Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure
    Nabil Azhar
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e78202. 2013
    ..We hypothesized that specific, dynamic, and measurable patterns of immune/inflammatory dysregulation will correlate with outcomes in PALF...
  16. ncbi Current perspectives on pediatric intestinal transplantation
    George V Mazariegos
    Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Curr Gastroenterol Rep 11:226-33. 2009
    ..Experience at centers of excellence demonstrates 1- and 5-year patient survival rates of 95% and 77%, respectively, with ongoing investigations focusing on lowering long-term causes of graft loss such as chronic rejection...
  17. ncbi Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause
    Laura P James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas, USA
    Pediatrics 118:e676-81. 2006
    ..The objective of this study was to use a new assay for the detection of acetaminophen cysteine protein adducts in children with acute liver failure to determine the role of acetaminophen toxicity in acute liver failure of unknown cause...
  18. doi Portal hypertension in children: expert pediatric opinion on the report of the Baveno v Consensus Workshop on Methodology of Diagnosis and Therapy in Portal Hypertension
    Benjamin L Shneider
    Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
    Pediatr Transplant 16:426-37. 2012
    ..The opinions of that expert panel are reported...
  19. pmc Acute liver failure: Summary of a workshop
    William M Lee
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical School, Dallas, TX 75390 8887, USA
    Hepatology 47:1401-15. 2008
    ..Advances in stem cell research may allow provision of cells for bioartificial liver support. ALF presents many challenging opportunities in both clinical and basic research...
  20. ncbi Liver disease caused by failure to racemize trihydroxycholestanoic acid: gene mutation and effect of bile acid therapy
    Kenneth D R Setchell
    Division of Clinical Mass Spectrometry, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Gastroenterology 124:217-32. 2003
    ....
  21. ncbi Liver transplantation for cholestasis associated with cystic fibrosis in the pediatric population
    Ernesto P Molmenti
    Baylor University Medical Center, Dallas, TX, USA
    Pediatr Transplant 7:93-7. 2003
    ..The presence of Aspergillus in the sputum does not constitute a contraindication for OLTX...
  22. ncbi Acute liver failure in children
    John Bucuvalas
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Clin Liver Dis 10:149-68, vii. 2006
    ..This article examines current knowledge of the epidemiology, pathobiology, and treatment of ALF in children and identifies potential gaps in this knowledge for future study...
  23. ncbi Isolated liver transplantation in infants with short gut syndrome: is less better?
    George V Mazariegos
    Liver Transpl 12:1040-1. 2006
  24. pmc Growth failure and outcomes in infants with biliary atresia: a report from the Biliary Atresia Research Consortium
    Patricia A DeRusso
    Johns Hopkins School of Medicine and The Johns Hopkins Children s Center, Baltimore, Maryland, USA
    Hepatology 46:1632-8. 2007
    ..The combination of intermediate bilirubin concentrations and poor mean weight z-scores 3 months after HPE was also associated with poor clinical outcome...
  25. doi Screening for Wilson disease in acute liver failure: a comparison of currently available diagnostic tests
    Jessica D Korman
    Montefiore Medical Center, Bronx, NY, USA
    Hepatology 48:1167-74. 2008
    ..In addition, an AST:ALT ratio >2.2 yielded a sensitivity of 94%, a specificity of 86%, and a likelihood ratio of 7 for diagnosing fulminant WD. Combining the tests provided a diagnostic sensitivity and specificity of 100%...
  26. ncbi Treatment of unresectable hepatoblastoma with liver transplantation in the pediatric population
    Ernesto P Molmenti
    Baylor University Medical Center, Transplantation Services, Dallas, TX 75246, USA
    Am J Transplant 2:535-8. 2002
    ..Early diagnosis and treatment were found to be associated with better results. Response to chemotherapy may be an important factor influencing survival. Rising AFP levels after transplantation are associated with recurrence...