Giuseppe L Squadrito

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc On the hydrophobicity of nitrogen dioxide: could there be a "lens" effect for NO(2) reaction kinetics?
    Giuseppe L Squadrito
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Nitric Oxide 21:104-9. 2009
  2. pmc Elucidating mechanisms of chlorine toxicity: reaction kinetics, thermodynamics, and physiological implications
    Giuseppe L Squadrito
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Am J Physiol Lung Cell Mol Physiol 299:L289-300. 2010
  3. pmc Administration of nitrite after chlorine gas exposure prevents lung injury: effect of administration modality
    Andrey A Samal
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 53:1431-9. 2012
  4. pmc Post-exposure antioxidant treatment in rats decreases airway hyperplasia and hyperreactivity due to chlorine inhalation
    Michelle V Fanucchi
    Department of Environmental Health Science, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Respir Cell Mol Biol 46:599-606. 2012
  5. pmc Targeted aerosolized delivery of ascorbate in the lungs of chlorine-exposed rats
    Andreas Bracher
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Aerosol Med Pulm Drug Deliv 25:333-41. 2012
  6. pmc Mechanisms and modification of chlorine-induced lung injury in animals
    Amit K Yadav
    Department of Anesthesiology, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35294, USA
    Proc Am Thorac Soc 7:278-83. 2010
  7. pmc Ascorbate and deferoxamine administration after chlorine exposure decrease mortality and lung injury in mice
    Sotirios G Zarogiannis
    Department of Anesthesiology, School of Medicine and Public Health, University of Alabama at Birmingham, 35294, USA
    Am J Respir Cell Mol Biol 45:386-92. 2011
  8. pmc Mitigation of chlorine gas lung injury in rats by postexposure administration of sodium nitrite
    Amit K Yadav
    Departments of Environmental Health Sciences, Schools of Public Health and Medicine, University of Alabama at Birmingham, USA
    Am J Physiol Lung Cell Mol Physiol 300:L362-9. 2011
  9. pmc Desferrioxamine inhibits protein tyrosine nitration: mechanisms and implications
    Margaret A Adgent
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 53:951-61. 2012
  10. pmc Chlorine gas exposure causes systemic endothelial dysfunction by inhibiting endothelial nitric oxide synthase-dependent signaling
    Jaideep Honavar
    Department of Pathology, University of Alabama at Birmingham, 35294, USA
    Am J Respir Cell Mol Biol 45:419-25. 2011

Collaborators

Detail Information

Publications12

  1. pmc On the hydrophobicity of nitrogen dioxide: could there be a "lens" effect for NO(2) reaction kinetics?
    Giuseppe L Squadrito
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Nitric Oxide 21:104-9. 2009
    ..In comparison to other gases, nitrogen dioxide is less hydrophobic than NO, O(2) and N(2)...
  2. pmc Elucidating mechanisms of chlorine toxicity: reaction kinetics, thermodynamics, and physiological implications
    Giuseppe L Squadrito
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Am J Physiol Lung Cell Mol Physiol 299:L289-300. 2010
    ....
  3. pmc Administration of nitrite after chlorine gas exposure prevents lung injury: effect of administration modality
    Andrey A Samal
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 53:1431-9. 2012
    ..These data highlight the potential for nitrite as a postexposure therapeutic for Cl(2) gas-induced lung injury and also suggest that administration modality is a key consideration in nitrite therapeutics...
  4. pmc Post-exposure antioxidant treatment in rats decreases airway hyperplasia and hyperreactivity due to chlorine inhalation
    Michelle V Fanucchi
    Department of Environmental Health Science, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Respir Cell Mol Biol 46:599-606. 2012
    ....
  5. pmc Targeted aerosolized delivery of ascorbate in the lungs of chlorine-exposed rats
    Andreas Bracher
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Aerosol Med Pulm Drug Deliv 25:333-41. 2012
    ..Post-Cl(2) administration of aerosolized ascorbate in rodents decreased lung injury and mortality. However, the extent to which aerosolized ascorbate augments depleted ascorbate stores in distal lung compartments has not been assessed...
  6. pmc Mechanisms and modification of chlorine-induced lung injury in animals
    Amit K Yadav
    Department of Anesthesiology, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35294, USA
    Proc Am Thorac Soc 7:278-83. 2010
    ..The clinical challenge is to deliver sufficient quantities of antioxidants noninvasively, after Cl(2) exposure, to decrease morbidity and mortality...
  7. pmc Ascorbate and deferoxamine administration after chlorine exposure decrease mortality and lung injury in mice
    Sotirios G Zarogiannis
    Department of Anesthesiology, School of Medicine and Public Health, University of Alabama at Birmingham, 35294, USA
    Am J Respir Cell Mol Biol 45:386-92. 2011
    ..Administration of ascorbate and deferoxamine reduces mortality and decreases lung injury through reduction of alveolar-capillary permeability, inflammation, and epithelial sloughing and lipid peroxidation...
  8. pmc Mitigation of chlorine gas lung injury in rats by postexposure administration of sodium nitrite
    Amit K Yadav
    Departments of Environmental Health Sciences, Schools of Public Health and Medicine, University of Alabama at Birmingham, USA
    Am J Physiol Lung Cell Mol Physiol 300:L362-9. 2011
    ..F(2)-isoprostane levels increased at 6 and 24 h after Cl(2) exposure in NO(2)(-)- and saline-injected rats. This is the first demonstration that systemic NO(2)(-) administration mitigates airway and epithelial injury...
  9. pmc Desferrioxamine inhibits protein tyrosine nitration: mechanisms and implications
    Margaret A Adgent
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 53:951-61. 2012
    ....
  10. pmc Chlorine gas exposure causes systemic endothelial dysfunction by inhibiting endothelial nitric oxide synthase-dependent signaling
    Jaideep Honavar
    Department of Pathology, University of Alabama at Birmingham, 35294, USA
    Am J Respir Cell Mol Biol 45:419-25. 2011
    ..These results highlight the potential for Cl(2) exposure to promote postexposure systemic endothelial dysfunction via disruption of vascular NO homeostasis mechanisms...
  11. pmc Mitigation of chlorine-induced lung injury by low-molecular-weight antioxidants
    Martin Leustik
    Department of Anesthesiology, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35205 3703, USA
    Am J Physiol Lung Cell Mol Physiol 295:L733-43. 2008
    ..These findings suggest that Cl(2) inhalation damages both airway and alveolar epithelial tissues and that resulting effects were ameliorated by prophylactic administration of low-molecular-weight antioxidants...
  12. pmc Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloramines
    Weifeng Song
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama 35205, USA
    J Biol Chem 285:9716-28. 2010
    ..We concluded that HOCl and its reactive intermediates (such as organic chloramines) inhibit ENaC by affecting channel gating, which could be relieved by proteases cleavage...