Spotswood Spruance

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint Single-dose, patient-initiated famciclovir: a randomized, double-blind, placebo-controlled trial for episodic treatment of herpes labialis
    Spotswood L Spruance
    Division of Infectious Diseases, University of Utah School of Medicine, Salt Lake City, UT 84132 2405, USA
    J Am Acad Dermatol 55:47-53. 2006
  2. pmc Hazard ratio in clinical trials
    Spotswood L Spruance
    Division of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84132 2405, USA
    Antimicrob Agents Chemother 48:2787-92. 2004
  3. pmc Acyclovir cream for treatment of herpes simplex labialis: results of two randomized, double-blind, vehicle-controlled, multicenter clinical trials
    Spotswood L Spruance
    Division of Infectious Diseases, University of Utah, Salt Lake City, Utah 84132, USA
    Antimicrob Agents Chemother 46:2238-43. 2002
  4. ncbi request reprint Short-course therapy for recurrent genital herpes and herpes labialis
    Spotswood Spruance
    Division of Infectious Diseases, University of Utah School of Medicine, Room 4B319, 30 North 1900 East, Salt Lake City, UT 84132 2405, USA
    J Fam Pract 56:30-6. 2007
  5. ncbi request reprint Treatment of herpes simplex labialis
    Spotswood L Spruance
    Division of Infectious Diseases, University of Utah School of Medicine, Room 4B319, 30 North 1900 East, Salt Lake City, UT 84132 2405, USA
    Herpes 9:64-9. 2002
  6. pmc High-dose, short-duration, early valacyclovir therapy for episodic treatment of cold sores: results of two randomized, placebo-controlled, multicenter studies
    Spotswood L Spruance
    University of Utah, Division of Infectious Diseases, School of Medicine, Salt Lake City 84132, USA
    Antimicrob Agents Chemother 47:1072-80. 2003
  7. ncbi request reprint Clinical significance of antiviral therapy for episodic treatment of herpes labialis: exploratory analyses of the combined data from two valaciclovir trials
    Spotswood L Spruance
    Division of Infectious Diseases, RM 4B319, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    J Antimicrob Chemother 53:703-7. 2004
  8. ncbi request reprint Single-dose famciclovir for the treatment of herpes labialis
    Christopher Hull
    Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT 84132 2405, USA
    Curr Med Res Opin 22:1699-702. 2006
  9. ncbi request reprint Situational antiviral drug prophylaxis for HSV type 1 recurrences
    Christopher Hull
    Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Herpes 14:37-40. 2007
  10. ncbi request reprint Recurrent antiviral-resistant genital herpes in an immunocompetent patient
    John D Kriesel
    Department of Medicine, University of Utah, Salt Lake City, Utah 84132, USA
    J Infect Dis 192:156-61. 2005

Detail Information

Publications16

  1. ncbi request reprint Single-dose, patient-initiated famciclovir: a randomized, double-blind, placebo-controlled trial for episodic treatment of herpes labialis
    Spotswood L Spruance
    Division of Infectious Diseases, University of Utah School of Medicine, Salt Lake City, UT 84132 2405, USA
    J Am Acad Dermatol 55:47-53. 2006
    ..The brief period of viral replication in recurrent herpes labialis lesions suggests shorter therapeutic regimens are a logical episodic treatment strategy...
  2. pmc Hazard ratio in clinical trials
    Spotswood L Spruance
    Division of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84132 2405, USA
    Antimicrob Agents Chemother 48:2787-92. 2004
  3. pmc Acyclovir cream for treatment of herpes simplex labialis: results of two randomized, double-blind, vehicle-controlled, multicenter clinical trials
    Spotswood L Spruance
    Division of Infectious Diseases, University of Utah, Salt Lake City, Utah 84132, USA
    Antimicrob Agents Chemother 46:2238-43. 2002
    ..Acyclovir cream did not prevent the development of classical lesions (progression to vesicles, ulcers, and/or crusts). Adverse events were mild and infrequent...
  4. ncbi request reprint Short-course therapy for recurrent genital herpes and herpes labialis
    Spotswood Spruance
    Division of Infectious Diseases, University of Utah School of Medicine, Room 4B319, 30 North 1900 East, Salt Lake City, UT 84132 2405, USA
    J Fam Pract 56:30-6. 2007
  5. ncbi request reprint Treatment of herpes simplex labialis
    Spotswood L Spruance
    Division of Infectious Diseases, University of Utah School of Medicine, Room 4B319, 30 North 1900 East, Salt Lake City, UT 84132 2405, USA
    Herpes 9:64-9. 2002
    ..Selected subgroups of patients are candidates for prophylactic treatment with perorally administered nucleoside antiviral agents. Prophylaxis with topical agents is not effective...
  6. pmc High-dose, short-duration, early valacyclovir therapy for episodic treatment of cold sores: results of two randomized, placebo-controlled, multicenter studies
    Spotswood L Spruance
    University of Utah, Division of Infectious Diseases, School of Medicine, Salt Lake City 84132, USA
    Antimicrob Agents Chemother 47:1072-80. 2003
    ..The 1-day valacyclovir regimen offers patients a unique and convenient dosing alternative compared to available topical therapies...
  7. ncbi request reprint Clinical significance of antiviral therapy for episodic treatment of herpes labialis: exploratory analyses of the combined data from two valaciclovir trials
    Spotswood L Spruance
    Division of Infectious Diseases, RM 4B319, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    J Antimicrob Chemother 53:703-7. 2004
    ..We also introduce a new measure that combines the two observed drug effects (reduced lesion duration, increased aborted lesions) into a single endpoint that captures the global benefit of the drug to the patient...
  8. ncbi request reprint Single-dose famciclovir for the treatment of herpes labialis
    Christopher Hull
    Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT 84132 2405, USA
    Curr Med Res Opin 22:1699-702. 2006
    ..The pharmacokinetic/pharmacodynamic profile of famciclovir suggests that it could be utilized for episodic treatment for immunocompetent individuals as well...
  9. ncbi request reprint Situational antiviral drug prophylaxis for HSV type 1 recurrences
    Christopher Hull
    Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Herpes 14:37-40. 2007
    ..Controlled trials demonstrate that antiviral drug prophylaxis can be efficacious in selected circumstances; even for other situations, clinical reports suggest that such antiviral drug prophylaxis remains effective...
  10. ncbi request reprint Recurrent antiviral-resistant genital herpes in an immunocompetent patient
    John D Kriesel
    Department of Medicine, University of Utah, Salt Lake City, Utah 84132, USA
    J Infect Dis 192:156-61. 2005
    ..These findings support the conclusion that both drug-sensitive and drug-resistant HSV-2 strains established latency in this patient and that both strains are capable of frequent reactivation...
  11. ncbi request reprint Susceptibility of herpes simplex virus isolates to nucleoside analogues and the proportion of nucleoside-resistant variants after repeated topical application of penciclovir to recurrent herpes labialis
    Young Kyoo Shin
    Section of Pediatric Infectious Diseases, School of Medicine, University of Colorado, Denver, Colorado, USA
    J Infect Dis 187:1241-5. 2003
    ..We conclude that antiviral-resistant variants, which are readily detected in HSV isolates from peripheral lesions, do not accumulate in the sensory ganglia of immunocompetent patients receiving multiple courses of nucleoside analogues...
  12. ncbi request reprint Topical iontophoretic administration of acyclovir for the episodic treatment of herpes labialis: a randomized, double-blind, placebo-controlled, clinic-initiated trial
    Eric M Morrel
    Transport Pharmaceuticals, Framingham, Massachusetts 01701, USA
    Clin Infect Dis 43:460-7. 2006
    ....
  13. ncbi request reprint Glycoprotein-D-adjuvant vaccine to prevent genital herpes
    Lawrence R Stanberry
    Department of Pediatrics and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston 77555 0351, USA
    N Engl J Med 347:1652-61. 2002
    ..An effective prophylactic vaccine would help control the spread of genital herpes...
  14. ncbi request reprint N-docosanol (Abreva) for herpes labialis: problems and questions
    Spotswood L Spruance
    J Am Acad Dermatol 47:457-8. 2002
  15. ncbi request reprint Effective treatment of herpes simplex labialis with penciclovir cream: combined results of two trials
    G Wayne Raborn
    Department of Dentistry, University of Alberta, Faculty of Medicine and Dentistry, Edmonton, Canada
    J Am Dent Assoc 133:303-9. 2002
    ..Two randomized, double-blind, parallel-group clinical trials were conducted in Europe and North America to compare the efficacy and safety of topical 1 percent penciclovir cream with a placebo cream...
  16. ncbi request reprint Evaluation of imiquimod 5% cream to modify the natural history of herpes labialis: a pilot study
    David I Bernstein
    Children s Hospital Medical Center Division of Infectious Diseases, Cincinnati, OH 45229, USA
    Clin Infect Dis 41:808-14. 2005
    ..Therefore, we evaluated the safety and potential of topical imiquimod to decrease the rate of recurrence in humans with a history of recurrent herpes labialis...