Matthew L Springer

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography
    Matthew L Springer
    Division of Cardiology, Department of Medicine, University of California, San Francisco, California 94143 0124, USA
    Am J Physiol Heart Circ Physiol 289:H1307-14. 2005
  2. ncbi request reprint Localization of vascular response to VEGF is not dependent on heparin binding
    Matthew L Springer
    Division of Cardiology, Box 0124, 513 Parnassus Ave, Rm S1136, University of California, San Francisco, San Francisco, CA 94143 0124, USA
    FASEB J 21:2074-85. 2007
  3. ncbi request reprint A balancing act: therapeutic approaches for the modulation of angiogenesis
    Matthew L Springer
    Department of Medicine, Division of Cardiology, University of California, San Francisco 94143 0124, USA
    Curr Opin Investig Drugs 7:243-50. 2006
  4. doi request reprint Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease
    Christian Heiss
    Division of Cardiology, University of California San Francisco, San Francisco, California, USA
    J Am Coll Cardiol 56:218-24. 2010
  5. pmc Nitric oxide synthase expression and functional response to nitric oxide are both important modulators of circulating angiogenic cell response to angiogenic stimuli
    Christian Heiss
    Division of Cardiology, University of California, San Francisco, San Francisco, CA 94143 0124, USA
    Arterioscler Thromb Vasc Biol 30:2212-8. 2010
  6. doi request reprint Timing of bone marrow cell therapy is more important than repeated injections after myocardial infarction
    Yan Zhang
    Division of Cardiology, Department of Medicine, University of California San Francisco, CA 94143 0103, USA
    Cardiovasc Pathol 20:204-12. 2011
  7. pmc Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy
    Yerem Yeghiazarians
    Department of Medicine, University of California San Francisco, 94143 0103, USA
    Mol Ther 17:1250-6. 2009
  8. pmc Pharmacological inhibition of S-nitrosoglutathione reductase improves endothelial vasodilatory function in rats in vivo
    Qiumei Chen
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143 0124, USA
    J Appl Physiol (1985) 114:752-60. 2013
  9. doi request reprint Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production
    Christian Heiss
    Division of Cardiology, Department of Medicine, University of California, San Francisco, California 94143 0103, USA
    J Am Coll Cardiol 51:1760-71. 2008
  10. pmc Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches
    Junya Takagawa
    Department of Medicine, Division of Cardiology, University of California, San Francisco, 513 Parnassus Ave, Rm S1136, Box 0124, San Francisco, CA 94143 0124, USA
    J Appl Physiol 102:2104-11. 2007

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography
    Matthew L Springer
    Division of Cardiology, Department of Medicine, University of California, San Francisco, California 94143 0124, USA
    Am J Physiol Heart Circ Physiol 289:H1307-14. 2005
    ..The use of this system will allow more precise cellular implantation into the mouse myocardium by accurately guiding injections to desired locations, confirming successful implantation of cells, in a clinically relevant time frame...
  2. ncbi request reprint Localization of vascular response to VEGF is not dependent on heparin binding
    Matthew L Springer
    Division of Cardiology, Box 0124, 513 Parnassus Ave, Rm S1136, University of California, San Francisco, San Francisco, CA 94143 0124, USA
    FASEB J 21:2074-85. 2007
    ..These results indicate that heparin binding is not essential for the localization of VEGF in adult tissue and suggest that the preferential delivery of VEGF121 cDNA for clinical applications may not have a physiological basis...
  3. ncbi request reprint A balancing act: therapeutic approaches for the modulation of angiogenesis
    Matthew L Springer
    Department of Medicine, Division of Cardiology, University of California, San Francisco 94143 0124, USA
    Curr Opin Investig Drugs 7:243-50. 2006
    ....
  4. doi request reprint Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease
    Christian Heiss
    Division of Cardiology, University of California San Francisco, San Francisco, California, USA
    J Am Coll Cardiol 56:218-24. 2010
    ....
  5. pmc Nitric oxide synthase expression and functional response to nitric oxide are both important modulators of circulating angiogenic cell response to angiogenic stimuli
    Christian Heiss
    Division of Cardiology, University of California, San Francisco, San Francisco, CA 94143 0124, USA
    Arterioscler Thromb Vasc Biol 30:2212-8. 2010
    ..The role of nitric oxide (NO) in CAC function is poorly understood. We hypothesized that CAC migration toward angiogenic signals is modulated by both NO synthase (NOS) expression and functional response to NO...
  6. doi request reprint Timing of bone marrow cell therapy is more important than repeated injections after myocardial infarction
    Yan Zhang
    Division of Cardiology, Department of Medicine, University of California San Francisco, CA 94143 0103, USA
    Cardiovasc Pathol 20:204-12. 2011
    ..Bone marrow cell treatment has been proposed as a therapy for myocardial infarction, but the optimal timing and number of injections remain unknown...
  7. pmc Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy
    Yerem Yeghiazarians
    Department of Medicine, University of California San Francisco, 94143 0103, USA
    Mol Ther 17:1250-6. 2009
    ..Intact cells are not necessary and death of implanted cells may be a major component of the benefit...
  8. pmc Pharmacological inhibition of S-nitrosoglutathione reductase improves endothelial vasodilatory function in rats in vivo
    Qiumei Chen
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143 0124, USA
    J Appl Physiol (1985) 114:752-60. 2013
    ..GSNOR inhibition preserves FMD under conditions of impaired NO production and protects against both microvascular and conduit artery dysfunction in a model of hypertension...
  9. doi request reprint Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production
    Christian Heiss
    Division of Cardiology, Department of Medicine, University of California, San Francisco, California 94143 0103, USA
    J Am Coll Cardiol 51:1760-71. 2008
    ..This study sought to analyze the effects of acute secondhand smoke (SHS) exposure on the number and function of endothelial progenitor cells (EPCs) over 24 h...
  10. pmc Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches
    Junya Takagawa
    Department of Medicine, Division of Cardiology, University of California, San Francisco, 513 Parnassus Ave, Rm S1136, Box 0124, San Francisco, CA 94143 0124, USA
    J Appl Physiol 102:2104-11. 2007
    ....
  11. pmc Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response
    Xiaoyin Wang
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Sci Transl Med 3:100ra90. 2011
    ..Our findings offer an explanation of why human trials have not matched the success of rodent experiments and suggest potential strategies to improve the success of clinical autologous BMC therapy...
  12. ncbi request reprint In vivo measurement of flow-mediated vasodilation in living rats using high-resolution ultrasound
    Christian Heiss
    Division of Cardiology, Department of Medicine, University of California, San Francisco 94143 0124, USA
    Am J Physiol Heart Circ Physiol 294:H1086-93. 2008
    ..To our knowledge, this is the first integrative physiological model to reproducibly study FMD of conduit arteries in living rats...
  13. ncbi request reprint Validation of the wall motion score and myocardial performance indexes as novel techniques to assess cardiac function in mice after myocardial infarction
    Yan Zhang
    Division of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0124, USA
    Am J Physiol Heart Circ Physiol 292:H1187-92. 2007
    ..These novel parameters provide additional noninvasive assessment of regional and global LV function in mice after MI...
  14. pmc Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cells
    Christian Heiss
    Department of Medicine, Division of Cardiology, University of California, San Francisco, San Francisco, California 94143 0124, USA
    J Cell Physiol 215:366-73. 2008
    ..These data suggest that PTN may mediate its pro-angiogenic effects by increasing the local number of not only endothelial cells but also early EPCs at angiogenic sites...
  15. pmc Brief exposure to secondhand smoke reversibly impairs endothelial vasodilatory function
    Kranthi Pinnamaneni
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA
    Nicotine Tob Res 16:584-90. 2014
    ..In humans, SHS exposure for 30min impairs FMD. It is important to gain a better understanding of the acute effects of exposure to SHS at low concentrations and for brief periods of time...
  16. pmc Nitric oxide counters the inhibitory effects of uremic toxin indoxyl sulfate on endothelial cells by governing ERK MAP kinase and myosin light chain activation
    Sourabh Kharait
    Division of Nephrology, University of California, San Francisco, CA 94143, USA
    Biochem Biophys Res Commun 409:758-63. 2011
    ..Thus, we conclude that the negative effects of IS on endothelial cells are prevented, to a major extent, by NO, via its divergent actions on ERK MAP kinase and MLC...
  17. ncbi request reprint VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
    Tomomi Kamba
    Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 290:H560-76. 2006
    ..Our findings of VEGF dependency of normal fenestrated capillaries and rapid regrowth after regression demonstrate the plasticity of the adult microvasculature...
  18. doi request reprint Assessment of myocardial angiogenesis and vascularity in small animal models
    Matthew L Springer
    Department of Medicine, Cardiovascular Research Institute and Institute of Regeneration Medicine, University of California, San Francisco, CA, USA
    Methods Mol Biol 660:149-67. 2010
    ....
  19. ncbi request reprint Microenvironmental VEGF distribution is critical for stable and functional vessel growth in ischemia
    Georges von Degenfeld
    Baxter Laboratory in Genetic Pharmacology, Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305 5175, USA
    FASEB J 20:2657-9. 2006
    ..Blood flow was only improved if vessels were increased both in size and in number. Microenvironmental VEGF concentrations determine efficacy and safety in a therapeutic setting...
  20. ncbi request reprint Myoblast-mediated gene transfer for therapeutic angiogenesis
    Andrea Banfi
    Department of Molecular Pharmacology, Stanford University School of Medicine, CCSR 4215, Stanford, California 94305, USA
    Methods Enzymol 346:145-57. 2002
  21. ncbi request reprint Transient production of alpha-smooth muscle actin by skeletal myoblasts during differentiation in culture and following intramuscular implantation
    Matthew L Springer
    Baxter Laboratory for Genetic Pharmacology, Stanford University, Stanford, California 94305 5175, USA
    Cell Motil Cytoskeleton 51:177-86. 2002
    ..Thus, both neonatal primary myoblasts and an established myoblast cell line appear to similarly reprise an embryonic developmental program during differentiation in culture as well as differentiation within adult mouse muscles...
  22. pmc RIP2, a checkpoint in myogenic differentiation
    Barbara Munz
    Baxter Laboratory for Genetic Pharmacology, Stanford University Medical Center, Stanford, California 94305 5175, USA
    Mol Cell Biol 22:5879-86. 2002
    ..These results implicate RIP2 in a previously unrecognized role: a checkpoint for myogenic proliferation and differentiation...
  23. ncbi request reprint Localized arteriole formation directly adjacent to the site of VEGF-induced angiogenesis in muscle
    Matthew L Springer
    Baxter Laboratory in Genetic Pharmacology, Stanford University School of Medicine, Stanford, California 94305 5175, USA
    Mol Ther 7:441-9. 2003
    ..In contrast with the distant arteriogenesis resulting from VEGF delivery described in previous studies, we report here that highly localized arterioles also form adjacent to the site of delivery...
  24. pmc Myoblast-mediated gene transfer for therapeutic angiogenesis and arteriogenesis
    Georges von Degenfeld
    Departments of Molecular Pharmacology and Microbiology and Immunology, Stanford University School of Medicine, 269 Campus Drive, CCSR 4215A, Stanford, CA 94305 5175, USA
    Br J Pharmacol 140:620-6. 2003
    ..Finally, the autologous cell-based approach using transduced myoblasts could be an alternative gene delivery system for therapeutic angiogenesis in patients, avoiding the toxicities seen with some viral vectors...
  25. pmc Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis
    Clare R Ozawa
    Baxter Laboratory in Genetic Pharmacology, Stanford University School of Medicine, Stanford, California 94305 5175, USA
    J Clin Invest 113:516-27. 2004
    ..Long-term continuous delivery of VEGF, when maintained below a threshold microenvironmental level, can lead to normal angiogenesis without other exogenous growth factors...
  26. pmc Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium
    Xuri Li
    Vesalius Research Center, VIB, 3000 Leuven, Belgium
    Arterioscler Thromb Vasc Biol 28:1614-20. 2008
    ..The endogenous role of the VEGF family member vascular endothelial growth factor-B (VEGF-B) in pathological angiogenesis remains unclear...
  27. doi request reprint Gene delivery to muscle
    Matthew L Springer
    Stanford University School of Medicine, Stanford, California, USA
    Curr Protoc Hum Genet . 2002
    ..A procedure describing the injection of plasmid DNA into muscle with or without electric charge is also included...
  28. ncbi request reprint VEGF therapy in heart disease: for better or for worse?
    Matthew L Springer
    Drug Discov Today 7:209-11. 2002