NICHOLAS CANADAY SPITZER

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Activity-dependent neurotransmitter respecification
    Nicholas C Spitzer
    Neurobiology Section, Division of Biological Sciences, Kavli Institute for Brain and Mind, University of California at San Diego, La Jolla, California 92093, USA
    Nat Rev Neurosci 13:94-106. 2012
  2. pmc Improved molecular toolkit for cAMP studies in live cells
    Kwan Pyo Hong
    Neurobiology Section, Division of Biological Sciences, Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, CA 92093, USA
    BMC Res Notes 4:241. 2011
  3. pmc Coincidence detection enhances appropriate wiring of the nervous system
    Nicholas C Spitzer
    Neurobiology Section and Center for Molecular Genetics, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093 0357, USA
    Proc Natl Acad Sci U S A 101:5311-2. 2004
  4. ncbi request reprint Activity-dependent neuronal differentiation prior to synapse formation: the functions of calcium transients
    Nicholas C Spitzer
    Neurobiology Section 0357, Division of Biology and Center for Molecular Genetics, UCSD, 9500 Gilman Drive, La Jolla, CA 92093 0357, USA
    J Physiol Paris 96:73-80. 2002
  5. ncbi request reprint Differentiation of electrical excitability in motoneurons
    N C Spitzer
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0357, USA
    Brain Res Bull 53:547-52. 2000
  6. ncbi request reprint Coding of neuronal differentiation by calcium transients
    N C Spitzer
    Department of Biology and Center for Molecular Genetics, UCSD, La Jolla, California 92093 0357, USA
    Bioessays 22:811-7. 2000
  7. ncbi request reprint Orchestrating neuronal differentiation: patterns of Ca2+ spikes specify transmitter choice
    Nicholas C Spitzer
    Neurobiology Section and Center for Molecular Genetics, Division of Biological Sciences, UCSD, La Jolla, CA 92093, USA
    Trends Neurosci 27:415-21. 2004
  8. ncbi request reprint Homeostatic activity-dependent paradigm for neurotransmitter specification
    Nicholas C Spitzer
    Neurobiology Section, Division of Biological Sciences and Center for Molecular Genetics, UCSD, La Jolla, CA 92093 0357, USA
    Cell Calcium 37:417-23. 2005
  9. ncbi request reprint Electrical activity in early neuronal development
    Nicholas C Spitzer
    Neurobiology Section, Division of Biological Sciences and Centre for Molecular Genetics, Kavli Institute for Brain and Mind, University of California San Diego, La Jolla, California 92093 0357, USA
    Nature 444:707-12. 2006
  10. pmc Implications of activity-dependent neurotransmitter-receptor matching
    Nicholas C Spitzer
    Neurobiology Section, Division of Biological Sciences, Center for Molecular Genetics, Kavli Institute for Brain and Mind, UCSD, La Jolla, CA 92093, USA
    Philos Trans R Soc Lond B Biol Sci 363:1393-9. 2008

Research Grants

  1. Developing Neurons
    NICHOLAS CANADAY SPITZER; Fiscal Year: 2010
  2. DEVELOPMENT OF NEURONS
    Nicholas Spitzer; Fiscal Year: 2003
  3. NEUROBIOLOGY TRAINING GRANT
    Nicholas Spitzer; Fiscal Year: 2007
  4. DEVELOPMENT OF NEURONS
    Nicholas Spitzer; Fiscal Year: 2007
  5. Genetic screens for analysis of Ca-dependent transmitter specification
    NICHOLAS CANADAY SPITZER; Fiscal Year: 2010
  6. Mechanisms of Calcium Transients in Neuronal Development
    Nicholas Spitzer; Fiscal Year: 2009
  7. Developing Neurons
    Nicholas Spitzer; Fiscal Year: 2009
  8. DEVELOPMENT OF NEURONS
    Nicholas Spitzer; Fiscal Year: 1993
  9. THE DEVELOPMENT OF NEURONS
    Nicholas Spitzer; Fiscal Year: 1980
  10. DEVELOPMENT OF NEURONS
    Nicholas Spitzer; Fiscal Year: 1992

Collaborators

Detail Information

Publications31

  1. doi request reprint Activity-dependent neurotransmitter respecification
    Nicholas C Spitzer
    Neurobiology Section, Division of Biological Sciences, Kavli Institute for Brain and Mind, University of California at San Diego, La Jolla, California 92093, USA
    Nat Rev Neurosci 13:94-106. 2012
    ..Activation of this novel form of plasticity by sensorimotor stimuli may provide clinical benefits...
  2. pmc Improved molecular toolkit for cAMP studies in live cells
    Kwan Pyo Hong
    Neurobiology Section, Division of Biological Sciences, Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, CA 92093, USA
    BMC Res Notes 4:241. 2011
    ..abstract:..
  3. pmc Coincidence detection enhances appropriate wiring of the nervous system
    Nicholas C Spitzer
    Neurobiology Section and Center for Molecular Genetics, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093 0357, USA
    Proc Natl Acad Sci U S A 101:5311-2. 2004
  4. ncbi request reprint Activity-dependent neuronal differentiation prior to synapse formation: the functions of calcium transients
    Nicholas C Spitzer
    Neurobiology Section 0357, Division of Biology and Center for Molecular Genetics, UCSD, 9500 Gilman Drive, La Jolla, CA 92093 0357, USA
    J Physiol Paris 96:73-80. 2002
    ....
  5. ncbi request reprint Differentiation of electrical excitability in motoneurons
    N C Spitzer
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0357, USA
    Brain Res Bull 53:547-52. 2000
    ..These changes associated with differentiation of young motoneurons may presage those occurring later in the context of plasticity in the mature nervous system...
  6. ncbi request reprint Coding of neuronal differentiation by calcium transients
    N C Spitzer
    Department of Biology and Center for Molecular Genetics, UCSD, La Jolla, California 92093 0357, USA
    Bioessays 22:811-7. 2000
    ..We review the mechanisms by which Ca(2+) transients are generated and their effects in regulating motility via the cytoskeleton and differentiation via transcription...
  7. ncbi request reprint Orchestrating neuronal differentiation: patterns of Ca2+ spikes specify transmitter choice
    Nicholas C Spitzer
    Neurobiology Section and Center for Molecular Genetics, Division of Biological Sciences, UCSD, La Jolla, CA 92093, USA
    Trends Neurosci 27:415-21. 2004
    ..changes in presynaptic transmitter expression pose a matching problem: are there corresponding changes in postsynaptic transmitter receptor expression, or are axons rerouted to novel targets with which functional synapses can be formed?..
  8. ncbi request reprint Homeostatic activity-dependent paradigm for neurotransmitter specification
    Nicholas C Spitzer
    Neurobiology Section, Division of Biological Sciences and Center for Molecular Genetics, UCSD, La Jolla, CA 92093 0357, USA
    Cell Calcium 37:417-23. 2005
    ....
  9. ncbi request reprint Electrical activity in early neuronal development
    Nicholas C Spitzer
    Neurobiology Section, Division of Biological Sciences and Centre for Molecular Genetics, Kavli Institute for Brain and Mind, University of California San Diego, La Jolla, California 92093 0357, USA
    Nature 444:707-12. 2006
    ..The extensive involvement of activity makes it likely that it is required at all developmental stages as a necessary partner with genetic programs...
  10. pmc Implications of activity-dependent neurotransmitter-receptor matching
    Nicholas C Spitzer
    Neurobiology Section, Division of Biological Sciences, Center for Molecular Genetics, Kavli Institute for Brain and Mind, UCSD, La Jolla, CA 92093, USA
    Philos Trans R Soc Lond B Biol Sci 363:1393-9. 2008
    ..Matching of postsynaptic receptor expression with the novel expression of transmitters ensues. These findings have intriguing implications for development, mature function and evolution of the nervous system...
  11. pmc A Rosetta stone for analysis of human membrane protein function
    Nicholas C Spitzer
    Neurobiology Section, Division of Biological Sciences, Center for Molecular Genetics, and Kavli Institute for Brain and Mind, University of California at Sand Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:10641-2. 2008
  12. ncbi request reprint Filopodial calcium transients promote substrate-dependent growth cone turning
    T M Gomez
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093, USA
    Science 291:1983-7. 2001
    ..These rapid signals appear to serve both as autonomous regulators of filopodial movement and as frequency-coded signals integrated within the growth cone and could be a common signaling process for many motile cells...
  13. ncbi request reprint Properties of ectopic neurons induced by Xenopus neurogenin1 misexpression
    E C Olson
    Department of Biology, University of California, San Diego, California, 92093, USA
    Mol Cell Neurosci 12:281-99. 1998
    ....
  14. ncbi request reprint Spontaneous calcium transients regulate myofibrillogenesis in embryonic Xenopus myocytes
    M B Ferrari
    Department of Biology, University of California at San Diego, La Jolla 92093 0357, USA
    Dev Biol 178:484-97. 1996
    ..Our results suggest that spontaneous Cai2+ transients play a role in cytoskeletal organization during myofibrillogenesis...
  15. ncbi request reprint Biological information processing: bits of progress
    N C Spitzer
    Department of Biology, University of California at San Diego, La Jolla, CA 92093, USA
    Science 277:1060-1. 1997
  16. pmc A calcium signaling cascade essential for myosin thick filament assembly in Xenopus myocytes
    M B Ferrari
    Department of Biology and Center for Molecular Genetics, University of California San Diego, La Jolla, California 92093 0357, USA
    J Cell Biol 141:1349-56. 1998
    ..The results indicate that both RyRs and MLCK, which have well-described calcium signaling roles in mature muscle contraction, have essential developmental roles during construction of the contractile apparatus...
  17. ncbi request reprint Sustained upregulation in embryonic spinal neurons of a Kv3.1 potassium channel gene encoding a delayed rectifier current
    D Gurantz
    Department of Biology and Center for Molecular Genetics, 9500 Gilman Drive, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurobiol 42:347-56. 2000
    ..Expression of xKv3.1 mRNA generates a delayed rectifier potassium current in oocytes, suggesting that xKv3. 1 contributes to the maturation of I(Kv) and shortening of the action potential...
  18. ncbi request reprint Regulation of calcineurin by growth cone calcium waves controls neurite extension
    N J Lautermilch
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 20:315-25. 2000
    ..The results identify components of the cascade by which Ca(2+) waves act to regulate neurite extension...
  19. ncbi request reprint In vivo regulation of axon extension and pathfinding by growth-cone calcium transients
    T M Gomez
    Department of Biology and Center for Molecular Genetics, University of California at San Diego, La Jolla 92093 0357, USA
    Nature 397:350-5. 1999
    ..Our results indicate that environmentally regulated growth-cone Ca2+ transients control axon growth in the developing spinal cord...
  20. ncbi request reprint Calcium signaling in the developing Xenopus myotome
    M B Ferrari
    Department of Biology and Center for Molecular Genetics, University of California at San Diego, La Jolla, CA, 92093 0357, USA
    Dev Biol 213:269-82. 1999
    ..As in culture, transients in vivo depend on Ca(2+) release from ryanodine receptor (RyR) stores, and blocking RyR during development interferes with somite maturation...
  21. pmc Embryonically expressed GABA and glutamate drive electrical activity regulating neurotransmitter specification
    Cory M Root
    Neurobiology Section, Division of Biological Sciences and Center for Molecular Genetics, Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 28:4777-84. 2008
    ..We find that calcium spikes are triggered by metabotropic GABA and glutamate receptors, which engage protein kinases A and C. The results reveal a novel role for embryonically expressed neurotransmitters...
  22. doi request reprint Calcium: first messenger
    Nicholas C Spitzer
    Nat Neurosci 11:243-4. 2008
  23. pmc Activity-dependent neurotransmitter-receptor matching at the neuromuscular junction
    Laura N Borodinsky
    Neurobiology Section, Division of Biological Sciences and Center for Molecular Genetics, Kavli Institute for Brain and Mind, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:335-40. 2007
    ..In these cases, glutamatergic, GABAergic, and glycinergic synaptic currents are recorded from muscle cells, demonstrating that activity regulates matching of transmitters and their receptors in the assembly of functional synapses...
  24. ncbi request reprint Dynamic interactions of cyclic AMP transients and spontaneous Ca(2+) spikes
    Yuliya V Gorbunova
    Department of Physics, University of California San Diego, La Jolla, California 92093, USA
    Nature 418:93-6. 2002
    ..Our findings may prove useful in the investigation of the regulation of gene expression by second-messenger transients...
  25. ncbi request reprint Second messenger pas de deux: the coordinated dance between calcium and cAMP
    Laura N Borodinsky
    Neurobiology Section, Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, CA 92093, USA
    Sci STKE 2006:pe22. 2006
    ..Second messenger reporters are now available to track multiple players and so provide a dynamic picture of signaling networks...
  26. ncbi request reprint Local calcium transients contribute to disappearance of pFAK, focal complex removal and deadhesion of neuronal growth cones and fibroblasts
    Matthew W Conklin
    Neurobiology Section, Division of Biological Sciences, UCSD, La Jolla, CA 92093 0357, USA
    Dev Biol 287:201-12. 2005
    ..These results identify an intrinsic mechanism for local cell detachment that may be modulated by agents that regulate motility...
  27. ncbi request reprint Activity-dependent homeostatic specification of transmitter expression in embryonic neurons
    Laura N Borodinsky
    Neurobiology Section, Division of Biological Sciences and Center for Molecular Genetics, UCSD, La Jolla, California 92093 0357, USA
    Nature 429:523-30. 2004
    ..The results identify a new role of patterned activity in development of the central nervous system...
  28. ncbi request reprint Adaptation in the chemotactic guidance of nerve growth cones
    Guo li Ming
    Division of Biology, University of California at San Diego, La Jolla, California 92093, USA
    Nature 417:411-8. 2002
    ..Such adaptive behaviour allows the growth cone to re-adjust its sensitivity over a wide range of concentrations of the guidance factor, an essential feature for long-range chemotaxis...
  29. ncbi request reprint Outside and in: development of neuronal excitability
    Nicholas C Spitzer
    Neurobiology Section 0357, Biology Division, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0357, USA
    Curr Opin Neurobiol 12:315-23. 2002
    ..The parallels between excitability in these two locations motivate future work, because comparison of their properties identifies shared attributes...
  30. doi request reprint Neurite outgrowth and in vivo sensory innervation mediated by a Ca(V)2.2-laminin beta 2 stop signal
    Sharon B Sann
    Neurobiology Section, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 28:2366-74. 2008
    ..2 leads to increased numbers of sensory terminals in vivo. These findings suggest that interactions between extracellular matrix molecules and calcium channels regulate connectivity in the developing nervous system...
  31. ncbi request reprint Calcium transients regulate patterned actin assembly during myofibrillogenesis
    Hongyan Li
    Department of Biological Sciences, University of Arkansas, Fayetteville, Arkansas, USA
    Dev Dyn 229:231-42. 2004
    ....

Research Grants41

  1. Developing Neurons
    NICHOLAS CANADAY SPITZER; Fiscal Year: 2010
    ..It is expected that this work will contribute to understanding developmental disorders of the nervous system in which neurotransmitter expression is altered during embryonic and post-embryonic development. ..
  2. DEVELOPMENT OF NEURONS
    Nicholas Spitzer; Fiscal Year: 2003
    ..It is expected that this work will contribute to an understanding of developmental disorders of the nervous system. ..
  3. NEUROBIOLOGY TRAINING GRANT
    Nicholas Spitzer; Fiscal Year: 2007
    ....
  4. DEVELOPMENT OF NEURONS
    Nicholas Spitzer; Fiscal Year: 2007
    ..Understanding the functions of embryonic excitability analyzed in the research outlined in this proposal are expected to provide the basis for understanding and preventing developmental disorders of the nervous system. ..
  5. Genetic screens for analysis of Ca-dependent transmitter specification
    NICHOLAS CANADAY SPITZER; Fiscal Year: 2010
    ..It is expected that this work will contribute to understanding developmental disorders of the nervous system in which neurotransmitter expression is altered during embryonic and post-embryonic development. ..
  6. Mechanisms of Calcium Transients in Neuronal Development
    Nicholas Spitzer; Fiscal Year: 2009
    ..The long term goal is to provide information about the cellular and molecular machinery that governs processes of development, which will contribute to understanding developmental disorders of the nervous system. ..
  7. Developing Neurons
    Nicholas Spitzer; Fiscal Year: 2009
    ..It is expected that this work will contribute to understanding developmental disorders of the nervous system in which neurotransmitter expression is altered during embryonic and post-embryonic development. ..
  8. DEVELOPMENT OF NEURONS
    Nicholas Spitzer; Fiscal Year: 1993
    ..It is expected that this work will promote understanding of developmental disorders of the central nervous system...
  9. THE DEVELOPMENT OF NEURONS
    Nicholas Spitzer; Fiscal Year: 1980
    ..These studies should permit distinction between simultaneous and sequential syntheses of RNA and protein underlying the expression of these neuronal phenotypes during development...
  10. DEVELOPMENT OF NEURONS
    Nicholas Spitzer; Fiscal Year: 1992
    ..If such critical periods exist, it will be possible to examine the consequences of the absence of one phenotype on the expression of others...