Affiliation: University of Missouri-St. Louis
- Mer1p is a modular splicing factor whose function depends on the conserved U2 snRNP protein Snu17pMarc Spingola
Center for the Molecular Biology of RNA, Sinsheimer Laboratories, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
Nucleic Acids Res 32:1242-50. 2004..We conclude that Mer1p is a modular splicing regulator that can activate splicing at several early steps of spliceosome assembly and depends on the activities of both U1 and U2 snRNP proteins to activate splicing...
- A subset of Mer1p-dependent introns requires Bud13p for splicing activation and nuclear retentionFrederick W Scherrer
Department of Biology, University of Missouri St Louis, MO 63121, USA
RNA 12:1361-72. 2006..The results also support models for cytoplasmic degradation of unspliced pre-mRNAs that fail to assemble into spliceosomes in yeast...
- Recognition of diverse RNAs by a single protein structural frameworkMarc Spingola
Department of Molecular Genetics and Microbiology, University of New Mexico School of MedicineAlbuquerque, NM 87131, USA
Arch Biochem Biophys 405:122-9. 2002....
- Regulation of mRNA Splicing by Mer1pMarc Spingola; Fiscal Year: 2007..This project will elucidate how Mer1p and similar proteins function and will offer important insights towards the basis of diseases like Fragile X Syndrome in humans. ..