Research Topics
| Stephen R SpindlerSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Caloric restriction: from soup to nutsStephen R Spindler
Department of Biochemistry, University of California, Riverside, Riverside, CA, USA
Ageing Res Rev 9:324-53. 2010..Paradoxically, low body weight in middle aged and elderly humans is associated with increased mortality. Thus, enhancement of human longevity may require pharmaceutical interventions...
Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylationStephen R Spindler
Department of Biochemistry, University of California Riverside, Riverside, California, United States of America
PLoS ONE 7:e39581. 2012..These data are the most direct evidence to date that decreased protein prenylation can increase cardiac health and lifespan in any metazoan species, and may explain the pleiotropic (non-cholesterol related) health effects of statins...- Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using DrosophilaStephen R Spindler
Department of Biochemistry, University of California Riverside, Riverside, California, United States of America
PLoS ONE 7:e29782. 2012..If confirmed, many of these kinases will be novel additions to the signaling cascades known to regulate metazoan longevity... 
Screening candidate longevity therapeutics using gene-expression arraysStephen R Spindler
Department of Biochemistry, University of California, Riverside, Calif 92521, USA
Gerontology 53:306-21. 2007..Thus, pharmaceuticals capable of mimicking the effects of CR (and other methods of lifespan extension) may have application to human health...- Conserved and tissue-specific genic and physiologic responses to caloric restriction and altered IGFI signaling in mitotic and postmitotic tissuesStephen R Spindler
Department of Biochemistry, University of California, Riverside, CA 92521, USA
Annu Rev Nutr 27:193-217. 2007..We also discuss evidence from liver and heart indicating that many benefits of lifelong CR are recapitulated in mitotic and postmitotic tissues when CR is initiated late in life... - Use of microarray biomarkers to identify longevity therapeuticsStephen R Spindler
Department of Biochemistry, University of California, Riverside, CA 92521, USA
Aging Cell 5:39-50. 2006..Phenformin, a close chemical relative of metformin, extends lifespan and reduces tumor incidence in C3H mice. These results indicate that gene-expression biomarkers can be used to identify promising candidate CR mimetics... - Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restrictionStephen R Spindler
Department of Biochemistry, University of California, Riverside, CA 92521, USA
Mech Ageing Dev 126:960-6. 2005..These data argue that highly conserved mechanisms for the rapid and reversible enhancement of life- and health-span exist for mitotic and postmitotic tissues... - Review of the literature and suggestions for the design of rodent survival studies for the identification of compounds that increase health and life spanStephen Richard Spindler
Department of Biochemistry, University of California, Riverside, CA 92521, USA
Age (Dordr) 34:111-20. 2012..These procedures should improve the reliability of the scientific literature and accelerate the identification of longevity and health span-enhancing agents... - Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restrictionJoseph M Dhahbi
Department of Biochemistry, University of California-Riverside, CA 92521, USA
J Gerontol A Biol Sci Med Sci 61:218-31. 2006..Thus, key CR-induced effects are rapidly responsive to diet, suggesting reduced caloric intake has rapid, positive effects on the heart... - mRNA-Seq reveals complex patterns of gene regulation and expression in the mouse skeletal muscle transcriptome associated with calorie restrictionJoseph M Dhahbi
Department of Biochemistry, University of California at Riverside, 92521, USA
Physiol Genomics 44:331-44. 2012..mRNA-Seq generates a rich picture of the changes in gene expression associated with CR, and may facilitate identification of genes that are primary mediators of CR's effects... - Identification of potential caloric restriction mimetics by microarray profilingJoseph M Dhahbi
Department of Biochemistry, University of California, Riverside, California 92521, USA
Physiol Genomics 23:343-50. 2005..Phenformin, a chemical cousin of metformin, extends lifespan and reduces tumor incidence in mice. Taken together, these results indicate that gene expression biomarkers can be used to identify promising candidate CR mimetics... - Additive regulation of hepatic gene expression by dwarfism and caloric restrictionTomoshi Tsuchiya
Department of Biochemistry, University of California, Riverside 92521, USA
Physiol Genomics 17:307-15. 2004..These results provide a novel and focused group of genes closely associated with the regulation of life span in mammals... - Hepatic gene expression profiling of streptozotocin-induced diabetesJoseph M Dhahbi
Department of Biochemistry, University of California, Riverside, Riverside, California 92521, USA
Diabetes Technol Ther 5:411-20. 2003..The novel results reported here should open new areas of investigation in diabetes research and facilitate the development of novel strategies for gene therapy and drug discovery... - Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restrictionJoseph M Dhahbi
Department of Biochemistry, University of California at Riverside, Riverside, CA 92521, USA
Aging (Albany NY) 5:130-41. 2013..This finding implicates circulating miRNAs in the aging process, raising questions about their tissues of origin, their cellular targets, and their functional role in metabolic changes that occur with aging... - Deep sequencing reveals novel microRNAs and regulation of microRNA expression during cell senescenceJoseph M Dhahbi
Center for Genetics, Children s Hospital Oakland Research Institute, Oakland, California, United States of America
PLoS ONE 6:e20509. 2011..This result greatly extends existing information on the role of miRNAs in cell senescence and is consistent with miRNAs having a causal role in the process... - Postprandial induction of chaperone gene expression is rapid in miceJoseph M Dhahbi
Department of Biochemistry, University of California, Riverside, Riverside, CA 92521, USA
J Nutr 132:31-7. 2002..Adrenalectomy enhanced the feeding induction, but dexamethasone administration had no effect. Thus, postprandial changes in insulin and glucagon may link chaperone gene expression to feeding, possibly in several tissues including liver... - Influence on longevity of blueberry, cinnamon, green and black tea, pomegranate, sesame, curcumin, morin, pycnogenol, quercetin, and taxifolin fed iso-calorically to long-lived, f1 hybrid miceStephen R Spindler
1 Department of Biochemistry, University of California at Riverside, Riverside, California
Rejuvenation Res 16:143-51. 2013.... - Delayed and accelerated aging share common longevity assurance mechanismsBjörn Schumacher
Department of Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
PLoS Genet 4:e1000161. 2008.... - Temporal linkage between the phenotypic and genomic responses to caloric restrictionJoseph M Dhahbi
BioMarker Pharmaceuticals, Incorporated, 900 East Hamilton Avenue, Campbell, CA 95008, USA
Proc Natl Acad Sci U S A 101:5524-9. 2004..Therefore, therapeutics mimicking the gene-expression biomarkers of CR may reproduce its physiological effects...