Stephen R Spindler

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Caloric restriction: from soup to nuts
    Stephen R Spindler
    Department of Biochemistry, University of California, Riverside, Riverside, CA, USA
    Ageing Res Rev 9:324-53. 2010
  2. doi request reprint Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice
    Stephen R Spindler
    Department of Biochemistry, University of California at Riverside, Riverside, CA, 92521, USA
    Age (Dordr) 36:705-18. 2014
  3. pmc β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice
    Stephen R Spindler
    Department of Biochemistry, University of California at Riverside, Riverside, CA, 92521, USA
    Age (Dordr) 35:2099-109. 2013
  4. doi request reprint Influence on longevity of blueberry, cinnamon, green and black tea, pomegranate, sesame, curcumin, morin, pycnogenol, quercetin, and taxifolin fed iso-calorically to long-lived, F1 hybrid mice
    Stephen R Spindler
    Department of Biochemistry, University of California at Riverside, California 92521, USA
    Rejuvenation Res 16:143-51. 2013
  5. pmc Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation
    Stephen R Spindler
    Department of Biochemistry, University of California Riverside, Riverside, California, United States of America
    PLoS ONE 7:e39581. 2012
  6. pmc Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila
    Stephen R Spindler
    Department of Biochemistry, University of California Riverside, Riverside, California, United States of America
    PLoS ONE 7:e29782. 2012
  7. pmc Review of the literature and suggestions for the design of rodent survival studies for the identification of compounds that increase health and life span
    Stephen Richard Spindler
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Age (Dordr) 34:111-20. 2012
  8. ncbi request reprint Screening candidate longevity therapeutics using gene-expression arrays
    Stephen R Spindler
    Department of Biochemistry, University of California, Riverside, Calif 92521, USA
    Gerontology 53:306-21. 2007
  9. ncbi request reprint Conserved and tissue-specific genic and physiologic responses to caloric restriction and altered IGFI signaling in mitotic and postmitotic tissues
    Stephen R Spindler
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Annu Rev Nutr 27:193-217. 2007
  10. ncbi request reprint Use of microarray biomarkers to identify longevity therapeutics
    Stephen R Spindler
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Aging Cell 5:39-50. 2006

Collaborators

Detail Information

Publications24

  1. doi request reprint Caloric restriction: from soup to nuts
    Stephen R Spindler
    Department of Biochemistry, University of California, Riverside, Riverside, CA, USA
    Ageing Res Rev 9:324-53. 2010
    ..Paradoxically, low body weight in middle aged and elderly humans is associated with increased mortality. Thus, enhancement of human longevity may require pharmaceutical interventions...
  2. doi request reprint Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice
    Stephen R Spindler
    Department of Biochemistry, University of California at Riverside, Riverside, CA, 92521, USA
    Age (Dordr) 36:705-18. 2014
    ..The results are consistent with epidemiological studies suggesting that dietary supplements are not beneficial and even may be harmful for otherwise healthy individuals. ..
  3. pmc β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice
    Stephen R Spindler
    Department of Biochemistry, University of California at Riverside, Riverside, CA, 92521, USA
    Age (Dordr) 35:2099-109. 2013
    ..Thus, long-term use of β-blockers, which are generally well-tolerated, may enhance the longevity of healthy humans...
  4. doi request reprint Influence on longevity of blueberry, cinnamon, green and black tea, pomegranate, sesame, curcumin, morin, pycnogenol, quercetin, and taxifolin fed iso-calorically to long-lived, F1 hybrid mice
    Stephen R Spindler
    Department of Biochemistry, University of California at Riverside, California 92521, USA
    Rejuvenation Res 16:143-51. 2013
    ....
  5. pmc Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation
    Stephen R Spindler
    Department of Biochemistry, University of California Riverside, Riverside, California, United States of America
    PLoS ONE 7:e39581. 2012
    ..These data are the most direct evidence to date that decreased protein prenylation can increase cardiac health and lifespan in any metazoan species, and may explain the pleiotropic (non-cholesterol related) health effects of statins...
  6. pmc Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila
    Stephen R Spindler
    Department of Biochemistry, University of California Riverside, Riverside, California, United States of America
    PLoS ONE 7:e29782. 2012
    ..If confirmed, many of these kinases will be novel additions to the signaling cascades known to regulate metazoan longevity...
  7. pmc Review of the literature and suggestions for the design of rodent survival studies for the identification of compounds that increase health and life span
    Stephen Richard Spindler
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Age (Dordr) 34:111-20. 2012
    ..These procedures should improve the reliability of the scientific literature and accelerate the identification of longevity and health span-enhancing agents...
  8. ncbi request reprint Screening candidate longevity therapeutics using gene-expression arrays
    Stephen R Spindler
    Department of Biochemistry, University of California, Riverside, Calif 92521, USA
    Gerontology 53:306-21. 2007
    ..Thus, pharmaceuticals capable of mimicking the effects of CR (and other methods of lifespan extension) may have application to human health...
  9. ncbi request reprint Conserved and tissue-specific genic and physiologic responses to caloric restriction and altered IGFI signaling in mitotic and postmitotic tissues
    Stephen R Spindler
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Annu Rev Nutr 27:193-217. 2007
    ..We also discuss evidence from liver and heart indicating that many benefits of lifelong CR are recapitulated in mitotic and postmitotic tissues when CR is initiated late in life...
  10. ncbi request reprint Use of microarray biomarkers to identify longevity therapeutics
    Stephen R Spindler
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Aging Cell 5:39-50. 2006
    ..Phenformin, a close chemical relative of metformin, extends lifespan and reduces tumor incidence in C3H mice. These results indicate that gene-expression biomarkers can be used to identify promising candidate CR mimetics...
  11. ncbi request reprint Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction
    Stephen R Spindler
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Mech Ageing Dev 126:960-6. 2005
    ..These data argue that highly conserved mechanisms for the rapid and reversible enhancement of life- and health-span exist for mitotic and postmitotic tissues...
  12. pmc 5' tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction
    Joseph M Dhahbi
    Department of Biochemistry, University of California at Riverside, Riverside, CA 92521, USA
    BMC Genomics 14:298. 2013
    ....
  13. pmc Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restriction
    Joseph M Dhahbi
    Department of Biochemistry, University of California at Riverside, Riverside, CA 92521, USA
    Aging (Albany NY) 5:130-41. 2013
    ..This finding implicates circulating miRNAs in the aging process, raising questions about their tissues of origin, their cellular targets, and their functional role in metabolic changes that occur with aging...
  14. ncbi request reprint Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restriction
    Joseph M Dhahbi
    Department of Biochemistry, University of California Riverside, CA 92521, USA
    J Gerontol A Biol Sci Med Sci 61:218-31. 2006
    ..Thus, key CR-induced effects are rapidly responsive to diet, suggesting reduced caloric intake has rapid, positive effects on the heart...
  15. pmc mRNA-Seq reveals complex patterns of gene regulation and expression in the mouse skeletal muscle transcriptome associated with calorie restriction
    Joseph M Dhahbi
    Department of Biochemistry, University of California at Riverside, 92521, USA
    Physiol Genomics 44:331-44. 2012
    ..mRNA-Seq generates a rich picture of the changes in gene expression associated with CR, and may facilitate identification of genes that are primary mediators of CR's effects...
  16. ncbi request reprint Identification of potential caloric restriction mimetics by microarray profiling
    Joseph M Dhahbi
    Department of Biochemistry, University of California, Riverside, California 92521, USA
    Physiol Genomics 23:343-50. 2005
    ..Phenformin, a chemical cousin of metformin, extends lifespan and reduces tumor incidence in mice. Taken together, these results indicate that gene expression biomarkers can be used to identify promising candidate CR mimetics...
  17. ncbi request reprint Additive regulation of hepatic gene expression by dwarfism and caloric restriction
    Tomoshi Tsuchiya
    Department of Biochemistry, University of California, Riverside 92521, USA
    Physiol Genomics 17:307-15. 2004
    ..These results provide a novel and focused group of genes closely associated with the regulation of life span in mammals...
  18. ncbi request reprint Hepatic gene expression profiling of streptozotocin-induced diabetes
    Joseph M Dhahbi
    Department of Biochemistry, University of California, Riverside, Riverside, California 92521, USA
    Diabetes Technol Ther 5:411-20. 2003
    ..The novel results reported here should open new areas of investigation in diabetes research and facilitate the development of novel strategies for gene therapy and drug discovery...
  19. doi request reprint 5'-YRNA fragments derived by processing of transcripts from specific YRNA genes and pseudogenes are abundant in human serum and plasma
    Joseph M Dhahbi
    Department of Biochemistry, University of California at Riverside, Riverside, California
    Physiol Genomics 45:990-8. 2013
    ..The function of the 5'-YRNA fragments is at present unknown, but the processing and secretion of specific YRNAs to produce 5'-end fragments that circulate in stable complexes are consistent with a signaling function. ..
  20. pmc Deep sequencing reveals novel microRNAs and regulation of microRNA expression during cell senescence
    Joseph M Dhahbi
    Center for Genetics, Children s Hospital Oakland Research Institute, Oakland, California, United States of America
    PLoS ONE 6:e20509. 2011
    ..This result greatly extends existing information on the role of miRNAs in cell senescence and is consistent with miRNAs having a causal role in the process...
  21. ncbi request reprint Postprandial induction of chaperone gene expression is rapid in mice
    Joseph M Dhahbi
    Department of Biochemistry, University of California, Riverside, Riverside, CA 92521, USA
    J Nutr 132:31-7. 2002
    ..Adrenalectomy enhanced the feeding induction, but dexamethasone administration had no effect. Thus, postprandial changes in insulin and glucagon may link chaperone gene expression to feeding, possibly in several tissues including liver...
  22. doi request reprint Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response
    Yong Wu
    Department of Biochemistry, University of California, Riverside, Riverside, CA 92521, USA
    Mol Cell 53:63-74. 2014
    ..ChIP-sequencing analysis reveals p53 dissociates from promoters genome wide as cells recover from DNA damage, suggesting the general nature of this mechanism...
  23. pmc Delayed and accelerated aging share common longevity assurance mechanisms
    Björn Schumacher
    Department of Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS Genet 4:e1000161. 2008
    ....
  24. pmc Temporal linkage between the phenotypic and genomic responses to caloric restriction
    Joseph M Dhahbi
    BioMarker Pharmaceuticals, Incorporated, 900 East Hamilton Avenue, Campbell, CA 95008, USA
    Proc Natl Acad Sci U S A 101:5524-9. 2004
    ..Therefore, therapeutics mimicking the gene-expression biomarkers of CR may reproduce its physiological effects...