Henry Spiller

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi request reprint Multicenter case series of valproic acid ingestion: serum concentrations and toxicity
    H A Spiller
    Kentucky Regional Poison Center of Kosair Children s Hospital, Louisville 40232 5070, USA
    J Toxicol Clin Toxicol 38:755-60. 2000
  2. ncbi request reprint Drug facilitated sexual assault using an over-the-counter ocular solution containing tetrahydrozoline (Visine)
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, KY, USA
    Leg Med (Tokyo) 9:192-5. 2007
  3. pmc Amlodipine fatality in an infant with postmortem blood levels
    Henry A Spiller
    Kentucky Regional Poison Control Center of Kosair Children s Hospital, Louisville, KY 40232 5070, USA
    J Med Toxicol 8:179-82. 2012
  4. doi request reprint Toxicity from modafinil ingestion
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, USA
    Clin Toxicol (Phila) 47:153-6. 2009
  5. doi request reprint Multiple seizures after bupropion overdose in a small child
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, KY 40232 5070, USA
    Pediatr Emerg Care 24:474-5. 2008
  6. doi request reprint Methemoglobinemia due to malachite green ingestion in a child
    Henry Spiller
    Kentucky Regional Poison Center, Louisville, Kentucky, USA
    Clin Toxicol (Phila) 46:320-1. 2008
  7. doi request reprint Prolonged cardiovascular effects after unintentional ingestion of tetrahydrozoline
    Henry Spiller
    Kentucky Regional Poison Center, Louisville, Kentucky 40232 5070, USA
    Clin Toxicol (Phila) 46:171-2. 2008
  8. ncbi request reprint Two fatal cases of selenium toxicity
    Henry A Spiller
    Kentucky Regional Poison Center, PO Box 35070, Louisville, KY 40232 5070, USA
    Forensic Sci Int 171:67-72. 2007
  9. ncbi request reprint Toxicology of oral antidiabetic medications
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, KY 40232 5070, USA
    Am J Health Syst Pharm 63:929-38. 2006
  10. ncbi request reprint Retrospective evaluation of tiagabine overdose
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, Kentucky 40232 5070, USA
    Clin Toxicol (Phila) 43:855-9. 2005

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Multicenter case series of valproic acid ingestion: serum concentrations and toxicity
    H A Spiller
    Kentucky Regional Poison Center of Kosair Children s Hospital, Louisville 40232 5070, USA
    J Toxicol Clin Toxicol 38:755-60. 2000
    ..Valproic acid exposures reported to poison centers have increased more than 4-fold over the last 5 years. There are no large case series published on valproic acid ingestion...
  2. ncbi request reprint Drug facilitated sexual assault using an over-the-counter ocular solution containing tetrahydrozoline (Visine)
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, KY, USA
    Leg Med (Tokyo) 9:192-5. 2007
    ..It may be warranted to include imidazoline derivatives in the testing for cases of DFSA...
  3. pmc Amlodipine fatality in an infant with postmortem blood levels
    Henry A Spiller
    Kentucky Regional Poison Control Center of Kosair Children s Hospital, Louisville, KY 40232 5070, USA
    J Med Toxicol 8:179-82. 2012
    ..We report a rare fatality in an infant after ingestion of amlodipine with benazepril, with postmortem blood concentrations...
  4. doi request reprint Toxicity from modafinil ingestion
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, USA
    Clin Toxicol (Phila) 47:153-6. 2009
    ..Modafanil, a non-amphetamine stimulant, is used for narcolepsy, sleep apnea, and shift work sleep disorder. There is little available information on the toxicity of modafinil overdose...
  5. doi request reprint Multiple seizures after bupropion overdose in a small child
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, KY 40232 5070, USA
    Pediatr Emerg Care 24:474-5. 2008
    ..The potential for severe toxicity in the setting of pediatric overdose should be recognized...
  6. doi request reprint Methemoglobinemia due to malachite green ingestion in a child
    Henry Spiller
    Kentucky Regional Poison Center, Louisville, Kentucky, USA
    Clin Toxicol (Phila) 46:320-1. 2008
    ..We report a case of methemoglobinemia of 51% in a 3 year old girl after acute ingestion of malachite green from a commercially available aquarium product...
  7. doi request reprint Prolonged cardiovascular effects after unintentional ingestion of tetrahydrozoline
    Henry Spiller
    Kentucky Regional Poison Center, Louisville, Kentucky 40232 5070, USA
    Clin Toxicol (Phila) 46:171-2. 2008
    ..We report a case of unintentional tetrahydrozoline ingestion with cardiovascular effects persisting for 36 hours...
  8. ncbi request reprint Two fatal cases of selenium toxicity
    Henry A Spiller
    Kentucky Regional Poison Center, PO Box 35070, Louisville, KY 40232 5070, USA
    Forensic Sci Int 171:67-72. 2007
    ....
  9. ncbi request reprint Toxicology of oral antidiabetic medications
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, KY 40232 5070, USA
    Am J Health Syst Pharm 63:929-38. 2006
    ..The toxicology of oral antidiabetic agents is reviewed...
  10. ncbi request reprint Retrospective evaluation of tiagabine overdose
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, Kentucky 40232 5070, USA
    Clin Toxicol (Phila) 43:855-9. 2005
    ..Tiagabine is an anticonvulsant that blocks reuptake of the inhibitory neurotransmitter GABA. There are no published studies or case series of tiagabine overdoses...
  11. doi request reprint Increasing burden of pill identification requests to US Poison Centers
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, KY 40232 5070, USA
    Clin Toxicol (Phila) 47:253-5. 2009
    ..Information calls to poison centers, particularly for pill identification (PID), have been increasing...
  12. doi request reprint Fatal bupropion overdose with post mortem blood concentrations
    Henry A Spiller
    Kentucky Regional Poison Center, P O Box 35070, Louisville, KY 40232 5070, USA
    Forensic Sci Med Pathol 4:47-50. 2008
    ..The pills found in these patients may represent the residual matrix/shell with significant portions of the actual bupropion released and absorbed by the patients...
  13. doi request reprint Epidemiological trends in abuse and misuse of prescription opioids
    Henry Spiller
    Kentucky Regional Poison Center, Louisville, KY 40232 5070, USA
    J Addict Dis 28:130-6. 2009
    ..No consistent trend was identified with population density and prescription opioid drug rates. Understanding trends may help guide distribution of scarce resources and prevention efforts to where they may have their greatest impact...
  14. doi request reprint Clinical experience with and analytical confirmation of "bath salts" and "legal highs" (synthetic cathinones) in the United States
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, KY 40232 5070, USA
    Clin Toxicol (Phila) 49:499-505. 2011
    ..We report the experience of the first 8 months of two regional poison centers after the emergence of a new group of substances of abuse...
  15. pmc Comparison of incidence of hospital utilization for poisoning and other injury types
    Henry A Spiller
    Kentucky Regional Poison Control Center, PO Box 35070, Louisville, KY 40232, USA
    Public Health Rep 126:94-9. 2011
    ..We investigated the incidence of hospital utilization for injuries and compared poisoning with other forms of injury. Previous studies have suggested poison control centers reduce health-care costs by decreasing hospital utilization...
  16. doi request reprint Unintentional therapeutic errors involving insulin in the ambulatory setting reported to poison centers
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, KY, USA
    Ann Pharmacother 45:17-22. 2011
    ..Adverse drug events in the ambulatory care setting are not uncommon and can cause significant morbidity. Little research has been published on the management of adverse drug events involving insulin in the outpatient setting...
  17. doi request reprint Use of antivenom for snakebites reported to United States poison centers
    Henry A Spiller
    Kentucky Regional Poison Center, PO Box 35070, Louisville, KY 40232 5070, USA
    Am J Emerg Med 28:780-5. 2010
    ..In 2001, a new antivenin was introduced to the United States and became widely available in the snakebite season of 2002. We investigated what impact this may have had on snakebite treatment and medical outcome...
  18. doi request reprint Epidemiological trends of suicide and attempted suicide by poisoning in the US: 2000-2008
    Henry A Spiller
    Kentucky Regional Poison Control Center, Louisville, KY, USA
    Leg Med (Tokyo) 12:177-83. 2010
    ..The purpose of this study was to examine trends in suspected suicide (SS) cases reported to the National Poison Data System (NPDS), over a 9-year period (2000-2008)...
  19. doi request reprint Effect of scheduling tramadol as a controlled substance on poison center exposures to tramadol
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, KY 30232, USA
    Ann Pharmacother 44:1016-21. 2010
    ..There is limited information on the effect of scheduling a drug as a controlled substance with comparable data from both a pre-scheduling and post-scheduling time period...
  20. doi request reprint Investigation of temporal changes of abuse and misuse of prescription opioids
    Henry Spiller
    Kentucky Regional Poison Center, Louisville, KY 40232 5070, USA
    J Addict Dis 29:78-83. 2010
    ..No temporally related increase in abuse and misuse of prescription drugs was noted and conversely a trend toward decreased abuse and misuse of prescription drugs was suggested...
  21. doi request reprint Trends in volatile substance abuse
    Henry Spiller
    Kentucky Regional Poison Center, Louisville, KY 402320 5070, USA
    J Addict Dis 28:164-70. 2009
    ..Volatile substance abuse appears to increase as percentage of population with a bachelor's degree decreases...
  22. ncbi request reprint Atomoxetine ingestions in children: a report from poison centers
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, KY 40232 5070, USA
    Ann Pharmacother 39:1045-8. 2005
    ..Atomoxetine uses a novel non-stimulant approach to the treatment of attention deficit hyperactivity disorder. There is limited information on overdose of atomoxetine in children or adults...
  23. ncbi request reprint Multicenter case series of pediatric metformin ingestion
    H A Spiller
    Kentucky Regional Poison Center of Kosair Children s Hospital, Louisville, 40232 5070, USA
    Ann Pharmacother 34:1385-8. 2000
    ..This study summarizes the clinical course and outcomes of metformin ingestion in children reported to the American Association of Poison Control Centers-certified regional poison centers...
  24. ncbi request reprint Fatal cyclobenzaprine overdose with postmortem values
    Henry A Spiller
    Kentucky Regional Poison Control Center, Louisville, KY 40232 5070, USA
    J Forensic Sci 48:883-4. 2003
    ..Additionally, the blood was drawn from a femoral site, so that postmortem redistribution is not a likely factor. Blood concentration of > or = 0.8 mg/L cyclobenzaprine may be associated with a fatal outcome...
  25. ncbi request reprint Prospective study of morbidity associated with snakebite envenomation
    Henry A Spiller
    Kentucky Regional Poison Center of Kosair Children s Hospital, Louisville, Kentucky 40232 5070, USA
    J Toxicol Clin Toxicol 41:125-30. 2003
    ..The morbidity associated with snakebite envenomation has not been well documented...
  26. ncbi request reprint Skin breakdown and blisters from senna-containing laxatives in young children
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, KY 40232 5070, USA
    Ann Pharmacother 37:636-9. 2003
    ..No data are available on the safety of senna use in children <6 years of age...
  27. ncbi request reprint Postmortem oxycodone and hydrocodone blood concentrations
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, KY 40232 5070, USA
    J Forensic Sci 48:429-31. 2003
    ..This may represent enhanced information because of the larger sample group. Hydrocodone values associated with a fatality were similar to previously published values...
  28. ncbi request reprint Toxic effects from metformin exposure
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, KY 40232 5070, USA
    Ann Pharmacother 38:776-80. 2004
    ..The major risk associated with metformin is lactic acidosis. The incidence of lactic acidosis is not clear. Hypoglycemia is not expected to be a major concern after metformin exposure...
  29. ncbi request reprint Use of dosage as a triage guideline for unintentional cyclic antidepressant (UCA) ingestions in children
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, Kentucky 40232, USA
    Am J Emerg Med 21:422-4. 2003
    ..The majority of UCA ingestions produced limited or no symptomatology. In this series, all children with ingestions of <5 mg/kg developed no or minor effects. Home monitoring might be appropriate in such cases...
  30. ncbi request reprint Epidemiology of volatile substance abuse (VSA) cases reported to US poison centers
    Henry A Spiller
    Kentucky Regional Poison Center of Kosair Children s Hospital, Louisville, Kentucky, USA
    Am J Drug Alcohol Abuse 30:155-65. 2004
    ..A small group of substances appears responsible for the majority of deaths. It is imperative that we continue to educate the public and healthcare professionals regarding the risks of VSA and hopefully impact the incidence of VSA...
  31. ncbi request reprint The Delphic oracle: a multidisciplinary defense of the gaseous vent theory
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville 40232 5070, USA
    J Toxicol Clin Toxicol 40:189-96. 2002
    ....
  32. ncbi request reprint Status epilepticus after massive carbamazepine overdose
    Henry A Spiller
    Kentucky Regional Poison Center of Kosair Children s Hospital, Louisville 40232 5070, USA
    J Toxicol Clin Toxicol 40:81-90. 2002
    ..The seizures abated with the infusion of midazolam. This is a report of status epilepticus associated with wide complex tachycardia after carbamazepine overdose, which may be resistant to conventional therapy...
  33. ncbi request reprint Evaluation of administration of activated charcoal in the home
    H A Spiller
    Kentucky Regional Poison Center, Louisville, Kentucky 40232 5070, USA
    Pediatrics 108:E100. 2001
    ..AC use in the home has been limited by concerns that parents would not administer it properly and that children would refuse to take AC. Previous descriptions of home administration have reported mixed results...
  34. ncbi request reprint Retrospective review of Tizanidine (Zanaflex) overdose
    Henry A Spiller
    Kentucky Regional Poison Center, PO Box 35070, Louisville, KY 40232 5070, USA
    J Toxicol Clin Toxicol 42:593-6. 2004
    ..Tizanidine is a centrally acting muscle relaxant with a novel mechanism of action and structurally related to clonidine. There are no large case series of tizanidine exposure...
  35. doi request reprint Unintentional ingestion of bupropion in children
    Henry A Spiller
    Kentucky Regional Poison Center of Kosair Children s Hospital, Louisville, Kentucky 40232 5070, USA
    J Emerg Med 38:332-6. 2010
    ..2%. However, in many poison centers, > 80% of these patients are referred to the Emergency Department (ED) for evaluation...
  36. ncbi request reprint Lethal envenomation: medicolegal aspects of snakebites and religious snake handlers in Kentucky: a report of three cases with comment on medical, legal, and public policy ramifications
    Donna M Hunsaker
    Department of Pathology and Laboratory Medicine, University of Louisville School of Medicine in Louisville, KY, USA
    J Ky Med Assoc 103:542-56. 2005
    ..We underscore the view that a thoroughly documented medicolegal investigation and autopsy are indispensable to both inform matters of public health and thereby contribute to the formulation of sound public policy...
  37. ncbi request reprint Massive gabapentin and presumptive quetiapine overdose
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, USA
    Vet Hum Toxicol 44:243-4. 2002
    ..5 u/ml) associated with coma, respiratory depression requiring mechanical ventilation, and hypotension...
  38. ncbi request reprint Toxic clonidine ingestion in children
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, Kentucky 40232 5070, USA
    J Pediatr 146:263-6. 2005
    ..We performed a prospective case series to seek dosage or clinical parameters to better identify patients who need direct medical evaluation...
  39. ncbi request reprint Impact of activated charcoal after acute acetaminophen overdoses treated with N-acetylcysteine
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, Kentucky, USA
    J Emerg Med 33:141-4. 2007
    ..Evaluation of 12 years of acute APAP overdoses suggests that the use of AC, in addition to NAC therapy, may provide improved patient outcomes...
  40. pmc A fatal case of venlafaxine overdose
    George M Bosse
    Department of Emergency Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Med Toxicol 4:18-20. 2008
    ..Based on its primary action of serotonin reuptake inhibition, venlafaxine overdose would be expected to result in serotonergic effects...
  41. ncbi request reprint Acute selenium poisoning: suicide by ingestion
    Donna M Hunsaker
    Office of the Chief Medial Examiner, Urban Govermnent Center, Louisville, Kentucky 40204, USA
    J Forensic Sci 50:942-6. 2005
    ..The manner of death was suicide. This case report, which presents an overview of acute and chronic selenium poisoning, underscores the value of thorough toxicologic analyses of tissue and body fluids in humans...
  42. ncbi request reprint Efficacy of activated charcoal administered more than four hours after acetaminophen overdose
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, Kentucky 40232 5070, USA
    J Emerg Med 30:1-5. 2006
    ....
  43. ncbi request reprint Evaluation of the effect of a public educator on calls and poisonings reported to a regional poison center
    Henry A Spiller
    Kentucky Regional Poison Center, PO Box 35070, Louisville, Kentucky 40232 5070, USA
    Vet Hum Toxicol 46:206-8. 2004
    ..The addition of a public educator was associated with a positive impact on human exposures and penetrance reported to a regional poison center...
  44. ncbi request reprint Multi-center retrospective evaluation of carbonyl iron ingestions
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville 40232 5070, USA
    Vet Hum Toxicol 44:28-9. 2002
    ..In this limited first case series of iron carbonyl ingestion, serious toxicity did not occur...
  45. doi request reprint Acute ethanol poisoning in a 4-year-old as a result of ethanol-based hand-sanitizer ingestion
    Jeffrey S Engel
    King s Daughters Medical Center, Ashland, KY, USA
    Pediatr Emerg Care 26:508-9. 2010
    ..She recovered over the next day without sequelae. As with other potentially toxic products, we would recommend caution and direct supervision of use when this product is available to young children...
  46. pmc A case of hypercalcemia and gastric necrosis from hot pack ingestion
    Pradeep Padmanabhan
    Department of Pediatrics, Division of Pediatric Emergency Medicine, Kosair Children s Hospital, University of Louisville, Louisville, KY 40202, USA
    J Med Toxicol 6:139-42. 2010
    ..Ingestions of calcium salts can result in necrosis of the stomach. Management includes aggressive treatment of hypercalcemia, supportive care and upper gastrointestinal endoscopy...
  47. ncbi request reprint Intermediate syndrome after exposure to chlorpyrifos in a 16-month-old girl
    Jason E Mattingly
    Department of Emergency Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    J Emerg Med 25:379-81. 2003
    ..This is an unusual case in that it occurred in a young child, was related to chlorpyrifos, and occurred despite continuous and adequate oxime therapy...
  48. ncbi request reprint Envenomations as a novel drug-seeking method
    Henry A Spiller
    Kentucky Regional Poison Center, Kosair Children s Hospital, Louisville 40232 5070, USA
    Vet Hum Toxicol 44:297-8. 2002
    ..A 3rd patient complained of lionfish envenomation with no tissue reaction and was refused analgesia. Inconsistent clinical presentations of envenomations may signal drug-seeking behaviors...
  49. ncbi request reprint Dermal absorption of a liquid diphacinone rodenticide causing coagulaopathy
    Henry A Spiller
    Kentucky Regional Poison Center, Louisville, KY, USA
    Vet Hum Toxicol 45:313-4. 2003
    ..Factors increasing the dermal absorption of the diphacinone were: prolonged skin contact in a confined area and exposure to a concentrated solution...
  50. ncbi request reprint Fatal fluoxetine ingestion with postmortem blood concentrations
    Russel Compton
    Lewis Gale Medical Center, Salem, Virginia, USA
    Clin Toxicol (Phila) 43:277-9. 2005
    ..No other drugs were detected. We report an unusual case of massive fluoxetine ingestion resulting in neurological and cardiovascular toxicity resulting in death...
  51. ncbi request reprint Questioning the Delphic oracle
    John R Hale
    University of Louisville, USA
    Sci Am 289:66-73. 2003
  52. doi request reprint The effect of poison control center consultation on accidental poisoning inpatient hospitalizations with preexisting medical conditions
    Terry L Bunn
    Kentucky Injury Prevention and Research Center, University of Kentucky, Lexington, Kentucky 40504, USA
    J Toxicol Environ Health A 71:283-8. 2008
    ....
  53. ncbi request reprint Prospective observational multi-poison center study of ziprasidone exposures
    Wendy Klein-Schwartz
    Maryland Poison Center, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, USA
    Clin Toxicol (Phila) 45:782-6. 2007
    ..We characterized the clinical manifestations associated with ziprasidone overdoses, in particular the incidence and severity of QTc prolongation...
  54. ncbi request reprint Reply to clonidine exposures, not toxicity
    Henry A Spiller
    J Pediatr 149:282-3. 2006
  55. ncbi request reprint Evaluation of pramoxine ingestion as reported to poison centers
    Henry A Spiller
    Ann Pharmacother 40:996-7. 2006
  56. doi request reprint Poison centers detect an unexpectedly frequent number of adverse drug reactions to lisdexamfetamine
    Henry A Spiller
    Ann Pharmacother 42:1142-3. 2008
  57. ncbi request reprint Home administration of charcoal
    Henry A Spiller
    J Emerg Med 25:106-7; author reply 107. 2003
  58. ncbi request reprint Evaluation of centrally acting cholinesterase inhibitor exposures in adults
    Keith R McCain
    Arkansas Poison Control Center, Little Rock, AR 72205, USA
    Ann Pharmacother 41:1632-7. 2007
    ..Documented clinical experience involving exposure to these agents is limited. The lack of information makes decisions involving excessive or unintended CA-ChEI exposure difficult...