Brennan Spiegel

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Development and validation of a novel patient educational booklet to enhance colonoscopy preparation
    Brennan M R Spiegel
    Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Am J Gastroenterol 106:875-83. 2011
  2. pmc Patient-reported outcomes in gastroenterology: clinical and research applications
    Brennan M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System Division of Digestive Diseases, David Geffen School of Medicine at UCLA Department of Health Services, UCLA School of Public Health and UCLA VA Center for Outcomes Research and Education, Los Angeles, California, USA
    J Neurogastroenterol Motil 19:137-48. 2013
  3. doi request reprint The development and validation of a Nocturnal Gastro-oesophageal Reflux Disease Symptom Severity and Impact Questionnaire for adults
    B M Spiegel
    Internal Medicine, Digestive Diseases Division, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 32:591-602. 2010
  4. pmc Dialysis practices that distinguish facilities with below- versus above-expected mortality
    Brennan Spiegel
    Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Clin J Am Soc Nephrol 5:2024-33. 2010
  5. doi request reprint Characterizing abdominal pain in IBS: guidance for study inclusion criteria, outcome measurement and clinical practice
    B M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Aliment Pharmacol Ther 32:1192-202. 2010
  6. ncbi request reprint Do physicians follow evidence-based guidelines in the diagnostic work-up of IBS?
    Brennan M R Spiegel
    Division of Gastroenterology and Hepatology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Nat Clin Pract Gastroenterol Hepatol 4:296-7. 2007
  7. ncbi request reprint Erythropoietic growth factors for treatment-induced anemia in hepatitis C: a cost-effectiveness analysis
    Brennan M R Spiegel
    Division of Gastroenterology, VA Greater Los Angeles Healthcare System, and Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California 90073, USA
    Clin Gastroenterol Hepatol 3:1034-42. 2005
  8. doi request reprint Dialysis practices that distinguish top- versus bottom-performing facilities by hemoglobin outcomes
    Brennan M R Spiegel
    Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Am J Kidney Dis 56:86-94. 2010
  9. ncbi request reprint Comparing rates of dyspepsia with Coxibs vs NSAID+PPI: a meta-analysis
    Brennan M R Spiegel
    Division of Gastroenterology and Hepatology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, Calif 90073, USA
    Am J Med 119:448.e27-36. 2006
  10. doi request reprint Measuring symptoms in the irritable bowel syndrome: development of a framework for clinical trials
    B M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, CA, USA
    Aliment Pharmacol Ther 32:1275-91. 2010

Collaborators

Detail Information

Publications55

  1. doi request reprint Development and validation of a novel patient educational booklet to enhance colonoscopy preparation
    Brennan M R Spiegel
    Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Am J Gastroenterol 106:875-83. 2011
    ..The success of colonoscopy depends on high-quality bowel preparation by patients; yet inadequate preparation is common. We developed and tested an educational booklet to improve bowel preparation quality...
  2. pmc Patient-reported outcomes in gastroenterology: clinical and research applications
    Brennan M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System Division of Digestive Diseases, David Geffen School of Medicine at UCLA Department of Health Services, UCLA School of Public Health and UCLA VA Center for Outcomes Research and Education, Los Angeles, California, USA
    J Neurogastroenterol Motil 19:137-48. 2013
    ..This review article summarizes the latest approaches to PRO measuring for clinical trials and clinical practice, with a focus on use of PROs in gastroenterology...
  3. doi request reprint The development and validation of a Nocturnal Gastro-oesophageal Reflux Disease Symptom Severity and Impact Questionnaire for adults
    B M Spiegel
    Internal Medicine, Digestive Diseases Division, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 32:591-602. 2010
    ..Current questionnaires for assessing gastro-oesophageal reflux disease (GERD) symptoms are limited in their ability to capture nocturnal symptoms...
  4. pmc Dialysis practices that distinguish facilities with below- versus above-expected mortality
    Brennan Spiegel
    Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Clin J Am Soc Nephrol 5:2024-33. 2010
    ..Practices were identified that distinguish top- from bottom-performing facilities by SMR...
  5. doi request reprint Characterizing abdominal pain in IBS: guidance for study inclusion criteria, outcome measurement and clinical practice
    B M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Aliment Pharmacol Ther 32:1192-202. 2010
    ..Despite consensus that IBS trials should measure pain to define study entry and determine efficacy, the optimal method of measuring pain remains uncertain...
  6. ncbi request reprint Do physicians follow evidence-based guidelines in the diagnostic work-up of IBS?
    Brennan M R Spiegel
    Division of Gastroenterology and Hepatology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Nat Clin Pract Gastroenterol Hepatol 4:296-7. 2007
  7. ncbi request reprint Erythropoietic growth factors for treatment-induced anemia in hepatitis C: a cost-effectiveness analysis
    Brennan M R Spiegel
    Division of Gastroenterology, VA Greater Los Angeles Healthcare System, and Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California 90073, USA
    Clin Gastroenterol Hepatol 3:1034-42. 2005
    ..We sought to determine the cost effectiveness of adjunctive treatment with an EGF vs standard care in the treatment of hepatitis C...
  8. doi request reprint Dialysis practices that distinguish top- versus bottom-performing facilities by hemoglobin outcomes
    Brennan M R Spiegel
    Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Am J Kidney Dis 56:86-94. 2010
    ..The Identifying Best Practices in Dialysis (IBPiD) Study seeks to identify practices that distinguish top- from bottom-performing facilities by key outcomes, including achievement of recommended hemoglobin targets...
  9. ncbi request reprint Comparing rates of dyspepsia with Coxibs vs NSAID+PPI: a meta-analysis
    Brennan M R Spiegel
    Division of Gastroenterology and Hepatology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, Calif 90073, USA
    Am J Med 119:448.e27-36. 2006
    ....
  10. doi request reprint Measuring symptoms in the irritable bowel syndrome: development of a framework for clinical trials
    B M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, CA, USA
    Aliment Pharmacol Ther 32:1275-91. 2010
    ..The Food and Drug Administration (FDA) emphasizes that PROs must be couched in a conceptual framework, yet existing IBS PROs were not based on such a framework...
  11. ncbi request reprint Minimizing complications from nonsteroidal antiinflammatory drugs: cost-effectiveness of competing strategies in varying risk groups
    Brennan M R Spiegel
    Veteran s Affairs Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90073, USA
    Arthritis Rheum 53:185-97. 2005
    ..To appraise the cost-effectiveness of competing therapeutic strategies in patient cohorts eligible for aspirin prophylaxis with varying degrees of gastrointestinal (GI) and cardiovascular risk...
  12. doi request reprint Questioning the bacterial overgrowth hypothesis of irritable bowel syndrome: an epidemiologic and evolutionary perspective
    Brennan M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, California, USA
    Clin Gastroenterol Hepatol 9:461-9; quiz e59. 2011
    ..The article concludes that bacteria may contribute to some IBS symptoms, but that bacteria cannot be the only explanation, and a causal link between SIBO and IBS is not secure...
  13. pmc Biomarkers and health-related quality of life in end-stage renal disease: a systematic review
    Brennan M R Spiegel
    Department of Medicine, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Clin J Am Soc Nephrol 3:1759-68. 2008
    ....
  14. pmc Developing valid and reliable health utilities in irritable bowel syndrome: results from the IBS PROOF Cohort
    Brennan Spiegel
    VA Greater Los Angeles Healthcare System UCLA, Digestive Diseaes, 11301 Wilshire Blvd, Building 11, Room 21E, Los Angeles, California 90073, USA
    Am J Gastroenterol 104:1984-91. 2009
    ..To inform future cost-utility analyses in IBS, we measured and validated the IBS utilities...
  15. ncbi request reprint The burden of IBS: looking at metrics
    Brennan M R Spiegel
    VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, UCLA VA Center for Outcomes Research and Education, 11301 Wilshire Boulevard, Building 115, Room 215, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 11:265-9. 2009
    ..Resource utilization is highest in patients with severe symptoms and poor HRQOL. Treatment decisions should be tailored to the severity of each patient's symptoms and HRQOL decrement...
  16. ncbi request reprint Clinical impact of adjuvant chemotherapy in glioblastoma multiforme : a meta-analysis
    Brennan M R Spiegel
    VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    CNS Drugs 21:775-87. 2007
    ..We sought to update prior analyses by focusing exclusively on GBM, including new trials of novel treatments, assessing effectiveness of individual treatment categories and presenting data in a clinically useful format...
  17. ncbi request reprint Development and validation of a disease-targeted quality of life instrument in chronic hepatitis B: the hepatitis B quality of life instrument, version 1.0
    Brennan M R Spiegel
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Hepatology 46:113-21. 2007
    ..Internal consistency and test-retest reliability were excellent. The HBQOL v1.0 discriminated between viral responders versus nonresponders and correlated highly with SF-36 scores and global health...
  18. pmc Measuring irritable bowel syndrome patient-reported outcomes with an abdominal pain numeric rating scale
    B Spiegel
    VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Aliment Pharmacol Ther 30:1159-70. 2009
    ..Pain numeric rating scales (NRS) are widely used in the non-IBS pain literature. The Food and Drug Administration has proposed using the NRS in IBS...
  19. ncbi request reprint Long-term risk of acute diverticulitis among patients with incidental diverticulosis found during colonoscopy
    Kamyar Shahedi
    University of California Los Angeles Veteran s Affairs Center for Outcomes Research and Education, Los Angeles, California
    Clin Gastroenterol Hepatol 11:1609-13. 2013
    ..We measured the long-term risk of acute diverticulitis among patients with confirmed diverticulosis discovered incidentally on colonoscopy...
  20. pmc Psychometric evaluation of patient-reported outcomes in irritable bowel syndrome randomized controlled trials: a Rome Foundation report
    Brennan Spiegel
    Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Gastroenterology 137:1944-53.e1-3. 2009
    ..We pooled data to measure the psychometric properties of IBS end points, including binary responses (eg, "adequate relief") and 50% improvement in symptom severity...
  21. pmc Predictors of patient-assessed illness severity in irritable bowel syndrome
    Brennan Spiegel
    VA Greater Los Angeles Healthcare System, Center for Outcomes Research and Education, Los Angeles, California, USA
    Am J Gastroenterol 103:2536-43. 2008
    ..Since severity is a patient-centered outcome, it is essential that future instruments are based on patients' self-perceptions of severity. We measured patient-derived predictors of severity in a large cohort of IBS patients...
  22. ncbi request reprint The cost-effectiveness of cyclooxygenase-2 selective inhibitors in the management of chronic arthritis
    Brennan M R Spiegel
    Veterans Administration Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California, CURE Digestive Diseases Research Center, Los Angeles, CA 90073, USA
    Ann Intern Med 138:795-806. 2003
    ..However, their absolute risk reduction is small and the cost-effectiveness of treatment is uncertain...
  23. ncbi request reprint Increased risk for irritable bowel syndrome after acute diverticulitis
    Erica Cohen
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, California
    Clin Gastroenterol Hepatol 11:1614-9. 2013
    ..We compared the incidence of IBS and functional bowel and related affective disorders among patients with diverticulitis...
  24. ncbi request reprint Treatment alternatives for hepatitis B cirrhosis: a cost-effectiveness analysis
    Fasiha Kanwal
    Division of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Am J Gastroenterol 101:2076-89. 2006
    ..Lamivudine is effective but is limited by viral resistance. In contrast, adefovir and entecavir have lower viral resistance, but are more expensive. The most cost-effective approach is uncertain...
  25. ncbi request reprint Impact of chronic viral hepatitis on health-related quality of life in HIV: results from a nationally representative sample
    Fasiha Kanwal
    VA Greater Los Angeles Health Care System, Division of Gastroenterology Hepatology, David Geffen School of Medicine at UCLA, 90073, USA
    Am J Gastroenterol 100:1984-94. 2005
    ..We compared health-related quality of life (HRQOL) of patients with HIV and hepatitis C virus (HCV) or HIV and hepatitis B virus (HBV) coinfection to those with HIV monoinfection...
  26. ncbi request reprint Clinical determinants of health-related quality of life in patients with irritable bowel syndrome
    Brennan M R Spiegel
    Division of Gastroenterology, the VA Greater Los Angeles Healthcare System, CA 90073, USA
    Arch Intern Med 164:1773-80. 2004
    ..The identification of predictive factors could allow physicians to better assess HRQOL without using misleading clinical clues. We, therefore, sought to identify determinants of HRQOL in patients with IBS...
  27. ncbi request reprint Testing for celiac sprue in irritable bowel syndrome with predominant diarrhea: a cost-effectiveness analysis
    Brennan M R Spiegel
    Division of Gastroenterology and Hepatology, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Building 115, Room 215B, Los Angeles, CA 90073, USA
    Gastroenterology 126:1721-32. 2004
    ..Because the symptoms of CS respond to a gluten-free diet, testing for CS in IBS may prevent years of morbidity and attendant expense. We sought to determine whether this might be a cost-effective diagnostic strategy in IBS-D...
  28. ncbi request reprint The quality of published health economic analyses in digestive diseases: a systematic review and quantitative appraisal
    Brennan M R Spiegel
    Division of Gastroenterology, Veteran s Affairs Greater Los Angeles Healthcare System, California, USA
    Gastroenterology 127:403-11. 2004
    ..We sought to appraise the quality of health economic analyses in digestive diseases, and to identify predictors of study quality...
  29. doi request reprint Assessing health status in inflammatory bowel disease using a novel single-item numeric rating scale
    Bijal Surti
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, 8635 W 3rd St 960 Wv, Los Angeles, CA 90048, USA
    Dig Dis Sci 58:1313-21. 2013
    ..A numeric rating scale (NRS) is a quick, inexpensive, and convenient patient-reported outcome that can capture the patient's overall perception of health...
  30. ncbi request reprint Dyspepsia management in primary care: a decision analysis of competing strategies
    Brennan M R Spiegel
    Department of Medicine and Health Services Research, Cedars Sinai Medical Center, Los Angeles, California, USA
    Gastroenterology 122:1270-85. 2002
  31. ncbi request reprint The impact of somatization on the use of gastrointestinal health-care resources in patients with irritable bowel syndrome
    Brennan M R Spiegel
    Division of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Am J Gastroenterol 100:2262-73. 2005
    ..We sought to determine whether higher levels of somatization are associated with higher levels of gastrointestinal (GI) resource utilization in IBS...
  32. ncbi request reprint Treatment alternatives for chronic hepatitis B virus infection: a cost-effectiveness analysis
    Fasiha Kanwal
    Veterans Affairs Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California, Los Angeles, and Center for the Study of Digestive Healthcare Quality and Outcomes, Los Angeles, California 90073, USA
    Ann Intern Med 142:821-31. 2005
    ..Interferon has clinically significant side effects, and lamivudine is associated with viral resistance. In contrast, adefovir is safe and has lower viral resistance but is more expensive. The most cost-effective approach is uncertain...
  33. pmc Identifying best practices in dialysis care: results of cognitive interviews and a national survey of dialysis providers
    Amar A Desai
    Department of Medicine, University of California San Francisco, San Francisco, California, USA
    Clin J Am Soc Nephrol 3:1066-76. 2008
    ..We sought to catalogue "best practices" that may account for interfacility variations in outcomes...
  34. ncbi request reprint Is a negative colonoscopy associated with reassurance or improved health-related quality of life in irritable bowel syndrome?
    Brennan M R Spiegel
    Division of Gastroenterology, VA Greater Los Angeles Healthcare System, CA 90073, USA
    Gastrointest Endosc 62:892-9. 2005
    ..However, no previous data have measured these effects. We sought to measure the association of a normal colonoscopy with reassurance and HRQOL in patients with IBS aged <50 years...
  35. pmc Is there "cherry picking" in the ESRD Program? Perceptions from a Dialysis Provider Survey
    Amar A Desai
    Department of Medicine, StanfordUniversity School of Medicine, Stanford, California, USA
    Clin J Am Soc Nephrol 4:772-7. 2009
    ..Changes in ESRD reimbursement policy, including proposed bundled payment, have raised concern that dialysis facilities may use "cherry picking" practices to attract a healthier, better insured, or more adherent patient population...
  36. ncbi request reprint Impact of hepatitis C on health related quality of life: a systematic review and quantitative assessment
    Brennan M R Spiegel
    Division of Gastroenterology, VA Greater Los Angeles Healthcare System, USA
    Hepatology 41:790-800. 2005
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://www.interscience.wiley.com/jpages/0270-9139/suppmat/index.html)...
  37. ncbi request reprint Dysplasia and risk of further neoplastic progression in a regional Veterans Administration Barrett's cohort
    Gareth S Dulai
    Greater Los Angeles Veterans Administration Healthcare System, Department of Medicine, Division of Gastroenterology, UCLA School of Medicine, Los Angeles, CA 90073, USA
    Am J Gastroenterol 100:775-83. 2005
    ..Our aims were to estimate and compare the risk of progression to high-grade dysplasia or cancer in groups of Barrett's patients stratified by baseline dysplasia status...
  38. ncbi request reprint Endoscopic screening for esophageal varices in cirrhosis: Is it ever cost effective?
    Brennan M R Spiegel
    Division of Gastroenterology, Greater Los Angeles VA Healthcare System, CA 90073, USA
    Hepatology 37:366-77. 2003
    ....
  39. doi request reprint Methodology for randomized trials of patients with nonvariceal upper gastrointestinal bleeding: recommendations from an international consensus conference
    Loren Laine
    Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Am J Gastroenterol 105:540-50. 2010
    ..In general, the primary population for analysis is all patients randomized, although a per-protocol population may be used if this is the more conservative approach (e.g., equivalence study)...
  40. pmc Cost-effectiveness analysis of behavioral interventions to improve vaccination compliance in homeless adults
    Barbara Greengold
    University of California, Los Angeles, School of Nursing, Box 956917, Los Angeles, CA 90095 6917, USA
    Vaccine 27:718-25. 2009
    ..To estimate the cost-effectiveness of three behavioral interventions provided to enhance hepatitis A virus (HAV) and hepatitis B virus (HBV) joint vaccination (HAV/HBV) compliance among homeless persons living in Los Angeles County...
  41. ncbi request reprint The cost-effectiveness and budget impact of intravenous versus oral proton pump inhibitors in peptic ulcer hemorrhage
    Brennan M R Spiegel
    Division of Gastroenterology, Veteran s Administration Greater Los Angeles Healthcare System, California, USA
    Clin Gastroenterol Hepatol 4:988-997. 2006
    ....
  42. ncbi request reprint Minimizing recurrent peptic ulcer hemorrhage after endoscopic hemostasis: the cost-effectiveness of competing strategies
    Brennan M R Spiegel
    Department of Digestive Diseases, University of California at Los Angeles School of Medicine, Los Angeles, California, USA
    Am J Gastroenterol 98:86-97. 2003
    ..Our objective was to evaluate the cost-effectiveness of competing strategies for the posthemostasis management of patients with high risk ulcer stigmata...
  43. pmc Asymptomatic pancreatic cystic neoplasms: maximizing survival and quality of life using Markov-based clinical nomograms
    Benjamin M Weinberg
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, USA
    Gastroenterology 138:531-40. 2010
    ..The natural history and management of pancreatic cysts, especially for branch duct intraductal papillary mucinous neoplasms (BD-IPMNs), remain uncertain. We developed evidence-based nomograms to assist with clinical decision making...
  44. doi request reprint Fewer polyps detected by colonoscopy as the day progresses at a Veteran's Administration teaching hospital
    Michael Y Chan
    Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Clin Gastroenterol Hepatol 7:1217-23; quiz 1143. 2009
    ..Providers are predisposed to cognitive errors because the procedure is often performed repetitively throughout the day. We measured the adjusted relationship between colonoscopy start time and polyp yield...
  45. pmc Is irritable bowel syndrome a diagnosis of exclusion?: a survey of primary care providers, gastroenterologists, and IBS experts
    Brennan M R Spiegel
    Department of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Am J Gastroenterol 105:848-58. 2010
    ..Yet many clinicians are concerned about overlooking alternative diagnoses. We measured beliefs about whether IBS is a diagnosis of exclusion, and measured testing proclivity between IBS experts and community providers...
  46. doi request reprint The relationship between laboratory-based outcome measures and mortality in end-stage renal disease: a systematic review
    Amar A Desai
    VA Greater Los Angeles Healthcare System, Department of Medicine, Los Angeles, California, USA
    Hemodial Int 13:347-59. 2009
    ..Renewed consideration of cardiovascular, inflammatory, and nutritional markers that are especially strong predictors of mortality may have important implications for risk stratification and targeted therapeutic interventions...
  47. pmc Controversies in ulcerative colitis: a survey comparing decision making of experts versus community gastroenterologists
    Brennan M R Spiegel
    Veteran s Administration Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Clin Gastroenterol Hepatol 7:168-74, 174.e1. 2009
    ..We performed a national vignette survey to measure variations in decision-making in areas of controversy...
  48. pmc Bacterial overgrowth and irritable bowel syndrome: unifying hypothesis or a spurious consequence of proton pump inhibitors?
    Brennan M R Spiegel
    VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Am J Gastroenterol 103:2972-6. 2008
    ..Our article explores these premises, lays out the argument supporting this "PPI hypothesis," discusses potential implications, and outlines next steps to further investigate this possibility...
  49. ncbi request reprint The budget impact of endoscopic screening for esophageal varices in cirrhosis
    Brennan M R Spiegel
    Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, UCLA VA Center for Outcomes Research and Education CORE, 11301 Wilshire Blvd, Bldg 115 Rm 215, Los Angeles, CA 90073, USA
    Gastrointest Endosc 66:679-92. 2007
    ..However, these models were conducted before advances in variceal screening, including capsule endoscopy (CE), and they did not measure the budget impact (vs cost-effectiveness) of variceal screening...
  50. doi request reprint Comparison of health-related quality of life between populations
    Serena Slavenburg
    Liver Int 28:285-6; author reply 286-7. 2008
  51. ncbi request reprint Esomeprazole versus other proton pump inhibitors in erosive esophagitis: a meta-analysis of randomized clinical trials
    Ian M Gralnek
    Rambam Medical Center, Department of Gastroenterology, GI Outcomes Unit, Faculty of Medicine, Technion Institute of Technology, Haifa, Israel
    Clin Gastroenterol Hepatol 4:1452-8. 2006
    ..We performed a meta-analysis to calculate the pooled effect of esomeprazole on healing rates, symptom relief, and adverse events versus competing PPIs in EE...
  52. pmc The cost-effectiveness of colonic stenting as a bridge to curative surgery in patients with acute left-sided malignant colonic obstruction: a Canadian perspective
    Harminder Singh
    Department of Internal Medicine, University of Manitoba, Winnipeg
    Can J Gastroenterol 20:779-85. 2006
    ..The aim of the present study was to determine the most cost-effective strategy in a Canadian setting. patients and..
  53. ncbi request reprint Budget impact of tegaserod on a managed care organization formulary
    Michael A Bloom
    Innovative Health Solutions, Brookline, Massachusetts, USA
    Am J Manag Care 11:S27-34. 2005
    ..When the associated budget impact of adding tegaserod to its formulary is absorbed across an entire MCO population, the PMPM impact of tegaserod is small...
  54. ncbi request reprint The cost-effectiveness of hepatic venous pressure gradient monitoring in the prevention of recurrent variceal hemorrhage
    Laura E Targownik
    Section of Gastroenterology, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 99:1306-15. 2004
    ..Combination of beta-blocker and nitrate therapy, guided by hepatic venous pressure gradient (HVPG) monitoring, is a novel alternative strategy. We sought to determine the cost-effectiveness of these competing strategies...
  55. ncbi request reprint Predictors of treatment in patients with chronic hepatitis C infection - role of patient versus nonpatient factors
    Fasiha Kanwal
    John Cochran VA Medical Center, St Louis, MO, USA
    Hepatology 46:1741-9. 2007
    ..These potentially modifiable provider-level factors may serve as high-yield targets for future quality improvement initiatives in HCV...