Research Topics
| Jason L SperrySummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
Racial disparities and sex-based outcomes differences after severe injuryJason L Sperry
Division of General Surgery andTrauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Am Coll Surg 214:973-80. 2012..The prevalence of these variants is known to differ across race. We sought to characterize racial differences and the strength of any sex-based dimorphism post-injury...- Incidental radiographic findings after injury: dedicated attention results in improved capture, documentation, and managementJason L Sperry
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Surgery 148:618-24. 2010..We hypothesized a dedicated incidental finding coordinator would increase incidental finding capture and promote notification, follow-up, and documentation of incidental finding events... 
Characterization of persistent hyperglycemia: what does it mean postinjury?Jason L Sperry
Division of Trauma and General Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma 66:1076-82. 2009....- An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusionJason L Sperry
Division of General Surgery and Trauma, Departments of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Trauma 65:986-93. 2008.... - Characterization of the gender dimorphism after injury and hemorrhagic shock: are hormonal differences responsible?Jason L Sperry
Division of Trauma and General Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Crit Care Med 36:1838-45. 2008..old, >52 yrs of age) in a cohort of severely injured trauma patients for which significant variation in postinjury care is minimized... - Male gender is associated with excessive IL-6 expression following severe injuryJason L Sperry
Division of Trauma and General Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Trauma 64:572-8; discussion 578-9. 2008.... - Early use of vasopressors after injury: caution before constrictionJason L Sperry
Division of Burn, Trauma, Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Trauma 64:9-14. 2008..We sought to characterize early vasopressor (EV) use and aggressive early crystalloid resuscitation (ECR) and their association with mortality in severely injured patients... 
Gender dimorphism following injury: making the connection from bench to bedsideJason L Sperry
Department of Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
J Leukoc Biol 83:499-506. 2008..This may ultimately promote therapeutic interventions, which will allow for improved outcomes for males and females in the near future...- Debunking the survival bias myth: characterization of mortality during the initial 24 hours for patients requiring massive transfusionJoshua B Brown
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma Acute Care Surg 73:358-64; discussion 364. 2012..We sought to characterize mortality during the first 24 hours while controlling for time varying effects of transfusion to minimize survival bias... - Hypothermia in massive transfusion: have we been paying enough attention to it?Benjamin R Reynolds
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma Acute Care Surg 73:486-91. 2012..We sought to characterize the importance of temperature as a risk factor for poor outcome relative to the changes in MT resuscitation that have occurred... - Body adipose content is independently associated with a higher risk of organ failure and nosocomial infection in the nonobese patient postinjuryRebecca D Edmonds
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma 70:292-8. 2011..We sought to avoid the confounding effects attributable to obesity and determine the association of BMI and outcomes following injury in nonobese patients... - Crystalloid to packed red blood cell transfusion ratio in the massively transfused patient: when a little goes a long wayMatthew D Neal
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma Acute Care Surg 72:892-8. 2012..We hypothesized that an increased crystalloid:PRBC (C:PRBC) ratio would be associated with increased morbidity and poor outcome after MT... - Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysisMatthew D Neal
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma 67:476-82; discussion 482-4. 2009..We sought to determine whether preinjury statin (PIS) use was associated with improved outcome in severely injured blunt trauma patients... - Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndromeGregory A Watson
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma 67:221-7; discussion 228-30. 2009..We hypothesized that plasma-rich transfusion components would be independently associated with a lower risk of mortality but result in a greater risk of morbid complications... - Prestorage leukoreduction ameliorates the effects of aging on banked bloodHerb A Phelan
Division of Burns Trauma Critical Care, Department of Surgery, UT Southwestern Medical Center, Dallas, Texas 75390 9158, USA
J Trauma 69:330-7. 2010..The purpose of this retrospective cohort study was to describe the effect of prestorage leukoreduction (PS-LR) on the detrimental clinical effects of increasing age on blood products used in trauma patients... - Early lower extremity fracture fixation and the risk of early pulmonary embolus: filter before fixation?Raquel M Forsythe
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma 70:1381-8. 2011..Those patients at highest risk in this early vulnerable window postinjury are not well characterized. We sought to determine those patients at highest risk for an early pulmonary embolism (PE) after injury... - Early hyperglycemia predicts multiple organ failure and mortality but not infectionJason L Sperry
Division of Burn, Trauma, Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Trauma 63:487-93; discussion 493-4. 2007..We sought to characterize the clinical outcomes associated with EH in a cohort of severely injured trauma patients, when a strict glycemic control protocol was used... - Early blood product and crystalloid volume resuscitation: risk association with multiple organ dysfunction after severe blunt traumatic injuryScott C Brakenridge
Department of Surgery, Division of Burn Trauma Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9158, USA
J Trauma 71:299-305. 2011..We sought to further delineate the relevance of the major individual components of early volume resuscitation to onset of MOD after severe blunt traumatic injury... - Delay to therapeutic interventional radiology postinjury: time is of the essenceGina M Howell
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Trauma 68:1296-300. 2010..The importance of time to control of hemorrhage for therapeutic IR procedures has not been adequately characterized... - Defining geriatric trauma: when does age make a difference?Nicholas W Goodmanson
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Surgery 152:668-74; discussion 674-5. 2012.... - Over reliance on computed tomography imaging in patients with severe abdominal injury: is the delay worth the risk?Matthew D Neal
Department of Surgery, Division of General Surgery and Trauma, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma 70:278-84. 2011..We sought to analyze whether the use of abdominal CT (ABD CT) in patients with abdominal injury requiring laparotomy results in a significant delay and a higher risk of poor outcome... - The implications of alcohol intoxication and the Uniform Policy Provision Law on trauma centers; a national trauma data bank analysis of minimally injured patientsTerence O'Keeffe
Division of Trauma, Critical Care, and Emergency Surgery, Department of Surgery, University of Arizona, Tucson, Arizona 85724, USA
J Trauma 66:495-8. 2009..We hypothesized that patients injured while under the influence of alcohol require more diagnostic tests, procedures, and hospital admissions, leading to higher hospital charges... - Characterization of acute coagulopathy and sexual dimorphism after injury: females and coagulopathy just do not mixJoshua B Brown
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Trauma Acute Care Surg 73:1395-400; discussion 1400. 2012..It remains unclear whether presence of ATC alters sex-based outcomes after injury. This study's objective was to characterize the sex dimorphism after severe injury in the presence and absence of ATC... - Radiographic assessment of splenic injury without contrast: is contrast truly needed?Douglas R Murken
Division of General Surgery and Trauma, Department of Surgery, Presbyterian Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Surgery 152:676-82; discussion 682-4. 2012..However, a substantial proportion of injured patients have contraindications to i.v. contrast. Little information exists concerning the repercussions of CT imaging without i.v. contrast, specifically for splenic injury... - Massive transfusion: an evidence-based review of recent developmentsMatthew D Neal
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, 200 Lothrop St, F675 Watson Surgical Education Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
Arch Surg 147:563-71. 2012.... - Predictors of acute posttraumatic stress disorder symptoms following civilian trauma: highest incidence and severity of symptoms after assaultLouis H Alarcon
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Trauma Acute Care Surg 72:629-35; discussion 635-7. 2012..The incidence and risk factors for PTSD are not well described in the civilian trauma population. We proposed to screen all trauma patients in the outpatient trauma clinic for acute PTSD symptoms and identify risk factors for PTSD... - Changes in massive transfusion over time: an early shift in the right direction?Benjamin C Kautza
Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Trauma Acute Care Surg 72:106-11. 2012..We sought to characterize changes in resuscitation which have occurred over time in a cohort severely injured patients requiring MT... - The use of leukoreduced red blood cell products is associated with fewer infectious complications in trauma patientsRandall S Friese
Division of Burn, Trauma, Critical Care, Department of Surgery, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
Am J Surg 196:56-61. 2008..The purpose of this study was to determine the effect of prestorage leukoreduction on infectious complications in injured patients... - Increased risk of death associated with hypotension is not altered by the presence of brain injury in pediatric trauma patientsMark A Gunst
Division of Burns, Trauma and Surgical Critical Care, Department of Surgery, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd, Dallas, TX 75390 9158, USA
Am J Surg 194:741-4; discussion 744-5. 2007..We hypothesized that systemic hypotension increases mortality in pediatric patients with TBI more than it does in pediatric patients with extracranial injuries only... - Long-term fetal outcomes in pregnant trauma patientsJason L Sperry
Department of Surgery, Division of Burns, Trauma and Surgical Critical Care, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Mail Stop 9158, Dallas, TX 75390-9158, USA
Am J Surg 192:715-21. 2006..A history of trauma during gestation is a risk factor for poor pregnancy outcome... - Persistence of elevated plasma CXCL8 concentrations following red blood cell transfusion in a trauma cohortJanet S Lee
Pulmonary, Allergy, and Critical Care Medicine Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Shock 37:373-7. 2012..Other bioanalytes showed no differences across time. Red blood cell transfusion is associated with persistently elevated neutrophil chemokine CXCL8 concentrations following traumatic injury... - Effect of the modified Glasgow Coma Scale score criteria for mild traumatic brain injury on mortality prediction: comparing classic and modified Glasgow Coma Scale score model scores of 13Jorge Humberto Mena
Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Trauma 71:1185-92; discussion 1193. 2011..We investigated the effect of this modification on mortality prediction, comparing patients with a GCS score of 13 classified as moderate TBI (classic model) to patients with GCS score of 13 classified as mild TBI (modified model)... - Leukoreduction before red blood cell transfusion has no impact on mortality in trauma patientsHerb A Phelan
Department of Surgery, Division of Trauma Critical Care, University of South Alabama Medical Center, Mobile, Alabama, USA
J Surg Res 138:32-6. 2007..Many institutions now mandate leukoreduction (LR) of transfusion products, which increases costs by approximately $30/unit. The purpose of this study was to examine the effect of LR on mortality and LOS in trauma patients... - Assessment of platelet transfusion for reversal of aspirin after traumatic brain injuryArshad M Bachelani
Division of General Surgery and Trauma, Department of Surgery, Mercy and Presbyterian Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Surgery 150:836-43. 2011..Assessment of platelet inhibition and reversal by platelet transfusion after TBI has not been adequately characterized... - Evolving role of endovascular techniques for traumatic vascular injury: a changing landscape?Laura E Avery
Department of Surgery, Mercy and Presbyterian Hospitals, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Trauma Acute Care Surg 72:41-6; discussion 46-7. 2012.... - The association between air ambulance distribution and trauma mortalityZachary J Rhinehart
Departments of Surgery Emergency Medicine, University of Pittsburgh, Pittsburgh, PA
Ann Surg 257:1147-53. 2013..To determine whether increasing distance between helicopter ambulance airbase and either home residence or referring facility is associated with an increased risk of injury-related mortality... - CTA-based screening reduces time to diagnosis and stroke rate in blunt cervical vascular injuryAlexander L Eastman
The Division of Burns, Trauma and Critical Care, Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Trauma 67:551-6; discussion 555-6. 2009..We hypothesized that the use of CTA-alone screening and diagnostic methods would reduce the time interval from admission to diagnosis and, hence, also reduce the stroke rates associated with these injuries... - Waiting for the patient to "sober up": Effect of alcohol intoxication on glasgow coma scale score of brain injured patientsJason L Sperry
Division of Burns, Trauma and Surgical Critical Care, Department of Surgery, University of Texas Southwestern Medical School, Dallas, Texas 75390-9158, USA
J Trauma 61:1305-11. 2006..Hence, alterations in GCS score after TBI should not be attributed to alcohol intoxication, as doing so might result in inappropriate delays in monitoring and therapeutic interventions... - Early loss of thrombomodulin expression impairs vein graft thromboresistance: implications for vein graft failureAntony Y Kim
Divisions of Cardiology, The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Circ Res 90:205-12. 2002..Although enhanced local thrombin generation may predispose to early vein graft failure due to thrombosis, it does not seem to contribute significantly to late vein graft failure due to neointimal hyperplasia...