Jason L Sperry

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Racial disparities and sex-based outcomes differences after severe injury
    Jason L Sperry
    Division of General Surgery andTrauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Am Coll Surg 214:973-80. 2012
  2. doi An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion
    Jason L Sperry
    Division of General Surgery and Trauma, Departments of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Trauma 65:986-93. 2008
  3. doi Characterization of the gender dimorphism after injury and hemorrhagic shock: are hormonal differences responsible?
    Jason L Sperry
    Division of Trauma and General Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Crit Care Med 36:1838-45. 2008
  4. doi Male gender is associated with excessive IL-6 expression following severe injury
    Jason L Sperry
    Division of Trauma and General Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Trauma 64:572-8; discussion 578-9. 2008
  5. doi Early use of vasopressors after injury: caution before constriction
    Jason L Sperry
    Division of Burn, Trauma, Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Trauma 64:9-14. 2008
  6. pmc Incidental radiographic findings after injury: dedicated attention results in improved capture, documentation, and management
    Jason L Sperry
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Surgery 148:618-24. 2010
  7. ncbi Gender dimorphism following injury: making the connection from bench to bedside
    Jason L Sperry
    Department of Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Leukoc Biol 83:499-506. 2008
  8. doi Characterization of persistent hyperglycemia: what does it mean postinjury?
    Jason L Sperry
    Division of Trauma and General Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 66:1076-82. 2009
  9. ncbi Debunking the survival bias myth: characterization of mortality during the initial 24 hours for patients requiring massive transfusion
    Joshua B Brown
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 73:358-64; discussion 364. 2012
  10. ncbi Hypothermia in massive transfusion: have we been paying enough attention to it?
    Benjamin R Reynolds
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 73:486-91. 2012

Collaborators

Detail Information

Publications43

  1. pmc Racial disparities and sex-based outcomes differences after severe injury
    Jason L Sperry
    Division of General Surgery andTrauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Am Coll Surg 214:973-80. 2012
    ..The prevalence of these variants is known to differ across race. We sought to characterize racial differences and the strength of any sex-based dimorphism post-injury...
  2. doi An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion
    Jason L Sperry
    Division of General Surgery and Trauma, Departments of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Trauma 65:986-93. 2008
    ....
  3. doi Characterization of the gender dimorphism after injury and hemorrhagic shock: are hormonal differences responsible?
    Jason L Sperry
    Division of Trauma and General Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Crit Care Med 36:1838-45. 2008
    ..old, >52 yrs of age) in a cohort of severely injured trauma patients for which significant variation in postinjury care is minimized...
  4. doi Male gender is associated with excessive IL-6 expression following severe injury
    Jason L Sperry
    Division of Trauma and General Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Trauma 64:572-8; discussion 578-9. 2008
    ....
  5. doi Early use of vasopressors after injury: caution before constriction
    Jason L Sperry
    Division of Burn, Trauma, Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Trauma 64:9-14. 2008
    ..We sought to characterize early vasopressor (EV) use and aggressive early crystalloid resuscitation (ECR) and their association with mortality in severely injured patients...
  6. pmc Incidental radiographic findings after injury: dedicated attention results in improved capture, documentation, and management
    Jason L Sperry
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Surgery 148:618-24. 2010
    ..We hypothesized a dedicated incidental finding coordinator would increase incidental finding capture and promote notification, follow-up, and documentation of incidental finding events...
  7. ncbi Gender dimorphism following injury: making the connection from bench to bedside
    Jason L Sperry
    Department of Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Leukoc Biol 83:499-506. 2008
    ..This may ultimately promote therapeutic interventions, which will allow for improved outcomes for males and females in the near future...
  8. doi Characterization of persistent hyperglycemia: what does it mean postinjury?
    Jason L Sperry
    Division of Trauma and General Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 66:1076-82. 2009
    ....
  9. ncbi Debunking the survival bias myth: characterization of mortality during the initial 24 hours for patients requiring massive transfusion
    Joshua B Brown
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 73:358-64; discussion 364. 2012
    ..We sought to characterize mortality during the first 24 hours while controlling for time varying effects of transfusion to minimize survival bias...
  10. ncbi Hypothermia in massive transfusion: have we been paying enough attention to it?
    Benjamin R Reynolds
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 73:486-91. 2012
    ..We sought to characterize the importance of temperature as a risk factor for poor outcome relative to the changes in MT resuscitation that have occurred...
  11. pmc Goal-directed resuscitation in the prehospital setting: a propensity-adjusted analysis
    Joshua B Brown
    Department of Surgery, Division of General Surgery and Trauma, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 74:1207-12; discussion 1212-4. 2013
    ..Optimal PH crystalloid resuscitation strategies remain unclear in blunt trauma as does the influence of PH hypotension. The objective was to characterize outcomes for PH crystalloid volume in patients with and without PH hypotension...
  12. pmc American College of Surgeons trauma center verification versus state designation: are Level II centers slipping through the cracks?
    Joshua B Brown
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 75:44-9; discussion 49. 2013
    ..Single-center experience has shown that American College of Surgeons (ACS) trauma verification can improve outcomes. The current objective was to compare mortality between ACS-verified and state-designated centers in a national sample...
  13. doi Body adipose content is independently associated with a higher risk of organ failure and nosocomial infection in the nonobese patient postinjury
    Rebecca D Edmonds
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 70:292-8. 2011
    ..We sought to avoid the confounding effects attributable to obesity and determine the association of BMI and outcomes following injury in nonobese patients...
  14. pmc Crystalloid to packed red blood cell transfusion ratio in the massively transfused patient: when a little goes a long way
    Matthew D Neal
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 72:892-8. 2012
    ..We hypothesized that an increased crystalloid:PRBC (C:PRBC) ratio would be associated with increased morbidity and poor outcome after MT...
  15. doi Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome
    Gregory A Watson
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 67:221-7; discussion 228-30. 2009
    ..We hypothesized that plasma-rich transfusion components would be independently associated with a lower risk of mortality but result in a greater risk of morbid complications...
  16. doi Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysis
    Matthew D Neal
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 67:476-82; discussion 482-4. 2009
    ..We sought to determine whether preinjury statin (PIS) use was associated with improved outcome in severely injured blunt trauma patients...
  17. pmc Prestorage leukoreduction ameliorates the effects of aging on banked blood
    Herb A Phelan
    Division of Burns Trauma Critical Care, Department of Surgery, UT Southwestern Medical Center, Dallas, Texas 75390 9158, USA
    J Trauma 69:330-7. 2010
    ..The purpose of this retrospective cohort study was to describe the effect of prestorage leukoreduction (PS-LR) on the detrimental clinical effects of increasing age on blood products used in trauma patients...
  18. doi Early lower extremity fracture fixation and the risk of early pulmonary embolus: filter before fixation?
    Raquel M Forsythe
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 70:1381-8. 2011
    ..Those patients at highest risk in this early vulnerable window postinjury are not well characterized. We sought to determine those patients at highest risk for an early pulmonary embolism (PE) after injury...
  19. ncbi Early hyperglycemia predicts multiple organ failure and mortality but not infection
    Jason L Sperry
    Division of Burn, Trauma, Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Trauma 63:487-93; discussion 493-4. 2007
    ..We sought to characterize the clinical outcomes associated with EH in a cohort of severely injured trauma patients, when a strict glycemic control protocol was used...
  20. pmc Characterization of acute coagulopathy and sexual dimorphism after injury: females and coagulopathy just do not mix
    Joshua B Brown
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Trauma Acute Care Surg 73:1395-400. 2012
    ..It remains unclear whether presence of ATC alters sex-based outcomes after injury. This study's objective was to characterize the sex dimorphism after severe injury in the presence and absence of ATC...
  21. doi The association between air ambulance distribution and trauma mortality
    Zachary J Rhinehart
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Ann Surg 257:1147-53. 2013
    ..To determine whether increasing distance between helicopter ambulance airbase and either home residence or referring facility is associated with an increased risk of injury-related mortality...
  22. doi Use of a massive transfusion protocol in nontrauma patients: activate away
    Lauren M McDaniel
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Am Coll Surg 216:1103-9. 2013
    ..The current study was designed to investigate whether an MTP could be used effectively in GMS patients without detrimentally impacting resource allocation...
  23. doi Delay to therapeutic interventional radiology postinjury: time is of the essence
    Gina M Howell
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Trauma 68:1296-300. 2010
    ..The importance of time to control of hemorrhage for therapeutic IR procedures has not been adequately characterized...
  24. pmc Early blood product and crystalloid volume resuscitation: risk association with multiple organ dysfunction after severe blunt traumatic injury
    Scott C Brakenridge
    Department of Surgery, Division of Burn Trauma Critical Care, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9158, USA
    J Trauma 71:299-305. 2011
    ..We sought to further delineate the relevance of the major individual components of early volume resuscitation to onset of MOD after severe blunt traumatic injury...
  25. doi Defining geriatric trauma: when does age make a difference?
    Nicholas W Goodmanson
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Surgery 152:668-74; discussion 674-5. 2012
    ....
  26. doi The implications of alcohol intoxication and the Uniform Policy Provision Law on trauma centers; a national trauma data bank analysis of minimally injured patients
    Terence O'Keeffe
    Division of Trauma, Critical Care, and Emergency Surgery, Department of Surgery, University of Arizona, Tucson, Arizona 85724, USA
    J Trauma 66:495-8. 2009
    ..We hypothesized that patients injured while under the influence of alcohol require more diagnostic tests, procedures, and hospital admissions, leading to higher hospital charges...
  27. doi Over reliance on computed tomography imaging in patients with severe abdominal injury: is the delay worth the risk?
    Matthew D Neal
    Department of Surgery, Division of General Surgery and Trauma, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 70:278-84. 2011
    ..We sought to analyze whether the use of abdominal CT (ABD CT) in patients with abdominal injury requiring laparotomy results in a significant delay and a higher risk of poor outcome...
  28. pmc Radiographic assessment of splenic injury without contrast: is contrast truly needed?
    Douglas R Murken
    Division of General Surgery and Trauma, Department of Surgery, Presbyterian Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Surgery 152:676-82; discussion 682-4. 2012
    ..However, a substantial proportion of injured patients have contraindications to i.v. contrast. Little information exists concerning the repercussions of CT imaging without i.v. contrast, specifically for splenic injury...
  29. doi Massive transfusion: an evidence-based review of recent developments
    Matthew D Neal
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, 200 Lothrop St, F675 Watson Surgical Education Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
    Arch Surg 147:563-71. 2012
    ....
  30. doi Predictors of acute posttraumatic stress disorder symptoms following civilian trauma: highest incidence and severity of symptoms after assault
    Louis H Alarcon
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 72:629-35; discussion 635-7. 2012
    ..The incidence and risk factors for PTSD are not well described in the civilian trauma population. We proposed to screen all trauma patients in the outpatient trauma clinic for acute PTSD symptoms and identify risk factors for PTSD...
  31. pmc Changes in massive transfusion over time: an early shift in the right direction?
    Benjamin C Kautza
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 72:106-11. 2012
    ..We sought to characterize changes in resuscitation which have occurred over time in a cohort severely injured patients requiring MT...
  32. doi The use of leukoreduced red blood cell products is associated with fewer infectious complications in trauma patients
    Randall S Friese
    Division of Burn, Trauma, Critical Care, Department of Surgery, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Am J Surg 196:56-61. 2008
    ..The purpose of this study was to determine the effect of prestorage leukoreduction on infectious complications in injured patients...
  33. ncbi Increased risk of death associated with hypotension is not altered by the presence of brain injury in pediatric trauma patients
    Mark A Gunst
    Division of Burns, Trauma and Surgical Critical Care, Department of Surgery, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd, Dallas, TX 75390 9158, USA
    Am J Surg 194:741-4; discussion 744-5. 2007
    ..We hypothesized that systemic hypotension increases mortality in pediatric patients with TBI more than it does in pediatric patients with extracranial injuries only...
  34. ncbi Long-term fetal outcomes in pregnant trauma patients
    Jason L Sperry
    Department of Surgery, Division of Burns, Trauma and Surgical Critical Care, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Mail Stop 9158, Dallas, TX 75390 9158, USA
    Am J Surg 192:715-21. 2006
    ..Less is known about the delayed effects of trauma on pregnancy outcome once the patient has been discharged from the hospital with a viable fetus...
  35. pmc Persistence of elevated plasma CXCL8 concentrations following red blood cell transfusion in a trauma cohort
    Janet S Lee
    Pulmonary, Allergy, and Critical Care Medicine Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Shock 37:373-7. 2012
    ..Other bioanalytes showed no differences across time. Red blood cell transfusion is associated with persistently elevated neutrophil chemokine CXCL8 concentrations following traumatic injury...
  36. pmc Effect of the modified Glasgow Coma Scale score criteria for mild traumatic brain injury on mortality prediction: comparing classic and modified Glasgow Coma Scale score model scores of 13
    Jorge Humberto Mena
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Trauma 71:1185-92; discussion 1193. 2011
    ..We investigated the effect of this modification on mortality prediction, comparing patients with a GCS score of 13 classified as moderate TBI (classic model) to patients with GCS score of 13 classified as mild TBI (modified model)...
  37. doi Assessment of platelet transfusion for reversal of aspirin after traumatic brain injury
    Arshad M Bachelani
    Division of General Surgery and Trauma, Department of Surgery, Mercy and Presbyterian Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Surgery 150:836-43. 2011
    ..Assessment of platelet inhibition and reversal by platelet transfusion after TBI has not been adequately characterized...
  38. ncbi Leukoreduction before red blood cell transfusion has no impact on mortality in trauma patients
    Herb A Phelan
    Department of Surgery, Division of Trauma Critical Care, University of South Alabama Medical Center, Mobile, Alabama, USA
    J Surg Res 138:32-6. 2007
    ..Many institutions now mandate leukoreduction (LR) of transfusion products, which increases costs by approximately $30/unit. The purpose of this study was to examine the effect of LR on mortality and LOS in trauma patients...
  39. doi Evolving role of endovascular techniques for traumatic vascular injury: a changing landscape?
    Laura E Avery
    Department of Surgery, Mercy and Presbyterian Hospitals, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Trauma Acute Care Surg 72:41-6; discussion 46-7. 2012
    ....
  40. pmc Multidisciplinary acute care research organization (MACRO): if you build it, they will come
    Barbara J Early
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Trauma Acute Care Surg 75:106-9. 2013
    ..We sought to characterize the effects of implementation of a multidisciplinary acute care research organization (MACRO) at a busy tertiary referral university setting...
  41. doi CTA-based screening reduces time to diagnosis and stroke rate in blunt cervical vascular injury
    Alexander L Eastman
    The Division of Burns, Trauma and Critical Care, Department of Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Trauma 67:551-6; discussion 555-6. 2009
    ..We hypothesized that the use of CTA-alone screening and diagnostic methods would reduce the time interval from admission to diagnosis and, hence, also reduce the stroke rates associated with these injuries...
  42. ncbi Waiting for the patient to "sober up": Effect of alcohol intoxication on glasgow coma scale score of brain injured patients
    Jason L Sperry
    Division of Burns, Trauma and Surgical Critical Care, Department of Surgery, University of Texas Southwestern Medical School, Dallas, Texas 75390 9158, USA
    J Trauma 61:1305-11. 2006
    ..Alcohol intoxication may limit the ability of the Glasgow Coma Scale (GCS) to accurately assess severity of TBI. We hypothesized that alcohol intoxication significantly depresses GCS scores of TBI patients...
  43. ncbi Early loss of thrombomodulin expression impairs vein graft thromboresistance: implications for vein graft failure
    Antony Y Kim
    Divisions of Cardiology, The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Circ Res 90:205-12. 2002
    ..Although enhanced local thrombin generation may predispose to early vein graft failure due to thrombosis, it does not seem to contribute significantly to late vein graft failure due to neointimal hyperplasia...