A I Sperling

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma
    Yutong Zhao
    Department of Medicine, The University of Chicago, Chicago, Illinois, USA
    Respir Res 10:114. 2009
  2. ncbi request reprint ICOS costimulation: It's not just for TH2 cells anymore
    A I Sperling
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, and the Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    Nat Immunol 2:573-4. 2001
  3. ncbi request reprint TCR signaling induces selective exclusion of CD43 from the T cell-antigen-presenting cell contact site
    A I Sperling
    Department of Medicine, University of Chicago, IL 60637, USA
    J Immunol 161:6459-62. 1998
  4. ncbi request reprint CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma
    P A Padrid
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Am J Respir Cell Mol Biol 18:453-62. 1998
  5. ncbi request reprint CD28 costimulation promotes the production of Th2 cytokines
    I C Rulifson
    Ben May Institute for Cancer Research, Department of Pathology, University of Chicago, IL 60637, USA
    J Immunol 158:658-65. 1997
  6. ncbi request reprint ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse
    E J Allenspach
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Immunity 15:739-50. 2001
  7. ncbi request reprint CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance
    T L Walunas
    Ben May Institute, University of Chicago, IL 60637, USA
    J Immunol 156:1006-13. 1996
  8. ncbi request reprint Absence of B7-dependent responses in CD28-deficient mice
    J M Green
    Department of Medicine, University of Chicago, Illinois 60637
    Immunity 1:501-8. 1994
  9. ncbi request reprint Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease
    A G Tesciuba
    Committee on Immunology and Section of Pulmonary and Critical Care, Department of Medicine, and Ben May Institute for Cancer Research, University of Chicago, Chicago, IL, 60637, USA
    J Immunol 167:1996-2003. 2001
  10. pmc CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation
    J L Cannon
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Mol Biol Cell 22:954-63. 2011

Collaborators

Detail Information

Publications19

  1. pmc Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma
    Yutong Zhao
    Department of Medicine, The University of Chicago, Chicago, Illinois, USA
    Respir Res 10:114. 2009
    ..We have demonstrated that LPA induced cytokine and lipid mediator release in human bronchial epithelial cells. Here we provide evidence for the role of LPA and LPA receptors in Th2-dominant airway inflammation...
  2. ncbi request reprint ICOS costimulation: It's not just for TH2 cells anymore
    A I Sperling
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, and the Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    Nat Immunol 2:573-4. 2001
    ..A current paradigm has ICOS participating in TH2 costimulation. New data indicates ICOS regulates not only TH2 cells, but also TH1s...
  3. ncbi request reprint TCR signaling induces selective exclusion of CD43 from the T cell-antigen-presenting cell contact site
    A I Sperling
    Department of Medicine, University of Chicago, IL 60637, USA
    J Immunol 161:6459-62. 1998
    ..Thus, CD43 may represent a novel regulatory molecule on the T cell surface that can direct T cell interactions by changing its location on the cell surface...
  4. ncbi request reprint CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma
    P A Padrid
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Am J Respir Cell Mol Biol 18:453-62. 1998
    ..mansoni-sensitized and airway-challenged mice, most likely due to attenuated secretion of Th2-type cytokines and increased secretion of Th1-type cytokines...
  5. ncbi request reprint CD28 costimulation promotes the production of Th2 cytokines
    I C Rulifson
    Ben May Institute for Cancer Research, Department of Pathology, University of Chicago, IL 60637, USA
    J Immunol 158:658-65. 1997
    ..Therefore, CD28 ligation promotes the production of Th2-type cytokines by naive murine T cells via an IL-4-dependent mechanism...
  6. ncbi request reprint ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse
    E J Allenspach
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Immunity 15:739-50. 2001
    ..These results indicate that ERM proteins organize a complex distal to the T cell/APC interaction site and provide evidence that full T cell activation may involve removal of inhibitory proteins from the immunological synapse...
  7. ncbi request reprint CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance
    T L Walunas
    Ben May Institute, University of Chicago, IL 60637, USA
    J Immunol 156:1006-13. 1996
    ..Therefore, it appears that CD28, although not essential for the selection of T cells during development, may allow for additional signals that increase the efficiency of selection and/or expansion of peripheral T cell populations...
  8. ncbi request reprint Absence of B7-dependent responses in CD28-deficient mice
    J M Green
    Department of Medicine, University of Chicago, Illinois 60637
    Immunity 1:501-8. 1994
    ..Furthermore, our data suggest that CD28 is the primary, and perhaps exclusive, costimulatory receptor used by traditional antigen-presenting cells to augment the proliferation of antigen-activated T cells...
  9. ncbi request reprint Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease
    A G Tesciuba
    Committee on Immunology and Section of Pulmonary and Critical Care, Department of Medicine, and Ben May Institute for Cancer Research, University of Chicago, Chicago, IL, 60637, USA
    J Immunol 167:1996-2003. 2001
    ..Thus, blockade of ICOS signaling can significantly reduce airway inflammation without affecting Th2 differentiation in this model of allergic airway disease...
  10. pmc CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation
    J L Cannon
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Mol Biol Cell 22:954-63. 2011
    ..These results show that while CD43 binding to ERM proteins is crucial for S76 phosphorylation, CD43 movement and regulation of T-cell migration can occur through an ERM-independent, phosphorylation-dependent mechanism...
  11. pmc CD43 is a murine T cell costimulatory receptor that functions independently of CD28
    A I Sperling
    Ben May Institute, University of Chicago, Chicago, Illinois 60637, USA
    J Exp Med 182:139-46. 1995
    ..Expression cloning of the R2/60 antigen identified the ligand as murine CD43. Together, these data demonstrate that CD43 can serve as a receptor on T cells that can provide CD28-independent costimulation...
  12. ncbi request reprint Repertoire development and ligand specificity of murine TCR gamma delta cells
    J A Bluestone
    Department of Pathology, University of Chicago, IL 60637
    Immunol Rev 120:5-33. 1991
    ..In summary, these studies provides a basis for understanding and determining the ligand(s) of the TCR gamma delta heterodimer and the factors which shape the peripheral TCR gamma delta repertoire...
  13. ncbi request reprint Characterization of monoclonal antibodies specific for 14-kDa human group V secretory phospholipase A2 (hVPLA2)
    N M Munoz
    Department of Medicine, The University of Chicago, IL 60637, USA
    Hybridoma 19:171-6. 2000
    ..Although specific for hVPLA2, a relatively modest signal was recognized with MCL-1B7 and MCL-2A5. These newly developed MAbs allow for determination of tissue distribution and cell-specific functions of hVPLA2...
  14. pmc RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation
    K Rajagopal
    Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    J Exp Med 190:1657-68. 1999
    ..These data suggest that RIBP plays an important role in TCR-mediated signal transduction pathways and that its binding to Itk and Rlk/Txk may regulate T cell differentiation...
  15. ncbi request reprint CD4+ T cell and eosinophil adhesion is mediated by specific ICAM-3 ligation and results in eosinophil activation
    I S Douglas
    Department of Medicine, University of Chicago, IL 60637, USA
    J Immunol 164:3385-91. 2000
    ..We demonstrate that eosinophils and CD4+ T cells are capable of ligand-specific adhesion that is mediated predominantly by ICAM-3 ligation and that this binding causes augmented eosinophil secretion...
  16. ncbi request reprint Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen
    D J Lenschow
    Committee on Immunology, University of Chicago, IL 60637
    J Immunol 153:1990-7. 1994
    ..Thus, the effectiveness of Ag-specific B cells as APCs depends on both their enhanced Ag uptake, mediated by the B cell receptor, and immediate up-regulation of a potent costimulatory molecule, B7-2...
  17. ncbi request reprint CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation
    A I Sperling
    Ben May Institute, University of Chicago, IL 60637, USA
    J Immunol 157:3909-17. 1996
    ..Together, these results suggest that the unique role of CD28 signaling is not to costimulate the initial activation of naive T cells, but is, in fact, to sustain the late proliferative response and enhance long term cell survival...
  18. ncbi request reprint Expression of Fas (CD95) and FasL (CD95L) in human airway epithelium
    K J Hamann
    Section of Pulmonary and Critical Care Medicine, Division of Biological Sciences, University of Chicago, Chicago, Illinois, USA
    Am J Respir Cell Mol Biol 19:537-42. 1998
    ..We demonstrate that both Fas and FasL are expressed by human airway epithelial cell subtypes. Expression of these molecules may play an important role in regulation of the inflammatory response...
  19. ncbi request reprint Peripheral T cell receptor gamma delta variable gene repertoire maps to the T cell receptor loci and is influenced by positive selection
    A I Sperling
    Ben May Institute, University of Chicago, IL 60637
    J Immunol 149:3200-7. 1992
    ..Back-cross analysis confirmed that the TCR loci dominantly influenced the level of V delta 4+ cells and V gamma 2+ cells; however, there was clear evidence that multiple genes affect the TCR-gamma delta repertoire...