F A Spencer

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Heart failure and shock complicating acute coronary syndromes
    Frederick A Spencer
    Department of Internal Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Curr Cardiol Rep 7:276-82. 2005
  2. ncbi request reprint Asymptomatic thrombophilia--a family affair
    F A Spencer
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Thromb Haemost 3:457-8. 2005
  3. ncbi request reprint Heterogeneity in the management and outcomes of patients with acute myocardial infarction complicated by heart failure: the National Registry of Myocardial Infarction
    Frederick A Spencer
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Mass 01655, USA
    Circulation 105:2605-10. 2002
  4. ncbi request reprint Decade-long changes in the use of combination evidence-based medical therapy at discharge for patients surviving acute myocardial infarction
    Frederick A Spencer
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am Heart J 150:838-44. 2005
  5. ncbi request reprint Impact of aspirin on presentation and hospital outcomes in patients with acute coronary syndromes (The Global Registry of Acute Coronary Events [GRACE])
    Frederick A Spencer
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Am J Cardiol 90:1056-61. 2002
  6. ncbi request reprint Early withdrawal of statin therapy in patients with non-ST-segment elevation myocardial infarction: national registry of myocardial infarction
    Frederick A Spencer
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Arch Intern Med 164:2162-8. 2004
  7. ncbi request reprint Association of statin therapy with outcomes of acute coronary syndromes: the GRACE study
    Frederick A Spencer
    Department of Medicine Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Ann Intern Med 140:857-66. 2004
  8. ncbi request reprint Trends (1986 to 1999) in the incidence and outcomes of in-hospital stroke complicating acute myocardial infarction (The Worcester Heart Attack Study)
    Frederick A Spencer
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Cardiol 92:383-8. 2003
  9. ncbi request reprint Declining length of hospital stay for acute myocardial infarction and postdischarge outcomes: a community-wide perspective
    Frederick A Spencer
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, USA
    Arch Intern Med 164:733-40. 2004
  10. ncbi request reprint Use of combination evidence-based medical therapy prior to acute myocardial infarction (from the National Registry of Myocardial Infarction-4)
    Frederick A Spencer
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Am J Cardiol 96:922-6. 2005

Collaborators

Detail Information

Publications82

  1. ncbi request reprint Heart failure and shock complicating acute coronary syndromes
    Frederick A Spencer
    Department of Internal Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Curr Cardiol Rep 7:276-82. 2005
    ..This manuscript reviews recent insights from work in this area, including recent important trials evaluating the impact of renin-angiotensin system inhibition, early beta-blockade, and aggressive reperfusion strategies...
  2. ncbi request reprint Asymptomatic thrombophilia--a family affair
    F A Spencer
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Thromb Haemost 3:457-8. 2005
  3. ncbi request reprint Heterogeneity in the management and outcomes of patients with acute myocardial infarction complicated by heart failure: the National Registry of Myocardial Infarction
    Frederick A Spencer
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Mass 01655, USA
    Circulation 105:2605-10. 2002
    ..A secondary objective was to determine differences in demographic and clinical characteristics, treatment, and hospital death rates in patients presenting with HF compared with those developing HF after presentation...
  4. ncbi request reprint Decade-long changes in the use of combination evidence-based medical therapy at discharge for patients surviving acute myocardial infarction
    Frederick A Spencer
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am Heart J 150:838-44. 2005
    ....
  5. ncbi request reprint Impact of aspirin on presentation and hospital outcomes in patients with acute coronary syndromes (The Global Registry of Acute Coronary Events [GRACE])
    Frederick A Spencer
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Am J Cardiol 90:1056-61. 2002
    ....
  6. ncbi request reprint Early withdrawal of statin therapy in patients with non-ST-segment elevation myocardial infarction: national registry of myocardial infarction
    Frederick A Spencer
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Arch Intern Med 164:2162-8. 2004
    ..It has been suggested that withdrawal of statin therapy during an acute coronary syndrome may attenuate any benefits of pretreatment, thereby providing indirect evidence of the importance of their non-lipid-lowering effects...
  7. ncbi request reprint Association of statin therapy with outcomes of acute coronary syndromes: the GRACE study
    Frederick A Spencer
    Department of Medicine Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Ann Intern Med 140:857-66. 2004
    ..Statins administered early in patients with acute coronary syndromes may lead to modest reductions in recurrent ischemic events...
  8. ncbi request reprint Trends (1986 to 1999) in the incidence and outcomes of in-hospital stroke complicating acute myocardial infarction (The Worcester Heart Attack Study)
    Frederick A Spencer
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Cardiol 92:383-8. 2003
    ..26, 95% confidence interval 2.49 to 7.31). The results of this community-wide study provide insights into recent trends in the development of acute stroke after AMI and into the profile of high-risk patients...
  9. ncbi request reprint Declining length of hospital stay for acute myocardial infarction and postdischarge outcomes: a community-wide perspective
    Frederick A Spencer
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, USA
    Arch Intern Med 164:733-40. 2004
    ....
  10. ncbi request reprint Use of combination evidence-based medical therapy prior to acute myocardial infarction (from the National Registry of Myocardial Infarction-4)
    Frederick A Spencer
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Am J Cardiol 96:922-6. 2005
    ..In conclusion, data from this large national registry have indicated that most patients with a history of CAD were not receiving the recommended combination of cardiac medications before their AMI...
  11. pmc Upper extremity deep vein thrombosis: a community-based perspective
    Frederick A Spencer
    Department of Medicine, University of Massachusetts Medical School, Worcester, USA
    Am J Med 120:678-84. 2007
    ..The purpose of this study was to examine the magnitude, risk factors, management strategies, and outcomes in a population-based investigation of patients with upper, as compared with lower, extremity deep vein thrombosis diagnosed in 1999...
  12. ncbi request reprint Temporal trends and associated factors of inpatient cardiac rehabilitation in patients with acute myocardial infarction: a community-wide perspective
    F A Spencer
    Department of Medicine, University of Massachusetts Medical School, Worcester, 01655, USA
    J Cardiopulm Rehabil 21:377-84. 2001
    ..Inpatient CR often represents cardiac patients' first exposure to risk factor modification education and acts as a gateway to outpatient programs...
  13. ncbi request reprint Age and the utilization of cardiac catheterization following uncomplicated first acute myocardial infarction treated with thrombolytic therapy (The Second National Registry of Myocardial Infarction [NRMI-2])
    F A Spencer
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Cardiol 88:107-11. 2001
    ..The efficacy and cost effectiveness of this strategy in these patients has not yet been determined in clinical trials...
  14. pmc Factors associated with adverse outcomes in outpatients presenting with pulmonary embolism: the Worcester Venous Thromboembolism Study
    Frederick A Spencer
    Department of Medicine, McMaster University Medical Center, and Thrombosis and Atherosclerosis Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Circ Cardiovasc Qual Outcomes 3:390-4. 2010
    ..However, subjects enrolled in these studies may not be representative of patients seen in the community setting...
  15. ncbi request reprint Early assessment and in-hospital management of patients with acute myocardial infarction at increased risk for adverse outcomes: a nationwide perspective of current clinical practice. The National Registry of Myocardial Infarction (NRMI-2) Participants
    R C Becker
    Cardiovascular Thrombosis Research Center, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    Am Heart J 135:786-96. 1998
    ....
  16. doi request reprint Antithrombotic drugs in coronary artery disease: risk benefit ratio and bleeding
    S Schulman
    Department of Medicine, McMaster University and Henderson Research Center, Hamilton, ON, Canada
    J Thromb Haemost 8:641-50. 2010
    ..However, as the patient slowly stabilizes after appropriate interventions, it is necessary to de-escalate the treatment in accordance with decreasing net benefit of prolonged combination therapy...
  17. ncbi request reprint Fatal cardiac rupture among patients treated with thrombolytic agents and adjunctive thrombin antagonists: observations from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction 9 Study
    R C Becker
    Cardiovascular Thrombosis Research Center, University of Massachusetts Medical School, Worcester 01655 0214, USA
    J Am Coll Cardiol 33:479-87. 1999
    ..Unlike major hemorrhagic complications, there is no evidence that the intensity of anticoagulation associated with heparin or hirudin administration influences the occurrence of rupture...
  18. ncbi request reprint Early clinical outcomes and routine management of patients with non-ST-segment elevation myocardial infarction: a nationwide perspective
    R C Becker
    Division of Cardiovascular Medicine, University of Massachusetts Medical School, 55 Lake Ave N, Worcester, MA 01655, USA
    Arch Intern Med 161:601-7. 2001
    ..Despite its prevalence, the common demographic features, current hospital-based management, and short-term clinical outcome among patients with non-ST-segment elevation MI remain poorly defined...
  19. pmc A 30-year perspective (1975-2005) into the changing landscape of patients hospitalized with initial acute myocardial infarction: Worcester Heart Attack Study
    Kevin C Floyd
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Circ Cardiovasc Qual Outcomes 2:88-95. 2009
    ....
  20. ncbi request reprint Comparison of utilization of statin therapy at hospital discharge and six-month outcomes in patients with an acute coronary syndrome and serum low-density lipoprotein>or=100 mg/dl versus<100 mg/dl
    Frederick A Spencer
    Department of Medicine, McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada, and Coronary Care Unit, Concord Hospital, Sydney, Australia
    Am J Cardiol 100:913-8. 2007
    ....
  21. ncbi request reprint Treatment practices and outcomes of patients with established peripheral arterial disease hospitalized with acute myocardial infarction in a community setting
    Frederick A Spencer
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Am Heart J 153:140-6. 2007
    ..The objectives of our population-based study were to examine the hospital and long-term outcomes, as well as the use of different treatment practices, among patients with established PAD who were hospitalized with AMI...
  22. ncbi request reprint Use of disease-modifying therapies in patients hospitalized with heart failure: a population-based perspective
    Robert J Goldberg
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Mass, USA
    Am J Med 120:98.e1-8. 2007
    ..The purpose of our study was to describe the use of different cardiac medications in 2463 patients with new-onset HF who were discharged from all greater Worcester, Massachusetts, hospitals during 2000...
  23. ncbi request reprint Influence of patient characteristics and renal function on factor Xa inhibition pharmacokinetics and pharmacodynamics after enoxaparin administration in non-ST-segment elevation acute coronary syndromes
    Richard C Becker
    Cardiovascular Thrombosis Research Center, Division of Cardiology, University of Massachusetts Medical School, Boston 01655, USA
    Am Heart J 143:753-9. 2002
    ..Although emerging data suggest that low-molecular weight preparations offer distinct advantages over unfractionated heparin, limited information on patient-related factors that may influence dosing, safety, and efficacy is available...
  24. pmc Clinical features, treatment practices, and hospital and long-term outcomes of older patients hospitalized with decompensated heart failure: The Worcester Heart Failure Study
    Jane S Saczynski
    Department of Medicine, Division of GeriatricMedicine, University of Massachusetts Medical School, Biotech Four, Suite 315, 377 Plantation Street, Worcester, MA 01605, USA
    J Am Geriatr Soc 57:1587-94. 2009
    ..To examine age-specific differences in clinical presentation, receipt of therapeutic practices and lifestyle recommendations, and hospital and long-term survival in patients hospitalized for acute heart failure HF...
  25. ncbi request reprint Seasonal distribution of acute myocardial infarction in the second National Registry of Myocardial Infarction
    F A Spencer
    Cardiovascular Thrombosis Research Center, Department of Medicine, University of Massachusetts Medical Center, Worcester 01655, USA
    J Am Coll Cardiol 31:1226-33. 1998
    ..This observational study sought to determine whether cases of acute myocardial infarction (AMI) reported to the second National Registry of Myocardial Infarction (NRMI-2) varied by season...
  26. ncbi request reprint Thrombin generation after the abrupt cessation of intravenous unfractionated heparin among patients with acute coronary syndromes: potential mechanisms for heightened prothrombotic potential
    R C Becker
    Cardiovascular Thrombosis Research Center, Laboratory for Vascular Biology Research, University of Massachusetts Medical School, Worcester 01655, USA
    J Am Coll Cardiol 34:1020-7. 1999
    ..v.) unfractionated heparin among patients with acute coronary syndromes...
  27. ncbi request reprint Changes over time in the use of aspirin in patients hospitalized with acute myocardial infarction (1975 to 1997): a population-based perspective
    Elizabeth A Jackson
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Mass 01655, USA
    Am Heart J 144:259-68. 2002
    ..The purpose of this study was to examine 2 decade-long trends in the use of aspirin and associated outcomes in patients hospitalized with acute myocardial infarction...
  28. ncbi request reprint Does comorbidity account for the excess mortality in patients with major bleeding in acute myocardial infarction?
    Frederick A Spencer
    Department of Medicine, McMaster University, Faculty of Health Sciences, 1200 Main St W, Hamilton, Canada, L8N 3Z5
    Circulation 116:2793-801. 2007
    ..Because these data are not generalizable to all patients with acute myocardial infarction, we sought to better understand the scope of this problem in a "real-world" setting...
  29. ncbi request reprint Two-decade-long trends (1975-1997) in the incidence, hospitalization, and long-term death rates associated with complete heart block complicating acute myocardial infarction: a community-wide perspective
    Frederick A Spencer
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Mass 01655, USA
    Am Heart J 145:500-7. 2003
    ..Limited population-based data exist describing recent, and changes with time therein, incidence and case-fatality rates associated with CHB complicating AMI...
  30. pmc Venous thromboembolism in the elderly. A community-based perspective
    Frederick A Spencer
    Department of Medicine, McMaster University Faculty of Health Sciences, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Thromb Haemost 100:780-8. 2008
    ..These decisions must be tempered by our observation that major bleeding occurs frequently in these patients...
  31. ncbi request reprint Low molecular weight heparin and unfractionated heparin in the early pharmacologic management of acute coronary syndromes: a meta-analysis of randomized clinical trials
    M T Le Nguyen
    Cardiovascular Thrombosis Research Center, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Thromb Thrombolysis 12:289-95. 2001
    ..The superiority of LMWH preparations characterized by high in vitro factor Xa to thrombin inhibitory capacity is supported by clinic trial data but requires further investigation...
  32. pmc Thirty-year trends (1975-2005) in the magnitude and hospital death rates associated with complete heart block in patients with acute myocardial infarction: a population-based perspective
    Hoa L Nguyen
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am Heart J 156:227-33. 2008
    ....
  33. pmc The Worcester Venous Thromboembolism study: a population-based study of the clinical epidemiology of venous thromboembolism
    Frederick A Spencer
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    J Gen Intern Med 21:722-7. 2006
    ..While there have been marked advances in diagnostic and therapeutic strategies for venous thromboembolism, our understanding of its clinical epidemiology is based on studies conducted more than a decade ago...
  34. ncbi request reprint Enoxaparin, a low molecular weight heparin, inhibits platelet-dependent prothrombinase assembly and activity by factor-Xa neutralization
    F A Spencer
    Cardiovascular Thrombosis Research Center, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01685, USA
    J Thromb Thrombolysis 9:223-8. 2000
    ....
  35. ncbi request reprint Incidence and hospital death rates associated with heart failure: a community-wide perspective
    Robert J Goldberg
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Med 118:728-34. 2005
    ....
  36. ncbi request reprint Increasing use of single and combination medical therapy in patients hospitalized for acute myocardial infarction in the 21st century: a multinational perspective
    Robert J Goldberg
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, 55 Lake Ave, Worcester, MA 01655, USA
    Arch Intern Med 167:1766-73. 2007
    ..Current practice guidelines recommend the routine use of several effective cardiac medications in hospital survivors of acute myocardial infarction (AMI)...
  37. pmc Thirty-year trends (1975-2005) in the magnitude, patient characteristics, and hospital outcomes of patients with acute myocardial infarction complicated by ventricular fibrillation
    Robert J Goldberg
    Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Am J Cardiol 102:1595-601. 2008
    ..In conclusion, our results indicate that the incidence and hospital death rates associated with VF have decreased during recent years...
  38. doi request reprint Thrombocytopenia in patients with an acute coronary syndrome (from the Global Registry of Acute Coronary Events [GRACE])
    Joel M Gore
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Am J Cardiol 103:175-80. 2009
    ..3% being HIT. Regardless of whether patients had clinically recognized HIT, GAT, or other thrombocytopenia, all 3 groups had significantly higher rates of major bleeding, recurrent infarction, stroke, and death...
  39. pmc Thirty-year trends (1975 to 2005) in the magnitude of, management of, and hospital death rates associated with cardiogenic shock in patients with acute myocardial infarction: a population-based perspective
    Robert J Goldberg
    Department of Medicine, University of Massachusetts Medical School, Worcester, 01655, USA
    Circulation 119:1211-9. 2009
    ....
  40. pmc Venous thromboembolism and bleeding in a community setting. The Worcester Venous Thromboembolism Study
    Frederick A Spencer
    McMaster University, Medical Centre, 1200 Main Street West, HSC 3X28, Hamilton, Ontario L8N 3Z5, Canada
    Thromb Haemost 101:878-85. 2009
    ..Future study of antithrombotic strategies for VTE should be informed by this finding. Advances that result in decreased bleeding rates may paradoxically decrease the risk of VTE recurrence...
  41. ncbi request reprint Use of heparins in Non-ST-elevation acute coronary syndromes
    Joel M Gore
    University of Massachusetts Medical School, Worcester, Mass 01655, USA
    Am J Med 120:63-71. 2007
    ..We describe the use of antithrombotic therapy in the management of patients with acute coronary syndromes...
  42. ncbi request reprint Long-term trends in the use of coronary reperfusion strategies in acute myocardial infarction: a community-wide perspective
    Robert J Goldberg
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Thromb Thrombolysis 23:163-71. 2007
    ....
  43. pmc Long-term trends (1986-2003) in the use of coronary reperfusion strategies in patients hospitalized with acute myocardial infarction in central Massachusetts
    Robert J Goldberg
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Int J Cardiol 131:83-9. 2008
    ..Limited contemporary data are available about changing trends in the use of coronary reperfusion strategies, particularly from a population-based perspective...
  44. pmc Declining length of stay for patients hospitalized with AMI: impact on mortality and readmissions
    Jane S Saczynski
    University of Massachusetts Medical School, Worcester, MA, USA
    Am J Med 123:1007-15. 2010
    ....
  45. doi request reprint Temporal trend of in-hospital major bleeding among patients with non ST-elevation acute coronary syndromes
    Basem Elbarouni
    Terrence Donnelly Heart Centre, St Michael s Hospital, University of Toronto, Ontario, Canada
    Am Heart J 160:420-7. 2010
    ..We sought to determine the temporal trend of in-hospital major bleeding among patients with NSTE-ACS, in relation to the evolving management pattern...
  46. ncbi request reprint Trends in mortality attributed to heart failure in Worcester, Massachusetts, 1992 to 2001
    Robert J Goldberg
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Cardiol 95:1324-8. 2005
    ..The results of this study suggest changing patterns in death rates due to HF in a large northeastern community...
  47. ncbi request reprint A 25-year perspective into the changing landscape of patients hospitalized with acute myocardial infarction (the Worcester Heart Attack Study)
    Robert J Goldberg
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Cardiol 94:1373-8. 2004
    ..Given the magnitude of AMI and evolving approaches to manage it, continued monitoring of these trends remains of considerable clinical and public health importance...
  48. ncbi request reprint Use of nonpharmacologic treatment approaches in patients with heart failure
    Robert J Goldberg
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, 55 Lake Avenue North Worcester, MA 01655, United States
    Int J Cardiol 110:348-53. 2006
    ....
  49. doi request reprint D-dimer testing in pregnant patients: towards determining the next 'level' in the diagnosis of deep vein thrombosis
    W S Chan
    Department of Medicine, Women s College Hospital, Toronto, ON, USA
    J Thromb Haemost 8:1004-11. 2010
    ..We hypothesized that the specificity of sensitive D-dimer assays could be improved without compromising sensitivity by using higher D-dimer cut-off values...
  50. doi request reprint Temporal trends and patterns of early clopidogrel use across the spectrum of acute coronary syndromes
    Rajeev V Rao
    Terrence Donnelly Heart Centre, St Michael s Hospital, University of Toronto, and The Canadian Heart Research Centre, Ontario, Canada
    Am Heart J 157:642-50.e1. 2009
    ..The objective of this study was to examine the temporal trends and patterns of early clopidogrel use (within the first 24 hours of hospitalization) across the spectrum of patients with ACS in Canada...
  51. pmc Trends in prehospital delay in patients with acute myocardial infarction (from the Worcester Heart Attack Study)
    Jane S Saczynski
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Am J Cardiol 102:1589-94. 2008
    ..In conclusion, results of this population-based study suggest that a large proportion of patients with AMI continue to show prolonged prehospital delay...
  52. pmc A population-based study of inferior vena cava filters in patients with acute venous thromboembolism
    Frederick A Spencer
    Department of Medicine, Divisions of Cardiology and Hematology Thrombosis, Faculty of Health Sciences, McMaster University, 1200 Main St W, Hamilton, ON L8N 3Z5, Canada
    Arch Intern Med 170:1456-62. 2010
    ....
  53. pmc Symptom presentation in patients hospitalized with acute heart failure
    Robert J Goldberg
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Clin Cardiol 33:E73-80. 2010
    ....
  54. pmc Epidemiology of decompensated heart failure in a single community in the northeastern United States
    Robert J Goldberg
    Department of Medicine, University of Massachusetts, Medical School, Worcester, Massachusetts, USA
    Am J Cardiol 104:377-82. 2009
    ....
  55. pmc Incidence rates, clinical profile, and outcomes of patients with venous thromboembolism. The Worcester VTE study
    Frederick A Spencer
    Department of Medicine, McMaster University Faculty of Health Sciences, 1200 Main Street West, Hamilton, ON, L8N3Z5, Canada
    J Thromb Thrombolysis 28:401-9. 2009
    ..Whether these changes will result in future declines in VTE incidence and/or improved outcomes in the community setting will require further surveillance...
  56. ncbi request reprint Plasmin-mediated proteolysis of vascular endothelial cell heparin releasable tissue factor pathway inhibitor
    You Fu Li
    Cardiovascular Thrombosis Research Center, Laboratory for Vascular Biology Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Thromb Thrombolysis 15:19-23. 2003
    ..Fibrinolytic therapy represents a widely available and effective treatment modality for ST segment elevation myocardial infarction (MI). Its overall benefit is attenuated by a high incidence of coronary arterial reocclusion...
  57. ncbi request reprint A review of the oral direct thrombin inhibitor ximelagatran: not yet the end of the warfarin era
    Robert Mohapatra
    Department of Internal Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am Heart J 150:19-26. 2005
    ..The potential benefit that may be achieved by the replacement of these historically problematic narrow therapeutic index agents must be weighed against as yet undetermined long-term risks of hepatotoxicity...
  58. pmc Venous thromboembolism in the outpatient setting
    Frederick A Spencer
    Department of Medicine, University of Massachusetts Medical School, Worcester, USA
    Arch Intern Med 167:1471-5. 2007
    ..The purposes of this observational study were to describe the frequency of VTEs occurring in the outpatient setting, characterize the prevalence of previously identified risk factors for VTE, and identify previous use of VTE prophylaxis...
  59. ncbi request reprint Comparative efficacy of fibrinogen and platelet supplementation on the in vitro reversibility of competitive glycoprotein IIb/IIIa (alphaIIb/beta3) receptor-directed platelet inhibition
    Y F Li
    Cardiovascular Thrombosis Research Center, Laboratory for Vascular Biology Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am Heart J 142:204-10. 2001
    ....
  60. doi request reprint The relationship between unprovoked venous thromboembolism, age, and acute myocardial infarction
    F A Spencer
    Department of Medicine, McMaster University Medical Center, Hamilton, ON, Canada
    J Thromb Haemost 6:1507-13. 2008
    ..However, the nature and clinical significance of this association remain unclear, particularly as it relates to age of presentation...
  61. ncbi request reprint Comparative efficacy of fibrinogen and platelet supplementation on the in vitro reversibility of competitive glycoprotein IIb/IIIa receptor-directed platelet inhibition
    You Fu Li
    Cardiovascular Thrombosis Research Center, Laboratory for Vascular Biology Research, University of Massachusetts Medical School, Worcester, Mass 01655, USA
    Am Heart J 143:725-32. 2002
    ....
  62. ncbi request reprint Predicting deep venous thrombosis in pregnancy: out in "LEFt" field?
    Wee Shian Chan
    Department of Medicine, Women s College Hospital, Toronto, Ontario, Canada
    Ann Intern Med 151:85-92. 2009
    ..Pretest probability assessment for DVT diagnosis has never been evaluated in pregnant women...
  63. ncbi request reprint Long-term survival after heart failure: a contemporary population-based perspective
    Robert J Goldberg
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Arch Intern Med 167:490-6. 2007
    ..Despite the considerable prevalence of HF in the United States, there are limited published data describing the contemporary long-term prognosis of patients hospitalized with decompensated HF...
  64. pmc A community-wide perspective into changing trends in the utilization of diagnostic and interventional procedures in patients hospitalized with acute myocardial infarction
    Jessica Hahn
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Am Heart J 153:594-605. 2007
    ..We examined the demographic and clinical characteristics of patients who received these diagnostic and interventional procedures and determined whether the profile of patients undergoing these procedures had changed over time...
  65. pmc Twenty-year trends in the incidence of stroke complicating acute myocardial infarction: Worcester Heart Attack Study
    Jane S Saczynski
    Division of Geriatric Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Arch Intern Med 168:2104-10. 2008
    ..Trends in the magnitude of stroke in the setting of AMI are not well characterized, however, and neither have contemporary trends in the hospital death rates of patients developing acute stroke been examined...
  66. doi request reprint Bleeding risk in randomized controlled trials comparing warfarin and aspirin: a systematic review and meta-analysis
    A E Warkentin
    Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    J Thromb Haemost 10:512-20. 2012
    ..Warfarin and aspirin (acetylsalicylic acid [ASA]) are the most commonly used anticoagulant and antiplatelet drugs in the treatment of cardiovascular disease...
  67. pmc Patient outcomes after deep vein thrombosis and pulmonary embolism: the Worcester Venous Thromboembolism Study
    Frederick A Spencer
    Department of Medicine, McMaster University, Faculty of Health Sciences and Blood Institute, Hamilton, ON, Canada
    Arch Intern Med 168:425-30. 2008
    ..The purpose of this study was to measure and compare clinical characteristics and outcomes of patients with validated symptomatic PE and isolated DVT in a New England community...
  68. ncbi request reprint Risk factors for venous thromboembolism
    Frederick A Anderson
    Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Circulation 107:I9-16. 2003
    ..Nevertheless, individual risk factors, or combinations thereof, can have important implications for the type and duration of appropriate prophylaxis and should be carefully reviewed to assess the overall risk of VTE in each patient...
  69. ncbi request reprint Comparative effects of unfractionated heparin and low molecular weight heparin on vascular endothelial cell tissue factor pathway inhibitor release: a model for assessing intrinsic thromboresistance
    Youfu Li
    Laboratory for Vascular Biology Research, Cardiovascular Thrombosis Research Center, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Thromb Thrombolysis 14:123-9. 2002
    ....
  70. ncbi request reprint Changing trends in the long-term prognosis of patients with acute myocardial infarction: a population-based perspective
    Naomi F Botkin
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am Heart J 151:199-205. 2006
    ..The purpose of our study was to examine recent and multidecade-long (1975-2001) trends in the long-term prognosis of greater Worcester (MA) residents discharged from all metropolitan Worcester hospitals after confirmed AMI...
  71. doi request reprint Prehospital Delay in Patients With Acute Coronary Syndromes (from the Global Registry of Acute Coronary Events [GRACE])
    Robert J Goldberg
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Am J Cardiol 103:598-603. 2009
    ..In conclusion, results of this large multinational registry provided insights into contemporary patterns of care-seeking behavior in patients with acute coronary disease...
  72. pmc Delays in seeking medical care in hospitalized patients with decompensated heart failure
    Robert J Goldberg
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am J Med 121:212-8. 2008
    ....
  73. ncbi request reprint Effect of statin use within the first 24 hours of admission for acute myocardial infarction on early morbidity and mortality
    Gregg C Fonarow
    The Ahmanson UCLA Cardiomyopathy Center, UCLA Division of Cardiology, Los Angeles, California, USA
    Am J Cardiol 96:611-6. 2005
    ..0001). In conclusion, the use of statin therapy within the first 24 hours of hospitalization for AMI is associated with a significantly lower rate of early complications and in-hospital mortality...
  74. ncbi request reprint Treating patients with acute coronary syndromes with aggressive antiplatelet therapy (from the Global Registry of Acute Coronary Events)
    Michael J Lim
    Saint Louis University, St Louis, Missouri, USA
    Am J Cardiol 96:917-21. 2005
    ..Although no differences in hospital death rates were evident in patients receiving triple therapy, this population was at significantly increased risk of major bleeding episodes during hospitalization...
  75. ncbi request reprint Impact of combined pharmacologic treatment with clopidogrel and a statin on outcomes of patients with non-ST-segment elevation acute coronary syndromes: perspectives from a large multinational registry
    Michael J Lim
    Division of Cardiology, School of Medicine, Saint Louis University, St Louis, MO, USA
    Eur Heart J 26:1063-9. 2005
    ..To evaluate clinical outcomes associated with the combined use of clopidogrel and statins vs. clopidogrel alone on a background of aspirin therapy in patients with the spectrum of acute coronary syndromes (ACS)...
  76. ncbi request reprint Decompensated heart failure in the setting of kidney dysfunction: a community-wide perspective
    Rovshan M Ismailov
    Department of Community Health, Brown University, Providence, RI, USA
    Nephron Clin Pract 107:c147-55. 2007
    ....
  77. ncbi request reprint Magnitude of and risk factors for in-hospital and postdischarge stroke in patients with acute coronary syndromes: findings from a Global Registry of Acute Coronary Events
    Andrzej Budaj
    Postgraduate Medical School, Grochowski Hospital, Grenadierow 51 59, 04 073 Warsaw, Poland
    Circulation 111:3242-7. 2005
    ..This study examined the incidence and outcomes of hemorrhagic and nonhemorrhagic stroke and risk factors associated with stroke in patients with ACS...
  78. ncbi request reprint When guidelines collide
    Frederick A Spencer
    Am Heart J 147:395-7. 2004
  79. ncbi request reprint Venous thromboembolism prophylaxis in acutely ill hospitalized medical patients: findings from the International Medical Prevention Registry on Venous Thromboembolism
    Victor F Tapson
    Division of Pulmonary and Critical Care, Box 31175, Room 351 Bell Building, Duke University Medical Center, Durham, NC 27710, USA
    Chest 132:936-45. 2007
    ..Our aim was to characterize the clinical practices for VTE prophylaxis in acutely ill hospitalized medical patients enrolled in the International Medical Prevention Registry on Venous Thromboembolism (IMPROVE)...
  80. ncbi request reprint Thromboepidemiology: identifying patients with heritable risk for thrombin-mediated thromboembolic events
    Maichi Tran
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Mass 01655, USA
    Am Heart J 149:S9-18. 2005
  81. ncbi request reprint Combined coagulation phase-directed factor Xa inhibition with heparin compounds and DX-9065a - a direct and selective antagonist
    Richard C Becker
    Thromb Haemost 92:1229-31. 2004
  82. ncbi request reprint Circadian variations in acute myocardial infarction: patients or health care delivery?
    Frederick A Spencer
    J Am Coll Cardiol 41:2143-6. 2003