Marc Spehr

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi Odorant receptors and olfactory-like signaling mechanisms in mammalian sperm
    Marc Spehr
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Cell Endocrinol 250:128-36. 2006
  2. ncbi Essential role of the main olfactory system in social recognition of major histocompatibility complex peptide ligands
    Marc Spehr
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 26:1961-70. 2006
  3. ncbi Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis
    Marc Spehr
    Department of Anatomy and Neurobiology, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 279:40194-203. 2004
  4. ncbi Pheromonal recognition memory induced by TRPC2-independent vomeronasal sensing
    Kevin R Kelliher
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore MD 21201, USA
    Eur J Neurosci 23:3385-90. 2006
  5. ncbi One neuron--multiple receptors: increased complexity in olfactory coding?
    Marc Spehr
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA
    Sci STKE 2005:pe25. 2005
  6. ncbi The tuning properties of antennal lobe projection neurons
    Jason Aungst
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 25:10339-40. 2005
  7. ncbi A potential role of odorant receptor agonists and antagonists in the treatment of infertility and contraception
    Marc Spehr
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA
    Curr Opin Investig Drugs 6:364-8. 2005
  8. ncbi 3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons
    Marc Spehr
    Department of Cell Physiology, Ruhr University Bochum, Bochum, Germany
    Neuron 33:731-9. 2002
  9. ncbi Dual capacity of a human olfactory receptor
    Marc Spehr
    Curr Biol 14:R832-3. 2004
  10. ncbi hOR17-4 as a potential therapeutic target
    Marc Spehr
    Department of Cell Physiology, Ruhr-University Bochum, Bochum, Germany
    Drug News Perspect 17:165-71. 2004

Collaborators

Detail Information

Publications16

  1. ncbi Odorant receptors and olfactory-like signaling mechanisms in mammalian sperm
    Marc Spehr
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Cell Endocrinol 250:128-36. 2006
    ..Further insight into the basic principles that govern sperm OR operation as well as into the molecular logic that underlies OR-mediated signaling could set the stage for pioneering future applications in procreation and/or contraception...
  2. ncbi Essential role of the main olfactory system in social recognition of major histocompatibility complex peptide ligands
    Marc Spehr
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 26:1961-70. 2006
    ..These results suggest a general role for MHC peptides in chemical communication even in those vertebrates that lack a functional VNO...
  3. ncbi Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis
    Marc Spehr
    Department of Anatomy and Neurobiology, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 279:40194-203. 2004
    ..Particulate AC is therefore required for induction of hOR17-4-mediated human sperm behavior and represents a promising target for future design of contraceptive drugs...
  4. ncbi Pheromonal recognition memory induced by TRPC2-independent vomeronasal sensing
    Kevin R Kelliher
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore MD 21201, USA
    Eur J Neurosci 23:3385-90. 2006
    ..This indicates that a previously unrecognized TRPC2-independent signal transduction mechanism in the VNO underlies the sensing of cues required for the formation of this pheromonal recognition memory...
  5. ncbi One neuron--multiple receptors: increased complexity in olfactory coding?
    Marc Spehr
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA
    Sci STKE 2005:pe25. 2005
    ..However, recent reports regarding Drosophila have found exceptions to the rule that could have important implications for the logic of olfactory coding...
  6. ncbi The tuning properties of antennal lobe projection neurons
    Jason Aungst
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 25:10339-40. 2005
  7. ncbi A potential role of odorant receptor agonists and antagonists in the treatment of infertility and contraception
    Marc Spehr
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA
    Curr Opin Investig Drugs 6:364-8. 2005
    ....
  8. ncbi 3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons
    Marc Spehr
    Department of Cell Physiology, Ruhr University Bochum, Bochum, Germany
    Neuron 33:731-9. 2002
    ....
  9. ncbi Dual capacity of a human olfactory receptor
    Marc Spehr
    Curr Biol 14:R832-3. 2004
  10. ncbi hOR17-4 as a potential therapeutic target
    Marc Spehr
    Department of Cell Physiology, Ruhr-University Bochum, Bochum, Germany
    Drug News Perspect 17:165-71. 2004
    ....
  11. ncbi Identification of a testicular odorant receptor mediating human sperm chemotaxis
    Marc Spehr
    Department of Cell Physiology, Ruhr University Bochum, 150 University Street, D 44780 Bochum, Germany
    Science 299:2054-8. 2003
    ..In contrast, undecanal was a potent OR antagonist to bourgeonal and related compounds. Taken together, these results indicate that hOR17-4 functions in human sperm chemotaxis and may be a critical component of the fertilization process...
  12. ncbi Arachidonic acid plays a role in rat vomeronasal signal transduction
    Marc Spehr
    Department of Cell Physiology, Ruhr-University Bochum, 44780 Bochum, Germany
    J Neurosci 22:8429-37. 2002
    ..These data provide evidence for a role of PUFAs in rat vomeronasal signal transduction...
  13. ncbi Odorant-receptor interactions and odor percept: a chemical perspective
    Annika Triller
    Institut für Zellphysiologie, Ruhr Universitat, Universitatsstrasse 150, D 44780 Bochum
    Chem Biodivers 5:862-86. 2008
    ..Those seeking to understand the odorant-receptor interaction should use receptor activation rather than odor as input data...
  14. ncbi Subunit-specific P2X-receptor expression defines chemosensory properties of trigeminal neurons
    Jennifer Spehr
    Lehrstuhl fuer Zellphysiologie, Ruhr-Universitaet Bochum, Universitaetsstr. 150, 44780 Bochum, Germany
    Eur J Neurosci 19:2497-510. 2004
    ..Therefore, we assume a functional role for the newly identified subpopulation in chemodetection of certain trigeminal stimuli...
  15. ncbi Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping
    Stylianos Michalakis
    Department Pharmazie, Zentrum für Pharmaforschung, Ludwig Maximilians Universitüt München, D 81377 Munchen, Germany
    J Biol Chem 281:35156-66. 2006
    ..Second, together with the CNGA4 subunit, CNGB1 is needed for ciliary targeting of the olfactory CNG channel...
  16. ncbi Beta-arrestin2-mediated internalization of mammalian odorant receptors
    Anastasia Mashukova
    Cell Physiology, Ruhr Universitaet Bochum, 44780 Bochum, Germany
    J Neurosci 26:9902-12. 2006
    ....