Stephen Spector

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Factors impacting on drug choices. Issues for developing countries
    S A Spector
    University of California, San Diego, Department of Pediatrics, Center for Molecular Genetics and Center for AIDS Research, La Jolla, California 92093 0672, USA
    Ann N Y Acad Sci 918:346-50. 2000
  2. ncbi request reprint Lymphocyte subsets in healthy children from birth through 18 years of age: the Pediatric AIDS Clinical Trials Group P1009 study
    William T Shearer
    Baylor College of Medicine, Houston, Tex, USA
    J Allergy Clin Immunol 112:973-80. 2003
  3. ncbi request reprint The monocyte chemotactic protein-1 -2578G allele is associated with elevated MCP-1 concentrations in cerebrospinal fluid
    Scott Letendre
    Department of Medicine, The HIV Neurobehavioral Research Center, 150 West Washington Street, San Diego, CA 92103, USA
    J Neuroimmunol 157:193-6. 2004
  4. pmc Endothelial damage from cytomegalovirus-specific host immune response can be prevented by targeted disruption of fractalkine-CX3CR1 interaction
    Cynthia A Bolovan-Fritts
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, CA 92093 0672, USA
    Blood 111:175-82. 2008
  5. pmc Impact of nucleoside reverse transcriptase inhibitors on mitochondrial DNA and RNA in human skeletal muscle cells
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    Antimicrob Agents Chemother 52:2825-30. 2008
  6. pmc Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy
    Grant R Campbell
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, California, United States of America
    PLoS Pathog 8:e1002689. 2012
  7. pmc Toll-like receptor 8 ligands activate a vitamin D mediated autophagic response that inhibits human immunodeficiency virus type 1
    Grant R Campbell
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, California, United States of America
    PLoS Pathog 8:e1003017. 2012
  8. pmc Genetic variants in toll-like receptor 2 (TLR2), TLR4, TLR9, and FCγ receptor II are associated with antibody response to quadrivalent meningococcal conjugate vaccine in HIV-infected youth
    Stephen A Spector
    University of California, San Diego, La Jolla, CA, USA
    Clin Vaccine Immunol 20:900-6. 2013
  9. pmc APOE epsilon4 and MBL-2 O/O genotypes are associated with neurocognitive impairment in HIV-infected plasma donors
    Stephen A Spector
    Department of Pediatrics, University of California San Diego, La Jolla, California 92093 0672, USA
    AIDS 24:1471-9. 2010
  10. pmc Plasma cytomegalovirus (CMV) DNA load predicts CMV disease and survival in AIDS patients
    S A Spector
    University of California at San Diego, La Jolla, California 92093, USA
    J Clin Invest 101:497-502. 1998

Research Grants

  1. University of California, San Diego Clinical Trial Unit
    Stephen Spector; Fiscal Year: 2007
  2. PEDIATRIC AIDS CLINICAL TRIALS GROUP
    Stephen Spector; Fiscal Year: 2006
  3. Pediatric ACTG Coordinating and Operations Center
    Stephen Spector; Fiscal Year: 2005
  4. ADOLESCENT MEDICINE TRIALS UNIT (AMTU)
    Stephen Spector; Fiscal Year: 2005
  5. FACTORS IN PEDIATRIC AIDS TRANSMISSION AND PATHOGENESIS
    Stephen Spector; Fiscal Year: 2005
  6. FACTORS IN PEDIATRIC AIDS TRANSMISSION AND PATHOGENESIS
    Stephen Spector; Fiscal Year: 2004
  7. FACTORS IN PEDIATRIC AIDS TRANSMISSION AND PATHOGENESIS
    Stephen Spector; Fiscal Year: 2003
  8. FACTORS IN PEDIATRIC AIDS TRANSMISSION AND PATHOGENESIS
    Stephen Spector; Fiscal Year: 2002
  9. FACTORS IN PEDIATRIC AIDS TRANSMISSION AND PATHOGENESIS
    Stephen Spector; Fiscal Year: 2001
  10. PEDIATRIC AIDS--FACTORS IN TRANSMISSION AND PATHOLOGY
    Stephen Spector; Fiscal Year: 1999

Detail Information

Publications79

  1. ncbi request reprint Factors impacting on drug choices. Issues for developing countries
    S A Spector
    University of California, San Diego, Department of Pediatrics, Center for Molecular Genetics and Center for AIDS Research, La Jolla, California 92093 0672, USA
    Ann N Y Acad Sci 918:346-50. 2000
    ..It is only through a unified effort that we will be able to adequately treat all children infected with HIV regardless of where they might live...
  2. ncbi request reprint Lymphocyte subsets in healthy children from birth through 18 years of age: the Pediatric AIDS Clinical Trials Group P1009 study
    William T Shearer
    Baylor College of Medicine, Houston, Tex, USA
    J Allergy Clin Immunol 112:973-80. 2003
    ....
  3. ncbi request reprint The monocyte chemotactic protein-1 -2578G allele is associated with elevated MCP-1 concentrations in cerebrospinal fluid
    Scott Letendre
    Department of Medicine, The HIV Neurobehavioral Research Center, 150 West Washington Street, San Diego, CA 92103, USA
    J Neuroimmunol 157:193-6. 2004
    ..Our findings suggest that this MCP-1 promoter polymorphism influences HIV neuropathogenesis by regulating MCP-1 protein expression in the central nervous system (CNS)...
  4. pmc Endothelial damage from cytomegalovirus-specific host immune response can be prevented by targeted disruption of fractalkine-CX3CR1 interaction
    Cynthia A Bolovan-Fritts
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, CA 92093 0672, USA
    Blood 111:175-82. 2008
    ..These findings support CMV as a member of a class of persistent pathogens in which a high T-cell response and chemokine-mediated effects are a risk factor for development of chronic inflammation and endothelial cell injury...
  5. pmc Impact of nucleoside reverse transcriptase inhibitors on mitochondrial DNA and RNA in human skeletal muscle cells
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    Antimicrob Agents Chemother 52:2825-30. 2008
    ..These findings may be of particular importance in developing countries, where ddI is widely used for first-line treatment of HIV-infected children...
  6. pmc Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy
    Grant R Campbell
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, California, United States of America
    PLoS Pathog 8:e1002689. 2012
    ..tuberculosis-infected persons, and provide new insights into novel approaches to prevent and treat HIV infection and related opportunistic infections...
  7. pmc Toll-like receptor 8 ligands activate a vitamin D mediated autophagic response that inhibits human immunodeficiency virus type 1
    Grant R Campbell
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, California, United States of America
    PLoS Pathog 8:e1003017. 2012
    ..These findings also provide new insights into potential novel targets to prevent and treat HIV infection...
  8. pmc Genetic variants in toll-like receptor 2 (TLR2), TLR4, TLR9, and FCγ receptor II are associated with antibody response to quadrivalent meningococcal conjugate vaccine in HIV-infected youth
    Stephen A Spector
    University of California, San Diego, La Jolla, CA, USA
    Clin Vaccine Immunol 20:900-6. 2013
    ..001). These findings suggest that for HIV-infected youth, the initial antibody response to MCV4 is associated with variants in TLR2 and TLR4 while the long-term response is associated with genetic polymorphisms in TLR9 and FcγRIIa...
  9. pmc APOE epsilon4 and MBL-2 O/O genotypes are associated with neurocognitive impairment in HIV-infected plasma donors
    Stephen A Spector
    Department of Pediatrics, University of California San Diego, La Jolla, California 92093 0672, USA
    AIDS 24:1471-9. 2010
    ..This study examined associations of host genetic variants and neurocognitive impairment in Chinese individuals infected through contaminated blood products...
  10. pmc Plasma cytomegalovirus (CMV) DNA load predicts CMV disease and survival in AIDS patients
    S A Spector
    University of California at San Diego, La Jolla, California 92093, USA
    J Clin Invest 101:497-502. 1998
    ..001). These data indicate that the risk of developing CMV disease and death in persons with advanced AIDS is directly related to the quantity of CMV DNA in plasma, and is a better predictor than CD4+ lymphocyte count in this population...
  11. pmc Autophagy: an overlooked mechanism of HIV-1 pathogenesis and neuroAIDS?
    Stephen A Spector
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, California 92093 0672, USA
    Autophagy 4:704-6. 2008
    ..A model is presented that describes the potential role of autophagy in NeuroAIDS...
  12. pmc Cytomegalovirus (CMV) DNA load is an independent predictor of CMV disease and survival in advanced AIDS
    S A Spector
    Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
    J Virol 73:7027-30. 1999
    ..These data provide support for CMV as an independent risk factor for mortality in persons with advanced AIDS and further suggest that effective preemptive therapy for CMV can improve patient survival rates...
  13. ncbi request reprint Patterns of plasma human immunodeficiency virus type 1 RNA response to highly active antiretroviral therapy in infected children
    S A Spector
    Dept of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0672, USA
    J Infect Dis 182:1769-73. 2000
    ....
  14. pmc CYP2C19 genetic variants affect nelfinavir pharmacokinetics and virologic response in HIV-1-infected children receiving highly active antiretroviral therapy
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
    J Acquir Immune Defic Syndr 54:285-9. 2010
    ....
  15. ncbi request reprint Persistence of human immunodeficiency virus (HIV) type 1 DNA in peripheral blood despite prolonged suppression of plasma HIV-1 RNA in children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    J Infect Dis 185:1409-16. 2002
    ..Thus, despite prolonged maintenance of undetectable levels of plasma HIV-1 RNA, HIV-1 DNA remains detectable in PBMC of children and may be a useful marker of further virus suppression...
  16. ncbi request reprint Genetic influence of CCR5, CCR2, and SDF1 variants on human immunodeficiency virus 1 (HIV-1)-related disease progression and neurological impairment, in children with symptomatic HIV-1 infection
    Kumud K Singh
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, California 92093 0672, USA
    J Infect Dis 188:1461-72. 2003
    ..These data suggest that, in children, host genetics plays an important role in HIV-1-related disease progression and neurological impairment...
  17. ncbi request reprint An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    AIDS 19:371-80. 2005
    ..This research examined the impact of single nucleotide polymorphisms (SNP) of MDR1 and CYP genes on nelfinavir and efavirenz pharmacokinetics and the response to highly active antiretroviral therapy (HAART) in HIV-1 infected children...
  18. pmc Analyses of HIV-1 drug-resistance profiles among infected adolescents experiencing delayed antiretroviral treatment switch after initial nonsuppressive highly active antiretroviral therapy
    Allison Agwu
    Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins Medical Institution, Baltimore, Maryland, USA
    AIDS Patient Care STDS 22:545-52. 2008
    ..This finding may have implications for initial treatment regimens and transmission risk in HIV-infected youth, a group with rising infection rates...
  19. ncbi request reprint Genetic polymorphisms in CX3CR1 predict HIV-1 disease progression in children independently of CD4+ lymphocyte count and HIV-1 RNA load
    Kumud K Singh
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, California 92093 0672, USA
    J Infect Dis 191:1971-80. 2005
    ..The impact of CX3CR1 polymorphisms on human immunodeficiency virus type 1 (HIV-1) pathogenesis is controversial, with conflicting reports of their role in disease progression in HIV-1-infected adults...
  20. pmc Association of CD4+ T-lymphocyte counts and new thymic emigrants in HIV-infected children during successful highly active antiretroviral therapy
    Akihiko Saitoh
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla 92093 0672, USA
    J Allergy Clin Immunol 117:909-15. 2006
    ....
  21. pmc Associations of chemokine receptor polymorphisms With HIV-1 mother-to-child transmission in sub-Saharan Africa: possible modulation of genetic effects by antiretrovirals
    Kumud K Singh
    Department of Pediatrics, University of California San Diego, La Jolla, CA 92093 0672, USA
    J Acquir Immune Defic Syndr 49:259-65. 2008
    ..HIV-1 mother-to-child transmission (MTCT) remains an important route of infection in sub-Saharan Africa...
  22. ncbi request reprint Longitudinal analysis of lymphocyte ratios and HIV-1 intracellular DNA levels in children
    Akihiko Saitoh
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, California 92093 0672, USA
    J Infect Dis 189:1216-20. 2004
    ..These data suggest that the increased proportion of naive lymphocytes found in children are less susceptible to HIV-1 infection than are the memory lymphocytes that dominate immune reconstitution in adults...
  23. ncbi request reprint Undiagnosed respiratory viruses in children
    John C Arnold
    Division of Infectious Diseases, Department of Pediatrics, Center for AIDS Research, University of California, San Diego, California, USA
    Pediatrics 121:e631-7. 2008
    ..Using polymerase chain reaction, we sought to diagnose adenoviruses, human bocavirus, and human metapneumovirus at our children's hospital...
  24. pmc Antiretroviral treatment of US children with perinatally acquired HIV infection: temporal changes in therapy between 1991 and 2009 and predictors of immunologic and virologic outcomes
    Russell B Van Dyke
    Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, LA, USA
    J Acquir Immune Defic Syndr 57:165-73. 2011
    ..We sought to describe the disease status of a large cohort of such children and identify predictors of their current CD4 count and HIV viral load (VL)...
  25. ncbi request reprint Human bocavirus: prevalence and clinical spectrum at a children's hospital
    John C Arnold
    Department of Pediatrics, Division of Infectious Diseases and Center for AIDS Research, University of California, San Diego, CA 92123, USA
    Clin Infect Dis 43:283-8. 2006
    ..Human bocavirus (HBoV), a proposed member of the family Parvoviridae, is one of the most recently described respiratory viruses. Initial reports indicate that HBoV is a common cause of respiratory tract infection in children...
  26. ncbi request reprint Impact of pregnancy on abacavir pharmacokinetics
    Brookie M Best
    University of California San Diego, California 92103 8214, USA
    AIDS 20:553-60. 2006
    ..To describe abacavir pharmacokinetics during pregnancy and postpartum; physiological changes during pregnancy are known to affect antiretroviral drug disposition...
  27. pmc Lopinavir exposure with an increased dose during pregnancy
    Mark Mirochnick
    Department of Pediatrics, Boston University School of Medicine, and Infectious Disease Division, Children s Hospital Boston, Boston, MA 02118, USA
    J Acquir Immune Defic Syndr 49:485-91. 2008
    ..The goal of this study was to determine LPV exposure during the third trimester of pregnancy and 2 weeks postpartum with a higher LPV/RTV dose...
  28. pmc Migration and risk factors for HIV acquisition in pregnant women in Baja California, Mexico
    Roland M Viani
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, School of Medicine, San Diego, California, USA
    MedGenMed 7:69. 2005
  29. ncbi request reprint Prevalence of primary HIV-1 drug resistance among recently infected adolescents: a multicenter adolescent medicine trials network for HIV/AIDS interventions study
    Rolando M Viani
    University of California, San Diego School of Medicine, San Diego, La Jolla, CA 92093 0672, USA
    J Infect Dis 194:1505-9. 2006
    ..5%) for PIs. The prevalence of primary HIV-1 drug resistance, particularly to NNRTIs, in this group of recently infected youth was high...
  30. ncbi request reprint Efavirenz pharmacokinetics in HIV-1-infected children are associated with CYP2B6-G516T polymorphism
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0672, USA
    J Acquir Immune Defic Syndr 45:280-5. 2007
    ..The impact of CYP2B6-G516T polymorphisms on EFV concentrations may be different in children because of differences in liver maturation and drug dosage...
  31. pmc Impact of nucleoside reverse transcriptase inhibitors on mitochondria in human immunodeficiency virus type 1-infected children receiving highly active antiretroviral therapy
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    Antimicrob Agents Chemother 51:4236-42. 2007
    ..This may be of particular importance in resource-limited countries where didanosine is widely used for the treatment of HIV-infected children...
  32. ncbi request reprint Progression to neuropsychological impairment in human immunodeficiency virus infection predicted by elevated cerebrospinal fluid levels of human immunodeficiency virus RNA
    Ronald J Ellis
    HIV Neurobehavioral Research Center, University of California, San Diego, 150 W Washington St, 2nd Floor, San Diego, CA 92103, USA
    Arch Neurol 59:923-8. 2002
    ....
  33. ncbi request reprint CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    AIDS 21:2191-9. 2007
    ....
  34. ncbi request reprint Clinical outcomes after an unstructured treatment interruption in children and adolescents with perinatally acquired HIV infection
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0672, USA
    Pediatrics 121:e513-21. 2008
    ..The objective of this study was to investigate the actual prevalence and clinical outcomes of a treatment interruption in children and adolescents with perinatally acquired HIV-1 infection...
  35. pmc An age-dependent association of mannose-binding lectin-2 genetic variants on HIV-1-related disease in children
    Kumud K Singh
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, Calif 92093 0672, USA
    J Allergy Clin Immunol 122:173-80, 180.e1-2. 2008
    ..Mannose-binding lectin (MBL) is part of the lectin pathway of complement activation against various pathogens; however, its role in innate immune responses against HIV-1 infection in children is unknown...
  36. ncbi request reprint Perinatal HIV counseling and rapid testing in Tijuana, Baja California, Mexico: seroprevalence and correlates of HIV infection
    Rolando M Viani
    Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA 92093 0672, USA
    J Acquir Immune Defic Syndr 41:87-92. 2006
    ..To evaluate the acceptance of counseling and rapid HIV testing and to determine the associated risk factors for HIV infection in pregnant women in Baja California, Mexico...
  37. ncbi request reprint Mother-to-child HIV transmission in a cohort of pregnant women diagnosed by rapid HIV testing at Tijuana General Hospital, Baja California, Mexico
    Rolando M Viani
    Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA
    J Int Assoc Physicians AIDS Care (Chic) 9:82-6. 2010
    ..8; P < .001) among the prenatal care group. Five (50%) of the HIV-infected infants had an AIDS diagnosis and 2 (20%) died within 18 months of birth. Women diagnosed during labor had a high HIV MTCT and poor postnatal outcome...
  38. ncbi request reprint Human metapneumovirus associated with central nervous system infection in children
    John C Arnold
    Division of Infectious Diseases, Department of Pediatrics, Naval Medical Center, San Diego, CA, USA
    Pediatr Infect Dis J 28:1057-60. 2009
    ..hMPV is related to other paramyxoviruses known to cause encephalitis. Reports suggest that hMPV may cause disease of the central nervous system (CNS)...
  39. ncbi request reprint CCR2 polymorphisms affect neuropsychological impairment in HIV-1-infected adults
    Kumud K Singh
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    J Neuroimmunol 157:185-92. 2004
    ....
  40. ncbi request reprint Decrease in hospitalization and mortality rates among children with perinatally acquired HIV type 1 infection receiving highly active antiretroviral therapy
    Rolando M Viani
    Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093 0672, USA
    Clin Infect Dis 39:725-31. 2004
    ..This study aims to identify the effect of evolving antiretroviral therapy on the immunologic and virologic status of and hospitalization and mortality rates among perinatally infected children...
  41. pmc Lopinavir protein binding in HIV-1-infected pregnant women
    F T Aweeka
    Drug Research Unit, University of California, San Francisco, CA 94143 0622, USA
    HIV Med 11:232-8. 2010
    ..We report lopinavir (LPV) PB during third trimester (antepartum, AP) compared to > or =1.7 weeks postpartum (PP) to determine if FU changes compensate for reduced total concentrations reported previously...
  42. ncbi request reprint Population pharmacokinetics and pharmacodynamics of zidovudine in HIV-infected infants and children
    Edmund V Capparelli
    University of California, San Diego, School of Medicine, La Jolla, California, USA
    J Clin Pharmacol 43:133-40. 2003
    ..It was concluded that ZDV oral clearance is reduced in infants compared to older children. This lower clearance leads to higher ZDV exposure in infants and contributes to increased hematologic toxicity...
  43. ncbi request reprint Lack of protective effects of interleukin-4 -589-C/T polymorphism against HIV-1-related disease progression and central nervous system impairment, in children
    Kumud K Singh
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, CA 92093 0672, USA
    J Infect Dis 189:587-92. 2004
    ..Our findings suggest that the IL-4 -589-C/T polymorphism is not an important determinant of HIV-1 disease progression in children...
  44. pmc Host genetic determinants of human immunodeficiency virus infection and disease progression in children
    Kumud K Singh
    Department of Pediatrics, University of California, San Diego, La Jolla, California 92093, USA
    Pediatr Res 65:55R-63R. 2009
    ..In this review, we summarize available data on the impact of host genetics on MTCT and disease progression of HIV-infected children...
  45. ncbi request reprint Prevalence of chemokine and chemokine receptor polymorphisms in seroprevalent children with symptomatic HIV-1 infection in the United States
    Kumud K Singh
    Department of Pediatrics, Division of Infectious Diseases, University of California at San Diego, La Jolla 92093 0672, USA
    J Acquir Immune Defic Syndr 35:309-13. 2004
    ..These analyses show that the distribution of chemokine receptor and chemokine genetic polymorphisms varies significantly across race/ethnicity subgroups of HIV-1-infected children in the United States...
  46. ncbi request reprint Mitochondrial dysfunction: prevention of HIV-1 mother-to-infant transmission outweighs fear
    Stephen A Spector
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, CA, USA
    AIDS 20:1777-8. 2006
  47. pmc Metabolic abnormalities and viral replication are associated with biomarkers of vascular dysfunction in HIV-infected children
    T I Miller
    Department of Pediatrics, Division of Pediatric Clinical Research, Miller School of Medicine at the University of Miami, Miami, FL, USA
    HIV Med 13:264-75. 2012
    ....
  48. ncbi request reprint Long-term safety and efficacy of a once-daily regimen of emtricitabine, didanosine, and efavirenz in HIV-infected, therapy-naive children and adolescents: Pediatric AIDS Clinical Trials Group Protocol P1021
    Ross E McKinney
    Department of Pediatrics, Duke University Medical Center, Box 3461, Durham, NC 27710, USA
    Pediatrics 120:e416-23. 2007
    ..Compliance with complex antiretroviral therapy regimens is a problem for HIV-1-infected children and their families. Simple, safe, and effective regimens are important for long-term therapeutic success...
  49. pmc Disparities in antiretroviral treatment: a comparison of behaviorally HIV-infected youth and adults in the HIV Research Network
    Allison L Agwu
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 58:100-7. 2011
    ..We hypothesized that behaviorally HIV-infected youth (BIY) ages 18 to 24 years are less likely than adults (25 years or older) to receive HAART and, once initiated, more likely to discontinue their first HAART regimen...
  50. pmc Virologic and immunologic correlates with the magnitude of antibody responses to the hepatitis A vaccine in HIV-infected children on highly active antiretroviral treatment
    Adriana Weinberg
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    J Acquir Immune Defic Syndr 52:17-24. 2009
    ..We sought to identify the immunologic and virologic factors associated with a robust response to hepatitis A virus (HAV) vaccine in children on highly active antiretroviral treatment...
  51. pmc Safety and immunogenicity of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine in HIV-infected children 7 to 12 years old
    Myron J Levin
    Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO, USA
    J Acquir Immune Defic Syndr 55:197-204. 2010
    ..Quadrivalent human papillomavirus vaccine (QHPV) is > 95% effective in preventing infection with vaccine-type human papillomavirus. The safety and immunogenicity of QHPV are unknown in HIV-infected children...
  52. pmc Differential induction of interleukin-10 in monocytes by HIV-1 clade B and clade C Tat proteins
    Justine K Wong
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:18319-25. 2010
    ..These findings provide further evidence that HIV-1 clades differ in their biological properties that may impact HIV-1 pathogenesis and disease progression...
  53. pmc HIV-1 clade B Tat, but not clade C Tat, increases X4 HIV-1 entry into resting but not activated CD4+ T cells
    Grant R Campbell
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, California 92093 0672, USA
    J Biol Chem 285:1681-91. 2010
    ..Thus, B Tat, but not C Tat, has the capacity to render resting, but not activated, CD4+ T cells more susceptible to X4 HIV-1 infection...
  54. pmc CCL2 increases X4-tropic HIV-1 entry into resting CD4+ T cells
    Grant R Campbell
    Department of Pediatrics, University of California San Diego, La Jolla, California 92093 0672, USA
    J Biol Chem 283:30745-53. 2008
    ..Thus, CCL2 has the capacity to render a large population of lymphocytes more susceptible to HIV-1 late in the course of infection...
  55. pmc Human immunodeficiency virus type-1 infection inhibits autophagy
    Dejiang Zhou
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, California, 92093 0672, USA
    AIDS 22:695-9. 2008
    ..This research examined the impact of HIV-1 infection on autophagy in HIV-1 infected cells...
  56. ncbi request reprint Protease inhibitors and decreased birth weight in HIV-infected pregnant women with impaired glucose tolerance
    Ramen Chmait
    Department of Reproductive Medicine, University of California San Diego, La Jolla, CA, USA
    J Perinatol 22:370-3. 2002
    ..To assess the impact of highly active antiretroviral therapy, including a protease inhibitor (HAART/PI), on maternal glucose tolerance and fetal growth...
  57. ncbi request reprint HIV-1 gp120 modulates the immunological function and expression of accessory and co-stimulatory molecules of monocyte-derived dendritic cells
    Marc A Williams
    Division of Pediatric Infectious Diseases, University of California at San Diego, The School of Medicine, La Jolla 92093, USA
    J Hematother Stem Cell Res 11:829-47. 2002
    ..Consequently, HIV-1 gp120 may actively contribute to the immunopathogenesis of AIDS...
  58. ncbi request reprint Myelomeningocele in an infant with intrauterine exposure to efavirenz
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0672, USA
    J Perinatol 25:555-6. 2005
    ..Thus, we suggest that efavirenz only be prescribed for women of childbearing potential when no other comparable antiretroviral options are available...
  59. ncbi request reprint The C terminus of HIV-1 Tat modulates the extent of CD178-mediated apoptosis of T cells
    Grant R Campbell
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, California 92093 0672, USA
    J Biol Chem 280:38376-82. 2005
    ..Moreover, the greater 86-residue Tat-induced apoptosis is via the extrinsic pathway of CD95-CD178...
  60. pmc Incidence of noninfectious conditions in perinatally HIV-infected children and adolescents in the HAART era
    Sharon A Nachman
    Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, NY 11794 8111, USA
    Arch Pediatr Adolesc Med 163:164-71. 2009
    ....
  61. pmc Human immunodeficiency virus type 1 subtype C Tat fails to induce intracellular calcium flux and induces reduced tumor necrosis factor production from monocytes
    Grant R Campbell
    Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    J Virol 81:5919-28. 2007
    ..This report therefore demonstrates the important functional differences between subtype C and subtype B Tat and highlights the need for further investigation into the different strains of HIV-1...
  62. ncbi request reprint Long-term effects of protease-inhibitor-based combination therapy on CD4 T-cell recovery in HIV-1-infected children and adolescents
    Chang Heok Soh
    Department of Biostatistics, Harvard School of Public Health, MA, Boston 02115, USA
    Lancet 362:2045-51. 2003
    ..Better understanding might help to resolve questions on when to initiate treatment...
  63. ncbi request reprint HIV prevalence during pregnancy in Tijuana, Baja California, Mexico
    Rolando M Viani
    AIDS 17:1113-4. 2003
  64. ncbi request reprint Efavirenz liquid formulation in human immunodeficiency virus-infected children
    Stuart E Starr
    Division of Infectious and Immunologic Diseases, Abramson Research Center, The Children s Hospital of Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 21:659-63. 2002
    ....
  65. ncbi request reprint Relationship of plasma HIV-1 RNA dynamics to baseline factors and virological responses to highly active antiretroviral therapy in adolescents (aged 12-22 years) infected through high-risk behavior
    Hulin Wu
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Infect Dis 189:593-601. 2004
    ....
  66. pmc Intrapatient variability of efavirenz concentrations as a predictor of virologic response to antiretroviral therapy
    Richard C Brundage
    University of Minnesota, Minneapolis, Minnesota, USA
    Antimicrob Agents Chemother 48:979-84. 2004
    ..This novel method for the quantitation of intrapatient concentration variability was independently predictive of virologic rebound. This measure may allow interventions to minimize therapeutic failure and is applicable to other drugs...
  67. ncbi request reprint Immunologic function and virologic suppression among children with perinatally acquired HIV Infection on highly active antiretroviral therapy
    Richard M Rutstein
    Division of General Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Med Care 43:III15-22. 2005
    ..Limited data are available on the level of virologic suppression and immune function of pediatric patients followed in clinical settings in the HAART era...
  68. ncbi request reprint Virologic and immunologic outcomes after 24 weeks in HIV type 1-infected adolescents receiving highly active antiretroviral therapy
    Patricia M Flynn
    Department of Infectious Diseases, St Jude Children s Research Hospital, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    J Infect Dis 190:271-9. 2004
    ..Adolescents represent the fastest growing demographic group of new human immunodeficiency virus (HIV) infections in the United States. At present, there is little information available about their response to therapy...
  69. pmc Detection of replication-competent human immunodeficiency virus type 1 (HIV-1) in cultures from patients with levels of HIV-1 RNA in plasma suppressed to less than 500 or 50 copies per milliliter
    Lisa M Demeter
    University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Clin Microbiol 40:2089-94. 2002
    ..The delay in the time required for HIV cultures to turn positive should be considered when attempting to obtain an HIV isolate from patients with suppression of plasma viral load...
  70. pmc Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and counting
    Kunjal Patel
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Clin Infect Dis 46:1751-60. 2008
    ....
  71. pmc Pharmacokinetics and safety of nelfinavir when used in combination with zidovudine and lamivudine in HIV-infected pregnant women: Pediatric AIDS Clinical Trials Group (PACTG) Protocol 353
    Y J Bryson
    David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    HIV Clin Trials 9:115-25. 2008
    ..We studied the safety, antiviral effect, and pharmacokinetics of NFV and its M8 metabolite with two dosing regimens in combination with zidovudine (ZDV) and lamivudine (3TC) in HIV-infected pregnant women...
  72. pmc Association of hypercholesterolemia incidence with antiretroviral treatment, including protease inhibitors, among perinatally HIV-infected children
    Katherine Tassiopoulos
    Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 47:607-14. 2008
    ..Antiretroviral therapy has been associated with hypercholesterolemia in HIV-infected children. Few longitudinal studies have been conducted to examine this association, however...
  73. ncbi request reprint Long-term observation of adolescents initiating HAART therapy: three-year follow-up
    Patricia M Flynn
    Department of Infectious Diseases, St Jude Children s Research Hospital, University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA
    AIDS Res Hum Retroviruses 23:1208-14. 2007
    ..Interventions, especially those focused on adherence, are necessary to improve HAART outcomes in adolescents...
  74. ncbi request reprint Impact of MCP-1-2518-G allele on the HIV-1 disease of children in the United States
    Kumud K Singh
    AIDS 20:475-8. 2006
  75. ncbi request reprint Hospital and outpatient health services utilization among HIV-infected children in care 2000-2001
    Richard M Rutstein
    Division of General Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Med Care 43:III31-9. 2005
    ..The aging of the pediatric HIV cohort and advances in antiretroviral therapy for children may have resulted in recent changes in patterns of healthcare utilization...
  76. pmc Association of site-specific and participant-specific factors with retention of children in a long-term pediatric HIV cohort study
    Paige L Williams
    Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115 6017, USA
    Am J Epidemiol 167:1375-86. 2008
    ..Although participant characteristics are difficult to modify, the authors identified several potentially modifiable site practices that could be targeted to improve retention...
  77. ncbi request reprint Treatment of infants coinfected with HIV-1 and cytomegalovirus with combination antiretrovirals and ganciclovir
    Akihiko Saitoh
    J Allergy Clin Immunol 114:983-5. 2004
  78. pmc Comparison of molecular tests for detection and quantification of cell-associated cytomegalovirus DNA
    Angela M Caliendo
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Clin Microbiol 41:3509-13. 2003
    ..Extending the incubation time of the standard to 24 h increased the analytical sensitivity of the NucliSens test to 3.0 log(10) target cells...
  79. pmc Impaired lymphoid chemokine-mediated migration due to a block on the chemokine receptor switch in human cytomegalovirus-infected dendritic cells
    Magdalena Moutaftsi
    Section of Infection and Immunity Department of Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    J Virol 78:3046-54. 2004
    ....

Research Grants15

  1. University of California, San Diego Clinical Trial Unit
    Stephen Spector; Fiscal Year: 2007
    ..The UCSD CTU has been rated 4th among all sites applying to participate within the IMPAACT Network and has been identified as a "highly preferred site" by IMPAACT. ADMINISTRATIVE COMPONENT: ..
  2. PEDIATRIC AIDS CLINICAL TRIALS GROUP
    Stephen Spector; Fiscal Year: 2006
    ..abstract_text> ..
  3. Pediatric ACTG Coordinating and Operations Center
    Stephen Spector; Fiscal Year: 2005
    ..abstract_text> ..
  4. ADOLESCENT MEDICINE TRIALS UNIT (AMTU)
    Stephen Spector; Fiscal Year: 2005
    ..The experience of our team in HIV care, clinical trials and laboratory studies, we believe, will enable our group to make a significant contribution to the success of the ATN. ..
  5. FACTORS IN PEDIATRIC AIDS TRANSMISSION AND PATHOGENESIS
    Stephen Spector; Fiscal Year: 2005
    ..The findings of this research will provide an improved understanding of the pathogenesis of HIV-1 infection of children and perinatal transmission, and help to develop improved treatment/prevention strategies. ..
  6. FACTORS IN PEDIATRIC AIDS TRANSMISSION AND PATHOGENESIS
    Stephen Spector; Fiscal Year: 2004
    ..The findings of this research will provide an improved understanding of the pathogenesis of HIV-1 infection of children and perinatal transmission, and help to develop improved treatment/prevention strategies. ..
  7. FACTORS IN PEDIATRIC AIDS TRANSMISSION AND PATHOGENESIS
    Stephen Spector; Fiscal Year: 2003
    ..The findings of this research will provide an improved understanding of the pathogenesis of HIV-1 infection of children and perinatal transmission, and help to develop improved treatment/prevention strategies. ..
  8. FACTORS IN PEDIATRIC AIDS TRANSMISSION AND PATHOGENESIS
    Stephen Spector; Fiscal Year: 2002
    ..The findings of this research will provide an improved understanding of the pathogenesis of HIV-1 infection of children and perinatal transmission, and help to develop improved treatment/prevention strategies. ..
  9. FACTORS IN PEDIATRIC AIDS TRANSMISSION AND PATHOGENESIS
    Stephen Spector; Fiscal Year: 2001
    ..The findings of this research will provide an improved understanding of the pathogenesis of HIV-1 infection of children and perinatal transmission, and help to develop improved treatment/prevention strategies. ..
  10. PEDIATRIC AIDS--FACTORS IN TRANSMISSION AND PATHOLOGY
    Stephen Spector; Fiscal Year: 1999
    ....