JANET DEHOFF SPARKS

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. doi request reprint Insulin-dependent apolipoprotein B degradation is mediated by autophagy and involves class I and class III phosphatidylinositide 3-kinases
    Janet D Sparks
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Box 626, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 435:616-20. 2013
  2. pmc Acute suppression of apo B secretion by insulin occurs independently of MTP
    Janet D Sparks
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Box 626, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 406:252-6. 2011
  3. pmc Interleukin-6 mediates hepatic hypersecretion of apolipoprotein B
    Janet D Sparks
    Dept of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Am J Physiol Gastrointest Liver Physiol 299:G980-9. 2010
  4. pmc Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase
    Janet D Sparks
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Biochem J 395:363-71. 2006
  5. pmc Overindulgence and metabolic syndrome: is FoxO1 a missing link?
    Janet D Sparks
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Clin Invest 118:2012-5. 2008
  6. pmc Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity
    Eungseok Kim
    Department of Pathology and the Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    Diabetes 60:1493-503. 2011
  7. pmc Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes
    Chad A Galloway
    University of Rochester, Department of Biochemistry and Biophysics, 601 Elmwood Ave Rochester, NY 14642, USA
    Biochim Biophys Acta 1802:976-85. 2010
  8. doi request reprint Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor
    Hung Yun Lin
    George Whipple Lab for Cancer Research, Department of Pathology, and Cancer Center, University of Rochester Medical Center, Rochester, NY, USA
    Hepatology 47:1924-35. 2008
  9. ncbi request reprint Insulin suppression of VLDL apo B secretion is not mediated by the LDL receptor
    Doru V Chirieac
    Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, P O Box 626, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 297:134-7. 2002
  10. ncbi request reprint Altered triglyceride-rich lipoprotein production in Zucker diabetic fatty rats
    Doru V Chirieac
    Dept of Pathology and Laboratory Medicine, Univ of Rochester School of Medicine and Dentistry, P O Box 626, 601 Elmwood Ave, Rochester, New York 14642, USA
    Am J Physiol Endocrinol Metab 287:E42-9. 2004

Research Grants

Collaborators

  • ROBERT MOONEY
  • N O Davidson
  • Mahmood M Hussain
  • Kevin L Schalinske
  • Eungseok Kim
  • Doru V Chirieac
  • Hung Yun Lin
  • Ning Chun Liu
  • Chawnshang Chang
  • Charles E Sparks
  • Chad A Galloway
  • I Chen Yu
  • Shuyuan Yeh
  • Kristin M Nieman
  • Crystal S Au
  • Heidi L Collins
  • Joanne Cianci
  • John Ashton
  • Harold C Smith
  • Wen Lung Ma
  • Ruey Shen Wang
  • Cheng Lung Hsu
  • Jenny Jokinen
  • Yei Tsung Chen
  • Saleh Altuwaijri
  • Loretta L Collins
  • Yi Fen Lee
  • Wen Jye Lin
  • Lu Min Chen
  • Cara S Hartz
  • Timothy A Garrow
  • Sandra S Szegedi
  • Ruey Sheng Wang
  • Qingquan Xu
  • Amy Wagner
  • Khosrow Adeli
  • Wei Qiu
  • Taryne Chong

Detail Information

Publications15

  1. doi request reprint Insulin-dependent apolipoprotein B degradation is mediated by autophagy and involves class I and class III phosphatidylinositide 3-kinases
    Janet D Sparks
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Box 626, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 435:616-20. 2013
    ..Insulin action resulting in hepatic apo B degradation is novel and important in understanding regulation of hepatic VLDL metabolism...
  2. pmc Acute suppression of apo B secretion by insulin occurs independently of MTP
    Janet D Sparks
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Box 626, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 406:252-6. 2011
    ..0±12.4% in control transfected hepatocytes. Results indicate that even under conditions of increased hepatic apo B secretion mediated by MTP, responsiveness of hepatocytes to insulin to suppress apo B secretion is maintained...
  3. pmc Interleukin-6 mediates hepatic hypersecretion of apolipoprotein B
    Janet D Sparks
    Dept of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Am J Physiol Gastrointest Liver Physiol 299:G980-9. 2010
    ..These changes may contribute to hypersecretion of VLDL associated with obesity, particularly under conditions where SOCS3 is not overexpressed to an extent capable of overcoming IL-6-stimulated apob gene transcription...
  4. pmc Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase
    Janet D Sparks
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Biochem J 395:363-71. 2006
    ....
  5. pmc Overindulgence and metabolic syndrome: is FoxO1 a missing link?
    Janet D Sparks
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Clin Invest 118:2012-5. 2008
    ..They demonstrate that MTP is a target of the transcription factor FoxO1 and that excessive VLDL production associated with insulin resistance is caused by the inability of insulin to regulate FoxO1 transcriptional activation of MTP...
  6. pmc Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity
    Eungseok Kim
    Department of Pathology and the Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    Diabetes 60:1493-503. 2011
    ..TR4 is a nuclear receptor without clear pathophysiological roles. We investigated the roles of hepatic TR4 in the regulation of lipogenesis and insulin sensitivity in vivo and in vitro...
  7. pmc Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes
    Chad A Galloway
    University of Rochester, Department of Biochemistry and Biophysics, 601 Elmwood Ave Rochester, NY 14642, USA
    Biochim Biophys Acta 1802:976-85. 2010
    ....
  8. doi request reprint Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor
    Hung Yun Lin
    George Whipple Lab for Cancer Research, Department of Pathology, and Cancer Center, University of Rochester Medical Center, Rochester, NY, USA
    Hepatology 47:1924-35. 2008
    ....
  9. ncbi request reprint Insulin suppression of VLDL apo B secretion is not mediated by the LDL receptor
    Doru V Chirieac
    Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, P O Box 626, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 297:134-7. 2002
    ..Results indicate: (1) mouse hepatocytes respond to insulin by reducing VLDL apo B output; (2) both VLDL B100 and B48 secretion are suppressed; and (3) insulin inhibition of VLDL apo B secretion is retained in Ldlr-/- hepatocytes...
  10. ncbi request reprint Altered triglyceride-rich lipoprotein production in Zucker diabetic fatty rats
    Doru V Chirieac
    Dept of Pathology and Laboratory Medicine, Univ of Rochester School of Medicine and Dentistry, P O Box 626, 601 Elmwood Ave, Rochester, New York 14642, USA
    Am J Physiol Endocrinol Metab 287:E42-9. 2004
    ..Increased triglyceride production in hyperinsulinemic rats likely relates to increased expression of SREBP-1c, whereas increased apoB production involves posttranscriptional processes...
  11. ncbi request reprint PI3-kinase activity modulates apo B available for hepatic VLDL production in apobec-1-/- mice
    Doru V Chirieac
    Dept of Pathology and Laboratory Medicine, Univ of Rochester School of Medicine and Dentistry, P O Box 626, 601 Elmwood Ave, Rochester, New York 14642, USA
    Am J Physiol Gastrointest Liver Physiol 291:G382-8. 2006
    ....
  12. ncbi request reprint Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis
    Ning Chun Liu
    Department of Pathology, Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Diabetes 56:2901-9. 2007
    ..In contrast, ectopic expression of TR4 increased PEPCK gene expression and hepatic glucose production in human and mouse hepatoma cells. Mice lacking TR4 also display reduction of PEPCK expression with impaired gluconeogenesis...
  13. ncbi request reprint Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor
    Hung Yun Lin
    Department of Pathology, Urology, Radiation Oncology, and the Cancer Center, 601 Elmwood Ave, Box 626, Rochester, NY 14642, USA
    Diabetes 54:1717-25. 2005
    ..Our in vivo studies demonstrate that androgen-AR plays key roles in the development of insulin and leptin resistance, which may contribute to the development of type 2 diabetes and cardiovascular disease...
  14. ncbi request reprint Insulin regulates hepatic apolipoprotein B production independent of the mass or activity of Akt1/PKBalpha
    Crystal S Au
    Division of Clinical Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Metabolism 53:228-35. 2004
    ..Overall, the data suggest that acute insulin-mediated inhibition of apoB may not be mediated by Akt1 and that insulin signaling molecules upstream of Akt1 may be more important in mediating control of apoB secretion...
  15. ncbi request reprint Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats
    Kristin M Nieman
    Dept of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    Am J Physiol Endocrinol Metab 291:E1235-42. 2006
    ..Moreover, the upregulation of BHMT and PEMT may indicate an increased choline requirement in the diabetic rat...

Research Grants18

  1. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ....
  2. Relationship of Apo B and BHMT: Nutrition and Physiology
    Janet Sparks; Fiscal Year: 2004
    ..A potential link of two pathways whose products or intermediates are associated with increased cardiovascular disease risk could be established. ..
  3. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ....