JANET DEHOFF SPARKS

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Acute suppression of apo B secretion by insulin occurs independently of MTP
    Janet D Sparks
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Box 626, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 406:252-6. 2011
  2. ncbi Interleukin-6 mediates hepatic hypersecretion of apolipoprotein B
    Janet D Sparks
    Dept of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Am J Physiol Gastrointest Liver Physiol 299:G980-9. 2010
  3. ncbi Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase
    Janet D Sparks
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Biochem J 395:363-71. 2006
  4. ncbi Overindulgence and metabolic syndrome: is FoxO1 a missing link?
    Janet D Sparks
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Clin Invest 118:2012-5. 2008
  5. ncbi Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity
    Eungseok Kim
    Department of Pathology and the Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    Diabetes 60:1493-503. 2011
  6. ncbi Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes
    Chad A Galloway
    University of Rochester, Department of Biochemistry and Biophysics, 601 Elmwood Ave Rochester, NY 14642, USA
    Biochim Biophys Acta 1802:976-85. 2010
  7. ncbi Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor
    Hung Yun Lin
    George Whipple Lab for Cancer Research, Department of Pathology, and Cancer Center, University of Rochester Medical Center, Rochester, NY, USA
    Hepatology 47:1924-35. 2008
  8. ncbi Insulin suppression of VLDL apo B secretion is not mediated by the LDL receptor
    Doru V Chirieac
    Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, P.O. Box 626, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 297:134-7. 2002
  9. ncbi Altered triglyceride-rich lipoprotein production in Zucker diabetic fatty rats
    Doru V Chirieac
    Dept. of Pathology and Laboratory Medicine, Univ. of Rochester School of Medicine and Dentistry, P. O. Box 626, 601 Elmwood Ave, Rochester, New York 14642, USA
    Am J Physiol Endocrinol Metab 287:E42-9. 2004
  10. ncbi PI3-kinase activity modulates apo B available for hepatic VLDL production in apobec-1-/- mice
    Doru V Chirieac
    Dept of Pathology and Laboratory Medicine, Univ of Rochester School of Medicine and Dentistry, P O Box 626, 601 Elmwood Ave, Rochester, New York 14642, USA
    Am J Physiol Gastrointest Liver Physiol 291:G382-8. 2006

Research Grants

  1. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
  2. Relationship of Apo B and BHMT: Nutrition and Physiology
    Janet Sparks; Fiscal Year: 2004
  3. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010

Collaborators

  • Eungseok Kim
  • ROBERT MOONEY
  • N O Davidson
  • Mahmood M Hussain
  • Kevin L Schalinske
  • Doru V Chirieac
  • Hung Yun Lin
  • Ning Chun Liu
  • Hung-Yun Lin
  • Chawnshang Chang
  • Charles E Sparks
  • Chad A Galloway
  • I-Chen Yu
  • I Chen Yu
  • Ning-Chun Liu
  • Shuyuan Yeh
  • Kristin M Nieman
  • Crystal S Au
  • Heidi L Collins
  • Joanne Cianci
  • Harold C Smith
  • John Ashton
  • Yei-Tsung Chen
  • Wen-Lung Ma
  • Ruey Shen Wang
  • Yei Tsung Chen
  • Wen Lung Ma
  • Cheng Lung Hsu
  • Ruey-Shen Wang
  • Cheng-Lung Hsu
  • Jenny Jokinen
  • Saleh Altuwaijri
  • Wen-Jye Lin
  • Yi Fen Lee
  • Lu-Min Chen
  • Yi-Fen Lee
  • Loretta L Collins
  • Wen Jye Lin
  • Lu Min Chen
  • Cara S Hartz
  • Timothy A Garrow
  • Sandra S Szegedi
  • Qingquan Xu
  • Ruey Sheng Wang
  • Ruey-Sheng Wang
  • Khosrow Adeli
  • Amy Wagner
  • Taryne Chong
  • Wei Qiu

Detail Information

Publications14

  1. ncbi Acute suppression of apo B secretion by insulin occurs independently of MTP
    Janet D Sparks
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Box 626, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 406:252-6. 2011
    ..0±12.4% in control transfected hepatocytes. Results indicate that even under conditions of increased hepatic apo B secretion mediated by MTP, responsiveness of hepatocytes to insulin to suppress apo B secretion is maintained...
  2. ncbi Interleukin-6 mediates hepatic hypersecretion of apolipoprotein B
    Janet D Sparks
    Dept of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Am J Physiol Gastrointest Liver Physiol 299:G980-9. 2010
    ..These changes may contribute to hypersecretion of VLDL associated with obesity, particularly under conditions where SOCS3 is not overexpressed to an extent capable of overcoming IL-6-stimulated apob gene transcription...
  3. ncbi Hepatic very-low-density lipoprotein and apolipoprotein B production are increased following in vivo induction of betaine-homocysteine S-methyltransferase
    Janet D Sparks
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Biochem J 395:363-71. 2006
    ....
  4. ncbi Overindulgence and metabolic syndrome: is FoxO1 a missing link?
    Janet D Sparks
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Clin Invest 118:2012-5. 2008
    ..They demonstrate that MTP is a target of the transcription factor FoxO1 and that excessive VLDL production associated with insulin resistance is caused by the inability of insulin to regulate FoxO1 transcriptional activation of MTP...
  5. ncbi Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity
    Eungseok Kim
    Department of Pathology and the Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    Diabetes 60:1493-503. 2011
    ..TR4 is a nuclear receptor without clear pathophysiological roles. We investigated the roles of hepatic TR4 in the regulation of lipogenesis and insulin sensitivity in vivo and in vitro...
  6. ncbi Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes
    Chad A Galloway
    University of Rochester, Department of Biochemistry and Biophysics, 601 Elmwood Ave Rochester, NY 14642, USA
    Biochim Biophys Acta 1802:976-85. 2010
    ....
  7. ncbi Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor
    Hung Yun Lin
    George Whipple Lab for Cancer Research, Department of Pathology, and Cancer Center, University of Rochester Medical Center, Rochester, NY, USA
    Hepatology 47:1924-35. 2008
    ..AR agonists that specifically target hepatic AR might be developed to provide a better strategy for treatment of metabolic syndrome in men...
  8. ncbi Insulin suppression of VLDL apo B secretion is not mediated by the LDL receptor
    Doru V Chirieac
    Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, P.O. Box 626, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 297:134-7. 2002
    ..Results indicate: (1) mouse hepatocytes respond to insulin by reducing VLDL apo B output; (2) both VLDL B100 and B48 secretion are suppressed; and (3) insulin inhibition of VLDL apo B secretion is retained in Ldlr-/- hepatocytes...
  9. ncbi Altered triglyceride-rich lipoprotein production in Zucker diabetic fatty rats
    Doru V Chirieac
    Dept. of Pathology and Laboratory Medicine, Univ. of Rochester School of Medicine and Dentistry, P. O. Box 626, 601 Elmwood Ave, Rochester, New York 14642, USA
    Am J Physiol Endocrinol Metab 287:E42-9. 2004
    ..Increased triglyceride production in hyperinsulinemic rats likely relates to increased expression of SREBP-1c, whereas increased apoB production involves posttranscriptional processes...
  10. ncbi PI3-kinase activity modulates apo B available for hepatic VLDL production in apobec-1-/- mice
    Doru V Chirieac
    Dept of Pathology and Laboratory Medicine, Univ of Rochester School of Medicine and Dentistry, P O Box 626, 601 Elmwood Ave, Rochester, New York 14642, USA
    Am J Physiol Gastrointest Liver Physiol 291:G382-8. 2006
    ....
  11. ncbi Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis
    Ning Chun Liu
    Department of Pathology, Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Diabetes 56:2901-9. 2007
    ....
  12. ncbi Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor
    Hung Yun Lin
    Department of Pathology, Urology, Radiation Oncology, and the Cancer Center, 601 Elmwood Ave, Box 626, Rochester, NY 14642, USA
    Diabetes 54:1717-25. 2005
    ..Our in vivo studies demonstrate that androgen-AR plays key roles in the development of insulin and leptin resistance, which may contribute to the development of type 2 diabetes and cardiovascular disease...
  13. ncbi Insulin regulates hepatic apolipoprotein B production independent of the mass or activity of Akt1/PKBalpha
    Crystal S Au
    Division of Clinical Biochemistry, Hospital for Sick Children, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Metabolism 53:228-35. 2004
    ..Overall, the data suggest that acute insulin-mediated inhibition of apoB may not be mediated by Akt1 and that insulin signaling molecules upstream of Akt1 may be more important in mediating control of apoB secretion...
  14. ncbi Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats
    Kristin M Nieman
    Dept. of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    Am J Physiol Endocrinol Metab 291:E1235-42. 2006
    ..Moreover, the upregulation of BHMT and PEMT may indicate an increased choline requirement in the diabetic rat...

Research Grants18

  1. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ....
  2. Relationship of Apo B and BHMT: Nutrition and Physiology
    Janet Sparks; Fiscal Year: 2004
    ..A potential link of two pathways whose products or intermediates are associated with increased cardiovascular disease risk could be established. ..
  3. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    ....