M F R Sowers

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Change in adipocytokines and ghrelin with menopause
    MaryFran R Sowers
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, United States
    Maturitas 59:149-57. 2008
  2. pmc Peripheral vascular disease and peripheral neuropathy in individuals with cardiometabolic clustering and obesity: National Health and Nutrition Examination Survey 2001-2004
    Kelly R Ylitalo
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Diabetes Care 34:1642-7. 2011
  3. pmc Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women
    Carolyn J Crandall
    Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, UCLA Medicine GIM, 911 Broxton Ave, 1st Floor, Los Angeles, CA 90024, USA
    Breast Cancer Res 11:R51. 2009
  4. pmc Physical functioning and menopause states
    MaryFran Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USA
    Obstet Gynecol 110:1290-6. 2007
  5. pmc Oestrogen metabolites in relation to isoprostanes as a measure of oxidative stress
    MaryFran Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, and Department of Obstetrics and Gynecology, University of Michigan Health Sciences System, Ann Arbor, MI 48104, USA
    Clin Endocrinol (Oxf) 68:806-13. 2008
  6. pmc Changes in body composition in women over six years at midlife: ovarian and chronological aging
    MaryFran Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, 339 East Liberty Street, Suite 310, Ann Arbor, Michigan 48104, USA
    J Clin Endocrinol Metab 92:895-901. 2007
  7. pmc Associations of anatomical measures from MRI with radiographically defined knee osteoarthritis score, pain, and physical functioning
    MaryFran Sowers
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    J Bone Joint Surg Am 93:241-51. 2011
  8. ncbi Sex steroid hormone polymorphisms, high-density lipoprotein cholesterol, and apolipoprotein A-1 from the Study of Women's Health Across the Nation (SWAN)
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USA
    Am J Med 119:S61-8. 2006
  9. ncbi CYP1A1 and CYP1B1 polymorphisms and their association with estradiol and estrogen metabolites in women who are premenopausal and perimenopausal
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USA
    Am J Med 119:S44-51. 2006
  10. ncbi Menstrual cycle markers of ovarian aging and sex steroid hormone genotypes
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USA
    Am J Med 119:S31-43. 2006

Research Grants

  1. FUNCTIONAL STATUS AND THE MENOPAUSAL TRANSITION
    MaryFran Sowers; Fiscal Year: 2001
  2. Estrogen, Metabolism, Menopause, and Health Outcomes
    MaryFran Sowers; Fiscal Year: 2006
  3. Functional Status and the Menopause Transition
    MaryFran Sowers; Fiscal Year: 2007
  4. FUNCTIONAL STATUS AND THE MENOPAUSAL TRANSITION
    MaryFran Sowers; Fiscal Year: 2004
  5. Sleep During the Perimenopause in a Multi-Ethnic Cohort
    MaryFran Sowers; Fiscal Year: 2002
  6. SWAN REPOSITORY
    MaryFran Sowers; Fiscal Year: 2007
  7. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2007
  8. SWAN Sleep Study II - Michigan Center
    MaryFran Sowers; Fiscal Year: 2006
  9. Functional Status and the Menopause Transition
    MaryFran Sowers; Fiscal Year: 2006
  10. FUNCTIONAL STATUS AND THE MENOPAUSAL TRANSITION
    MaryFran Sowers; Fiscal Year: 2002

Detail Information

Publications71

  1. pmc Change in adipocytokines and ghrelin with menopause
    MaryFran R Sowers
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, United States
    Maturitas 59:149-57. 2008
    ....
  2. pmc Peripheral vascular disease and peripheral neuropathy in individuals with cardiometabolic clustering and obesity: National Health and Nutrition Examination Survey 2001-2004
    Kelly R Ylitalo
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Diabetes Care 34:1642-7. 2011
    ..This study describes the prevalence of LEDs and examines the association of obesity and cardiometabolic clustering in a population-based sample...
  3. pmc Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women
    Carolyn J Crandall
    Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, UCLA Medicine GIM, 911 Broxton Ave, 1st Floor, Los Angeles, CA 90024, USA
    Breast Cancer Res 11:R51. 2009
    ....
  4. pmc Physical functioning and menopause states
    MaryFran Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USA
    Obstet Gynecol 110:1290-6. 2007
    ..To assess whether losses in physical functioning are related to the natural menopause, hysterectomy, or calendar time during midlife, after adjustment for body size and smoking...
  5. pmc Oestrogen metabolites in relation to isoprostanes as a measure of oxidative stress
    MaryFran Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, and Department of Obstetrics and Gynecology, University of Michigan Health Sciences System, Ann Arbor, MI 48104, USA
    Clin Endocrinol (Oxf) 68:806-13. 2008
    ..We related oestrogen levels to F(2a)-isoprostane levels, a biomarker of oxidative stress...
  6. pmc Changes in body composition in women over six years at midlife: ovarian and chronological aging
    MaryFran Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, 339 East Liberty Street, Suite 310, Ann Arbor, Michigan 48104, USA
    J Clin Endocrinol Metab 92:895-901. 2007
    ..Understanding the menopause association with body weight is important because excess weight increases risk for stroke, incident cardiovascular disease, cardiovascular mortality, and all-cause mortality among the middle-aged...
  7. pmc Associations of anatomical measures from MRI with radiographically defined knee osteoarthritis score, pain, and physical functioning
    MaryFran Sowers
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    J Bone Joint Surg Am 93:241-51. 2011
    ....
  8. ncbi Sex steroid hormone polymorphisms, high-density lipoprotein cholesterol, and apolipoprotein A-1 from the Study of Women's Health Across the Nation (SWAN)
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USA
    Am J Med 119:S61-8. 2006
    ..These genetic variants provide limited evidence of associations with lipids that may help explain the cardioprotective effect of premenopausal status in women...
  9. ncbi CYP1A1 and CYP1B1 polymorphisms and their association with estradiol and estrogen metabolites in women who are premenopausal and perimenopausal
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USA
    Am J Med 119:S44-51. 2006
    ..CYP1A1 rs2606345 may play an important role in estrogen metabolism in women who are premenopausal and perimenopausal...
  10. ncbi Menstrual cycle markers of ovarian aging and sex steroid hormone genotypes
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USA
    Am J Med 119:S31-43. 2006
    ..Using a candidate gene approach, 2 ESR1 polymorphisms are related to 3 phenotypic markers of ovarian aging, suggesting a possible role for the ESR1 gene in the timing of the menopausal transition...
  11. ncbi Aromatase gene (CYP 19) polymorphisms and endogenous androgen concentrations in a multiracial/multiethnic, multisite study of women at midlife
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USA
    Am J Med 119:S23-30. 2006
    ..Aromatase genetic markers may be important in understanding the emerging associations reported between endogenous androgens and women's health status...
  12. ncbi Endogenous estradiol and its association with estrogen receptor gene polymorphisms
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USA
    Am J Med 119:S16-22. 2006
    ..The 2 strongest associations explained <4% of the total variation in the circulating E2 concentrations...
  13. ncbi Sex steroid hormone pathway genes and health-related measures in women of 4 races/ethnicities: the Study of Women's Health Across the Nation (SWAN)
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USA
    Am J Med 119:S103-10. 2006
    ..The magnitude and breadth of these relationships should motivate further research to verify and extend the findings...
  14. pmc Anti-mullerian hormone and inhibin B in the definition of ovarian aging and the menopause transition
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory, Room 1846, Ann Arbor, Michigan 48109, USA
    J Clin Endocrinol Metab 93:3478-83. 2008
    ..The objective of the study was to determine whether anti-Mullerian hormone (AMH) and inhibin B are viable endocrine biomarkers for framing the menopause transition from initiation to the final menstrual period (FMP)...
  15. pmc Estradiol rates of change in relation to the final menstrual period in a population-based cohort of women
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Endocrinol Metab 93:3847-52. 2008
    ..The aim was to characterize rates of change in serum estradiol (E2) levels across the menopausal transition and into early postmenopause...
  16. pmc Genetic polymorphisms and obesity influence estradiol decline during the menopause
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Clin Endocrinol (Oxf) 74:618-23. 2011
    ..Obesity and genetic variation in aromatase and type 1 17-β hydroxysteroid dehydrogenase (HSD) could influence the E2 trajectory of decline during the menopause transition...
  17. pmc Relating smoking, obesity, insulin resistance, and ovarian biomarker changes to the final menstrual period
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
    Ann N Y Acad Sci 1204:95-103. 2010
    ..Insulin resistance was associated with shorter time to FMP independent of the biomarkers. Interventions targeting smoking and insulin resistance could curtail the undue advancement of reproductive aging...
  18. pmc The evolving role of obesity in knee osteoarthritis
    MaryFran R Sowers
    Department of Epidemiology, Unversity of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Curr Opin Rheumatol 22:533-7. 2010
    ..The increasing pervasiveness of obesity and the growing appreciation of obesity's accompanying metabolic/inflammatory activities suggest rethinking the knee osteoarthritis paradigm...
  19. pmc Amount of bone loss in relation to time around the final menstrual period and follicle-stimulating hormone staging of the transmenopause
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory Street, Ann Arbor, Michigan 48109, USA
    J Clin Endocrinol Metab 95:2155-62. 2010
    ..The objective of the study was to describe bone loss rates across the transmenopause related to FSH staging and the final menstrual period (FMP)...
  20. pmc Anti-Müllerian hormone and inhibin B variability during normal menstrual cycles
    MaryFran Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
    Fertil Steril 94:1482-6. 2010
    ..To describe anti-Müllerian hormone (AMH) variation across normal menstrual cycles...
  21. pmc Knee osteoarthritis in obese women with cardiometabolic clustering
    MaryFran Sowers
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Arthritis Rheum 61:1328-36. 2009
    ..To assess the role of obesity and metabolic dysfunctionality with knee osteoarthritis (OA), knee joint pain, and physical functioning performance, adjusted for joint space width (JSW) asymmetry...
  22. pmc Longitudinal changes of serum COMP and urinary CTX-II predict X-ray defined knee osteoarthritis severity and stiffness in women
    M F Sowers
    University of Michigan School of Public Health, Department of Epidemiology, Ann Arbor, MI 48109, USA
    Osteoarthritis Cartilage 17:1609-14. 2009
    ..To ascertain the predictive role of longitudinally acquired biochemical measures of cartilage turnover in relation to X-ray defined knee osteoarthritis (OAK), knee pain and functioning...
  23. pmc Testosterone, sex hormone-binding globulin and free androgen index among adult women: chronological and ovarian aging
    M F R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory, Room 1846, Ann Arbor, MI 48109, USA
    Hum Reprod 24:2276-85. 2009
    ....
  24. pmc Sex steroid hormone profiles are related to sleep measures from polysomnography and the Pittsburgh Sleep Quality Index
    Mary Fran Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USA
    Sleep 31:1339-49. 2008
    ..To relate reproductive hormones (and the preceding 7-year rates of their change) to objectively and subjectively assessed sleep measures, independent of age, vasomotor symptom frequency, depressive symptoms, and body size...
  25. pmc Follicle stimulating hormone and its rate of change in defining menopause transition stages
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Endocrinol Metab 93:3958-64. 2008
    ..The objective of the study was to identify menopause transition stages using acceleration or deceleration patterns of FSH rates of change from the late reproductive years to postmenopause...
  26. ncbi Estradiol and its metabolites and their association with knee osteoarthritis
    MaryFran R Sowers
    University of Michigan, Ann Arbor, MI 04184 2025, USA
    Arthritis Rheum 54:2481-7. 2006
    ..To determine if levels of endogenous estrogen or estrogen metabolites are associated with an increased risk of developing knee osteoarthritis (OA) in women...
  27. ncbi Insulin resistance, hemostatic factors, and hormone interactions in pre- and perimenopausal women: SWAN
    MaryFran Sowers
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    J Clin Endocrinol Metab 88:4904-10. 2003
    ..The longitudinal Study of Women's Health Across the Nation will help us discern whether this interaction contributes to heart disease and diabetes among postmenopausal women...
  28. ncbi Testosterone concentrations in women aged 25-50 years: associations with lifestyle, body composition, and ovarian status
    M F Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    Am J Epidemiol 153:256-64. 2001
    ....
  29. ncbi Sarcopenia is related to physical functioning and leg strength in middle-aged women
    MaryFran R Sowers
    School of Public Health, University of Michigan, Ann Arbor, MI 48104 2205, USA
    J Gerontol A Biol Sci Med Sci 60:486-90. 2005
    ..Also poorly understood is whether strength and functioning in aging are related to the amount of lean mass and its change as well as to the amount of fat mass and its change...
  30. ncbi Blood lead concentrations and pregnancy outcomes
    MaryFran Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Arch Environ Health 57:489-95. 2002
    ..Maternal blood lead concentration and its change were not significantly associated with other reproductive outcomes. Low levels of maternal blood lead concentrations were significantly associated with HIP/toxemia...
  31. ncbi The menopause transition and the aging process: a population perspective
    M F Sowers
    Department of Epidemiology, University of Michigan, Ann Arbor 48109 2029, USA
    Aging (Milano) 12:85-92. 2000
    ....
  32. ncbi Endogenous hormones and bone turnover markers in pre- and perimenopausal women: SWAN
    M R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Osteoporos Int 14:191-7. 2003
    ..In these pre- and early perimenopausal women, higher FSH concentrations, but not other serum reproductive hormone concentrations, are positively associated with greater bone turnover prior to the last menstrual period...
  33. ncbi IGF-I, osteocalcin, and bone change in pregnant normotensive and pre-eclamptic women
    M Sowers
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    J Clin Endocrinol Metab 86:5898-903. 2001
    ....
  34. ncbi Estrogen receptor genotypes and their association with the 10-year changes in bone mineral density and osteocalcin concentrations
    MaryFran Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USA
    J Clin Endocrinol Metab 89:733-9. 2004
    ....
  35. ncbi Magnetic resonance-detected subchondral bone marrow and cartilage defect characteristics associated with pain and X-ray-defined knee osteoarthritis
    M F Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Osteoarthritis Cartilage 11:387-93. 2003
    ....
  36. ncbi Bone loss in adolescent and adult pregnant women
    M F Sowers
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Obstet Gynecol 96:189-93. 2000
    ....
  37. ncbi Interpregnancy weight retention patterning in women who breastfed
    M Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor 48109 2029, USA
    J Matern Fetal Med 7:89-94. 1998
    ..These findings indicate that breastfeeding women begin the next postpartum interval weighing more than the amount observed in the initial postpartum period...
  38. ncbi Role of calciotrophic hormones in calcium mobilization of lactation
    M Sowers
    Department of Epidemiology, University of Michigan, Ann Arbor 48109 2029, USA
    Am J Clin Nutr 67:284-91. 1998
    ..These data do not support the hypothesis that these three calciotrophic hormones are a central part of the calcium mobilization associated with the bone loss of lactation...
  39. ncbi Selected diet and lifestyle factors are associated with estrogen metabolites in a multiracial/ethnic population of women
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48104, USA
    J Nutr 136:1588-95. 2006
    ....
  40. ncbi C-reactive protein as a biomarker of emergent osteoarthritis
    MaryFran Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Ml 48109 2029, USA
    Osteoarthritis Cartilage 10:595-601. 2002
    ..We evaluated C-reactive protein (C-RP), a quantitative marker of the acute phase response, as a potential biomarker of prevalent and incident osteoarthritis of the knee (OAK)...
  41. ncbi Performance-based physical functioning in African-American and Caucasian women at midlife: considering body composition, quadriceps strength, and knee osteoarthritis
    MaryFran Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, 48104, USA
    Am J Epidemiol 163:950-8. 2006
    ..Compromised physical functioning began earlier than expected, with indications that approximately 12-31% of women might benefit from interventions to forestall future decline...
  42. ncbi Hormone predictors of bone mineral density changes during the menopausal transition
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, 339 East Liberty Street, Suite 310, Ann Arbor, MI 48104, USA
    J Clin Endocrinol Metab 91:1261-7. 2006
    ..OBJECTIVE AND CONTEXT: Our objective was to examine predictability of reproductive hormone concentrations for bone mineral density (BMD) loss during the menopausal transition...
  43. ncbi Thyroid stimulating hormone (TSH) concentrations and menopausal status in women at the mid-life: SWAN
    MaryFran Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Clin Endocrinol (Oxf) 58:340-7. 2003
    ..We evaluated menopausal symptoms, menstrual cycle bleeding characteristics and reproductive hormones for their associations with thyroid stimulating hormone (TSH) concentrations in women at the mid-life from five ethnic groups...
  44. ncbi Epidemiology of risk factors for osteoarthritis: systemic factors
    M Sowers
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Curr Opin Rheumatol 13:447-51. 2001
    ..There is great opportunity for new prevention and intervention strategies as we expand our understanding of the role of these systemic risk factors...
  45. ncbi Elevated serum fluoride concentrations in women are not related to fractures and bone mineral density
    MaryFran Sowers
    Department of Epidemiology, University of Michigan, Ann Arbor, MI 48104, USA
    J Nutr 135:2247-52. 2005
    ..Serum fluoride concentrations were not associated with BMD or osteoporotic fractures among female residents of communities with water fluoride concentrations of 52.6 or 210.4 micromol/L...
  46. ncbi Hemostatic factors and estrogen during the menopausal transition
    MaryFran R Sowers
    Department of Epidemiology, University of Michigan School of Public Health, 339 East Liberty Street, Suite 310, Ann Arbor, Michigan 48104, USA
    J Clin Endocrinol Metab 90:5942-8. 2005
    ..Therefore, we evaluated endogenous hormone concentrations, menopause transition stages, and adoption of exogenous hormone use in relation to hemostatic and inflammation marker concentrations in women...
  47. ncbi Androgens are associated with hemostatic and inflammatory factors among women at the mid-life
    MaryFran R Sowers
    University of Michigan, Department of Epidemiology, School of Public Health, 339 East Liberty Street, Suite 310, Ann Arbor, Michigan 48104, USA
    J Clin Endocrinol Metab 90:6064-71. 2005
    ..The goal of this study was to relate annually measured endogenous androgens to hemostatic and inflammation markers in women longitudinally...
  48. ncbi Association of lipoprotein(a), insulin resistance, and reproductive hormones in a multiethnic cohort of pre- and perimenopausal women (The SWAN Study)
    MaryFran Sowers
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Cardiol 92:533-7. 2003
    ..Lp(a) was very modestly associated (r = -0.04) with insulin resistance after adjusting for ethnicity and BMI, and this association was not modified by reproductive hormones, including androgens...
  49. pmc Levels of sex steroid and cardiovascular disease measures in premenopausal and hormone-treated women at midlife: implications for the "timing hypothesis"
    MaryFran R Sowers
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Intern Med 168:2146-53. 2008
    ....
  50. pmc Assessment of physical functioning: a conceptual model encompassing environmental factors and individual compensation strategies
    Kristin M Tomey
    Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory St, Room 1867, Ann Arbor, MI 48109 2029, USA
    Phys Ther 89:705-14. 2009
    ..This article presents a new conceptual model for assessment of relevant physical functioning while accounting for habitual environmental factors and compensation strategies...
  51. pmc Physical functioning among mid-life women: associations with trajectory of depressive symptoms
    Kristin Tomey
    University of Michigan School of Public Health, Ann Arbor, MI, USA
    Soc Sci Med 71:1259-67. 2010
    ..In contrast, history of depressive symptoms played little or no role in current physical functioning of mid-life women. When evaluating physical function, women's current mental health status should be considered...
  52. pmc Dietary intake related to prevalent functional limitations in midlife women
    Kristin M Tomey
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    Am J Epidemiol 167:935-43. 2008
    ..0 and 1.2, 2.1) versus those in the lowest quartiles. Lower fruit, vegetable, and fiber intakes were related to reporting greater functional limitations. Modifying dietary practices could be important in minimizing physical limitations...
  53. pmc Change in follicle-stimulating hormone and estradiol across the menopausal transition: effect of age at the final menstrual period
    John F Randolph
    Division of Reproductive Endocrinology and Infertility, University of Michigan Health System, Ann Arbor, Michigan 48109 0276, USA
    J Clin Endocrinol Metab 96:746-54. 2011
    ..To determine whether patterns of change in serum estradiol (E2) and FSH across the menopausal transition were associated with age at the final menstrual period (FMP)...
  54. ncbi School performance, race, and other correlates of sleep-disordered breathing in children
    Ronald D Chervin
    Michael S Aldrich Sleep Disorders Laboratory, Department of Neurology, University of Michigan, 8D8702 University Hospital, Box 0117, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0117, USA
    Sleep Med 4:21-7. 2003
    ..Both problems are common among African-American (AA) children, but potential confounders such as low socioeconomic status (SES) and obesity have not been well studied...
  55. ncbi Characterizing variation in sex steroid hormone pathway genes in women of 4 races/ethnicities: the Study of Women's Health Across the Nation (SWAN)
    Sharon R Kardia
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USA
    Am J Med 119:S3-15. 2006
    ....
  56. ncbi Low bone mineral density in the early menopausal transition: role for ovulatory function
    Jagteshwar Grewal
    Department of Epidemiology, School of Public Health, University of Michigan, 339 East Liberty Street, Suite 310, Ann Arbor, MI 48104, USA
    J Clin Endocrinol Metab 91:3780-5. 2006
    ....
  57. pmc Dietary fat subgroups, zinc, and vegetable components are related to urine F2a-isoprostane concentration, a measure of oxidative stress, in midlife women
    Kristin M Tomey
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48104, USA
    J Nutr 137:2412-9. 2007
    ..346, SE = 0.14, P = 0.01), and -0.117, 0.04 (P = 0.001), respectively]. In conclusion, diet (fat subtypes, zinc, and vegetable components) and smoking were associated with urine F(2a)-isoprostanes, a marker of oxidative stress...
  58. ncbi Androgen profiles among Egyptian adults considering liver status
    Cristina E Aguilar
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA
    J Gastroenterol Hepatol 23:e137-45. 2008
    ..We aimed to evaluate liver diseases and sex steroid hormones in Egypt, which has the highest prevalence of HCV worldwide...
  59. ncbi Osteoarthritis of the knee: comparison of MR imaging findings with radiographic severity measurements and pain in middle-aged women
    Curtis W Hayes
    Department of Epidemiology, School of Public Health, University of Michigan, Room 2624, 109 Observatory St, Ann Arbor, MI 48109, USA
    Radiology 237:998-1007. 2005
    ..To prospectively compare magnetic resonance (MR) imaging-defined abnormalities of osteoarthritis (OA) of the knee with radiographic severity measurements of OA of the knee and self-reported pain...
  60. ncbi Lead in breast milk and maternal bone turnover
    MaryFran R Sowers
    School of Public Health, University of Michigan, Ann Arbor, USA
    Am J Obstet Gynecol 187:770-6. 2002
    ..Our purpose was to determine whether breast milk lead (Pb) levels are correlated with maternal blood Pb levels, bone loss, or bone turnover during reproduction...
  61. ncbi The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004)
    Rachel P Wildman
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Belfer Building, Room 1309, Bronx, NY 10461, USA
    Arch Intern Med 168:1617-24. 2008
    ....
  62. pmc Sleep disturbance during the menopausal transition in a multi-ethnic community sample of women
    Howard M Kravitz
    Rush University Medical Center, Department of Psychiatry, Rush West Campus, 2150 West Harrison Street, Chicago, IL, USA
    Sleep 31:979-90. 2008
    ....
  63. ncbi The association of genetic polymorphisms in sex hormone biosynthesis and action with insulin sensitivity and diabetes mellitus in women at midlife
    Joan C Lo
    Division of Research, Kaiser Permanente Northern California, Oakland, California, USA
    Am J Med 119:S69-78. 2006
    ..The strong association of 17HSD and diabetes in Caucasian women has not been previously reported and should be further investigated...
  64. ncbi The association of bone mineral density with estrogen receptor gene polymorphisms
    Gail A Greendale
    Division of Geriatrics, David Geffen School of Medicine at the University of California Los Angeles, California 90095 1687, USA
    Am J Med 119:S79-86. 2006
    ..Among these, ESR2 rs1256030 and ESR2 rs1256065 appear to have an effect at both the lumbar spine and hip in Chinese women and may warrant further study...
  65. ncbi Cognitive functioning and sex steroid hormone gene polymorphisms in women at midlife
    Howard M Kravitz
    Department of Psychiatry, Rush University Medical Center, Chicago, Illinois 60612, USA
    Am J Med 119:S94-S102. 2006
    ..We conclude that selected genes involved in estrogen synthesis and metabolism may be associated with performance differences on cognitive function tests. Also, the relevant estrogen-related polymorphisms may vary by race/ethnicity...
  66. ncbi Adiposity and reporting of vasomotor symptoms among midlife women: the study of women's health across the nation
    Rebecca C Thurston
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Epidemiol 167:78-85. 2008
    ..14, 1.42) in age- and site-adjusted models. Associations persisted in fully adjusted models and were not reduced when models included reproductive hormones. These findings support a thermoregulatory model of vasomotor symptoms...
  67. pmc Bone mineral density changes during the menopause transition in a multiethnic cohort of women
    Joel S Finkelstein
    Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 50 Blossom Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:861-8. 2008
    ..Rates of bone loss across the menopause transition and factors associated with variation in menopausal bone loss are poorly understood...
  68. pmc Abdominal adiposity and hot flashes among midlife women
    Rebecca C Thurston
    From the 1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15217, USA
    Menopause 15:429-34. 2008
    ..The study objective was to examine associations between abdominal adiposity and hot flashes, including the role of reproductive hormones in these associations...
  69. ncbi Bone mineral density changes over two years in first-time users of depot medroxyprogesterone acetate
    M Kathleen Clark
    College of Nursing, University of Iowa, Iowa City, Iowa 52242, USA
    Fertil Steril 82:1580-6. 2004
    ..To compare longitudinal changes in bone mineral density (BMD) among first-time depot medroxyprogesterone acetate (DMPA) users to women using no hormonal contraception, and evaluate user characteristics associated with that BMD change...
  70. doi Ethnic differences in C-reactive protein concentrations
    Alyson Kelley-Hedgepeth
    Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA
    Clin Chem 54:1027-37. 2008
    ..We hypothesized that known CVD risk factors, including anthropometric characteristics, would explain much of the observed ethnic variation in CRP...
  71. ncbi Circulating bioactive androgens in midlife women
    Jiangang Chen
    Center for Health and the Environment, University of California, Davis, California 95616, USA
    J Clin Endocrinol Metab 91:4387-94. 2006
    ..It is important to characterize the biological activity of circulating androgenic steroid hormones during the menopausal transition because these appear to impact the metabolic and cardiovascular health risk factors of women...

Research Grants24

  1. FUNCTIONAL STATUS AND THE MENOPAUSAL TRANSITION
    MaryFran Sowers; Fiscal Year: 2001
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men (NCHS, 1997). ..
  2. Estrogen, Metabolism, Menopause, and Health Outcomes
    MaryFran Sowers; Fiscal Year: 2006
    ..This is a unique opportunity to prospectively integrate lifestyle elements with measures of hormone metabolism pathways into a comprehensive examination of multiple human health effects. ..
  3. Functional Status and the Menopause Transition
    MaryFran Sowers; Fiscal Year: 2007
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men. ..
  4. FUNCTIONAL STATUS AND THE MENOPAUSAL TRANSITION
    MaryFran Sowers; Fiscal Year: 2004
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men (NCHS, 1997). ..
  5. Sleep During the Perimenopause in a Multi-Ethnic Cohort
    MaryFran Sowers; Fiscal Year: 2002
    ..All sleep study data, as well as relevant data from the Core SWAN study, will be merged and analyzed by the Michigan site. The Chicago and UC Davis PIs will co-chair the Sleep Study Steering Committee. ..
  6. SWAN REPOSITORY
    MaryFran Sowers; Fiscal Year: 2007
    ....
  7. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2007
    ....
  8. SWAN Sleep Study II - Michigan Center
    MaryFran Sowers; Fiscal Year: 2006
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. ..
  9. Functional Status and the Menopause Transition
    MaryFran Sowers; Fiscal Year: 2006
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men. ..
  10. FUNCTIONAL STATUS AND THE MENOPAUSAL TRANSITION
    MaryFran Sowers; Fiscal Year: 2002
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men (NCHS, 1997). ..
  11. FUNCTIONAL STATUS AND THE MENOPAUSAL TRANSITION
    MaryFran Sowers; Fiscal Year: 2003
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men (NCHS, 1997). ..
  12. Sleep During the Perimenopause in a Multi-Ethnic Cohort
    MaryFran Sowers; Fiscal Year: 2004
    ..All sleep study data, as well as relevant data from the Core SWAN study, will be merged and analyzed by the Michigan site. The Chicago and UC Davis PIs will co-chair the Sleep Study Steering Committee. ..
  13. Sleep During the Perimenopause in a Multi-Ethnic Cohort
    MaryFran Sowers; Fiscal Year: 2005
    ..All sleep study data, as well as relevant data from the Core SWAN study, will be merged and analyzed by the Michigan site. The Chicago and UC Davis PIs will co-chair the Sleep Study Steering Committee. ..
  14. Functional Status and the Menopause Transition
    MaryFran R Sowers; Fiscal Year: 2010
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men. ..
  15. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2005
    ....
  16. SWAN Sleep Study II - Michigan Center
    MaryFran Sowers; Fiscal Year: 2007
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. ..
  17. Sleep During the Perimenopause in a Multi-Ethnic Cohort
    MaryFran Sowers; Fiscal Year: 2003
    ..All sleep study data, as well as relevant data from the Core SWAN study, will be merged and analyzed by the Michigan site. The Chicago and UC Davis PIs will co-chair the Sleep Study Steering Committee. ..
  18. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2006
    ....
  19. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2009
    ....
  20. Functional Status and the Menopause Transition
    MaryFran Sowers; Fiscal Year: 2009
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men. ..