E R Sowell

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Brain abnormalities in early-onset schizophrenia spectrum disorder observed with statistical parametric mapping of structural magnetic resonance images
    E R Sowell
    Laboratory of Neuro Imaging, University of California, Los Angeles, CA 90095 1769, USA
    Am J Psychiatry 157:1475-84. 2000
  2. ncbi request reprint Functional magnetic resonance imaging of verbal learning in children with heavy prenatal alcohol exposure
    Elizabeth R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, California 90095 7334, USA
    Neuroreport 18:635-9. 2007
  3. pmc Abnormal cortical thickness and brain-behavior correlation patterns in individuals with heavy prenatal alcohol exposure
    Elizabeth R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, CA 90095 7334, USA
    Cereb Cortex 18:136-44. 2008
  4. pmc Mapping white matter integrity and neurobehavioral correlates in children with fetal alcohol spectrum disorders
    Elizabeth R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095 7334, USA
    J Neurosci 28:1313-9. 2008
  5. ncbi request reprint Longitudinal mapping of cortical thickness and brain growth in normal children
    Elizabeth R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095 1769, USA
    J Neurosci 24:8223-31. 2004
  6. ncbi request reprint Mapping changes in the human cortex throughout the span of life
    Elizabeth R Sowell
    David Geffen School of Medicine, Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles 90095 1769, USA
    Neuroscientist 10:372-92. 2004
  7. ncbi request reprint Cortical abnormalities in children and adolescents with attention-deficit hyperactivity disorder
    Elizabeth R Sowell
    University of California at Los Angeles, Laboratory of Neuro Imaging, Department of Neurology, 710 Westwood Plaza, Room 4 238, Los Angeles, CA 90095 1769, USA
    Lancet 362:1699-707. 2003
  8. ncbi request reprint Mapping cortical change across the human life span
    Elizabeth R Sowell
    University of California at Los Angeles, Laboratory of Neuro Imaging, Department of Neurology, 710 Westwood Plaza, Los Angeles, California 90095, USA
    Nat Neurosci 6:309-15. 2003
  9. ncbi request reprint Regional brain shape abnormalities persist into adolescence after heavy prenatal alcohol exposure
    Elizabeth R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California Los Angeles, 710 Westwood Plaza, Room 4 238, Los Angeles, CA 90095 1769, USA
    Cereb Cortex 12:856-65. 2002
  10. pmc Sex differences in cortical thickness mapped in 176 healthy individuals between 7 and 87 years of age
    Elizabeth R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, CA 90095 7334, USA
    Cereb Cortex 17:1550-60. 2007

Research Grants

Detail Information

Publications37

  1. ncbi request reprint Brain abnormalities in early-onset schizophrenia spectrum disorder observed with statistical parametric mapping of structural magnetic resonance images
    E R Sowell
    Laboratory of Neuro Imaging, University of California, Los Angeles, CA 90095 1769, USA
    Am J Psychiatry 157:1475-84. 2000
    ..Relatively few anatomical structures have been delineated and measured in this rare population, partly because of the labor involved in the slice-by-slice region definition required of conventional volumetric image analyses...
  2. ncbi request reprint Functional magnetic resonance imaging of verbal learning in children with heavy prenatal alcohol exposure
    Elizabeth R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, California 90095 7334, USA
    Neuroreport 18:635-9. 2007
    ....
  3. pmc Abnormal cortical thickness and brain-behavior correlation patterns in individuals with heavy prenatal alcohol exposure
    Elizabeth R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, CA 90095 7334, USA
    Cereb Cortex 18:136-44. 2008
    ..Further, the significant interactions show for the first time that brain-behavior relationships are altered as a function of heavy prenatal alcohol exposure...
  4. pmc Mapping white matter integrity and neurobehavioral correlates in children with fetal alcohol spectrum disorders
    Elizabeth R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095 7334, USA
    J Neurosci 28:1313-9. 2008
    ..This suggests that this region of white matter is particularly susceptible to damage from prenatal alcohol exposure and that disruption of splenial fibers in this group is associated with poorer visuomotor integration...
  5. ncbi request reprint Longitudinal mapping of cortical thickness and brain growth in normal children
    Elizabeth R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095 1769, USA
    J Neurosci 24:8223-31. 2004
    ..For the first time, developmental changes in gray matter thickness, brain size, and structure-function relationships have been traced within the same individuals studied longitudinally during a time of rapid cognitive development...
  6. ncbi request reprint Mapping changes in the human cortex throughout the span of life
    Elizabeth R Sowell
    David Geffen School of Medicine, Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles 90095 1769, USA
    Neuroscientist 10:372-92. 2004
    ....
  7. ncbi request reprint Cortical abnormalities in children and adolescents with attention-deficit hyperactivity disorder
    Elizabeth R Sowell
    University of California at Los Angeles, Laboratory of Neuro Imaging, Department of Neurology, 710 Westwood Plaza, Room 4 238, Los Angeles, CA 90095 1769, USA
    Lancet 362:1699-707. 2003
    ..We aimed to map these features in patients with attention-deficit hyperactivity disorder...
  8. ncbi request reprint Mapping cortical change across the human life span
    Elizabeth R Sowell
    University of California at Los Angeles, Laboratory of Neuro Imaging, Department of Neurology, 710 Westwood Plaza, Los Angeles, California 90095, USA
    Nat Neurosci 6:309-15. 2003
    ..Our findings also indicate that the posterior temporal cortices, primarily in the left hemisphere, which typically support language functions, have a more protracted course of maturation than any other cortical region...
  9. ncbi request reprint Regional brain shape abnormalities persist into adolescence after heavy prenatal alcohol exposure
    Elizabeth R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California Los Angeles, 710 Westwood Plaza, Room 4 238, Los Angeles, CA 90095 1769, USA
    Cereb Cortex 12:856-65. 2002
    ....
  10. pmc Sex differences in cortical thickness mapped in 176 healthy individuals between 7 and 87 years of age
    Elizabeth R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, CA 90095 7334, USA
    Cereb Cortex 17:1550-60. 2007
    ..Given the large sample and the large range of ages studied, these results help to address controversies in the study of central nervous system sexual dimorphisms...
  11. ncbi request reprint Brain abnormalities observed in childhood-onset schizophrenia: a review of the structural magnetic resonance imaging literature
    E R Sowell
    Department of Neurology, Laboratory of Neuro Imaging, University of California, Los Angeles, California 90095 1769, USA
    Ment Retard Dev Disabil Res Rev 6:180-5. 2000
    ..This is consistent with the lack of progressive changes noted in most longitudinal studies of adult-onset schizophrenia...
  12. ncbi request reprint Improved memory functioning and frontal lobe maturation between childhood and adolescence: a structural MRI study
    E R Sowell
    University of California, Los Angeles, Department of Neurology, 90095 1769, USA
    J Int Neuropsychol Soc 7:312-22. 2001
    ..The relationship between frontal lobe maturation and delayed recall observed here may be reflective of the children's development towards the more adult-like frontal lobe function revealed in the functional imaging studies...
  13. ncbi request reprint Mapping callosal morphology and cognitive correlates: effects of heavy prenatal alcohol exposure
    E R Sowell
    Laboratory of Neuroimaging, Department of Neurology, University of California, Los Angeles 90095 1769, USA
    Neurology 57:235-44. 2001
    ..Prenatal exposure to alcohol is also known to result in neurocognitive deficits...
  14. ncbi request reprint Mapping continued brain growth and gray matter density reduction in dorsal frontal cortex: Inverse relationships during postadolescent brain maturation
    E R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California Los Angeles, Los Angeles, California 90095 1769, USA
    J Neurosci 21:8819-29. 2001
    ....
  15. ncbi request reprint Development of cortical and subcortical brain structures in childhood and adolescence: a structural MRI study
    Elizabeth R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles 90095 1769, USA
    Dev Med Child Neurol 44:4-16. 2002
    ..Overall, these results are consistent with earlier reports and describe in greater detail the regional pattern of age-related differences in gray and white matter in normally developing children and adolescents...
  16. ncbi request reprint Mapping sulcal pattern asymmetry and local cortical surface gray matter distribution in vivo: maturation in perisylvian cortices
    Elizabeth R Sowell
    Department of Neurology, Laboratory of Neuro Imaging, University of California, Los Angeles, Los Angeles, CA 90095 1769, USA
    Cereb Cortex 12:17-26. 2002
    ..These morphological differences may be related to changing cognitive abilities and are relevant in interpreting results from studies of abnormal brain development where perisylvian brain regions are implicated...
  17. ncbi request reprint Increases in regional subarachnoid CSF without apparent cortical gray matter deficits in schizophrenia: modulating effects of sex and age
    Katherine L Narr
    Laboratory of Neuro Imaging, Department of Neurology, Division of Brain Mapping, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Am J Psychiatry 160:2169-80. 2003
    ....
  18. ncbi request reprint Voxel-based morphometric analyses of the brain in children and adolescents prenatally exposed to alcohol
    E R Sowell
    University of California, Los Angeles, Department of Neurology, 90095-1769, USA
    Neuroreport 12:515-23. 2001
    ..These results provide further support for dysmorphology in temporo-parietal cortices above and beyond the overall microcephaly that results from severe prenatal alcohol exposure...
  19. ncbi request reprint Mapping cortical gray matter asymmetry patterns in adolescents with heavy prenatal alcohol exposure
    Elizabeth R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California at Los Angeles, 90095, USA
    Neuroimage 17:1807-19. 2002
    ....
  20. ncbi request reprint Mapping cerebellar vermal morphology and cognitive correlates in prenatal alcohol exposure
    Elizabeth D O'Hare
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, California, USA
    Neuroreport 16:1285-90. 2005
    ..These observations expand on previous reports of cerebellar abnormalities in prenatal alcohol exposure, in that they localize the specific pattern of cerebellar vermal dysmorphology...
  21. pmc Altered frontal-parietal functioning during verbal working memory in children and adolescents with heavy prenatal alcohol exposure
    Elizabeth D O'Hare
    Department of Neurology, University of California, Los Angeles, CA, USA
    Hum Brain Mapp 30:3200-8. 2009
    ..These findings may suggest that frontal-parietal processing during verbal WM is less efficient in alcohol-exposed individuals...
  22. pmc Semi-automated method for delineation of landmarks on models of the cerebral cortex
    David W Shattuck
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Neurosci Methods 178:385-92. 2009
    ..Our new method was shown to be faster to use, to provide reduced inter-rater variability, and to provide results that were at least as accurate as those produced using Display...
  23. pmc Differentiating prenatal exposure to methamphetamine and alcohol versus alcohol and not methamphetamine using tensor-based brain morphometry and discriminant analysis
    Elizabeth R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 30:3876-85. 2010
    ....
  24. pmc Effects of prenatal methamphetamine exposure on verbal memory revealed with functional magnetic resonance imaging
    Lisa H Lu
    Developmental Cognitive Neuroimaging Group, Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, CA 90095 7334, USA
    J Dev Behav Pediatr 30:185-92. 2009
    ..We examined whether neurocognitive systems differed among children with differing prenatal teratogenic exposures when they engaged in a verbal memory task...
  25. pmc Tracking Alzheimer's disease
    Paul M Thompson
    Department of Neurology, Laboratory of Neuro Imaging, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
    Ann N Y Acad Sci 1097:183-214. 2007
    ..Strengths and weaknesses of these different imaging measures for basic neuroscience and drug trials are discussed...
  26. pmc Mapping brain maturation
    Arthur W Toga
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225, Los Angeles, CA 90095 7332, USA
    Trends Neurosci 29:148-59. 2006
    ..We relate these structural changes to the cellular processes that underlie them, and to cognitive and behavioral changes occurring throughout childhood and adolescence...
  27. ncbi request reprint Brain imaging in FAS: commentary on the article by Malisza et al
    Susan Y Bookheimer
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Pediatr Res 58:1148-9. 2005
  28. ncbi request reprint Mapping cortical change in Alzheimer's disease, brain development, and schizophrenia
    Paul M Thompson
    Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
    Neuroimage 23:S2-18. 2004
    ..Dynamically spreading waves of gray matter loss are tracked in dementia and schizophrenia, and these sequences are related to normally occurring changes in healthy subjects of various ages...
  29. doi request reprint Abnormal brain activation during working memory in children with prenatal exposure to drugs of abuse: the effects of methamphetamine, alcohol, and polydrug exposure
    Florence F Roussotte
    Department of Neurology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095 7332, USA
    Neuroimage 54:3067-75. 2011
    ....
  30. pmc Thinning of sensorimotor cortices in children with Tourette syndrome
    Elizabeth R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, 635 Charles Young Drive South, Suite 225, Los Angeles, California 90095, USA
    Nat Neurosci 11:637-9. 2008
    ..Correlations of cortical thickness in sensorimotor regions with tic symptoms suggest that these brain regions are important in the pathogenesis of Tourette syndrome...
  31. ncbi request reprint Mapping brain size and cortical gray matter changes in elderly depression
    Martina Ballmaier
    Laboratory of Neuro Imaging, Department of Neurology, David Geffen UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Biol Psychiatry 55:382-9. 2004
    ..Here, we conducted detailed spatial analyses of brain size and gray matter within the cortical mantle in elderly patients with major depression...
  32. ncbi request reprint Abnormal fMRI activation pattern during story listening in individuals with Down syndrome
    Elizabeth A Reynolds Losin
    University of California, Los Angeles, CA, USA
    Am J Intellect Dev Disabil 114:369-80. 2009
    ..The Down syndrome group showed almost no difference in activation patterns between the language (forward speech) and nonlanguage (backward speech) conditions...
  33. ncbi request reprint Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex
    Martina Ballmaier
    Department of Neurology, UCLA Neuropsychiatric Institute, David Geffen School of Medicine, Los Angeles, CA 90024, USA
    Am J Psychiatry 161:99-108. 2004
    ....
  34. pmc Neurodevelopmental changes in verbal working memory load-dependency: an fMRI investigation
    Elizabeth D O'Hare
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles 90095 7334, USA
    Neuroimage 42:1678-85. 2008
    ....
  35. ncbi request reprint Structural MRI and brain development
    Paul M Thompson
    Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, University of California, Los Angeles School of Medicine, Los Angeles, California 90095 1769, USA
    Int Rev Neurobiol 67:285-323. 2005
  36. pmc Relationships between brain activation and brain structure in normally developing children
    Lisa H Lu
    UCLA Laboratory of Neuro Imaging, Department of Neurology, Los Angeles, CA 90095, USA
    Cereb Cortex 19:2595-604. 2009
    ..These results localized cortical regions where mature morphology corresponds to mature patterns of activation, and may suggest a role for experience in mediating brain structure-activation relationships...
  37. ncbi request reprint Teratogenic effects of alcohol: a decade of brain imaging
    Edward P Riley
    Center for Behavioral Teratology, San Diego State University, 6363 Alvarado Court 209, San Diego, CA 92120, USA
    Am J Med Genet C Semin Med Genet 127:35-41. 2004
    ....

Research Grants7

  1. IMAGING BRAIN MATURATION AND NEUROBEHAVIORAL CORRELATES
    ELIZABETH SOWELL; Fiscal Year: 2003
    ..g., verbal memory vs. spatial memory), and similar brain regions will be implicated in the fMRI studies of memory, and the sMRI/memory correlation studies. ..
  2. Analyzing Functional and Structural MRI in FAS Children
    ELIZABETH SOWELL; Fiscal Year: 2004
    ..The results of these studies will help us in planning intervention strategies to optimize development in FAS children and provide more optimal image analysis techniques for other pediatric populations. ..
  3. Cross-cultural FASD: Brain Imaging (U24 Core)
    ELIZABETH SOWELL; Fiscal Year: 2005
    ..abstract_text> ..
  4. Mapping the Brain, the Face and Neurocognitive Function in FASD (U01)
    ELIZABETH SOWELL; Fiscal Year: 2007
    ..Ultimately, as part of the CIFASD, this project will enhance the capability for definitive FASD diagnoses that, in turn, will help clinicians manage and treat neurobehavioral deficits and associated secondary disabilities. ..