Research Topics
| E R SowellSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Brain abnormalities in early-onset schizophrenia spectrum disorder observed with statistical parametric mapping of structural magnetic resonance imagesE R Sowell
Laboratory of Neuro Imaging, University of California, Los Angeles, CA 90095 1769, USA
Am J Psychiatry 157:1475-84. 2000..Relatively few anatomical structures have been delineated and measured in this rare population, partly because of the labor involved in the slice-by-slice region definition required of conventional volumetric image analyses...- Functional magnetic resonance imaging of verbal learning in children with heavy prenatal alcohol exposureElizabeth R Sowell
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, California 90095 7334, USA
Neuroreport 18:635-9. 2007.... - Abnormal cortical thickness and brain-behavior correlation patterns in individuals with heavy prenatal alcohol exposureElizabeth R Sowell
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, CA 90095 7334, USA
Cereb Cortex 18:136-44. 2008..Further, the significant interactions show for the first time that brain-behavior relationships are altered as a function of heavy prenatal alcohol exposure... - Mapping white matter integrity and neurobehavioral correlates in children with fetal alcohol spectrum disordersElizabeth R Sowell
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095 7334, USA
J Neurosci 28:1313-9. 2008..This suggests that this region of white matter is particularly susceptible to damage from prenatal alcohol exposure and that disruption of splenial fibers in this group is associated with poorer visuomotor integration... - Longitudinal mapping of cortical thickness and brain growth in normal childrenElizabeth R Sowell
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095 1769, USA
J Neurosci 24:8223-31. 2004..For the first time, developmental changes in gray matter thickness, brain size, and structure-function relationships have been traced within the same individuals studied longitudinally during a time of rapid cognitive development... - Mapping changes in the human cortex throughout the span of lifeElizabeth R Sowell
David Geffen School of Medicine, Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles 90095 1769, USA
Neuroscientist 10:372-92. 2004.... - Cortical abnormalities in children and adolescents with attention-deficit hyperactivity disorderElizabeth R Sowell
University of California at Los Angeles, Laboratory of Neuro Imaging, Department of Neurology, 710 Westwood Plaza, Room 4 238, Los Angeles, CA 90095 1769, USA
Lancet 362:1699-707. 2003..We aimed to map these features in patients with attention-deficit hyperactivity disorder... - Mapping cortical change across the human life spanElizabeth R Sowell
University of California at Los Angeles, Laboratory of Neuro Imaging, Department of Neurology, 710 Westwood Plaza, Los Angeles, California 90095, USA
Nat Neurosci 6:309-15. 2003..Our findings also indicate that the posterior temporal cortices, primarily in the left hemisphere, which typically support language functions, have a more protracted course of maturation than any other cortical region... - Regional brain shape abnormalities persist into adolescence after heavy prenatal alcohol exposureElizabeth R Sowell
Laboratory of Neuro Imaging, Department of Neurology, University of California Los Angeles, 710 Westwood Plaza, Room 4 238, Los Angeles, CA 90095 1769, USA
Cereb Cortex 12:856-65. 2002.... - Sex differences in cortical thickness mapped in 176 healthy individuals between 7 and 87 years of ageElizabeth R Sowell
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, CA 90095 7334, USA
Cereb Cortex 17:1550-60. 2007..Given the large sample and the large range of ages studied, these results help to address controversies in the study of central nervous system sexual dimorphisms... - Brain abnormalities observed in childhood-onset schizophrenia: a review of the structural magnetic resonance imaging literatureE R Sowell
Department of Neurology, Laboratory of Neuro Imaging, University of California, Los Angeles, California 90095 1769, USA
Ment Retard Dev Disabil Res Rev 6:180-5. 2000..This is consistent with the lack of progressive changes noted in most longitudinal studies of adult-onset schizophrenia... - Improved memory functioning and frontal lobe maturation between childhood and adolescence: a structural MRI studyE R Sowell
University of California, Los Angeles, Department of Neurology, 90095 1769, USA
J Int Neuropsychol Soc 7:312-22. 2001..The relationship between frontal lobe maturation and delayed recall observed here may be reflective of the children's development towards the more adult-like frontal lobe function revealed in the functional imaging studies... - Mapping callosal morphology and cognitive correlates: effects of heavy prenatal alcohol exposureE R Sowell
Laboratory of Neuroimaging, Department of Neurology, University of California, Los Angeles 90095 1769, USA
Neurology 57:235-44. 2001..Prenatal exposure to alcohol is also known to result in neurocognitive deficits... - Mapping continued brain growth and gray matter density reduction in dorsal frontal cortex: Inverse relationships during postadolescent brain maturationE R Sowell
Laboratory of Neuro Imaging, Department of Neurology, University of California Los Angeles, Los Angeles, California 90095 1769, USA
J Neurosci 21:8819-29. 2001.... - Development of cortical and subcortical brain structures in childhood and adolescence: a structural MRI studyElizabeth R Sowell
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles 90095 1769, USA
Dev Med Child Neurol 44:4-16. 2002..Overall, these results are consistent with earlier reports and describe in greater detail the regional pattern of age-related differences in gray and white matter in normally developing children and adolescents... - Mapping sulcal pattern asymmetry and local cortical surface gray matter distribution in vivo: maturation in perisylvian corticesElizabeth R Sowell
Department of Neurology, Laboratory of Neuro Imaging, University of California, Los Angeles, Los Angeles, CA 90095 1769, USA
Cereb Cortex 12:17-26. 2002..These morphological differences may be related to changing cognitive abilities and are relevant in interpreting results from studies of abnormal brain development where perisylvian brain regions are implicated... - Increases in regional subarachnoid CSF without apparent cortical gray matter deficits in schizophrenia: modulating effects of sex and ageKatherine L Narr
Laboratory of Neuro Imaging, Department of Neurology, Division of Brain Mapping, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095-1769, USA
Am J Psychiatry 160:2169-80. 2003..Cortical gray matter reductions show aging effects but are below the threshold of significance in schizophrenia... - Voxel-based morphometric analyses of the brain in children and adolescents prenatally exposed to alcoholE R Sowell
University of California, Los Angeles, Department of Neurology, 90095-1769, USA
Neuroreport 12:515-23. 2001..These results provide further support for dysmorphology in temporo-parietal cortices above and beyond the overall microcephaly that results from severe prenatal alcohol exposure... - Mapping cortical gray matter asymmetry patterns in adolescents with heavy prenatal alcohol exposureElizabeth R Sowell
Laboratory of Neuro Imaging, Department of Neurology, University of California at Los Angeles, 90095, USA
Neuroimage 17:1807-19. 2002.... - Mapping cerebellar vermal morphology and cognitive correlates in prenatal alcohol exposureEric Kan
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, California, USA
Neuroreport 16:1285-90. 2005..These observations expand on previous reports of cerebellar abnormalities in prenatal alcohol exposure, in that they localize the specific pattern of cerebellar vermal dysmorphology... - Altered frontal-parietal functioning during verbal working memory in children and adolescents with heavy prenatal alcohol exposureElizabeth D O'Hare
Department of Neurology, University of California, Los Angeles, CA, USA
Hum Brain Mapp 30:3200-8. 2009..These findings may suggest that frontal-parietal processing during verbal WM is less efficient in alcohol-exposed individuals... - Semi-automated method for delineation of landmarks on models of the cerebral cortexDavid W Shattuck
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Neurosci Methods 178:385-92. 2009..Our new method was shown to be faster to use, to provide reduced inter-rater variability, and to provide results that were at least as accurate as those produced using Display... - Differentiating prenatal exposure to methamphetamine and alcohol versus alcohol and not methamphetamine using tensor-based brain morphometry and discriminant analysisElizabeth R Sowell
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA
J Neurosci 30:3876-85. 2010.... - Effects of prenatal methamphetamine exposure on verbal memory revealed with functional magnetic resonance imagingLisa H Lu
Developmental Cognitive Neuroimaging Group, Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, CA 90095 7334, USA
J Dev Behav Pediatr 30:185-92. 2009..We examined whether neurocognitive systems differed among children with differing prenatal teratogenic exposures when they engaged in a verbal memory task... - Tracking Alzheimer's diseasePaul M Thompson
Department of Neurology, Laboratory of Neuro Imaging, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
Ann N Y Acad Sci 1097:183-214. 2007..Strengths and weaknesses of these different imaging measures for basic neuroscience and drug trials are discussed... - Mapping brain maturationArthur W Toga
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225, Los Angeles, CA 90095 7332, USA
Trends Neurosci 29:148-59. 2006..We relate these structural changes to the cellular processes that underlie them, and to cognitive and behavioral changes occurring throughout childhood and adolescence... - Brain imaging in FAS: commentary on the article by Malisza et alSusan Y Bookheimer
Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA 90095, USA
Pediatr Res 58:1148-9. 2005 - Mapping cortical change in Alzheimer's disease, brain development, and schizophreniaPaul M Thompson
Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
Neuroimage 23:S2-18. 2004..Dynamically spreading waves of gray matter loss are tracked in dementia and schizophrenia, and these sequences are related to normally occurring changes in healthy subjects of various ages... - Abnormal brain activation during working memory in children with prenatal exposure to drugs of abuse: the effects of methamphetamine, alcohol, and polydrug exposureFlorence F Roussotte
Department of Neurology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095 7332, USA
Neuroimage 54:3067-75. 2011.... - Thinning of sensorimotor cortices in children with Tourette syndromeElizabeth R Sowell
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, 635 Charles Young Drive South, Suite 225, Los Angeles, California 90095, USA
Nat Neurosci 11:637-9. 2008..Correlations of cortical thickness in sensorimotor regions with tic symptoms suggest that these brain regions are important in the pathogenesis of Tourette syndrome... - Mapping brain size and cortical gray matter changes in elderly depressionMartina Ballmaier
Laboratory of Neuro Imaging, Department of Neurology, David Geffen UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095-1769, USA
Biol Psychiatry 55:382-9. 2004.... - Abnormal fMRI activation pattern during story listening in individuals with Down syndromeElizabeth A Reynolds Losin
University of California, Los Angeles, CA, USA
Am J Intellect Dev Disabil 114:369-80. 2009..The Down syndrome group showed almost no difference in activation patterns between the language (forward speech) and nonlanguage (backward speech) conditions... - Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortexMartina Ballmaier
Department of Neurology, UCLA Neuropsychiatric Institute, David Geffen School of Medicine, Los Angeles, CA 90024, USA
Am J Psychiatry 161:99-108. 2004..The differential pattern of abnormalities detected in the white matter and CSF compartments imply that distinct etiopathological mechanisms might underlie the structural cortical changes in these regions... - Neurodevelopmental changes in verbal working memory load-dependency: an fMRI investigationElizabeth D O'Hare
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles 90095 7334, USA
Neuroimage 42:1678-85. 2008.... - Structural MRI and brain developmentPaul M Thompson
Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, University of California, Los Angeles School of Medicine, Los Angeles, California 90095-1769, USA
Int Rev Neurobiol 67:285-323. 2005 - Relationships between brain activation and brain structure in normally developing childrenLisa H Lu
UCLA Laboratory of Neuro Imaging, Department of Neurology, Los Angeles, CA 90095, USA
Cereb Cortex 19:2595-604. 2009..These results localized cortical regions where mature morphology corresponds to mature patterns of activation, and may suggest a role for experience in mediating brain structure-activation relationships... - Teratogenic effects of alcohol: a decade of brain imagingEdward P Riley
Center for Behavioral Teratology, San Diego State University, 6363 Alvarado Court 209, San Diego, CA 92120, USA
Am J Med Genet C Semin Med Genet 127:35-41. 2004....
Research Grants
- IMAGING BRAIN MATURATION AND NEUROBEHAVIORAL CORRELATESELIZABETH SOWELL; Fiscal Year: 2003..g., verbal memory vs. spatial memory), and similar brain regions will be implicated in the fMRI studies of memory, and the sMRI/memory correlation studies. ..
- Analyzing Functional and Structural MRI in FAS ChildrenELIZABETH SOWELL; Fiscal Year: 2004..The results of these studies will help us in planning intervention strategies to optimize development in FAS children and provide more optimal image analysis techniques for other pediatric populations. ..
- Cross-cultural FASD: Brain Imaging (U24 Core)ELIZABETH SOWELL; Fiscal Year: 2005..abstract_text> ..
- Mapping the Brain, the Face and Neurocognitive Function in FASD (U01)ELIZABETH SOWELL; Fiscal Year: 2007..Ultimately, as part of the CIFASD, this project will enhance the capability for definitive FASD diagnoses that, in turn, will help clinicians manage and treat neurobehavioral deficits and associated secondary disabilities. ..