R F Souza

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury
    Rhonda F Souza
    Department of Medicine, VA North Texas Health Care System and University of Texas Southwestern Medical School, Irving, Texas, USA
    Gastroenterology 137:1776-84. 2009
  2. pmc Omeprazole blocks STAT6 binding to the eotaxin-3 promoter in eosinophilic esophagitis cells
    Xi Zhang
    Department of Internal Medicine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 7:e50037. 2012
  3. pmc Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD
    Edaire Cheng
    Department of Pediatrics, University of Texas Southwestern Medical Center and Children s Medical Center, Dallas, Texas, USA
    Gut 62:824-32. 2013
  4. pmc Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells
    Chunhua Yu
    Department of Medicine, Veterans Affairs North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, USA
    Am J Physiol Gastrointest Liver Physiol 303:G561-9. 2012
  5. ncbi request reprint GERD is associated with shortened telomeres in the squamous epithelium of the distal esophagus
    Rhonda F Souza
    Department of Medicine, University of Texas Southwestern Medical Center at Dallas, and the Veterans Affairs North Texas Health Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Am J Physiol Gastrointest Liver Physiol 293:G19-24. 2007
  6. ncbi request reprint Acid, bile, and CDX: the ABCs of making Barrett's metaplasia
    Rhonda F Souza
    Department of Medicine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical School, USA
    Am J Physiol Gastrointest Liver Physiol 295:G211-8. 2008
  7. pmc The role of acid and bile reflux in oesophagitis and Barrett's metaplasia
    Rhonda F Souza
    Department of Medicine, VA North Texas Health Care System, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Biochem Soc Trans 38:348-52. 2010
  8. ncbi request reprint Molecular mechanisms of acid exposure in Barrett's esophagus
    R F Souza
    Dallas VA Medical Center, University of Texas Southwestern Medical School, Harold C Simmons Comprehensive Cancer Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Inflammopharmacology 15:95-100. 2007
  9. ncbi request reprint Acid exposure activates the mitogen-activated protein kinase pathways in Barrett's esophagus
    Rhonda F Souza
    Department of Medicine, Dallas VA Medical Center and University of Texas Southwestern Medical School, Dallas, Texas 75216, USA
    Gastroenterology 122:299-307. 2002
  10. doi request reprint Bone marrow progenitor cells contribute to esophageal regeneration and metaplasia in a rat model of Barrett's esophagus
    G Sarosi
    Dallas VA Medical Center, Dallas, Texas 75216, USA
    Dis Esophagus 21:43-50. 2008

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury
    Rhonda F Souza
    Department of Medicine, VA North Texas Health Care System and University of Texas Southwestern Medical School, Irving, Texas, USA
    Gastroenterology 137:1776-84. 2009
    ....
  2. pmc Omeprazole blocks STAT6 binding to the eotaxin-3 promoter in eosinophilic esophagitis cells
    Xi Zhang
    Department of Internal Medicine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 7:e50037. 2012
    ..The objective of this study was to elucidate molecular mechanisms underlying PPI inhibition of IL-4-stimulated eotaxin-3 production by esophageal cells...
  3. pmc Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD
    Edaire Cheng
    Department of Pediatrics, University of Texas Southwestern Medical Center and Children s Medical Center, Dallas, Texas, USA
    Gut 62:824-32. 2013
    ..The objective of the authors was to explore the molecular mechanisms of Th2 cytokines on eotaxin-3 expression by oesophageal squamous cells from patients with GORD and EoE, and the effects of omeprazole on that eotaxin-3 expression...
  4. pmc Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells
    Chunhua Yu
    Department of Medicine, Veterans Affairs North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, USA
    Am J Physiol Gastrointest Liver Physiol 303:G561-9. 2012
    ..These findings suggest a potential role for targeting the intrinsic inflammatory pathways as a therapeutic strategy to prevent Barrett's carcinogenesis...
  5. ncbi request reprint GERD is associated with shortened telomeres in the squamous epithelium of the distal esophagus
    Rhonda F Souza
    Department of Medicine, University of Texas Southwestern Medical Center at Dallas, and the Veterans Affairs North Texas Health Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Am J Physiol Gastrointest Liver Physiol 293:G19-24. 2007
    ..Telomeres in the squamous epithelium of the distal esophagus of patients who have GERD, with and without Barrett's esophagus, are significantly shorter than those of patients without GERD despite similar levels of telomerase activity...
  6. ncbi request reprint Acid, bile, and CDX: the ABCs of making Barrett's metaplasia
    Rhonda F Souza
    Department of Medicine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical School, USA
    Am J Physiol Gastrointest Liver Physiol 295:G211-8. 2008
    ..The role of stem cells in the development of metaplasia and in carcinogenesis and the potential for therapies directed at those stem cells also is addressed...
  7. pmc The role of acid and bile reflux in oesophagitis and Barrett's metaplasia
    Rhonda F Souza
    Department of Medicine, VA North Texas Health Care System, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Biochem Soc Trans 38:348-52. 2010
    ....
  8. ncbi request reprint Molecular mechanisms of acid exposure in Barrett's esophagus
    R F Souza
    Dallas VA Medical Center, University of Texas Southwestern Medical School, Harold C Simmons Comprehensive Cancer Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Inflammopharmacology 15:95-100. 2007
    ....
  9. ncbi request reprint Acid exposure activates the mitogen-activated protein kinase pathways in Barrett's esophagus
    Rhonda F Souza
    Department of Medicine, Dallas VA Medical Center and University of Texas Southwestern Medical School, Dallas, Texas 75216, USA
    Gastroenterology 122:299-307. 2002
    ....
  10. doi request reprint Bone marrow progenitor cells contribute to esophageal regeneration and metaplasia in a rat model of Barrett's esophagus
    G Sarosi
    Dallas VA Medical Center, Dallas, Texas 75216, USA
    Dis Esophagus 21:43-50. 2008
    ..These observations suggest that multi-potential progenitor cells of bone marrow origin contribute to esophageal regeneration and metaplasia in this rat model of Barrett's esophagus...
  11. ncbi request reprint Acid increases MAPK-mediated proliferation in Barrett's esophageal adenocarcinoma cells via intracellular acidification through a Cl-/HCO3- exchanger
    George A Sarosi
    Dept of Surgery, Medical University of Texas Southwestern Medical Center, Dallas, TX 75216, USA
    Am J Physiol Gastrointest Liver Physiol 289:G991-7. 2005
    ..The magnitude of these effects is pH dependent, and the effects can be inhibited by preventing intracellular acidification with DIDS...
  12. pmc Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett's esophagus
    Hui Ying Zhang
    Department of Medcine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical School, MC 111B1, Dallas VA Medical Ctr, 4500 South Lancaster Rd, Dallas, TX 75216, USA
    Am J Physiol Gastrointest Liver Physiol 295:G470-8. 2008
    ..We speculate that these differences might underlie the development of Barrett's metaplasia...
  13. ncbi request reprint Mechanisms of oxidant production in esophageal squamous cell and Barrett's cell lines
    Linda A Feagins
    Department of Medicine, Dallas VA Medical Center, Dallas, TX 75216, USA
    Am J Physiol Gastrointest Liver Physiol 294:G411-7. 2008
    ....
  14. ncbi request reprint Bile salt exposure increases proliferation through p38 and ERK MAPK pathways in a non-neoplastic Barrett's cell line
    Kshama Jaiswal
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA
    Am J Physiol Gastrointest Liver Physiol 290:G335-42. 2006
    ..These findings suggest a potential mechanism whereby bile reflux may facilitate the neoplastic progression of BE...
  15. ncbi request reprint Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells
    R F Souza
    Department of Medicine, Dallas VA Medical Center, Texas 75216, USA
    Cancer Res 60:5767-72. 2000
    ..These observations suggest a potential role for selective COX-2 inhibitors in the prevention and treatment of esophageal adenocarcinoma for patients with Barrett's esophagus...
  16. ncbi request reprint Review article: a conceptual approach to understanding the molecular mechanisms of cancer development in Barrett's oesophagus
    R F Souza
    Harold C Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Texas, USA
    Aliment Pharmacol Ther 15:1087-100. 2001
    ..The goal of this review is to provide the clinician with a useful conceptual basis for evaluating studies on the molecular mechanisms underlying the progression from metaplasia to carcinoma in Barrett's oesophagus...
  17. doi request reprint Molecular markers and genetics in cancer development
    Kathy Hormi-Carver
    Division of Gastroenterology 111B1, Department of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, 4500 South Lancaster Road, Dallas, TX 75216, USA
    Surg Oncol Clin N Am 18:453-67. 2009
    ..Moreover, the role of stem cells and stem cell markers in Barrett's carcinogenesis is addressed...
  18. pmc Acid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett's esophagus
    Xiaofang Huo
    Department of Medicine, VA North Texas Health Care System and the University of Texas Southwestern Medical School, Dallas, Texas, USA
    Gastroenterology 139:194-203.e1. 2010
    ..We hypothesized that differences among individuals in molecular pathways activated when esophageal squamous epithelium is exposed to reflux underlie the development of Barrett's metaplasia...
  19. ncbi request reprint Characterization of telomerase-immortalized, non-neoplastic, human Barrett's cell line (BAR-T)
    K R Jaiswal
    Department of Surgery, University of Texas Southwestern Medical Center at Dallas and the VA North Texas Healthcare System, Dallas, TX 75216, USA
    Dis Esophagus 20:256-64. 2007
    ..This cell line should be a useful model for the study of the early events in carcinogenesis in Barrett's esophagus...
  20. ncbi request reprint In non-neoplastic Barrett's epithelial cells, acid exerts early antiproliferative effects through activation of the Chk2 pathway
    Hui Ying Zhang
    Department of Medicine, Dallas Veterans Affairs Medical Center, University of Texas Southwestern Medical School, Dallas, Texas, USA
    Cancer Res 67:8580-7. 2007
    ..Thus, we have elucidated a mechanism whereby acid can exert disparate effects on proliferation in neoplastic and non-neoplastic BAR-T cells...
  21. pmc Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma
    Jie Hong
    Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Gut 59:170-80. 2010
    ..Bile acids may have an important role in this progression. This study aimed at examining the role of NADPH oxidase NOX5-S and a novel bile acid receptor TGR5 in taurodeoxycholic acid (TDCA)-induced increase in cell proliferation...
  22. ncbi request reprint NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett's esophageal adenocarcinoma cells
    Jin Si
    Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, Rhode Island 02903, USA
    J Biol Chem 282:16244-55. 2007
    ..COX2-derived PGE2 production may contribute to NOX5-S-mediated cell proliferation in SEG1 cells...
  23. ncbi request reprint Acid increases proliferation via ERK and p38 MAPK-mediated increases in cyclooxygenase-2 in Barrett's adenocarcinoma cells
    Rhonda F Souza
    Department of Medicine, Dallas Veterans Affairs Medical Center, Dallas, TX 75216, USA
    Am J Physiol Gastrointest Liver Physiol 287:G743-8. 2004
    ..These findings suggest potential mechanisms whereby acid reflux might promote carcinogenesis in Barrett's esophagus...
  24. ncbi request reprint All trans-retinoic acid induces apoptosis via p38 and caspase pathways in metaplastic Barrett's cells
    Kathy Hormi-Carver
    1Departments of Medicine, Dallas Veterans Affairs Medical Center, University of Texas Southwestern Medical School, Dallas, Texas 75216, USA
    Am J Physiol Gastrointest Liver Physiol 292:G18-27. 2007
    ..This study elucidates molecular pathways whereby retinoid treatment might prevent carcinogenesis in Barrett's metaplasia and suggests a potential role for the use of safer retinoids for chemoprevention in Barrett's esophagus...
  25. ncbi request reprint Hallmarks of cancer progression in Barrett's oesophagus
    Carmela P Morales
    Department of Medicine, University of Texas Southwestern Medical Center and Dallas VA Medical Center, Dallas, Texas 75216, USA
    Lancet 360:1587-9. 2002
    ..The metaplastic cells of Barrett's oesophagus are predisposed to develop these cancer hallmarks...
  26. ncbi request reprint Gain of allelic gene expression for IGF-II occurs frequently in Barrett's esophagus
    Linda A Feagins
    Dept of Gastrointestinology, MC 111B1, Dallas Veterans Affairs Medical Center, 4500 S Lancaster Road, Dallas, TX 75216, USA
    Am J Physiol Gastrointest Liver Physiol 290:G871-5. 2006
    ..We conclude that in patients with Barrett's esophagus, GOAGE for IGF-II is found frequently in the metaplastic esophageal epithelium as well as in normal gastric and duodenal epithelia...
  27. ncbi request reprint Concepts in the prevention of adenocarcinoma of the distal esophagus and proximal stomach
    Rhonda F Souza
    Division of Gastroenterology, Dallas VA Medical Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    CA Cancer J Clin 55:334-51. 2005
    ..The similarities and differences in risk factors, molecular pathogenesis, and in preventive strategies for adenocarcinomas of the esophagus and gastric cardia are highlighted...
  28. ncbi request reprint Differences in ERK activation in squamous mucosa in patients who have gastroesophageal reflux disease with and without Barrett's esophagus
    Rhonda F Souza
    Department of Medicine, Dallas VA Medical Center, University of Texas Southwestern Medical School, Dallas, Texas, USA
    Am J Gastroenterol 100:551-9. 2005
    ....
  29. ncbi request reprint Molecular targets for treatment of Barrett's esophagus
    L A Feagins
    Department of Medicine, Dallas VA Medical Center and University of Texas Southwestern Medical School, Dallas 75216, USA
    Dis Esophagus 18:75-86. 2005
    ..Moreover, potential diagnostic and therapeutic strategies for Barrett's patients aimed at each of these cancer hallmarks will be reviewed...
  30. ncbi request reprint Induction of colonic epithelial cell apoptosis by p47-dependent oxidants
    Ying Gu
    Department of Internal Medicine, University of Texas Southwestern and the Dallas VAMC, Mail Code 151, 4500 S Lancaster Rd, Dallas, TX 75216, USA
    FEBS Lett 540:195-200. 2003
    ..Colonic epithelial p47(phox) may be specifically targeted to a c-Abl-containing complex that serves a physiologic tumor suppressing function...
  31. ncbi request reprint Acid has antiproliferative effects in nonneoplastic Barrett's epithelial cells
    Linda A Feagins
    Department of Medicine, Dallas VA Medical Center, University of Texas Southwestern Medical School, Dallas, Texas 75216, USA
    Am J Gastroenterol 102:10-20. 2007
    ..We studied the effects of acid on proliferation and apoptosis in a nonneoplastic, telomerase-immortalized Barrett's epithelial cell line...
  32. ncbi request reprint Molecular and biologic basis of upper gastrointestinal malignancy--esophageal carcinoma
    Rhonda F Souza
    Department of Medicine, Dallas VA Medical Center, Dept of GI, Harold C Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, TX, USA
    Surg Oncol Clin N Am 11:257-72, viii. 2002
    ..The goal of this article is to provide the clinician with a useful conceptual basis for evaluating studies on the molecular mechanisms underlying the development of esophageal carcinomas...
  33. pmc Unlike esophageal squamous cells, Barrett's epithelial cells resist apoptosis by activating the nuclear factor-kappaB pathway
    Kathy Hormi-Carver
    Department of Medicine, VA North Texas Health Care System, University of Texas Southwestern Medical School, Dallas, Texas 75216, USA
    Cancer Res 69:672-7. 2009
    ..This capacity to avoid apoptosis despite genotoxic damage may underlie the persistence and malignant predisposition of Barrett's metaplasia...
  34. pmc Esophageal adenocarcinoma arising in Barrett esophagus
    Hui Ying Zhang
    Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Cancer Lett 275:170-7. 2009
    ....
  35. pmc Acid-induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S
    Jie Hong
    Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, 02903, USA
    Am J Physiol Gastrointest Liver Physiol 299:G697-706. 2010
    ....
  36. doi request reprint Repeated exposure to acid and bile selectively induces colonic phenotype expression in a heterogeneous Barrett's epithelial cell line
    Manisha Bajpai
    Division of Gastroenterology and Hepatology, Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Lab Invest 88:643-51. 2008
    ..We conclude that BAR-T cells can be utilized as an 'in vitro' model to study the effect of environmental factors and their influence on the cellular phenotype and molecular changes in the pathogenesis of esophageal cancer...
  37. ncbi request reprint A molecular rationale for the how, when and why of colorectal cancer screening
    R F Souza
    Department of Medicine, Dallas VA Medical Center and University of Texas Southwestern Medical Center at Dallas, TX, USA
    Aliment Pharmacol Ther 15:451-62. 2001
    ....
  38. doi request reprint Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro
    Andres I Roig
    Department of Cell Biology, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Gastroenterology 138:1012-21.e1-5. 2010
    ..We sought to immortalize human colon biopsy-derived cells expressing stem cell markers and retaining multilineage epithelial differentiation capability...
  39. pmc In benign Barrett's epithelial cells, acid exposure generates reactive oxygen species that cause DNA double-strand breaks
    Hui Ying Zhang
    Department of Medicine, VA North Texas Health Care System, Dallas, Texas 75216, USA
    Cancer Res 69:9083-9. 2009
    ..Acid exposure causes DSBs in Barrett's epithelial cells through ROS produced as a consequence of intracellular acidification. These findings suggest that acid can be considered a carcinogen in Barrett's esophagus...
  40. ncbi request reprint Barrett's esophagus: chemoprevention
    Rhonda F Souza
    Division of Gastroenterology, Dallas VA Medical Center, Dallas, TX 75216, USA
    Gastrointest Endosc Clin N Am 13:419-32. 2003
    ..Results of well-designed, prospective clinical studies, however, are still needed to establish the efficacy of potent acid suppression, COX-2 inhibitors, and DFMO in the prevention of this malignancy...
  41. ncbi request reprint Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
    Ruben D Ramirez
    Hamon Center for Therapeutic Oncology Research and Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Res 64:9027-34. 2004
    ..These HBEC lines are a valuable new tool for studying of the pathogenesis of lung cancer...
  42. pmc Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells
    Hui Ying Zhang
    Department of Medicine, Veterans Affairs North Texas Health Care System, Children s Hospital, University of Texas Southwestern Medical Center, Dallas, USA
    Am J Physiol Gastrointest Liver Physiol 300:G454-60. 2011
    ..These findings demonstrate a possible contribution of the intrinsic inflammatory pathway to carcinogenesis in Barrett's esophagus...
  43. pmc Deoxycholic acid causes DNA damage while inducing apoptotic resistance through NF-κB activation in benign Barrett's epithelial cells
    Xiaofang Huo
    Department of Medicine, Veterans Affairs North Texas Health Care System, Children s Medical Center, USA
    Am J Physiol Gastrointest Liver Physiol 301:G278-86. 2011
    ..We have demonstrated molecular mechanisms whereby bile reflux might contribute to carcinogenesis in Barrett's esophagus...
  44. ncbi request reprint TNFalpha activates c-Jun amino terminal kinase through p47(phox)
    Ying Gu
    University of Texas Southwestern and Dallas VA Medical Center, Dallas, Texas 75216, USA
    Exp Cell Res 272:62-74. 2002
    ..We speculate that this physical targeting may prove important in conferring signal specificity and enhancing signaling efficiency of unstable oxidants...
  45. ncbi request reprint Assessment of oxidants in mitogen-activated protein kinase activation
    Lance S Terada
    University of Texas, Southwestern Medical Center, Dallas Veterans Administration Medical Center, Dallas, Texas 75216, USA
    Methods Enzymol 349:313-20. 2002
  46. ncbi request reprint Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis
    Stuart Jon Spechler
    Department of Medicine, Dallas Department of Veterans Affairs Medical Center, and The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75216, USA
    Am J Gastroenterol 102:1301-6. 2007
    ..Furthermore, we suggest that a favorable response to PPI therapy does not preclude a diagnosis of eosinophilic esophagitis...
  47. pmc Potential anti-inflammatory effects of proton pump inhibitors: a review and discussion of the clinical implications
    Ramalinga R Kedika
    VA North Texas Healthcare System, Dallas, TX, USA
    Dig Dis Sci 54:2312-7. 2009
    ....
  48. ncbi request reprint Activation of the esophagin promoter during esophageal epithelial cell differentiation
    Kara N Smolinski
    Department of Medicine, Gastroenterology Division and Greenebaum Cancer Center, University of Maryland School of Medicine, 22 S Greene Street, Baltimore, MD 21201, USA
    Genomics 79:875-80. 2002
    ....
  49. ncbi request reprint Is genomic evaluation feasible in endoscopic studies of Barrett's esophagus? A pilot study
    Hashem B El-Serag
    Divisions of Gastroenterology and Health Services Research, Houston Department of Veterans Affairs Medical Center 152, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Gastrointest Endosc 64:17-26. 2006
    ..The global gene expression in Barrett's esophagus (BE) in comparison to adjacent or histologically similar tissues has not been extensively studied...
  50. ncbi request reprint Stem cells in Barrett's esophagus: HALOs or horns?
    Stuart Jon Spechler
    Gastrointest Endosc 68:41-3. 2008
  51. ncbi request reprint Biomarkers and photodynamic therapy for Barrett's esophagus: time to FISH or cut bait?
    Stuart Jon Spechler
    Gastroenterology 135:354-7. 2008

Research Grants13

  1. Role of Acid in the Development of Barrett's Esophagus
    Rhonda Souza; Fiscal Year: 2002
    ..Our long term goals are to identify molecular markers of BE and molecular targets at which to direct chemopreventive and chemotheapeutic agents for patients with BE and esophageal adenocarcinoma. ..
  2. Role of Acid in the Development of Barrett's Esophagus
    Rhonda Souza; Fiscal Year: 2005
    ..Our long term goals are to identify molecular markers of BE and molecular targets at which to direct chemopreventive and chemotheapeutic agents for patients with BE and esophageal adenocarcinoma. ..
  3. Basic and Clinical Studies on the Role of Bile Acids in Barrett's Esophagus
    Stuart Jon Spechler; Fiscal Year: 2010
    ....
  4. Role of Acid in the Development of Barrett's Esophagus
    Rhonda Souza; Fiscal Year: 2003
    ..Our long term goals are to identify molecular markers of BE and molecular targets at which to direct chemopreventive and chemotheapeutic agents for patients with BE and esophageal adenocarcinoma. ..
  5. Role of Acid in the Development of Barrett's Esophagus
    Rhonda F Souza; Fiscal Year: 2010
    ....
  6. Role of Acid in the Development of Barrett's Esophagus
    Rhonda Souza; Fiscal Year: 2007
    ....
  7. Basic and Clinical Studies on the Role of Bile Acids in Barrett's Esophagus
    Rhonda Souza; Fiscal Year: 2009
    ....
  8. Role of Acid in the Development of Barrett's Esophagus
    Rhonda Souza; Fiscal Year: 2009
    ....
  9. Role of Acid in the Development of Barrett's Esophagus
    Rhonda Souza; Fiscal Year: 2006
    ..Our long term goals are to identify molecular markers of BE and molecular targets at which to direct chemopreventive and chemotheapeutic agents for patients with BE and esophageal adenocarcinoma. ..
  10. Role of Acid in the Development of Barrett's Esophagus
    Rhonda Souza; Fiscal Year: 2004
    ..Our long term goals are to identify molecular markers of BE and molecular targets at which to direct chemopreventive and chemotheapeutic agents for patients with BE and esophageal adenocarcinoma. ..
  11. Role of Acid in the Development of Barrett's Esophagus
    Rhonda F Souza; Fiscal Year: 2010
    ....