Nona Sotoodehnia

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
    Nona Sotoodehnia
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA
    Nat Genet 42:1068-76. 2010
  2. ncbi Beta2-adrenergic receptor genetic variants and risk of sudden cardiac death
    Nona Sotoodehnia
    Department of Medicine, University of Washington, Seattle, WA, USA
    Circulation 113:1842-8. 2006
  3. ncbi Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk
    Nona Sotoodehnia
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA
    Heart Rhythm 6:1306-14. 2009
  4. ncbi Endogenous red blood cell membrane fatty acids and sudden cardiac arrest
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
    Metabolism 59:1029-34. 2010
  5. ncbi Red blood cell membrane alpha-linolenic acid and the risk of sudden cardiac arrest
    Rozenn N Lemaitre
    Department of Medicine, University of Washington, Seattle, WA 98101, USA
    Metabolism 58:534-40. 2009
  6. ncbi Common variation in fatty acid genes and resuscitation from sudden cardiac arrest
    Catherine O Johnson
    Department of Medicine, University of Washington CHRU, 1730 Minor Ave, Seattle, WA 98101, USA
    Circ Cardiovasc Genet 5:422-9. 2012
  7. ncbi Atrial fibrillation and the risk of sudden cardiac death: the atherosclerosis risk in communities study and cardiovascular health study
    Lin Y Chen
    Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    JAMA Intern Med 173:29-35. 2013
  8. ncbi Major life events as potential triggers of sudden cardiac arrest
    April F Wicks
    Department of Epidemiology, University of Washington, Seattle, WA 98101, USA
    Epidemiology 23:482-5. 2012
  9. ncbi beta1- and beta2-adrenergic receptor gene variation, beta-blocker use and risk of myocardial infarction and stroke
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA
    Am J Hypertens 21:290-6. 2008
  10. ncbi N-terminal pro-B-type natriuretic peptide is associated with sudden cardiac death risk: the Cardiovascular Health Study
    Kristen K Patton
    Division of Cardiology, University of Washington, Seattle, Washington 98115, USA
    Heart Rhythm 8:228-33. 2011

Research Grants

  1. GENOMICS OF SUDDEN CARDIAC ARREST
    Nona Sotoodehnia; Fiscal Year: 2007
  2. Genetic risk factors for Sudden Cardiac Death
    Nona Sotoodehnia; Fiscal Year: 2007
  3. GENOMICS OF SUDDEN CARDIAC ARREST
    Nona Sotoodehnia; Fiscal Year: 2010

Detail Information

Publications22

  1. ncbi Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
    Nona Sotoodehnia
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA
    Nat Genet 42:1068-76. 2010
    ..These findings extend our current knowledge of ventricular depolarization and conduction...
  2. ncbi Beta2-adrenergic receptor genetic variants and risk of sudden cardiac death
    Nona Sotoodehnia
    Department of Medicine, University of Washington, Seattle, WA, USA
    Circulation 113:1842-8. 2006
    ..Sympathetic activation influences the risk of ventricular arrhythmias and sudden cardiac death (SCD), mediated in part by the beta2-adrenergic receptor (B2AR). We investigated whether variation in the B2AR gene is associated with SCD risk...
  3. ncbi Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk
    Nona Sotoodehnia
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA
    Heart Rhythm 6:1306-14. 2009
    ..Angiotensin-converting enzyme (ACE)-related pathways influence arrhythmias and sudden cardiac arrest (SCA) risk...
  4. ncbi Endogenous red blood cell membrane fatty acids and sudden cardiac arrest
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
    Metabolism 59:1029-34. 2010
    ..Further work is needed to investigate if conditions that favor de novo fatty acid synthesis, such as high-carbohydrate/low-fat diets, might also increase the risk of SCA...
  5. ncbi Red blood cell membrane alpha-linolenic acid and the risk of sudden cardiac arrest
    Rozenn N Lemaitre
    Department of Medicine, University of Washington, Seattle, WA 98101, USA
    Metabolism 58:534-40. 2009
    ..The association was independent of red blood cell levels of long-chain n-3 fatty acids, trans-fatty acids, and linoleic acid. Higher membrane levels of alpha-linolenic acid are associated with higher risk of sudden cardiac arrest...
  6. ncbi Common variation in fatty acid genes and resuscitation from sudden cardiac arrest
    Catherine O Johnson
    Department of Medicine, University of Washington CHRU, 1730 Minor Ave, Seattle, WA 98101, USA
    Circ Cardiovasc Genet 5:422-9. 2012
    ..We investigated whether genetic variation in fatty acid metabolism pathways was associated with SCA survival...
  7. ncbi Atrial fibrillation and the risk of sudden cardiac death: the atherosclerosis risk in communities study and cardiovascular health study
    Lin Y Chen
    Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    JAMA Intern Med 173:29-35. 2013
    ..It is unknown whether atrial fibrillation (AF) is associated with an increased risk of sudden cardiac death (SCD) in the general population. This association was examined in 2 population-based cohorts...
  8. ncbi Major life events as potential triggers of sudden cardiac arrest
    April F Wicks
    Department of Epidemiology, University of Washington, Seattle, WA 98101, USA
    Epidemiology 23:482-5. 2012
    ..We investigated the risk of sudden cardiac arrest in association with the recent loss of, or separation from, a family member or friend...
  9. ncbi beta1- and beta2-adrenergic receptor gene variation, beta-blocker use and risk of myocardial infarction and stroke
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA
    Am J Hypertens 21:290-6. 2008
    ..The benefits of beta-blocker therapy may depend on underlying genetic susceptibility...
  10. ncbi N-terminal pro-B-type natriuretic peptide is associated with sudden cardiac death risk: the Cardiovascular Health Study
    Kristen K Patton
    Division of Cardiology, University of Washington, Seattle, Washington 98115, USA
    Heart Rhythm 8:228-33. 2011
    ..The majority of those affected do not have a prior cardiovascular diagnosis. Elevated B-type natriuretic peptide levels have been associated with the risk of heart failure and mortality as well as with sudden death in women...
  11. ncbi Cystatin C and sudden cardiac death risk in the elderly
    Rajat Deo
    Division of Cardiology, University of Pennsylvania, Philadelphia 19104, USA
    Circ Cardiovasc Qual Outcomes 3:159-64. 2010
    ..Recent studies have demonstrated an association between moderate kidney dysfunction and sudden cardiac death in people with cardiovascular disease...
  12. ncbi Plasma phospholipid trans fatty acids, fatal ischemic heart disease, and sudden cardiac death in older adults: the cardiovascular health study
    Rozenn N Lemaitre
    University of Washington, Cardiovascular Health Research Unit, Department of Medicine, 1730 Minor Ave, Suite 1360, Seattle, Washington 98101, USA
    Circulation 114:209-15. 2006
    ..To extend these findings, we investigated the associations of plasma phospholipid trans fatty acids with fatal ischemic heart disease (IHD) and sudden cardiac death...
  13. ncbi Nonesterified fatty acids and risk of sudden cardiac death in older adults
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Boston Veterans Affairs Healthcare System, Boston, MA 02120, USA
    Circ Arrhythm Electrophysiol 5:273-8. 2012
    ..Although nonesterified fatty acids (NEFA) have been positively associated with coronary heart disease risk factors, limited and inconsistent data are available on the relation between NEFA and sudden cardiac death...
  14. ncbi Type 2 diabetes mellitus and the risk of sudden cardiac arrest in the community
    David S Siscovick
    Medicine and Epidemiology, University of Washington, Cardiovascular Health Research Unit, 1730 Minor Avenue, Seattle, WA 98101, USA
    Rev Endocr Metab Disord 11:53-9. 2010
    ....
  15. ncbi Incidence of out-of-hospital cardiac arrest
    Thomas D Rea
    Cardiovascular Health Research Unit, Department of Medicine, Seattle, Washington 98101, USA
    Am J Cardiol 93:1455-60. 2004
    ..The results provide insights regarding absolute and population-attributable risk in clinically defined subgroups, information that may aid strategies aimed at reducing mortality from CA...
  16. ncbi Genetics of sudden cardiac arrest
    Jordan M Prutkin
    Division of Cardiology, University of Washington, WA, USA
    Prog Cardiovasc Dis 50:390-403. 2008
    ..We review the evidence for genetic susceptibility to SCA in the general population and focus on the studies published to date that have explored genetic risk factors...
  17. ncbi Systematic localization of common disease-associated variation in regulatory DNA
    Matthew T Maurano
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Science 337:1190-5. 2012
    ..Our results suggest pervasive involvement of regulatory DNA variation in common human disease and provide pathogenic insights into diverse disorders...
  18. ncbi Trans-fatty acids and sudden cardiac death
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, USA
    Atheroscler Suppl 7:13-5. 2006
    ..While further studies are needed to investigate possible effects of trans-18:2 on arrhythmia, it would be prudent to limit dietary intake of trans-18:2...
  19. ncbi Hormone replacement therapy and the risk of incident congestive heart failure: the Cardiovascular Health Study
    Thomas D Rea
    Cardiovascular Health Research Unit, University of Washington, Metropolitan Park, East Tower, 1730 Minor Avenue, Seattle, WA 98101, USA
    J Womens Health (Larchmt) 12:341-50. 2003
    ..Hormone replacement therapy (HRT) affects several of the pathways that may be important in the development of CHF. We hypothesized that HRT would be associated with a decreased risk of incident CHF...
  20. ncbi Disaster events and the risk of sudden cardiac death: a Washington State investigation
    Laura S Gold
    University of Washington School of Public Health and Community Medicine, Department of Epidemiology, Seattle, Washington, USA
    Prehosp Disaster Med 22:313-7. 2007
    ..Psychological distress following disaster events may increase the risk of sudden cardiac death. In 2001, the Nisqually earthquake and the 11 September terrorist attacks profoundly affected Washington state residents...
  21. ncbi European ancestry as a risk factor for atrial fibrillation in African Americans
    Gregory M Marcus
    Electrophysiology Section, Division of Cardiology, University of California, San Francisco, 500 Parnassus Ave, MUE 434, San Francisco, CA 94143 1354, USA
    Circulation 122:2009-15. 2010
    ..Because African Americans have varying degrees of European ancestry, we sought to test the hypothesis that European ancestry is an independent risk factor for AF...
  22. ncbi Diabetes, glucose level, and risk of sudden cardiac death
    Xavier Jouven
    Service de cardiologie, Universite Paris 5, Faculté René Descartes, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
    Eur Heart J 26:2142-7. 2005
    ..The prevalence of diabetes mellitus in industrialized countries is rapidly increasing, and diabetes is suspected to carry a particular high risk for sudden cardiac death (SCD)...

Research Grants5

  1. GENOMICS OF SUDDEN CARDIAC ARREST
    Nona Sotoodehnia; Fiscal Year: 2007
    ..material from a large population-based repository of SCA cases (Cardiac Arrest Blood Repository), two case-control studies (Cardiac Arrest Blood Study and Group Health Cooperative study), and a cohort study (Cardiovascular Health Study): ..
  2. Genetic risk factors for Sudden Cardiac Death
    Nona Sotoodehnia; Fiscal Year: 2007
    The purpose of this award is to enable the Principle Investigator, Dr. Nona Sotoodehnia, to develop into an independent clinical scientist in the field of molecular epidemiology of cardiovascular diseases with a special focus on sudden ..
  3. GENOMICS OF SUDDEN CARDIAC ARREST
    Nona Sotoodehnia; Fiscal Year: 2010
    ..from a large population-based repository of SCA cases (Cardiac Arrest Blood Repository), two case-control studies (Cardiac Arrest Blood Study and Group Health Cooperative study), and a cohort study (Cardiovascular Health Study): ..