Alejandro Soto-Gutierrez

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Perspectives on whole-organ assembly: moving toward transplantation on demand
    Alejandro Soto-Gutierrez
    Department of Pathology, Transplantation Section of Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Clin Invest 122:3817-23. 2012
  2. ncbi A whole-organ regenerative medicine approach for liver replacement
    Alejandro Soto-Gutierrez
    Transplantation Section, Department of Surgery, Children s Hospital of Pittsburgh, Center for Innovative Regenerative Therapies, University of Pittsburgh, Pennsylvania, USA
    Tissue Eng Part C Methods 17:677-86. 2011
  3. ncbi Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1
    Hiroshi Yagi
    Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Boston, Massachusetts, USA
    Mol Ther 18:1857-64. 2010
  4. ncbi The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis
    Liping Liu
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA
    Hepatology 55:1529-39. 2012
  5. ncbi Liver repopulation and regeneration: new approaches to old questions
    Andrew W Duncan
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Curr Opin Organ Transplant 18:197-202. 2013
  6. ncbi Cellular therapy and bioartificial approaches to liver replacement
    Jason A Wertheim
    Department of Surgery, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Curr Opin Organ Transplant 17:235-40. 2012
  7. ncbi Human immune reactivity against liver sinusoidal endothelial cells from GalTα(1,3)GalT-deficient pigs
    Daan van Poll
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, and the Shriners Hospitals for Children, Center for Engineering in Medicine, Boston, MA 02114, USA
    Cell Transplant 19:783-9. 2010
  8. ncbi Bone marrow mesenchymal stromal cells attenuate organ injury induced by LPS and burn
    Hiroshi Yagi
    Department of Surgery, Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Boston, MA 02114, USA
    Cell Transplant 19:823-30. 2010
  9. ncbi Cell delivery: from cell transplantation to organ engineering
    Alejandro Soto-Gutierrez
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, and the Shriners Hospitals for Children, Center for Engineering in Medicine, Boston, MA 76104, USA
    Cell Transplant 19:655-65. 2010
  10. ncbi Differentiation and transplantation of human embryonic stem cell-derived hepatocytes
    Hesham Basma
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Gastroenterology 136:990-9. 2009

Collaborators

Detail Information

Publications10

  1. ncbi Perspectives on whole-organ assembly: moving toward transplantation on demand
    Alejandro Soto-Gutierrez
    Department of Pathology, Transplantation Section of Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Clin Invest 122:3817-23. 2012
    ..In this article, we summarize the most recent advances in this field and provide a perspective on the challenges of translating this promising new technology into a proven regenerative therapy...
  2. ncbi A whole-organ regenerative medicine approach for liver replacement
    Alejandro Soto-Gutierrez
    Transplantation Section, Department of Surgery, Children s Hospital of Pittsburgh, Center for Innovative Regenerative Therapies, University of Pittsburgh, Pennsylvania, USA
    Tissue Eng Part C Methods 17:677-86. 2011
    ..The present study investigates a new, minimally disruptive method for whole-organ liver decellularization and three different cell reseeding strategies to engineer functional liver tissue...
  3. ncbi Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1
    Hiroshi Yagi
    Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Boston, Massachusetts, USA
    Mol Ther 18:1857-64. 2010
    ..These results suggest that improvements of inflammatory responses in animal models after local transplantation of MSCs are at least, in part, explained by the NFκB-dependent secretion of sTNFR1 by MSCs...
  4. ncbi The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis
    Liping Liu
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA
    Hepatology 55:1529-39. 2012
    ....
  5. ncbi Liver repopulation and regeneration: new approaches to old questions
    Andrew W Duncan
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Curr Opin Organ Transplant 18:197-202. 2013
    ....
  6. ncbi Cellular therapy and bioartificial approaches to liver replacement
    Jason A Wertheim
    Department of Surgery, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Curr Opin Organ Transplant 17:235-40. 2012
    ..Despite efforts to expand the donor pool, mortality of patients waiting for a liver remains high due to the shortage of donor organs. Herein, we discuss options for liver replacement that are currently under development...
  7. ncbi Human immune reactivity against liver sinusoidal endothelial cells from GalTα(1,3)GalT-deficient pigs
    Daan van Poll
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, and the Shriners Hospitals for Children, Center for Engineering in Medicine, Boston, MA 02114, USA
    Cell Transplant 19:783-9. 2010
    ..Although insufficient to inhibit xenogeneic reactivity completely, transgenic GalT KO expression on pig livers might contribute to a successful application of clinical xenotransplantation in combination with other protective strategies...
  8. ncbi Bone marrow mesenchymal stromal cells attenuate organ injury induced by LPS and burn
    Hiroshi Yagi
    Department of Surgery, Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Boston, MA 02114, USA
    Cell Transplant 19:823-30. 2010
    ..These data suggest that MSCs emerge as key regulators of immune/inflammatory responses in vivo and as attractive candidates for cell-based treatments for systemic inflammatory-based disorders...
  9. ncbi Cell delivery: from cell transplantation to organ engineering
    Alejandro Soto-Gutierrez
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, and the Shriners Hospitals for Children, Center for Engineering in Medicine, Boston, MA 76104, USA
    Cell Transplant 19:655-65. 2010
    ....
  10. ncbi Differentiation and transplantation of human embryonic stem cell-derived hepatocytes
    Hesham Basma
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Gastroenterology 136:990-9. 2009
    ..Embryonic stem cells are pluripotent, potentially can differentiate into any cell type, and therefore could be developed as a source of human hepatocytes...