Caryl E Sortwell
Affiliation: University of Cincinnati
- Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survivalCaryl E Sortwell
Department of Neurology University of Cincinnati, PO Box 670537, ML0537, Cincinnati, OH 45267 0537, USA
Brain Res 1134:33-44. 2007..Even with highly efficient viral vector-mediated transduction, our results demonstrate that ex vivo gene transfer of bcl-2 to mesencephalic reaggregates is ineffective in increasing grafted DA neuron survival...
- Subthalamic nucleus stimulation increases brain derived neurotrophic factor in the nigrostriatal system and primary motor cortexAnne L Spieles-Engemann
Department of Neurology, University of Cincinnati, OH, USA
J Parkinsons Dis 1:123-36. 2011....
- Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine modelSara E Gombash
Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA
Mol Ther 20:544-54. 2012....
- 3,4-Methylenedioxy-N-methamphetamine (ecstasy) promotes the survival of fetal dopamine neurons in cultureJack W Lipton
Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267, USA
Neuropharmacology 55:851-9. 2008..Understanding how MDMA increases DA neuron survival may provide insight into normal DA neuron loss during development...
- Endogenous neural precursors influence grafted neural stem cells and contribute to neuroprotection in the parkinsonian ratLalitha Madhavan
Department of Neurology, University of Cincinnati, Cincinnati, OH, USA
Eur J Neurosci 35:883-95. 2012..Thus, both endogenous and transplanted NPCs are important in creating an environment suitable for neural protection and rescue, and harnessing their synergistic interaction may lead to the optimization of cell-based therapies for PD...
- Effect of levodopa priming on dopamine neuron transplant efficacy and induction of abnormal involuntary movements in parkinsonian ratsKathy Steece-Collier
Department of Neurology, Movement Disorders Division, University of Cincinnati, Cincinnati, Ohio 45267, USA
J Comp Neurol 515:15-30. 2009..Furthermore, dopamine terminal replacement prior to introduction of chronic levodopa is highly effective at preventing development of levodopa-induced dyskinesias, and GID-like behaviors occur regardless of pregraft levodopa status...
- Increased cell suspension concentration augments the survival rate of grafted tyrosine hydroxylase immunoreactive neuronsBrian T Terpstra
Department of Neurology, University of Cincinnati, PO Box 670525, Cincinnati, OH 45267 0525, United States
J Neurosci Methods 166:13-9. 2007..These data have the potential to identify optimal transplantation parameters that can be applied to procedures utilizing stem cells, neural progenitors, and primary mesencephalic cells...
- Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's diseaseTimothy J Collier
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
J Comp Neurol 442:320-30. 2002..These results encourage the further development of multiple-target grafting strategies as a means of restoring modulation of anatomically widespread basal ganglia structures relevant to treatment of Parkinson's disease...
- Exogenous erythropoietin provides neuroprotection of grafted dopamine neurons in a rodent model of Parkinson's diseaseNicholas M Kanaan
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Brain Res 1068:221-9. 2006..As direct neurotrophic effects of Epo were not observed in vitro, the mechanism of Epo neuroprotection remains to be elucidated...
- Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian ratsEleonora Maries
Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, N Chicago, IL 60064, USA
Neurobiol Dis 21:165-80. 2006..The onset of forelimb-facial stereotypy correlated with measures of increased graft function...
- Galanin inhibits tyrosine hydroxylase expression in midbrain dopaminergic neuronsScott E Counts
Department of Neurological Sciences and Pharmacology, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
J Neurochem 83:442-51. 2002..GAL inhibition of midbrain DA activity may involve a GALR1- mediated reduction of TH in midbrain dopaminergic neurons...
- Strategies for the augmentation of grafted dopamine neuron survivalCaryl E Sortwell
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Suite 200, 2242 West Harrison Street, Chicago, IL 60612, USA
Front Biosci 8:s522-32. 2003..Once identified, the optimal survival-enhancing treatment of grafted primary embryonic DA neurons should also benefit future transplant therapies utilizing alternatively derived DA neurons...
- Angiogenic and neurotrophic effects of vascular endothelial growth factor (VEGF165): studies of grafted and cultured embryonic ventral mesencephalic cellsMark R Pitzer
Department of Neurological Sciences and Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Exp Neurol 182:435-45. 2003..We conclude that with the proper method of delivery, VEGF165 may prove to be one of several strategies necessary to significantly improve the survival and function of fetal VM tissue grafts...
- Interference with anoikis-induced cell death of dopamine neurons: implications for augmenting embryonic graft survival in a rat model of Parkinson's diseaseDeanna M Marchionini
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, 2422 West Harrison St, Chicago, Illinois 60612, USA
J Comp Neurol 464:172-9. 2003....
- An in vitro interval before transplantation of mesencephalic reaggregates does not compromise survival or functionalityCaryl E Sortwell
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Exp Neurol 187:58-64. 2004..This ex vivo reaggregate system allows for extended pretreatment (3 days) of mesencephalic cells with survival-promoting agents and immunological screening of tissue before transplantation...
- Reassessment of caspase inhibition to augment grafted dopamine neuron survivalDeanna M Marchionini
Department of Neurological Sciences, Research Center for Brain Repair, Rush University Medical Center, Chicago, IL 60612, USA
Cell Transplant 13:273-82. 2004..Furthermore, we suggest that cell culture paradigms used to model grafting paradigms must more closely approximate the cell densities of mesencephalic grafts to effectively screen potential augmentative treatments...
- Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's diseaseDeanna M Marchionini
Dept Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Brain Res 1147:77-88. 2007..Thus, PTN was identified as a factor that plays a role in the nigrostriatal system during development and in response to disease, and may therefore be useful for neuroprotection or reconstruction of the DA system...
- Dietary supplementation with blueberry extract improves survival of transplanted dopamine neuronsSusan O McGuire
Department of Pathology, Loyola University Medical School, Loyola University Chicago, Maywood, IL 60153, USA
Nutr Neurosci 9:251-8. 2006..These findings provide support for the potential of dietary phytochemicals as an easily administered and well-tolerated therapy that can be used to improve the effectiveness of DA neuron replacement...
- Cellular models to study dopaminergic injury responsesTimothy J Collier
Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
Ann N Y Acad Sci 991:140-51. 2003..Thus, cell culture models provide an important bidirectional link between mechanistic studies and clinically relevant observations...
- Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeysJeffrey H Kordower
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Ann Neurol 60:264-8. 2006..Furthermore, administration of PSI or epoxomicin to monkeys in an attempt to extend the model to a primate species failed. Currently, systemic proteasome inhibition is not a reliable model for Parkinson's disease...