Research Topics
| Caryl E SortwellSummaryAffiliation: University of Cincinnati Country: USA Publications
Research Grants
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Detail Information
Publications
Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survivalCaryl E Sortwell
Department of Neurology University of Cincinnati, PO Box 670537, ML0537, Cincinnati, OH 45267 0537, USA
Brain Res 1134:33-44. 2007..Even with highly efficient viral vector-mediated transduction, our results demonstrate that ex vivo gene transfer of bcl-2 to mesencephalic reaggregates is ineffective in increasing grafted DA neuron survival...- Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine modelSara E Gombash
Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA
Mol Ther 20:544-54. 2012.... - 3,4-Methylenedioxy-N-methamphetamine (ecstasy) promotes the survival of fetal dopamine neurons in cultureJack W Lipton
Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267, USA
Neuropharmacology 55:851-9. 2008..Understanding how MDMA increases DA neuron survival may provide insight into normal DA neuron loss during development... 
Endogenous neural precursors influence grafted neural stem cells and contribute to neuroprotection in the parkinsonian ratLalitha Madhavan
Department of Neurology, University of Cincinnati, Cincinnati, OH, USA
Eur J Neurosci 35:883-95. 2012..Thus, both endogenous and transplanted NPCs are important in creating an environment suitable for neural protection and rescue, and harnessing their synergistic interaction may lead to the optimization of cell-based therapies for PD...- Effect of levodopa priming on dopamine neuron transplant efficacy and induction of abnormal involuntary movements in parkinsonian ratsKathy Steece-Collier
Department of Neurology, Movement Disorders Division, University of Cincinnati, Cincinnati, Ohio 45267, USA
J Comp Neurol 515:15-30. 2009..Furthermore, dopamine terminal replacement prior to introduction of chronic levodopa is highly effective at preventing development of levodopa-induced dyskinesias, and GID-like behaviors occur regardless of pregraft levodopa status... - Increased cell suspension concentration augments the survival rate of grafted tyrosine hydroxylase immunoreactive neuronsBrian T Terpstra
Department of Neurology, University of Cincinnati, PO Box 670525, Cincinnati, OH 45267 0525, United States
J Neurosci Methods 166:13-9. 2007..These data have the potential to identify optimal transplantation parameters that can be applied to procedures utilizing stem cells, neural progenitors, and primary mesencephalic cells... 
Exogenous erythropoietin provides neuroprotection of grafted dopamine neurons in a rodent model of Parkinson's diseaseNicholas M Kanaan
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Brain Res 1068:221-9. 2006..As direct neurotrophic effects of Epo were not observed in vitro, the mechanism of Epo neuroprotection remains to be elucidated...- Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian ratsEleonora Maries
Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, N. Chicago, IL 60064, USA
Neurobiol Dis 21:165-80. 2006..The onset of forelimb-facial stereotypy correlated with measures of increased graft function... - Reassessment of caspase inhibition to augment grafted dopamine neuron survivalDeanna M Marchionini
Department of Neurological Sciences, Research Center for Brain Repair, Rush University Medical Center, Chicago, IL 60612, USA
Cell Transplant 13:273-82. 2004..Furthermore, we suggest that cell culture paradigms used to model grafting paradigms must more closely approximate the cell densities of mesencephalic grafts to effectively screen potential augmentative treatments... - Galanin inhibits tyrosine hydroxylase expression in midbrain dopaminergic neuronsScott E Counts
Department of Neurological Sciences and Pharmacology, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
J Neurochem 83:442-51. 2002..GAL inhibition of midbrain DA activity may involve a GALR1- mediated reduction of TH in midbrain dopaminergic neurons... - Strategies for the augmentation of grafted dopamine neuron survivalCaryl E Sortwell
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Suite 200, 2242 West Harrison Street, Chicago, IL 60612, USA
Front Biosci 8:s522-32. 2003..Once identified, the optimal survival-enhancing treatment of grafted primary embryonic DA neurons should also benefit future transplant therapies utilizing alternatively derived DA neurons... - Angiogenic and neurotrophic effects of vascular endothelial growth factor (VEGF165): studies of grafted and cultured embryonic ventral mesencephalic cellsMark R Pitzer
Department of Neurological Sciences and Research Center for Brain Repair, Rush Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA
Exp Neurol 182:435-45. 2003..We conclude that with the proper method of delivery, VEGF165 may prove to be one of several strategies necessary to significantly improve the survival and function of fetal VM tissue grafts... - Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's diseaseTimothy J Collier
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
J Comp Neurol 442:320-30. 2002..These results encourage the further development of multiple-target grafting strategies as a means of restoring modulation of anatomically widespread basal ganglia structures relevant to treatment of Parkinson's disease... - Interference with anoikis-induced cell death of dopamine neurons: implications for augmenting embryonic graft survival in a rat model of Parkinson's diseaseDeanna M Marchionini
Department of Neurological Sciences, Research Center for Brain Repair, Rush-Presbyterian-St. Luke's Medical Center, 2422 West Harrison St, Chicago, Illinois 60612, USA
J Comp Neurol 464:172-9. 2003.... - An in vitro interval before transplantation of mesencephalic reaggregates does not compromise survival or functionalityCaryl E Sortwell
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
Exp Neurol 187:58-64. 2004..This ex vivo reaggregate system allows for extended pretreatment (3 days) of mesencephalic cells with survival-promoting agents and immunological screening of tissue before transplantation... - Dietary supplementation with blueberry extract improves survival of transplanted dopamine neuronsSusan O McGuire
Department of Pathology, Loyola University Medical School, Loyola University Chicago, Maywood, IL 60153, USA
Nutr Neurosci 9:251-8. 2006..These findings provide support for the potential of dietary phytochemicals as an easily administered and well-tolerated therapy that can be used to improve the effectiveness of DA neuron replacement... - Cellular models to study dopaminergic injury responsesTimothy J Collier
Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
Ann N Y Acad Sci 991:140-51. 2003..Thus, cell culture models provide an important bidirectional link between mechanistic studies and clinically relevant observations... - Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeysJeffrey H Kordower
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Ann Neurol 60:264-8. 2006..Furthermore, administration of PSI or epoxomicin to monkeys in an attempt to extend the model to a primate species failed. Currently, systemic proteasome inhibition is not a reliable model for Parkinson's disease... - Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's diseaseDeanna M Marchionini
Dept Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA
Brain Res 1147:77-88. 2007..Thus, PTN was identified as a factor that plays a role in the nigrostriatal system during development and in response to disease, and may therefore be useful for neuroprotection or reconstruction of the DA system...
Research Grants
- Angiogenic Enhancement of Dopamine Neuron GraftsCaryl Sortwell; Fiscal Year: 2003..This strategy will be evaluated using primary mesencephalic tissue. However, results from these studies will be applicable to alternative sources of DA neurons, including stem- and progenitor-derived cells. ..
- American Society for Neural Transplantation and RepairCaryl Sortwell; Fiscal Year: 2004..This application requests $15,000 in total direct costs to support travel awards for the top 15 graduate students/postdocs from US institutions that apply (awards of $1000 per student/postdoc). ..
- American Society for Neural Transplantation and RepairCaryl Sortwell; Fiscal Year: 2005..This application requests $15,000 in total direct costs to support travel awards for the top 15 graduate students/postdocs from US institutions that apply (awards of $1000 per student/postdoc). ..
- Evaluation of Hypoxia in Grafted Dopamine NeuronsCaryl Sortwell; Fiscal Year: 2005..abstract_text> ..
- American Society for Neural Therapy and RepairCaryl Sortwell; Fiscal Year: 2006....
- Pleiotrophin Overexpression to Facilitate Repair and Graft Efficacy in ParkinsoniCaryl Sortwell; Fiscal Year: 2007..These studies will determine whether PTN gene transfer can be used as a therapeutic strategy to treat PD. ..