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Genomes and Genes | Ronald L SorknessSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
Systemic and pulmonary effects of fluticasone administered through a metered-dose inhaler in ratsRonald L Sorkness
Morris Institute for Respiratory Research and the School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705, USA
J Allergy Clin Immunol 114:1027-32. 2004..Metered-dose inhalers (MDIs) are convenient, simple, inexpensive, and reproducible devices for administering aerosolized drugs through the pulmonary route, but methods have not been available for use of these devices in small animals...- Altered allergen-induced eosinophil trafficking and physiological dysfunction in airways with preexisting virus-induced injuryRonald L Sorkness
School of Pharmacy, Department of Medicine, University of Wisconsin at Madison, 777 Highland Ave, Madison, WI 53705, USA
Am J Physiol Lung Cell Mol Physiol 292:L85-91. 2007.... 
CAM and respiratory diseaseRonald L Sorkness
University of Wisconsin, School of Pharmacy, Madison WI 53705, USA
Nutr Clin Pract 24:609-15. 2009....- Contribution of airway closure to chronic postbronchiolitis airway dysfunction in ratsRonald L Sorkness
Department of Medicine, Morris Institute for Respiratory Research, School of Pharmacy, University of Wisconsin, Madison 53792, USA
J Appl Physiol 96:904-10. 2004..We conclude that airway instability and closure is a prominent mechanism of the chronic airway dysfunction in rats that have recovered from viral bronchiolitis at an early age... - Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilationRonald L Sorkness
Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
J Appl Physiol 104:394-403. 2008..We conclude that air trapping is a characteristic feature of the severe asthma population, suggesting that there is a pathological process associated with severe asthma that makes airways more vulnerable to this component... 
Lower respiratory tract infection induced by a genetically modified picornavirus in its natural murine hostLouis A Rosenthal
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
PLoS ONE 7:e32061. 2012..This novel murine model of picornaviral airway infection and inflammation should be useful for defining mechanisms of HRV pathogenesis in humans...- Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research ProgramNizar N Jarjour
University of Wisconsin, Madison, Wisconsin, USA
Am J Respir Crit Care Med 185:356-62. 2012.... - Attenuated innate mechanisms of interferon-gamma production in rats susceptible to postviral airway dysfunctionLouis A Rosenthal
Morris Institute for Respiratory Research, University of Wisconsin Medical School, Madison, WI 53792, USA
Am J Respir Cell Mol Biol 30:702-9. 2004..Attenuation of innate IFN-gamma-producing responses to SeV in BN weanlings may be a critical factor in their susceptibility to postbronchiolitis chronic airway dysfunction... - Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosisZhong Jian Shen
Waisman Center for Developmental Disabilities, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
J Clin Invest 118:479-90. 2008..These data suggest that pharmacologic suppression of Pin1 may be a novel therapeutic option to prevent airway fibrosis in individuals with chronic asthma... - Attenuated P2X7 pore function as a risk factor for virus-induced loss of asthma controlLoren C Denlinger
Section of Allergy, Pulmonary, and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, P O Box 9988, Madison, WI 53792, USA
Am J Respir Crit Care Med 179:265-70. 2009..Upper respiratory tract infection is a guideline accepted risk domain for the loss of asthma control. The ionotrophic nucleotide receptor P2X(7) regulates compartmentalized acute inflammation and the immune response to airway pathogens... - Three-dimensional imaging of ventilation dynamics in asthmatics using multiecho projection acquisition with constrained reconstructionJames H Holmes
Department of Medical Physics, University of Wisconsin Madison, Madison, Wisconsin, USA
Magn Reson Med 62:1543-56. 2009..While multidetector CT can provide information about static regional air trapping, it is unable to depict dynamics in a setting more comparable to a spirometry maneuver and explore the longitudinal time evolution of the trapped regions... - Persistence of viral RNA in 2 rat strains differing in susceptibility to postbronchiolitis airway dysfunctionRonald L Sorkness
Morris Institute for Respiratory Research, Department of Medicine, School of Pharmacy, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
J Allergy Clin Immunol 110:607-9. 2002..The persistent increase in IL-13 suggests instead that the strain-related variability in virus-associated airway pathology might be determined by the host response to infection rather than by the intensity or duration of infection... - Evaluation of structure-function relationships in asthma using multidetector CT and hyperpolarized He-3 MRISean B Fain
Department of Medical Physics, University of Wisconsin, Madison, WI 53792, USA
Acad Radiol 15:753-62. 2008.... - Effects of a DNA vaccine in an animal model of Alternaria alternata sensitivityHiram Sanchez
Allergy Section, William S Middleton Memorial VA Hospital, Madison, WI, USA Department of Medicine, University of Wisconsin, Madison, WI, USA
Rev Iberoam Micol 26:121-8. 2009.... - A rat model of picornavirus-induced airway infection and inflammationLouis A Rosenthal
Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792, USA
Virol J 6:122. 2009.... - Pin1 protein regulates Smad protein signaling and pulmonary fibrosisZhong Jian Shen
Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
J Biol Chem 287:23294-305. 2012..Therefore, Pin1 is essential for normal Smad6 function and ECM production in response to injury or TGF-β and thus may be an attractive therapeutic target to prevent excess scarring in diverse lung diseases... - Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized He-3 MRIJames H Holmes
Department of Medical Physics, University of Wisconsin Madison, Madison, Wisconsin, USA
J Magn Reson Imaging 26:630-6. 2007..To image respiratory dynamics and three-dimensional (3D) ventilation during inhalation, breath-hold, and exhalation for evaluation of obstructive lung disease using a single dose of hyperpolarized (HP) He-3 during MRI... - Effects of viral respiratory infections on lung development and childhood asthmaJames E Gern
Department of Pediatrics, University of Wisconsin Madison, 600 Highland Avenue, Madison, WI 53792 9988, USA
J Allergy Clin Immunol 115:668-74; quiz 675. 2005..Greater understanding of the effects of viral infections on lung development and growth in early childhood might lead to the discovery of additional strategies for the prevention of recurrent wheezing and chronic asthma... - Functional lung imaging using hyperpolarized gas MRISean B Fain
Department of Medical Physics, University of Wisconsin, Madison, WI 53792, USA
J Magn Reson Imaging 25:910-23. 2007..Recent advances in polarization, pulse sequence development for imaging with Xe-129, and prototype low magnetic field systems dedicated to lung imaging are highlighted as areas of future development for this rapidly evolving technology... - A critical role for Pin1 in allergic pulmonary eosinophilia in ratsStephane Esnault
Waisman Center for Developmental Disabilities, Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
J Allergy Clin Immunol 120:1082-8. 2007..We recently showed that in vitro Pin1 regulated eosinophil production of and response to GM-CSF... - Noninvasive mapping of regional response to segmental allergen challenge using magnetic resonance imaging and [F-18]fluorodeoxyglucose positron emission tomographyJames H Holmes
Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 83792, USA
Magn Reson Med 53:1243-50. 2005..This method demonstrates that fusion of functional and anatomic PET and MRI image data may be useful to elucidate the functional correlates of inflammatory processes in the lungs... - Chronic postbronchiolitis airway instability induced with anti-IFN-gamma antibody in F344 ratsRonald L Sorkness
Division of Allergy and Immunology, Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA
Pediatr Res 52:382-6. 2002..The presence of premature airway closure that is independent of airway wall inflammation or changes in lung elastic recoil suggests peripheral airway instability as a mechanism for the airway obstruction... - Liquid chromatographic determination of hydroxyproline in tissue samplesPaul R Hutson
UW School of Pharmacy, 777 Highland Avenue, Madison, WI 53705 2222 USA
J Chromatogr B Analyt Technol Biomed Life Sci 791:427-30. 2003..Normal rat (left) lung was found to have a hydroxyproline content of 1.08+/-0.18 mg/lung. This ability to measure minute amounts of hydroxyproline is being applied to the measure of collagen and pathological fibrosis...