Linda Sorkin

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn
    Jeong I L Choi
    Department of Anesthesiology and Pain Medicine Chonnam National University Medical School and Hospital, Gwangju, Korea
    Mol Pain 8:4. 2012
  2. pmc Anti-GD(2) with an FC point mutation reduces complement fixation and decreases antibody-induced allodynia
    Linda S Sorkin
    Department of Anesthesiology, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA
    Pain 149:135-42. 2010
  3. doi request reprint Behavioral models of pain states evoked by physical injury to the peripheral nerve
    Linda S Sorkin
    Department of Anesthesiology, University of California, San Diego, California 92093 0818, USA
    Neurotherapeutics 6:609-19. 2009
  4. pmc Spinal p38 mitogen-activated protein kinase mediates allodynia induced by first-degree burn in the rat
    Linda Sorkin
    Department of Anesthesiology, University of California San Diego, La Jolla, California, USA
    J Neurosci Res 87:948-55. 2009
  5. pmc Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase
    Linda S Sorkin
    Department of Anesthesiology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Eur J Pharmacol 587:118-23. 2008
  6. ncbi request reprint Covariance among age, spinal p38 MAP kinase activation and allodynia
    Camilla I Svensson
    Anesthesiology Research Labs, University of California San Diego, La Jolla, California 92093, USA
    J Pain 7:337-45. 2006
  7. ncbi request reprint Neuronal model of tactile allodynia produced by spinal strychnine: effects of excitatory amino acid receptor antagonists and a mu-opiate receptor agonist
    L S Sorkin
    Anesthesiology Research Laboratory, University of California, San Diego 92093 0818, USA
    Pain 68:283-92. 1996
  8. ncbi request reprint Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers
    Linda S Sorkin
    Department of Anesthesiology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Exp Neurol 184:162-8. 2003
  9. ncbi request reprint Antibody directed against GD(2) produces mechanical allodynia, but not thermal hyperalgesia when administered systemically or intrathecally despite its dependence on capsaicin sensitive afferents
    L S Sorkin
    Anesthesiology Research Laboratories, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
    Brain Res 930:67-74. 2002
  10. ncbi request reprint Pain models display differential sensitivity to Ca2+-permeable non-NMDA glutamate receptor antagonists
    L S Sorkin
    Department of Anesthesiology, University of California San Diego, La Jolla, USA
    Anesthesiology 95:965-73. 2001

Research Grants

Detail Information

Publications29

  1. pmc Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn
    Jeong I L Choi
    Department of Anesthesiology and Pain Medicine Chonnam National University Medical School and Hospital, Gwangju, Korea
    Mol Pain 8:4. 2012
    ..As the study progressed, our aims grew to include the question, whether carrageenan-induced GluA1 subunit trafficking was downstream of Akt phosphorylation...
  2. pmc Anti-GD(2) with an FC point mutation reduces complement fixation and decreases antibody-induced allodynia
    Linda S Sorkin
    Department of Anesthesiology, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA
    Pain 149:135-42. 2010
    ....
  3. doi request reprint Behavioral models of pain states evoked by physical injury to the peripheral nerve
    Linda S Sorkin
    Department of Anesthesiology, University of California, San Diego, California 92093 0818, USA
    Neurotherapeutics 6:609-19. 2009
    ..These models give rise to behaviors, which parallel those observed in the human after nerve injury. The present review considers these models and their application...
  4. pmc Spinal p38 mitogen-activated protein kinase mediates allodynia induced by first-degree burn in the rat
    Linda Sorkin
    Department of Anesthesiology, University of California San Diego, La Jolla, California, USA
    J Neurosci Res 87:948-55. 2009
    ..The effects of the inhibitors on tactile allodynia were lost when they were administered after injury. These studies identify p38 MAPK as a major mediator of tactile allodynia, most likely activated downstream of AMPA/kainate receptors...
  5. pmc Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase
    Linda S Sorkin
    Department of Anesthesiology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Eur J Pharmacol 587:118-23. 2008
    ..Thus, cyclooxygenase and nitric oxide synthase are assumed not to be downstream of Ca2+ permeable AMPA receptors. Voltage gated calcium channels blockers could exert their effects either pre- or post-synaptically...
  6. ncbi request reprint Covariance among age, spinal p38 MAP kinase activation and allodynia
    Camilla I Svensson
    Anesthesiology Research Labs, University of California San Diego, La Jolla, California 92093, USA
    J Pain 7:337-45. 2006
    ..Addition of a transection to the ligation produced restoration of the early peak along with intensification of allodynia. Alterations of spinal P-p38 at early time points thus seem to covary with intensity of tactile allodynia...
  7. ncbi request reprint Neuronal model of tactile allodynia produced by spinal strychnine: effects of excitatory amino acid receptor antagonists and a mu-opiate receptor agonist
    L S Sorkin
    Anesthesiology Research Laboratory, University of California, San Diego 92093 0818, USA
    Pain 68:283-92. 1996
    ..This model may help to provide pharmacological insights into more efficacious treatments for such pain states that are relatively refractory to opioid therapies...
  8. ncbi request reprint Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers
    Linda S Sorkin
    Department of Anesthesiology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Exp Neurol 184:162-8. 2003
    ..Information on pain and inflammation in the periphery is transmitted to the nervous system, where increased spinal adenosine levels can suppress peripheral inflammation...
  9. ncbi request reprint Antibody directed against GD(2) produces mechanical allodynia, but not thermal hyperalgesia when administered systemically or intrathecally despite its dependence on capsaicin sensitive afferents
    L S Sorkin
    Anesthesiology Research Laboratories, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
    Brain Res 930:67-74. 2002
    ..The lack of observed thermal hyperalgesia is surprising especially in light of the capsaicin-associated blockade, however, it is consistent with several other immune system related models of pain...
  10. ncbi request reprint Pain models display differential sensitivity to Ca2+-permeable non-NMDA glutamate receptor antagonists
    L S Sorkin
    Department of Anesthesiology, University of California San Diego, La Jolla, USA
    Anesthesiology 95:965-73. 2001
    ..This study characterized the analgesic profile associated with the blockade of these spinal receptors by intrathecally delivered agents known to act at these receptors, the spider venom Joro toxin (JST) and philanthotoxin...
  11. ncbi request reprint Spinal adenosine agonist reduces c-fos and astrocyte activation in dorsal horn of rats with adjuvant-induced arthritis
    Linda S Sorkin
    Department of Anesthesiology and Division of Rheumatology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
    Neurosci Lett 340:119-22. 2003
    ..Astrocyte activation was only partially attenuated by adenosine A1 receptor agonist treatment...
  12. ncbi request reprint Epineurial application of TNF elicits an acute mechanical hyperalgesia in the awake rat
    L S Sorkin
    Department of Anesthesiology, University of California, San Diego, La Jolla 92093 0818, USA
    J Peripher Nerv Syst 5:96-100. 2000
    ..These data indicate that effects of acutely administered TNF to the nerve trunk are capable of producing modality specific pain behavior. These changes may represent a first step in TNF-induced neuropathic pain...
  13. ncbi request reprint Spinal bicuculline produces hypersensitivity of dorsal horn neurons: effects of excitatory amino acid antagonists
    L S Sorkin
    Anesthesiology Research Laboratory, University of California, San Diego 92093 0818, USA
    Pain 77:181-90. 1998
    ..Removal of each influence may model a different component of neuropathic pain...
  14. pmc Regulation of peripheral inflammation by spinal p38 MAP kinase in rats
    David L Boyle
    Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, California, United States of America
    PLoS Med 3:e338. 2006
    ..We therefore determined whether these pathways also regulate peripheral inflammation in rat adjuvant arthritis, which is a model of rheumatoid arthritis...
  15. pmc Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior
    Jeong Il Choi
    Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92093, USA
    Pain 149:243-53. 2010
    ....
  16. ncbi request reprint Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38
    Camilla I Svensson
    Anesthesiology Research Labs, University of California, San Diego, La Jolla, CA 92093 0818, USA
    Neurosci Lett 379:209-13. 2005
    ..Combined systemic and intrathecal administration of etanercept was no more effective than intrathecal treatment alone. These data imply that TNF provides the trigger for phosphorylation of p38 in both DRG neurons and spinal microglia...
  17. ncbi request reprint Hyperpolarization-activated, cation-nonselective, cyclic nucleotide-modulated channel blockade alleviates mechanical allodynia and suppresses ectopic discharge in spinal nerve ligated rats
    Doo H Lee
    Johnson and Johnson Pharmaceutical Research and Development, San Diego, California, USA
    J Pain 6:417-24. 2005
    ..Thus, I(h) might substantially contribute to the pathophysiology of nerve injury-related neuropathic pain...
  18. ncbi request reprint Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model
    Toni L Jones
    The University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
    Pain 117:259-70. 2005
    ..These findings indicate that spinal sensitization in the thermal stimulus model does not involve CaMKIIalpha activation or AMPA GLUR1 receptor phosphorylation, and differs from that occurring in NMDAr-dependent pain states...
  19. pmc The sensitization of a broad spectrum of sensory nerve fibers in a rat model of acute postoperative pain and its response to intrathecal pharmacotherapy
    Yukinori Nagakura
    Department of Anesthesiology, University of California San Diego, La Jolla, 92093 0818, USA
    Pain 139:569-77. 2008
    ..Spinal AMPA/kainate receptors but not NMDA receptors play a significant role in this sensitization...
  20. ncbi request reprint Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons
    Maria Schäfers
    Anesthesiology Research Laboratory, University of California San Diego, La Jolla, California 92093 0818, USA
    J Neurosci 23:2517-21. 2003
    ..Parallel inhibition of p38 activation and allodynia may represent a clinically relevant therapeutic window. These data suggest a sequential role for TNF and p38 in the induction of neuropathic pain...
  21. ncbi request reprint Secondary hyperalgesia in the postoperative pain model is dependent on spinal calcium/calmodulin-dependent protein kinase II alpha activation
    Toni L Jones
    Department of Anesthesiology, University of California San Diego, La Jolla, California 92093 0818, USA
    Anesth Analg 105:1650-6, table of contents. 2007
    ..In the present study, we investigated whether spinal calcium/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha) mediates 1 degree and/or 2 degrees hyperalgesia and spontaneous pain behavior after plantar incision...
  22. ncbi request reprint Low-speed subcellular fractionation method for determining noxious stimulus-evoked spinal neurokinin-1 receptor internalization
    Toni L Jones
    University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
    J Neurosci Methods 161:23-31. 2007
    ..These data support previous findings demonstrating a role for spinal NK-1 receptors in nociceptive processing...
  23. ncbi request reprint Spinal adenosine receptor activation inhibits inflammation and joint destruction in rat adjuvant-induced arthritis
    David L Boyle
    Division of Rheumatology, Allergy and Immunology, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
    Arthritis Rheum 46:3076-82. 2002
    ..To examine the effect of spinal cord adenosine (Ado) receptor stimulation on rat adjuvant-induced arthritis (AIA)...
  24. ncbi request reprint Effects of full-thickness burns on nociceptor sensitization in anesthetized rats
    Heidi Junger
    Anesthesiology Research Laboratory, Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92093 0818, USA
    Burns 28:772-7. 2002
    ..As loperamide ameliorates nociceptor activation and sensitization, it is an appropriate candidate for burn pain management...
  25. ncbi request reprint Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation
    Maria Schäfers
    Anesthesiology Research Laboratory, University of California San Diego, La Jolla, California 92093 0818, USA
    J Neurosci 23:3028-38. 2003
    ..We conclude that injured and adjacent uninjured DRG neurons are sensitized to TNF after SNL. Sensitization to endogenous TNF may be essential for the development and maintenance of neuropathic pain...
  26. ncbi request reprint Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate receptors mediate development, but not maintenance, of secondary allodynia evoked by first-degree burn in the rat
    Toni L Jones
    Department of Anesthesiology, University of California San Diego, La Jolla, California 92093 0818, USA
    J Pharmacol Exp Ther 310:223-9. 2004
    ..This finding supports a role for AMPA/KA receptor function in responses occurring during spinal sensitization...
  27. ncbi request reprint Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat
    Maria Schäfers
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    Exp Neurol 185:160-8. 2004
    ..Nerve-injury- and TNF-induced pain-related behavior seem to be only partly dependent on peripheral prostaglandins...
  28. ncbi request reprint Spinal glutamate receptor antagonists differentiate primary and secondary mechanical hyperalgesia caused by incision
    Esther M Pogatzki
    Department of Anesthesia, University of Iowa, 200 Hawkins Drive 6 JCP, Iowa City, IA 52242, USA
    Pain 105:97-107. 2003
    ..Mechanisms for central sensitization causing secondary hyperalgesia in postoperative patients may therefore be separated from spontaneous pain and hyperalgesia that arises adjacent to the area of the incision...
  29. ncbi request reprint Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in rats
    Maria Schäfers
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    Pain 104:579-88. 2003
    ..These findings allow us to speculate that endogenous TNF may play a role in the development of muscle hyperalgesia. Targeting proinflammatory cytokines might be beneficial for the treatment of musculoskeletal pain syndromes...

Research Grants12

  1. Spinal TNF elicits AMPAr trafficking and hyperalgesia
    Linda S Sorkin; Fiscal Year: 2010
    ..The proposal explores the possibility that TNF, via several identified steps, causes insertion of more and more active glutamate receptors into neuronal membranes to make them more excitable. ..
  2. Cytokine and MAP Kinase Involvement in Neuropathic Pain
    Linda Sorkin; Fiscal Year: 2007
    ..This approach has the potential for avoiding some of the problems that occur with complete inhibition of p38 function. ..
  3. Annual Meeting of the American Pain Society
    Linda Sorkin; Fiscal Year: 2005
    ..Abstracts will be judged on scientific merit and published in The Journal of Pain. We believe that these awards will encourage meeting attendance by trainees. ..
  4. Ca permeable non-NMDAr: New spinal sensitization pathway
    Linda Sorkin; Fiscal Year: 2005
    ..We propose to investigate the effects of Ca-permeable non-NMDAr activation on ERK and CREB phosphorylation (using Western blots and immunohistochemistry), expression of c-fos and development of hyperalgesia. ..