Research Topics
Species | Linda SorkinSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal hornJeong I L Choi
Department of Anesthesiology and Pain Medicine Chonnam National University Medical School and Hospital, Gwangju, Korea
Mol Pain 8:4. 2012..As the study progressed, our aims grew to include the question, whether carrageenan-induced GluA1 subunit trafficking was downstream of Akt phosphorylation...
Anti-GD(2) with an FC point mutation reduces complement fixation and decreases antibody-induced allodyniaLinda S Sorkin
Department of Anesthesiology, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA
Pain 149:135-42. 2010....- Behavioral models of pain states evoked by physical injury to the peripheral nerveLinda S Sorkin
Department of Anesthesiology, University of California, San Diego, California 92093 0818, USA
Neurotherapeutics 6:609-19. 2009..These models give rise to behaviors, which parallel those observed in the human after nerve injury. The present review considers these models and their application... - Spinal p38 mitogen-activated protein kinase mediates allodynia induced by first-degree burn in the ratLinda Sorkin
Department of Anesthesiology, University of California San Diego, La Jolla, California, USA
J Neurosci Res 87:948-55. 2009..The effects of the inhibitors on tactile allodynia were lost when they were administered after injury. These studies identify p38 MAPK as a major mediator of tactile allodynia, most likely activated downstream of AMPA/kainate receptors... - Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthaseLinda S Sorkin
Department of Anesthesiology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
Eur J Pharmacol 587:118-23. 2008..Thus, cyclooxygenase and nitric oxide synthase are assumed not to be downstream of Ca2+ permeable AMPA receptors. Voltage gated calcium channels blockers could exert their effects either pre- or post-synaptically... 
Covariance among age, spinal p38 MAP kinase activation and allodyniaCamilla I Svensson
Anesthesiology Research Labs, University of California San Diego, La Jolla, California 92093, USA
J Pain 7:337-45. 2006..Early levels of spinal P-p38 seem to covary with allodynia intensity. This may mean that small variations of an injury could affect the therapeutic window of a p38 antagonist...- Neuronal model of tactile allodynia produced by spinal strychnine: effects of excitatory amino acid receptor antagonists and a mu-opiate receptor agonistL S Sorkin
Anesthesiology Research Laboratory, University of California, San Diego 92093 0818, USA
Pain 68:283-92. 1996..This model may help to provide pharmacological insights into more efficacious treatments for such pain states that are relatively refractory to opioid therapies... - Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibersLinda S Sorkin
Department of Anesthesiology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
Exp Neurol 184:162-8. 2003..Information on pain and inflammation in the periphery is transmitted to the nervous system, where increased spinal adenosine levels can suppress peripheral inflammation... - Antibody directed against GD(2) produces mechanical allodynia, but not thermal hyperalgesia when administered systemically or intrathecally despite its dependence on capsaicin sensitive afferentsL S Sorkin
Anesthesiology Research Laboratories, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
Brain Res 930:67-74. 2002..The lack of observed thermal hyperalgesia is surprising especially in light of the capsaicin-associated blockade, however, it is consistent with several other immune system related models of pain... - Pain models display differential sensitivity to Ca2+-permeable non-NMDA glutamate receptor antagonistsL S Sorkin
Department of Anesthesiology, University of California San Diego, La Jolla, USA
Anesthesiology 95:965-73. 2001..This study characterized the analgesic profile associated with the blockade of these spinal receptors by intrathecally delivered agents known to act at these receptors, the spider venom Joro toxin (JST) and philanthotoxin... - Spinal adenosine agonist reduces c-fos and astrocyte activation in dorsal horn of rats with adjuvant-induced arthritisLinda S Sorkin
Department of Anesthesiology and Division of Rheumatology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
Neurosci Lett 340:119-22. 2003..Astrocyte activation was only partially attenuated by adenosine A1 receptor agonist treatment... - Epineurial application of TNF elicits an acute mechanical hyperalgesia in the awake ratL S Sorkin
Department of Anesthesiology, University of California, San Diego, La Jolla 92093 0818, USA
J Peripher Nerv Syst 5:96-100. 2000..These data indicate that effects of acutely administered TNF to the nerve trunk are capable of producing modality specific pain behavior. These changes may represent a first step in TNF-induced neuropathic pain... - Spinal bicuculline produces hypersensitivity of dorsal horn neurons: effects of excitatory amino acid antagonistsL S Sorkin
Anesthesiology Research Laboratory, University of California, San Diego 92093 0818, USA
Pain 77:181-90. 1998..Removal of each influence may model a different component of neuropathic pain... - Regulation of peripheral inflammation by spinal p38 MAP kinase in ratsDavid L Boyle
Division of Rheumatology, Allergy, and Immunology, University of California San Diego School of Medicine, La Jolla, California, United States of America
PLoS Med 3:e338. 2006..Characterization of this mechanism could have clinical and basic research implications by supporting development of new treatments for arthritis and clarifying how the CNS regulates peripheral immune responses... - Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behaviorJeong Il Choi
Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92093, USA
Pain 149:243-53. 2010.... - Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38Camilla I Svensson
Anesthesiology Research Labs, University of California, San Diego, La Jolla, CA 92093-0818, USA
Neurosci Lett 379:209-13. 2005..Combined systemic and intrathecal administration of etanercept was no more effective than intrathecal treatment alone. These data imply that TNF provides the trigger for phosphorylation of p38 in both DRG neurons and spinal microglia... - Hyperpolarization-activated, cation-nonselective, cyclic nucleotide-modulated channel blockade alleviates mechanical allodynia and suppresses ectopic discharge in spinal nerve ligated ratsDoo H Lee
Johnson and Johnson Pharmaceutical Research and Development, San Diego, California, USA
J Pain 6:417-24. 2005..Ectopic discharges are a main driving source of nerve injury-induced neuropathic pain. Understanding the mechanism of ectopic discharges and identifying how to control them will be useful toward developing new therapies... - Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus modelToni L Jones
the University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0818, USA
Pain 117:259-70. 2005..These findings indicate that spinal sensitization in the thermal stimulus model does not involve CaMKIIalpha activation or AMPA GLUR1 receptor phosphorylation, and differs from that occurring in NMDAr-dependent pain states... - The sensitization of a broad spectrum of sensory nerve fibers in a rat model of acute postoperative pain and its response to intrathecal pharmacotherapyYukinori Nagakura
Department of Anesthesiology, University of California San Diego, La Jolla, 92093 0818, USA
Pain 139:569-77. 2008..Spinal AMPA/kainate receptors but not NMDA receptors play a significant role in this sensitization... - Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neuronsMaria Schäfers
Anesthesiology Research Laboratory, University of California San Diego, La Jolla, California 92093 0818, USA
J Neurosci 23:2517-21. 2003..Parallel inhibition of p38 activation and allodynia may represent a clinically relevant therapeutic window. These data suggest a sequential role for TNF and p38 in the induction of neuropathic pain... - Secondary hyperalgesia in the postoperative pain model is dependent on spinal calcium/calmodulin-dependent protein kinase II alpha activationToni L Jones
Department of Anesthesiology, University of California San Diego, La Jolla, California 92093 0818, USA
Anesth Analg 105:1650-6, table of contents. 2007..In the present study, we investigated whether spinal calcium/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha) mediates 1 degree and/or 2 degrees hyperalgesia and spontaneous pain behavior after plantar incision... - Low-speed subcellular fractionation method for determining noxious stimulus-evoked spinal neurokinin-1 receptor internalizationToni L Jones
University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
J Neurosci Methods 161:23-31. 2007..These data support previous findings demonstrating a role for spinal NK-1 receptors in nociceptive processing... - Spinal adenosine receptor activation inhibits inflammation and joint destruction in rat adjuvant-induced arthritisDavid L Boyle
Division of Rheumatology, Allergy and Immunology, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
Arthritis Rheum 46:3076-82. 2002..To examine the effect of spinal cord adenosine (Ado) receptor stimulation on rat adjuvant-induced arthritis (AIA)... - Effects of full-thickness burns on nociceptor sensitization in anesthetized ratsHeidi Junger
Anesthesiology Research Laboratory, Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92093 0818, USA
Burns 28:772-7. 2002..As loperamide ameliorates nociceptor activation and sensitization, it is an appropriate candidate for burn pain management... - Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligationMaria Schäfers
Anesthesiology Research Laboratory, University of California San Diego, La Jolla, California 92093 0818, USA
J Neurosci 23:3028-38. 2003..We conclude that injured and adjacent uninjured DRG neurons are sensitized to TNF after SNL. Sensitization to endogenous TNF may be essential for the development and maintenance of neuropathic pain... - Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate receptors mediate development, but not maintenance, of secondary allodynia evoked by first-degree burn in the ratToni L Jones
Department of Anesthesiology, University of California-San Diego, La Jolla, California 92093-0818, USA
J Pharmacol Exp Ther 310:223-9. 2004..This finding supports a role for AMPA/KA receptor function in responses occurring during spinal sensitization... - Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the ratMaria Schäfers
Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
Exp Neurol 185:160-8. 2004..Nerve-injury- and TNF-induced pain-related behavior seem to be only partly dependent on peripheral prostaglandins... - Spinal glutamate receptor antagonists differentiate primary and secondary mechanical hyperalgesia caused by incisionEsther M Pogatzki
Department of Anesthesia, University of Iowa, 200 Hawkins Drive 6 JCP, Iowa City, IA 52242, USA
Pain 105:97-107. 2003..Mechanisms for central sensitization causing secondary hyperalgesia in postoperative patients may therefore be separated from spontaneous pain and hyperalgesia that arises adjacent to the area of the incision... - Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in ratsMaria Schäfers
Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
Pain 104:579-88. 2003..These findings allow us to speculate that endogenous TNF may play a role in the development of muscle hyperalgesia. Targeting proinflammatory cytokines might be beneficial for the treatment of musculoskeletal pain syndromes...
Research Grants
- Spinal TNF elicits AMPAr trafficking and hyperalgesiaLinda S Sorkin; Fiscal Year: 2010..The proposal explores the possibility that TNF, via several identified steps, causes insertion of more and more active glutamate receptors into neuronal membranes to make them more excitable. ..
- Cytokine and MAP Kinase Involvement in Neuropathic PainLinda Sorkin; Fiscal Year: 2007..This approach has the potential for avoiding some of the problems that occur with complete inhibition of p38 function. ..
- Annual Meeting of the American Pain SocietyLinda Sorkin; Fiscal Year: 2005..Abstracts will be judged on scientific merit and published in The Journal of Pain. We believe that these awards will encourage meeting attendance by trainees. ..
- Ca permeable non-NMDAr: New spinal sensitization pathwayLinda Sorkin; Fiscal Year: 2005..We propose to investigate the effects of Ca-permeable non-NMDAr activation on ERK and CREB phosphorylation (using Western blots and immunohistochemistry), expression of c-fos and development of hyperalgesia. ..