Estelle Sontag

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex
    Viyada Nunbhakdi-Craig
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 158:967-78. 2002
  2. ncbi Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology
    Estelle Sontag
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    J Neuropathol Exp Neurol 63:287-301. 2004
  3. pmc Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation
    Jean Marie Sontag
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    J Neurosci 28:11477-87. 2008
  4. ncbi Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation
    Estelle Sontag
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 27:2751-9. 2007
  5. ncbi Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis
    Estelle Sontag
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
    J Neuropathol Exp Neurol 63:1080-91. 2004
  6. pmc Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain
    Teodoro Bottiglieri
    Institute of Metabolic Disease, Baylor Research Institute, Dallas, Texas 75226, USA
    J Neurosci 32:9173-81. 2012
  7. pmc Simian virus 40 small tumor antigen induces deregulation of the actin cytoskeleton and tight junctions in kidney epithelial cells
    Viyada Nunbhakdi-Craig
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    J Virol 77:2807-18. 2003
  8. ncbi Expression of protein phosphatase 2A mutants and silencing of the regulatory B alpha subunit induce a selective loss of acetylated and detyrosinated microtubules
    Viyada Nunbhakdi-Craig
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
    J Neurochem 101:959-71. 2007
  9. ncbi Synapse loss may be a minor contributor to decreased regional cerebral blood flow in Alzheimer disease
    Eileen H Bigio
    Department of Pathology, Northwestern University Medical School, Chicago, Ill 60611, USA
    Dement Geriatr Cogn Disord 15:72-8. 2003
  10. pmc A cholesterol-regulated PP2A/HePTP complex with dual specificity ERK1/2 phosphatase activity
    Ping Yuan Wang
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9039, USA
    EMBO J 22:2658-67. 2003

Research Grants

  1. Role of PP2A in tauopathies
    Estelle Sontag; Fiscal Year: 2006
  2. Role of PP2A in tauopathies
    Estelle Sontag; Fiscal Year: 2007

Collaborators

  • Teodoro Bottiglieri
  • Eileen H Bigio
  • Frederick J Bonte
  • Jian Weng
  • STEVEN LENTZ
  • Viyada Nunbhakdi-Craig
  • Jean Marie Sontag
  • Lisa Montgomery
  • Vincent Procaccio
  • Egon Ogris
  • Ping Yuan Wang
  • Thomas Machleidt
  • Erland Arning
  • Claudia Juno
  • Ingrid Mudrak
  • Stefan Schuechner
  • David C Pallas
  • Richard Jimenez
  • Marla Gearing
  • Victor Faundez
  • Bruce H Wainer
  • Shoichiro Ono
  • Melanie L Styers
  • Bianca Fontanella
  • Jorge Juncos
  • Claire Anne Gutekunst
  • Gloria Salazar
  • Germana Meroni
  • Antonio Davila
  • Pingsheng Liu
  • Richard G W Anderson
  • Leonard Craig
  • Charles L White
  • Dennis Bellotto

Detail Information

Publications11

  1. pmc Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex
    Viyada Nunbhakdi-Craig
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 158:967-78. 2002
    ....
  2. ncbi Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology
    Estelle Sontag
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    J Neuropathol Exp Neurol 63:287-301. 2004
    ..Increased glial PP2A immunoreactivity was observed in both AD and non-AD cases and may play a role in the brain's response to general inflammatory processes and amyloidogenesis...
  3. pmc Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation
    Jean Marie Sontag
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    J Neurosci 28:11477-87. 2008
    ..Our results suggest that counteracting the neuronal loss of LCMT-1 and B(alpha) could be beneficial for all tauopathies and folate-dependent disorders of the CNS...
  4. ncbi Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation
    Estelle Sontag
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 27:2751-9. 2007
    ..The link between homocysteine, PPMT, PP2A methylation, and key CNS proteins involved in AD pathogenesis provides new mechanistic insights into this disorder...
  5. ncbi Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis
    Estelle Sontag
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
    J Neuropathol Exp Neurol 63:1080-91. 2004
    ..In turn, PP2A dysfunction compromises the mechanisms that control tau, neuronal plasticity, and survival...
  6. pmc Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain
    Teodoro Bottiglieri
    Institute of Metabolic Disease, Baylor Research Institute, Dallas, Texas 75226, USA
    J Neurosci 32:9173-81. 2012
    ..These findings reveal a novel mechanism involving methylation-dependent pathways in L-dopa induces PP2A hypomethylation and increases Tau phosphorylation, which may be potentially detrimental to neuronal cells...
  7. pmc Simian virus 40 small tumor antigen induces deregulation of the actin cytoskeleton and tight junctions in kidney epithelial cells
    Viyada Nunbhakdi-Craig
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    J Virol 77:2807-18. 2003
    ....
  8. ncbi Expression of protein phosphatase 2A mutants and silencing of the regulatory B alpha subunit induce a selective loss of acetylated and detyrosinated microtubules
    Viyada Nunbhakdi-Craig
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
    J Neurochem 101:959-71. 2007
    ..They support the hypothesis that reduced amounts of neuronal B alpha-containing PP2A heterotrimers contribute to MT destabilization in Alzheimer's disease...
  9. ncbi Synapse loss may be a minor contributor to decreased regional cerebral blood flow in Alzheimer disease
    Eileen H Bigio
    Department of Pathology, Northwestern University Medical School, Chicago, Ill 60611, USA
    Dement Geriatr Cogn Disord 15:72-8. 2003
    ..The results of this study suggest that synapse loss may be a minor contributor to the decreased rCBF observed in AD...
  10. pmc A cholesterol-regulated PP2A/HePTP complex with dual specificity ERK1/2 phosphatase activity
    Ping Yuan Wang
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9039, USA
    EMBO J 22:2658-67. 2003
    ....
  11. pmc A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia
    Vincent Procaccio
    Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, CA 92697, USA
    Am J Hum Genet 78:947-60. 2006
    ..These findings suggest that mutations in nonmuscle actins may be associated with a broad spectrum of developmental malformations and/or neurological abnormalities such as dystonia...

Research Grants7

  1. Role of PP2A in tauopathies
    Estelle Sontag; Fiscal Year: 2006
    ....
  2. Role of PP2A in tauopathies
    Estelle Sontag; Fiscal Year: 2007
    ..If our model is validated, dietary folate supplementation and PPMT may be novel therapeutic targets for strategies aimed at slowing down the disease process in AD, and possibly other neurodegenerative dementias. ..