Research Topics
| Estelle SontagSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complexViyada Nunbhakdi-Craig
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Cell Biol 158:967-78. 2002....
Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathologyEstelle Sontag
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
J Neuropathol Exp Neurol 63:287-301. 2004..Increased glial PP2A immunoreactivity was observed in both AD and non-AD cases and may play a role in the brain's response to general inflammatory processes and amyloidogenesis...- Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesisEstelle Sontag
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
J Neuropathol Exp Neurol 63:1080-91. 2004..In turn, PP2A dysfunction compromises the mechanisms that control tau, neuronal plasticity, and survival... - Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylationJean Marie Sontag
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
J Neurosci 28:11477-87. 2008..Our results suggest that counteracting the neuronal loss of LCMT-1 and B(alpha) could be beneficial for all tauopathies and folate-dependent disorders of the CNS... - Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulationEstelle Sontag
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Neurosci 27:2751-9. 2007..The link between homocysteine, PPMT, PP2A methylation, and key CNS proteins involved in AD pathogenesis provides new mechanistic insights into this disorder... - Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brainTeodoro Bottiglieri
Institute of Metabolic Disease, Baylor Research Institute, Dallas, Texas 75226, USA
J Neurosci 32:9173-81. 2012..These findings reveal a novel mechanism involving methylation-dependent pathways in L-dopa induces PP2A hypomethylation and increases Tau phosphorylation, which may be potentially detrimental to neuronal cells... - Simian virus 40 small tumor antigen induces deregulation of the actin cytoskeleton and tight junctions in kidney epithelial cellsViyada Nunbhakdi-Craig
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9073, USA
J Virol 77:2807-18. 2003.... - Expression of protein phosphatase 2A mutants and silencing of the regulatory B alpha subunit induce a selective loss of acetylated and detyrosinated microtubulesViyada Nunbhakdi Craig
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
J Neurochem 101:959-71. 2007..They support the hypothesis that reduced amounts of neuronal B alpha-containing PP2A heterotrimers contribute to MT destabilization in Alzheimer's disease... - Synapse loss may be a minor contributor to decreased regional cerebral blood flow in Alzheimer diseaseEileen H Bigio
Department of Pathology, Northwestern University Medical School, Chicago, Ill 60611, USA
Dement Geriatr Cogn Disord 15:72-8. 2003..The results of this study suggest that synapse loss may be a minor contributor to the decreased rCBF observed in AD... - A cholesterol-regulated PP2A/HePTP complex with dual specificity ERK1/2 phosphatase activityPing-Yuan Wang
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039, USA
EMBO J 22:2658-67. 2003.... - A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystoniaVincent Procaccio
Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, CA 92697, USA
Am J Hum Genet 78:947-60. 2006..These findings suggest that mutations in nonmuscle actins may be associated with a broad spectrum of developmental malformations and/or neurological abnormalities such as dystonia...
Research Grants
- Role of PP2A in tauopathiesEstelle Sontag; Fiscal Year: 2006....
- Role of PP2A in tauopathiesEstelle Sontag; Fiscal Year: 2007..If our model is validated, dietary folate supplementation and PPMT may be novel therapeutic targets for strategies aimed at slowing down the disease process in AD, and possibly other neurodegenerative dementias. ..