J M Sonner

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone
    Liya Yang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 105:673-9. 2007
  2. doi request reprint Molecular mechanisms of drug action: an emerging view
    James M Sonner
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Annu Rev Biophys 42:143-67. 2013
  3. ncbi request reprint GABA(A) receptor blockade antagonizes the immobilizing action of propofol but not ketamine or isoflurane in a dose-related manner
    James M Sonner
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0464, USA
    Anesth Analg 96:706-12, table of contents. 2003
  4. ncbi request reprint Administration of epinephrine does not increase learning of fear to tone in rats anesthetized with isoflurane or desflurane
    James M Sonner
    Department of Anesthesia and Perioperative Care S 455, University of California San Francisco, San Francisco, CA 94143 0464, USA
    Anesth Analg 100:1333-7, table of contents. 2005
  5. ncbi request reprint Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane
    James M Sonner
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesthesiology 106:107-13. 2007
  6. ncbi request reprint Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration
    James M Sonner
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA
    Anesth Analg 97:718-40. 2003
  7. ncbi request reprint The effect of three inhaled anesthetics in mice harboring mutations in the GluR6 (kainate) receptor gene
    James M Sonner
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0464, USA
    Anesth Analg 101:143-8, table of contents. 2005
  8. ncbi request reprint Issues in the design and interpretation of minimum alveolar anesthetic concentration (MAC) studies
    James M Sonner
    Department of Anesthesia and Perioperative Care, Room S 455i, Box 0464, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 95:609-14, table of contents. 2002
  9. pmc A hypothesis on the origin and evolution of the response to inhaled anesthetics
    James M Sonner
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 107:849-54. 2008
  10. ncbi request reprint Naturally occurring variability in anesthetic potency among inbred mouse strains
    J M Sonner
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0464, USA
    Anesth Analg 91:720-6. 2000

Research Grants

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone
    Liya Yang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 105:673-9. 2007
    ..We tested the hypothesis that two metabolites that are elevated in ketosis (beta-hydroxybutyric acid, and acetone) modulate ion channels in a manner similar to anesthetics and produce anesthesia in animals...
  2. doi request reprint Molecular mechanisms of drug action: an emerging view
    James M Sonner
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Annu Rev Biophys 42:143-67. 2013
    ..Neuronal membranes may offer an appealing drug target, given the large number of compounds that adsorb to interfaces and hence membranes...
  3. ncbi request reprint GABA(A) receptor blockade antagonizes the immobilizing action of propofol but not ketamine or isoflurane in a dose-related manner
    James M Sonner
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0464, USA
    Anesth Analg 96:706-12, table of contents. 2003
    ....
  4. ncbi request reprint Administration of epinephrine does not increase learning of fear to tone in rats anesthetized with isoflurane or desflurane
    James M Sonner
    Department of Anesthesia and Perioperative Care S 455, University of California San Francisco, San Francisco, CA 94143 0464, USA
    Anesth Analg 100:1333-7, table of contents. 2005
    ..36 +/- 0.04 MAC in rats injected with 0.1 mg/kg of epinephrine i.p. We conclude that exogenous epinephrine does not decrease amnesia produced by inhaled isoflurane or desflurane, as assessed by fear conditioning to a tone in rats...
  5. ncbi request reprint Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane
    James M Sonner
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesthesiology 106:107-13. 2007
    ..To test this, the authors created gene knock-in mice harboring mutations that render the receptors insensitive to isoflurane while preserving sensitivity to halothane...
  6. ncbi request reprint Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration
    James M Sonner
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA
    Anesth Analg 97:718-40. 2003
    ..g., gamma-aminobutyric acid A, acetylcholine, potassium, 5-hydroxytryptamine-3, opioids, and alpha(2)-adrenergic), whereas other receptors/channels (e.g., glycine, N-methyl-D-aspartate, and sodium) remain credible candidates...
  7. ncbi request reprint The effect of three inhaled anesthetics in mice harboring mutations in the GluR6 (kainate) receptor gene
    James M Sonner
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0464, USA
    Anesth Analg 101:143-8, table of contents. 2005
    ..The mutations of GluR6 that were studied did not affect the capacity of isoflurane to interfere with fear conditioning...
  8. ncbi request reprint Issues in the design and interpretation of minimum alveolar anesthetic concentration (MAC) studies
    James M Sonner
    Department of Anesthesia and Perioperative Care, Room S 455i, Box 0464, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 95:609-14, table of contents. 2002
    ..An expression relating variability in terms of Hill coefficients and SD is presented. Evolutionary implications of low population variability in anesthetic phenotypes is discussed...
  9. pmc A hypothesis on the origin and evolution of the response to inhaled anesthetics
    James M Sonner
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 107:849-54. 2008
    ..The latter included metabolites that are increased in some types of end-stage organ failure, and genetic metabolic diseases. Several of these predictions have been tested and proved to be correct...
  10. ncbi request reprint Naturally occurring variability in anesthetic potency among inbred mouse strains
    J M Sonner
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0464, USA
    Anesth Analg 91:720-6. 2000
    ..Our results suggest that multiple genes underlie the observed variability in anesthetic potency...
  11. ncbi request reprint Mouse strain modestly influences minimum alveolar anesthetic concentration and convulsivity of inhaled compounds
    J M Sonner
    Department of Anesthesia, University of California, San Francisco 94143 0464, USA
    Anesth Analg 89:1030-4. 1999
    ..PKCgamma knockout mice had significantly higher MAC values than control animals for isoflurane, but not for halothane or desflurane, which implies that protein phosphorylation by PKCgamma can alter sensitivity to isoflurane...
  12. ncbi request reprint Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane
    Mark Liao
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 101:412-8, table of contents. 2005
    ....
  13. ncbi request reprint Spinal N-methyl-d-aspartate receptors may contribute to the immobilizing action of isoflurane
    Caroline Stabernack
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, 94143, USA
    Anesth Analg 96:102-7, table of contents. 2003
    ..Because neither IT nor IV MK 801 provide complete anesthesia, these findings also call into question the notion that NMDA blockade alone suffices to produce anesthesia as defined by immobility in the face of noxious stimulation...
  14. ncbi request reprint Neither GABA(A) nor strychnine-sensitive glycine receptors are the sole mediators of MAC for isoflurane
    Y Zhang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143-0464, USA
    Anesth Analg 92:123-7. 2001
    ..They are not, however, the only receptors that contribute to isoflurane-induced immobility (i.e., that determine the MAC of isoflurane)...
  15. ncbi request reprint Blockade of acetylcholine receptors does not change the dose of etomidate required to produce immobility in rats
    Yi Zhang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 104:850-2. 2007
    ..Sub-MAC concentrations of isoflurane alone profoundly block acetylcholine receptors, allowing for the possibility that atropine and mecamylamine have no effect because the receptors already are blocked...
  16. ncbi request reprint Ethanol concentrations approaching minimum alveolar anesthetic concentration are required to suppress learning in a fear-potentiated startle paradigm in rats
    J M Sonner
    Department of Anesthesia, University of California San Francisco, 94143 0464, USA
    Anesth Analg 87:1398-403. 1998
    ..This finding is consistent with the hypothesis that the capacity of anesthetics and nonimmobilizers to impair learning and memory depends mostly on an action at a nonpolar site...
  17. ncbi request reprint Glycine receptors mediate part of the immobility produced by inhaled anesthetics
    Yi Zhang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, 94143, USA
    Anesth Analg 96:97-101, table of contents. 2003
    ..82). These results support the hypothesis that glycine receptors mediate part of the immobilization produced by inhaled anesthetics...
  18. ncbi request reprint Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane
    Yi Zhang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 99:85-90. 2004
    ..This supports the view that GABAA receptors do not mediate immobilization for isoflurane...
  19. ncbi request reprint The concentration of isoflurane required to suppress learning depends on the type of learning
    R C Dutton
    Department of Anesthesia and Perioperative Care, University of California San Francisco, 94143 0464, USA
    Anesthesiology 94:514-9. 2001
    ..To determine whether these types of learning were differentially affected by anesthesia, the authors applied isoflurane during the training phases of fear conditioning paradigms for freezing to context and freezing to tone...
  20. ncbi request reprint Thiopental produces immobility primarily by supraspinal actions in rats
    Caroline Stabernack
    Department of Anesthesia and Perioperative Care, S 455, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 100:128-36. 2005
    ..We conclude that, unlike inhaled anesthetics, the immobilizing action of thiopental is largely supraspinal. Centers in the brain other than those near the third and fourth ventricles produce the greatest effect...
  21. ncbi request reprint Alterations in spinal, but not cerebral, cerebrospinal fluid Na+ concentrations affect the isoflurane minimum alveolar concentration in rats
    Michael J Laster
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 105:661-5. 2007
    ..Accordingly, in the present study, we examined the effect of altering intrathecal versus intracerebroventricular concentrations of Na+ on MAC...
  22. ncbi request reprint Desflurane and the nonimmobilizer 1,2-dichlorohexafluorocyclobutane suppress learning by a mechanism independent of the level of unconditioned stimulation
    J M Sonner
    Department of Anesthesia, University of California San Francisco 94143 0464, USA
    Anesth Analg 87:200-5. 1998
    ..We conclude that suppression of learning and memory by desflurane and 2N does not result from decreased sensitivity to the unconditioned stimulus (the footshock) and that the potency of 2N is consistent with its lipophilicity...
  23. doi request reprint Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats
    Edmond I Eger
    Department of Anesthesia, S 455, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 107:479-85. 2008
    ....
  24. pmc Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane
    Vinuta Rau
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94143 0464, USA
    Anesth Analg 109:1816-22. 2009
    ..GABA(A)-Rs containing the alpha4 subunit are highly concentrated in the hippocampus and thalamus, and when combined with delta subunits they mediate tonic inhibition, which is sensitive to low concentrations of isoflurane...
  25. pmc Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity
    C Spencer Yost
    Department of Anesthesia and Perioperative Care, Medical Sciences Building, 513 Parnassus Avenue, University of California, San Francisco, CA 94143, USA
    Behav Brain Res 193:192-6. 2008
    ..Additional studies with transgenic animals will help define the overall role of the K(2P) channels in normal neurophysiology and in volatile anesthetic mechanisms...
  26. ncbi request reprint Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics
    Edmond I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 102:1397-406. 2006
    ..We conclude that some aromatic anesthetics may produce immobility in the face of noxious stimulation by blocking the action of glutamate on NMDA receptors but that conventional inhaled anesthetics do not...
  27. doi request reprint The anesthetic-like effects of diverse compounds on wild-type and mutant gamma-aminobutyric acid type A and glycine receptors
    Liya Yang
    Department of Anesthesia and Perioperative Care, Room S 455i, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 106:838-45, table of contents. 2008
    ....
  28. ncbi request reprint Anaesthesia defined (gentlemen, this is no humbug)
    Edmond I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA
    Best Pract Res Clin Anaesthesiol 20:23-9. 2006
    ..These and myriad other changes produced by inhaled anaesthetics are side effects; they do not define anaesthesia; only immobility and amnesia supply such a definition...
  29. ncbi request reprint Chirality in anesthesia II: stereoselective modulation of ion channel function by secondary alcohol enantiomers
    Robert Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, USA
    Anesth Analg 103:86-91, table of contents. 2006
    ..We recommend that enantioselectivity not be used as a test of relevance for inhaled anesthetic targets...
  30. pmc Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel
    Yun Weng
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 110:59-63. 2010
    ..Ethanol and nitrous oxide did not modulate GLIC at surgical anesthetic concentrations. These investigations lay the groundwork for further structural and functional studies of anesthetic actions on GLIC...
  31. pmc Is a new paradigm needed to explain how inhaled anesthetics produce immobility?
    Edmond I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 107:832-48. 2008
    ..A few plausible targets (e.g., sodium channels) merit further study, but there remains the possibility that immobilization results from a nonspecific mechanism...
  32. ncbi request reprint Temporal summation governs part of the minimum alveolar concentration of isoflurane anesthesia
    Robert C Dutton
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California 94143 0464, USA
    Anesthesiology 98:1372-7. 2003
    ..General anesthesia may delay the onset of movement in response to noxious stimulation. The authors hypothesized that the production of immobility could involve depression of time-related processes involved in the generation of movement...
  33. pmc Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear
    James M Sonner
    Department of Anesthesiology, University of California, San Francisco, San Francisco, California, USA
    Mol Pharmacol 68:61-8. 2005
    ..These results indicate that alpha1-containing GABA(A)-Rs in the hippocampus, amygdala, and/or cortex influence the amnestic effects of inhaled anesthetics and may be an important molecular target of the drug isoflurane...
  34. ncbi request reprint Alpha-2 adrenoreceptors probably do not mediate the immobility produced by inhaled anesthetics
    Edmond I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0464, USA
    Anesth Analg 96:1661-4, table of contents. 2003
    ..Doses five-fold larger did not change MAC. Doses 10-fold larger decreased MAC. We conclude that alpha-adrenoreceptors do not or minimally mediate the capacity of inhaled anesthetics to produce immobility...
  35. ncbi request reprint Isoflurane antagonizes the capacity of flurothyl or 1,2-dichlorohexafluorocyclobutane to impair fear conditioning to context and tone
    Edmond I Eger
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA 94143 0464
    Anesth Analg 96:1010-8, table of contents. 2003
    ..We conclude that conventional inhaled anesthetics and nonimmobilizers impair learning and memory by different mechanisms. The basis for this impairment remains unknown...
  36. ncbi request reprint Isoflurane causes anterograde but not retrograde amnesia for pavlovian fear conditioning
    Robert C Dutton
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94143 0464, USA
    Anesthesiology 96:1223-9. 2002
    ..Such disruption would allow suppression of memory of previous untoward events. The authors examined whether isoflurane provides retrograde amnesia for classic (Pavlovian) fear conditioning...
  37. ncbi request reprint Short-term memory resists the depressant effect of the nonimmobilizer 1-2-dichlorohexafluorocyclobutane (2N) more than long-term memory
    Robert C Dutton
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0464, USA
    Anesth Analg 94:631-9; table of contents. 2002
    ..5% 2N does not preclude transmission of tone and shock signals to the site where tone-shock associations are formed...
  38. ncbi request reprint Blockade of 5-HT2A receptors may mediate or modulate part of the immobility produced by inhaled anesthetics
    Yi Zhang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143, USA
    Anesth Analg 97:475-9, table of contents. 2003
    ..However, because MAC for isoflurane is predominantly determined in the spinal cord, this result is consistent at most with a minor contribution of these receptors to the immobilizing action of isoflurane...
  39. ncbi request reprint Acetylcholine receptors do not mediate the immobilization produced by inhaled anesthetics
    Edmond I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 94:1500-4, table of contents. 2002
    ..We conclude that acetylcholine receptors do not seem to play a role as mediators of immobilization by inhaled anesthetics...
  40. ncbi request reprint Women appear to have the same minimum alveolar concentration as men: a retrospective study
    Edmond I Eger
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143, USA
    Anesthesiology 99:1059-61. 2003
    ..The authors assessed whether this finding applied to other/all anesthetics...
  41. ncbi request reprint Do dopamine receptors mediate part of MAC?
    Yasumasa Tanifuji
    Department of Anesthesia, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 103:1177-81. 2006
    ..Such findings suggest that dopamine receptors might mediate part of the capacity of inhaled anesthetics to provide immobility in the face of noxious stimulation...
  42. pmc Anesthetic-like modulation of receptor function by surfactants: a test of the interfacial theory of anesthesia
    Liya Yang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 107:868-74. 2008
    ....
  43. ncbi request reprint Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration?
    Robert C Dutton
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California 94143 0464, USA
    Anesth Analg 102:1412-8. 2006
    ..NMDA receptor blockade may contribute to the MAC produced by inhaled anesthetics that potently inhibit NMDA receptors in vitro but not those that have a limited in vitro effect...
  44. ncbi request reprint Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart
    E I Eger
    Department of Anesthesia and Perioperative Medicine, University of California, San Francisco 94143 0464, USA
    Anesth Analg 88:1395-400. 1999
    ..This reasoning suggests that a distance equivalent to a four or five carbon atom chain, approximately 5 A, separates the two sites...
  45. ncbi request reprint Mice with a melanocortin 1 receptor mutation have a slightly greater minimum alveolar concentration than control mice
    Yilei Xing
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesthesiology 101:544-6. 2004
  46. pmc Isovaleric, methylmalonic, and propionic acid decrease anesthetic EC50 in tadpoles, modulate glycine receptor function, and interact with the lipid 1,2-dipalmitoyl-Sn-glycero-3-phosphocholine
    Yun Weng
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 108:1538-45. 2009
    ..Third, that these compounds would affect physical properties of lipids...
  47. ncbi request reprint Naloxone does not increase the minimum alveolar anesthetic concentration of sevoflurane in mice
    Mark Liao
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 102:1452-5. 2006
    ..1% and 5.5% +/- 10.0% with the administration of 0.1 mg/kg and 1.0 mg/kg of naloxone. We do not find that naloxone increases MAC. Opioid receptors do not underlie a portion of the capacity of inhaled anesthetics to produce immobility...
  48. ncbi request reprint Mouse chromosome 7 harbors a quantitative trait locus for isoflurane minimum alveolar concentration
    Michael Cascio
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 105:381-5. 2007
    ..The location on the genome of genes or other genetic elements controlling quantiative traits is called quantitative trait loci (QTLs). In this study we sought to detect a quantitative trait locus underlying isoflurane MAC in mice...
  49. ncbi request reprint R (+) etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265M point mutation in the gamma-aminobutyric acid receptor beta3 subunit
    Mark Liao
    Department of Anesthesia and Perioperative Care, S 455, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 101:131-5, table of contents. 2005
    ..6 +/- 1.5 min and 7.2 +/- 1.8 min, respectively), emphasizing the contribution of this residue as a determinant of a behavioral response of azietomidate in mice...
  50. ncbi request reprint Chirality in anesthesia I: minimum alveolar concentration of secondary alcohol enantiomers
    Albert Won
    Department of Anesthesia and Perioperative Care, S 455, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 103:81-4, table of contents. 2006
    ..No stereoselectivity was observed for 2-hexanol and 2-heptanol. These findings may permit studies of chirality in anesthesia, particularly in in vitro systems where metabolism does not occur, using inexpensive volatile compounds...
  51. ncbi request reprint Anesthetic properties of carbon dioxide in the rat
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Anesth Analg 105:103-6. 2007
    ..Carbon dioxide decreases halothane minimum alveolar concentrations (MAC) in dogs when Paco(2) exceeds 95 mm Hg. We sought to confirm these findings for several potent inhaled anesthetics in rats...
  52. ncbi request reprint The plasticizer di(2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and glycine receptor function
    Liya Yang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0464, USA
    Anesth Analg 105:393-6. 2007
    ....
  53. ncbi request reprint Hypothermia decreases ethanol MAC in rats
    Albert Won
    Department of Anesthesia and Perioperative Care, S 455, University of California, San Francisco, CA 94143 0464, USA
    J Anesth 20:247-50. 2006
    ..Although this decrease is not large, it may be important for comparative estimates of the in vitro effects of ethanol at different temperatures...
  54. ncbi request reprint The minimum alveolar anesthetic concentration of 2-, 3-, and 4-alcohols and ketones in rats: relevance to anesthetic mechanisms
    Albert Won
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 102:1419-26. 2006
    ..The oil/gas partition coefficient predicted potency as well as, or better than, either chain length or oxygen placement. Hydrophilicity, as indicated by the saline/gas partition coefficient, also seemed to influence potency...
  55. ncbi request reprint Lidocaine, MK-801, and MAC
    Yi Zhang
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0464, USA
    Anesth Analg 104:1098-102, tables of contents. 2007
    ..We postulated that the net effect of lidocaine and MK-801 on MAC would be the same, albeit by affecting NMDA neurotransmission at different points...
  56. ncbi request reprint Ammonia has anesthetic properties
    Robert J Brosnan
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Calif 94143 0464, USA
    Anesth Analg 104:1430-3, table of contents. 2007
    ..Because in pathophysiologic concentrations, ammonia reversibly impairs memory, consciousness, and responsiveness to noxious stimuli in a manner similar to anesthetics, we investigated whether ammonia had anesthetic properties...
  57. ncbi request reprint Anesthetic-like modulation of a gamma-aminobutyric acid type A, strychnine-sensitive glycine, and N-methyl-d-aspartate receptors by coreleased neurotransmitters
    Pavle S Milutinovic
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Anesth Analg 105:386-92. 2007
    ..A mechanism of anesthesia has recently been proposed which predicts that coreleased neurotransmitters may modulate neurotransmitter receptors for which they are not the native agonist in a manner similar to anesthetics...
  58. ncbi request reprint Isoflurane hyperalgesia is modulated by nicotinic inhibition
    Pamela Flood
    Department of Anesthesiology, Columbia University, New York, New York 10032, USA
    Anesthesiology 97:192-8. 2002
    ..Because nicotinic agonists act as analgesics, the authors hypothesized that inhibition of nicotinic transmission by isoflurane causes hyperalgesia...
  59. ncbi request reprint Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue: implications for in vitro studies
    Claudia Benkwitz
    Department of Anesthesiology, University of Wisconsin, Madison 53711, USA
    Anesthesiology 106:114-23. 2007
    ..However, the free aqueous concentration of etomidate that corresponds to amnesia in vivo and the diffusion profile of etomidate in brain slices are not known...
  60. ncbi request reprint Acetylcholine receptors do not mediate isoflurane's actions on spinal cord in vitro
    Shirley M E Wong
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    Anesth Analg 94:1495-9, table of contents. 2002
    ..Because minimum alveolar anesthetic concentration is determined primarily in spinal cord, cholinergic receptors may be eliminated as molecular targets for this anesthetic end-point...
  61. ncbi request reprint Heteromeric nicotinic inhibition by isoflurane does not mediate MAC or loss of righting reflex
    Pamela Flood
    Department of Anesthesiology, Columbia University, New York, NY 10032, USA
    Anesthesiology 97:902-5. 2002
    ..Despite clear evidence for nicotinic inhibition at relevant isoflurane concentrations, it is unclear what behavioral result ensues, if any...
  62. ncbi request reprint The effect of meperidine on thermoregulation in mice: involvement of alpha2-adrenoceptors
    Andrea Paris
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel Schwanenweg 21, D 24105 Kiel, Germany
    Anesth Analg 100:102-6. 2005
    ..6 degrees C; P <0.05). Meperidine did not decrease the maximum intensity of nonshivering thermogenesis. The results suggest a major role of alpha2-adrenoceptors in the inhibition of thermoregulation by meperidine in mice...
  63. doi request reprint Is synergy the rule? A review of anesthetic interactions producing hypnosis and immobility
    Jan F A Hendrickx
    Department of Anesthesia, Onze Lieve Vrouw Hospital, Moorselbaan 164, 9300 Aalst, Belgium
    Anesth Analg 107:494-506. 2008
    ..We applied this reasoning in a review of published data on anesthetic drug interactions for the end-points of hypnosis and immobility...
  64. ncbi request reprint Ethnicity can affect anesthetic requirement
    James M Sonner
    Anesthesiology 107:4-5. 2007

Research Grants5

  1. Genes Underlying the Response to Inhaled Anesthetics
    James Sonner; Fiscal Year: 2007
    ....
  2. Genes Underlying the Response to Inhaled Anesthetics
    James Sonner; Fiscal Year: 2004
    ....
  3. Genes Underlying the Response to Inhaled Anesthetics
    James Sonner; Fiscal Year: 2005
    ....
  4. Genes Underlying the Response to Inhaled Anesthetics
    James Sonner; Fiscal Year: 2006
    ....