Research Topics
Species | Joshua A SonnenSummaryAffiliation: University of Washington Country: USA Publications
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Detail Information
Publications
Biomarkers for Alzheimer's diseaseJoshua A Sonnen
Department of Pathology, University of Washington, Seattle, WA 98104 2499, USA
Expert Rev Neurother 7:1021-8. 2007..The next 5 years will see standardization of more established approaches, and the combination of different modalities into the most effective means for assessing different stages of AD...
Nonsteroidal anti-inflammatory drugs are associated with increased neuritic plaquesJ A Sonnen
Department of Pathology, University of Washington, Seattle, WA 98104, USA
Neurology 75:1203-10. 2010..The objective of this study is to determine the relationship between common dementia-associated pathologies and mid- to late-life NSAID exposure...- Cerebrospinal fluid biomarkers in mild cognitive impairment and dementiaJoshua A Sonnen
Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA 98104 2420, USA
J Alzheimers Dis 19:301-9. 2010..A multimodal approach that brings independent information from risk factor assessment, neuroimaging, and biomarkers may soon guide physicians in the early diagnosis and management of cognitive impairment in the elderly... 
Neuropathology in the adult changes in thought study: a reviewJoshua A Sonnen
Department of Pathology, University of Washington, Seattle, WA 98104 2420, USA
J Alzheimers Dis 18:703-11. 2009..This study examines correlations between clinical characteristics including extensive, longitudinal medication histories, and longitudinal cognitive testing against structural and biochemical features of disease...- Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smokingJoshua A Sonnen
Department of Pathology, University of Washington, Seattle, USA
Ann Neurol 65:226-9. 2009.... - Pathological correlates of dementia in a longitudinal, population-based sample of agingJoshua A Sonnen
Department of Pathology, University of Washington, Seattle, WA, USA
Ann Neurol 62:406-13. 2007..Our goal was to determine the independent pathological correlates associated with dementia in a typical US population... - Adult Changes in Thought study: dementia is an individually varying convergent syndrome with prevalent clinically silent diseases that may be modified by some commonly used therapeuticsThomas J Montine
Department of Pathology, University of Washington, Seattle, WA 98104, USA
Curr Alzheimer Res 9:718-23. 2012.... - Different patterns of cerebral injury in dementia with or without diabetesJoshua A Sonnen
Department of Pathology, University of Washington, Seattle, USA
Arch Neurol 66:315-22. 2009..Diabetes mellitus (DM) increases the risk of dementia in the elderly. However, its underlying mechanisms, its connection with Alzheimer disease and vascular cognitive impairment, and effects of therapy remain unclear... - Association between lifetime cigarette smoking and lewy body accumulationDebby Tsuang
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98104, USA
Brain Pathol 20:412-8. 2010..Although cigarette smoking is too toxic to suggest as a treatment, if confirmed, these findings may guide future therapeutic strategies that attempt to suppress LRP in human brain by other means... - Ecology of the aging human brainJoshua A Sonnen
Department of Pathology, University of Washington, Seattle, 98104, USA
Arch Neurol 68:1049-56. 2011..Alzheimer disease, cerebral vascular brain injury, and isocortical Lewy body disease (LBD) are the major contributors to dementia in community- and population-based studies... - Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adultsNadia Postupna
Department of Pathology, University of Washington, Seattle, USA
Brain Pathol 22:472-84. 2012.... - Blood pressure and brain injury in older adults: findings from a community-based autopsy studyLucy Y Wang
Mental Illness Research and Education Clinical Center, Veterans Affairs Puget Sound Healthcare System, Seattle, Washington 98108, USA
J Am Geriatr Soc 57:1975-81. 2009..To examine correlations between blood pressure (BP) and dementia-related pathological brain changes in a community-based autopsy sample... - Pathologic correlates of dementia in individuals with Lewy body diseaseJoshua A Sonnen
Department of Pathology, University of Washington, Seattle, WA 98104, USA
Brain Pathol 20:654-9. 2010..Diseases contributing to cognitive impairment and dementia in patients with bLBD are heterogeneous, providing diagnostic challenges as well as multiple opportunities for successful intervention in patients with PD... - Biomarkers for cognitive impairment and dementia in elderly peopleJoshua A Sonnen
Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA 98104, USA
Lancet Neurol 7:704-14. 2008..An approach that efficiently combines independent information from risk-factor assessment, neuroimaging measures, and biomarkers might soon guide clinicians in the early diagnosis and management of cognitive impairment in elderly people... - Elevated ratio of urinary metabolites of thromboxane and prostacyclin is associated with adverse cardiovascular events in ADAPTThomas J Montine
Department of Pathology, University of Washington, Seattle, Washington, United States of America
PLoS ONE 5:e9340. 2010.... - Role of cerebrospinal fluid and plasma biomarkers in the diagnosis of neurodegenerative disorders and mild cognitive impairmentLuis F Gonzalez-Cuyar
Department of Pathology, University of Washington, Seattle, USA
Curr Neurol Neurosci Rep 11:455-63. 2011..Future applications will likely focus on diagnosis of latent or early-stage disease, assessment of disease progression, mechanism of injury, and response to experimental therapeutics... - Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse modelsJoshua A Sonnen
Department of Pathology and of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
Free Radic Biol Med 45:219-30. 2008..Future efforts in preclinical models and ultimately clinical trials are needed to define optimally effective agents and combinations, doses, and timing to suppress safely this facet of AD... - Associations between microinfarcts and other macroscopic vascular findings on neuropathologic examination in 2 databasesW T Longstreth
Department of Neurology, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104 2420, USA
Alzheimer Dis Assoc Disord 23:291-4. 2009..9, 95% CI: 1.4, 6.3). These neuropathologic associations suggest that people whose cranial MRI shows macroinfarcts, hemorrhages, or leukoencephalopathy are more likely also to have microinfarcts... - Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literaturePeter T Nelson
Sanders Brown Center on Aging, Department of Pathology, University of Kentucky, Lexington 40536 0230, USA
J Neuropathol Exp Neurol 71:362-81. 2012..Although Aβ plaques may play a key role in AD pathogenesis, the severity of cognitive impairment correlates best with the burden of neocortical neurofibrillary tangles... - Hippocampal sclerosis in advanced age: clinical and pathological featuresPeter T Nelson
Department of Pathology, Division of Neuropathology and the Sanders Brown Centre on Ageing, University of Kentucky, 800 S Limestone, Lexington, KY 40536 0230, USA
Brain 134:1506-18. 2011..In summary, in the largest series of autopsy-verified patients with hippocampal sclerosis to date, we characterized the clinical and pathological features associated with hippocampal sclerosis associated with ageing... - Male microchimerism in the human female brainWilliam F N Chan
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
PLoS ONE 7:e45592. 2012..06) of male microchimerism in the brains of women with Alzheimer's disease than the brains of women without neurologic disease. In conclusion, male microchimerism is frequent and widely distributed in the human female brain...