Joshua A Sonnen

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Biomarkers for Alzheimer's disease
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA 98104 2499, USA
    Expert Rev Neurother 7:1021-8. 2007
  2. pmc Cerebrospinal fluid biomarkers in mild cognitive impairment and dementia
    Joshua A Sonnen
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA 98104 2420, USA
    J Alzheimers Dis 19:301-9. 2010
  3. doi request reprint Neuropathology in the adult changes in thought study: a review
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA 98104 2420, USA
    J Alzheimers Dis 18:703-11. 2009
  4. pmc Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, USA
    Ann Neurol 65:226-9. 2009
  5. pmc Nonsteroidal anti-inflammatory drugs are associated with increased neuritic plaques
    J A Sonnen
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Neurology 75:1203-10. 2010
  6. ncbi request reprint Pathological correlates of dementia in a longitudinal, population-based sample of aging
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA, USA
    Ann Neurol 62:406-13. 2007
  7. pmc Adult Changes in Thought study: dementia is an individually varying convergent syndrome with prevalent clinically silent diseases that may be modified by some commonly used therapeutics
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Curr Alzheimer Res 9:718-23. 2012
  8. pmc Different patterns of cerebral injury in dementia with or without diabetes
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, USA
    Arch Neurol 66:315-22. 2009
  9. pmc Association between lifetime cigarette smoking and lewy body accumulation
    Debby Tsuang
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98104, USA
    Brain Pathol 20:412-8. 2010
  10. pmc Ecology of the aging human brain
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, 98104, USA
    Arch Neurol 68:1049-56. 2011

Detail Information

Publications22

  1. ncbi request reprint Biomarkers for Alzheimer's disease
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA 98104 2499, USA
    Expert Rev Neurother 7:1021-8. 2007
    ..The next 5 years will see standardization of more established approaches, and the combination of different modalities into the most effective means for assessing different stages of AD...
  2. pmc Cerebrospinal fluid biomarkers in mild cognitive impairment and dementia
    Joshua A Sonnen
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA 98104 2420, USA
    J Alzheimers Dis 19:301-9. 2010
    ..A multimodal approach that brings independent information from risk factor assessment, neuroimaging, and biomarkers may soon guide physicians in the early diagnosis and management of cognitive impairment in the elderly...
  3. doi request reprint Neuropathology in the adult changes in thought study: a review
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA 98104 2420, USA
    J Alzheimers Dis 18:703-11. 2009
    ..This study examines correlations between clinical characteristics including extensive, longitudinal medication histories, and longitudinal cognitive testing against structural and biochemical features of disease...
  4. pmc Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, USA
    Ann Neurol 65:226-9. 2009
    ....
  5. pmc Nonsteroidal anti-inflammatory drugs are associated with increased neuritic plaques
    J A Sonnen
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Neurology 75:1203-10. 2010
    ..The objective of this study is to determine the relationship between common dementia-associated pathologies and mid- to late-life NSAID exposure...
  6. ncbi request reprint Pathological correlates of dementia in a longitudinal, population-based sample of aging
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA, USA
    Ann Neurol 62:406-13. 2007
    ..Our goal was to determine the independent pathological correlates associated with dementia in a typical US population...
  7. pmc Adult Changes in Thought study: dementia is an individually varying convergent syndrome with prevalent clinically silent diseases that may be modified by some commonly used therapeutics
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Curr Alzheimer Res 9:718-23. 2012
    ....
  8. pmc Different patterns of cerebral injury in dementia with or without diabetes
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, USA
    Arch Neurol 66:315-22. 2009
    ..Diabetes mellitus (DM) increases the risk of dementia in the elderly. However, its underlying mechanisms, its connection with Alzheimer disease and vascular cognitive impairment, and effects of therapy remain unclear...
  9. pmc Association between lifetime cigarette smoking and lewy body accumulation
    Debby Tsuang
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98104, USA
    Brain Pathol 20:412-8. 2010
    ..Although cigarette smoking is too toxic to suggest as a treatment, if confirmed, these findings may guide future therapeutic strategies that attempt to suppress LRP in human brain by other means...
  10. pmc Ecology of the aging human brain
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, 98104, USA
    Arch Neurol 68:1049-56. 2011
    ..Alzheimer disease, cerebral vascular brain injury, and isocortical Lewy body disease (LBD) are the major contributors to dementia in community- and population-based studies...
  11. pmc Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults
    Nadia Postupna
    Department of Pathology, University of Washington, Seattle, USA
    Brain Pathol 22:472-84. 2012
    ....
  12. pmc Blood pressure and brain injury in older adults: findings from a community-based autopsy study
    Lucy Y Wang
    Mental Illness Research and Education Clinical Center, Veterans Affairs Puget Sound Healthcare System, Seattle, Washington 98108, USA
    J Am Geriatr Soc 57:1975-81. 2009
    ..To examine correlations between blood pressure (BP) and dementia-related pathological brain changes in a community-based autopsy sample...
  13. pmc Biomarkers for cognitive impairment and dementia in elderly people
    Joshua A Sonnen
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA 98104, USA
    Lancet Neurol 7:704-14. 2008
    ..An approach that efficiently combines independent information from risk-factor assessment, neuroimaging measures, and biomarkers might soon guide clinicians in the early diagnosis and management of cognitive impairment in elderly people...
  14. pmc Pathologic correlates of dementia in individuals with Lewy body disease
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Brain Pathol 20:654-9. 2010
    ..Diseases contributing to cognitive impairment and dementia in patients with bLBD are heterogeneous, providing diagnostic challenges as well as multiple opportunities for successful intervention in patients with PD...
  15. pmc Neuropathologic correlates of cognition in a population-based sample
    Brenna Cholerton
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 9600 Veterans Drive SW, Tacoma, WA 98493, USA
    J Alzheimers Dis 36:699-709. 2013
    ..These findings underscore that cognitive impairment is a complex convergent trait that has important implications for clinical investigation and medical management of older adults. ..
  16. pmc Role of cerebrospinal fluid and plasma biomarkers in the diagnosis of neurodegenerative disorders and mild cognitive impairment
    Luis F Gonzalez-Cuyar
    Department of Pathology, University of Washington, Seattle, USA
    Curr Neurol Neurosci Rep 11:455-63. 2011
    ..Future applications will likely focus on diagnosis of latent or early-stage disease, assessment of disease progression, mechanism of injury, and response to experimental therapeutics...
  17. pmc Elevated ratio of urinary metabolites of thromboxane and prostacyclin is associated with adverse cardiovascular events in ADAPT
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e9340. 2010
    ....
  18. pmc Associations between microinfarcts and other macroscopic vascular findings on neuropathologic examination in 2 databases
    W T Longstreth
    Department of Neurology, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104 2420, USA
    Alzheimer Dis Assoc Disord 23:291-4. 2009
    ..9, 95% CI: 1.4, 6.3). These neuropathologic associations suggest that people whose cranial MRI shows macroinfarcts, hemorrhages, or leukoencephalopathy are more likely also to have microinfarcts...
  19. pmc Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models
    Joshua A Sonnen
    Department of Pathology and of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
    Free Radic Biol Med 45:219-30. 2008
    ..Future efforts in preclinical models and ultimately clinical trials are needed to define optimally effective agents and combinations, doses, and timing to suppress safely this facet of AD...
  20. pmc Male microchimerism in the human female brain
    William F N Chan
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS ONE 7:e45592. 2012
    ..06) of male microchimerism in the brains of women with Alzheimer's disease than the brains of women without neurologic disease. In conclusion, male microchimerism is frequent and widely distributed in the human female brain...
  21. pmc Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature
    Peter T Nelson
    Sanders Brown Center on Aging, Department of Pathology, University of Kentucky, Lexington 40536 0230, USA
    J Neuropathol Exp Neurol 71:362-81. 2012
    ..Although Aβ plaques may play a key role in AD pathogenesis, the severity of cognitive impairment correlates best with the burden of neocortical neurofibrillary tangles...
  22. pmc Hippocampal sclerosis in advanced age: clinical and pathological features
    Peter T Nelson
    Department of Pathology, Division of Neuropathology and the Sanders Brown Centre on Ageing, University of Kentucky, 800 S Limestone, Lexington, KY 40536 0230, USA
    Brain 134:1506-18. 2011
    ..In summary, in the largest series of autopsy-verified patients with hippocampal sclerosis to date, we characterized the clinical and pathological features associated with hippocampal sclerosis associated with ageing...