J Glenn Songer

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Clostridium difficile: an important pathogen of food animals
    J Glenn Songer
    Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ 85721, USA
    Anaerobe 12:1-4. 2006
  2. pmc Clostridium difficile in retail meat products, USA, 2007
    J Glenn Songer
    University of Arizona, Tucson, 85721, USA
    Emerg Infect Dis 15:819-21. 2009
  3. ncbi request reprint Equine colitis X associated with infection by Clostridium difficile NAP1/027
    J Glenn Songer
    Department of Veterinary Science and Microbiology, 1117 East Lowell Street, The University of Arizona, Tucson, AZ 85721, USA
    J Vet Diagn Invest 21:377-80. 2009
  4. ncbi request reprint Prevention of porcine Clostridium difficile-associated disease by competitive exclusion with nontoxigenic organisms
    J Glenn Songer
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, AZ 85721, USA
    Vet Microbiol 124:358-61. 2007
  5. doi request reprint Clostridia as agents of zoonotic disease
    J Glenn Songer
    Department of Veterinary Science and Microbiology, The University of Arizona, 1117 East Lowell Street, Tucson, AZ 85721, USA
    Vet Microbiol 140:399-404. 2010
  6. ncbi request reprint Prevalence of cpb2, encoding beta2 toxin, in Clostridium perfringens field isolates: correlation of genotype with phenotype
    Dawn M Bueschel
    Department of Veterinary Science and Microbiology, The University of Arizona, 1117 East Lowell Street, Tucson, AZ 85721, USA
    Vet Microbiol 94:121-9. 2003
  7. ncbi request reprint A possible role for Clostridium difficile in the etiology of calf enteritis
    Melissa C Hammitt
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, AZ 85721, USA
    Vet Microbiol 127:343-52. 2008
  8. pmc Tylosin resistance in Arcanobacterium pyogenes is encoded by an erm X determinant
    B Helen Jost
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, Arizona 85721, USA
    Antimicrob Agents Chemother 47:3519-24. 2003
  9. doi request reprint Virulence for chickens of Clostridium perfringens isolated from poultry and other sources
    Kerry K Cooper
    Department of Veterinary Science and Microbiology, University of Arizona, 1117 E Lowell St, Tucson, AZ 85721, USA
    Anaerobe 16:289-92. 2010
  10. pmc Prevalence of PCR ribotypes among Clostridium difficile isolates from pigs, calves, and other species
    Kevin Keel
    Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ 85721, USA
    J Clin Microbiol 45:1963-4. 2007

Research Grants

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Clostridium difficile: an important pathogen of food animals
    J Glenn Songer
    Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ 85721, USA
    Anaerobe 12:1-4. 2006
    ..difficile alone, while an additional quarter of affected piglets may have had mixed infections. C. difficile may be the most important uncontrolled cause of neonatal diarrhea in pigs...
  2. pmc Clostridium difficile in retail meat products, USA, 2007
    J Glenn Songer
    University of Arizona, Tucson, 85721, USA
    Emerg Infect Dis 15:819-21. 2009
    ..difficile strains (either ribotype 078/toxinotype V [73%] or 027/toxinotype III [NAP1 or NAP1-related; 27%]). These findings indicate that food products may play a role in interspecies C. difficile transmission...
  3. ncbi request reprint Equine colitis X associated with infection by Clostridium difficile NAP1/027
    J Glenn Songer
    Department of Veterinary Science and Microbiology, 1117 East Lowell Street, The University of Arizona, Tucson, AZ 85721, USA
    J Vet Diagn Invest 21:377-80. 2009
    ..difficile-associated disease of greater than historical severity. The diagnosis was peracute typhlocolitis, with lesions and history typical of those attributed to colitis X...
  4. ncbi request reprint Prevention of porcine Clostridium difficile-associated disease by competitive exclusion with nontoxigenic organisms
    J Glenn Songer
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, AZ 85721, USA
    Vet Microbiol 124:358-61. 2007
    ..8% of litters and 3.4% of piglets given spores orally. These data support a contention that precolonization by a nontoxigenic strain can ameliorate the pre-weaning growth retardation associated with C. difficile infection in piglets...
  5. doi request reprint Clostridia as agents of zoonotic disease
    J Glenn Songer
    Department of Veterinary Science and Microbiology, The University of Arizona, 1117 East Lowell Street, Tucson, AZ 85721, USA
    Vet Microbiol 140:399-404. 2010
    ..difficile that in many cases are identical to those from food animals and diseased humans. Transmission, food animals to foods to humans, has not been documented...
  6. ncbi request reprint Prevalence of cpb2, encoding beta2 toxin, in Clostridium perfringens field isolates: correlation of genotype with phenotype
    Dawn M Bueschel
    Department of Veterinary Science and Microbiology, The University of Arizona, 1117 East Lowell Street, Tucson, AZ 85721, USA
    Vet Microbiol 94:121-9. 2003
    ..However, it may be important to consider the use of an additional method for the detection of beta2 toxin in non-porcine cpb2-positive isolates when making claims about the role of beta2 in enteritis in non-porcine species...
  7. ncbi request reprint A possible role for Clostridium difficile in the etiology of calf enteritis
    Melissa C Hammitt
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, AZ 85721, USA
    Vet Microbiol 127:343-52. 2008
    ..St. Louis, MO, U.S.A.] and add strength to a working hypothesis that C. difficile infection and the accompanying intoxication can manifest as diarrhea in calves. It seems clear that calves serve as multiplying hosts for this organism...
  8. pmc Tylosin resistance in Arcanobacterium pyogenes is encoded by an erm X determinant
    B Helen Jost
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, Arizona 85721, USA
    Antimicrob Agents Chemother 47:3519-24. 2003
    ..The repA gene from pAP2 was nonfunctional in Escherichia coli and at least one A. pyogenes isolate, suggesting that there may be host-encoded factors required for replication of this plasmid...
  9. doi request reprint Virulence for chickens of Clostridium perfringens isolated from poultry and other sources
    Kerry K Cooper
    Department of Veterinary Science and Microbiology, University of Arizona, 1117 E Lowell St, Tucson, AZ 85721, USA
    Anaerobe 16:289-92. 2010
    ..NE strains must have specific poultry-associated virulence attributes, such as the recently identified NetB and other factors, which allow for the development of disease...
  10. pmc Prevalence of PCR ribotypes among Clostridium difficile isolates from pigs, calves, and other species
    Kevin Keel
    Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ 85721, USA
    J Clin Microbiol 45:1963-4. 2007
    ..Porcine isolates comprised four PCR ribotypes, but one, ribotype 078, predominated (83%). This was also the most common ribotype (94%) among 33 calf isolates but was rarely identified in other species...
  11. pmc A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes
    B Helen Jost
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, Arizona 85721, USA
    Antimicrob Agents Chemother 48:721-7. 2004
    ..However, in three strains, this insertion resulted in a partial duplication of orfY...
  12. ncbi request reprint Association of genes encoding beta2 toxin and a collagen binding protein in Clostridium perfringens isolates of porcine origin
    B Helen Jost
    Department of Veterinary Science and Microbiology, The University of Arizona, 1117 E Lowell Street, Tucson, AZ 85721, USA
    Vet Microbiol 115:173-82. 2006
    ..The finding that CpCna binds collagen and that the cna gene is associated with the consensus cpb2 allele implicates CpCna as a potential virulence factor in porcine enteritis caused by C. perfringens...
  13. ncbi request reprint Clonal relationships among Clostridium perfringens of porcine origin as determined by multilocus sequence typing
    B Helen Jost
    Department of Veterinary Science and Microbiology, The University of Arizona, 1117 E Lowell Street, Tucson, AZ 85721, USA
    Vet Microbiol 116:158-65. 2006
    ..6% of porcine isolates not present in clonal complex 3 (n=28). The data obtained indicates that MLST may be used to identify host species relationships with respect to these C. perfringens isolates...
  14. doi request reprint Immunization with recombinant alpha toxin partially protects broiler chicks against experimental challenge with Clostridium perfringens
    K K Cooper
    Department of Veterinary Science and Microbiology, University of Arizona, 1117 E Lowell Street, Tucson, AZ 85721, United States
    Vet Microbiol 133:92-7. 2009
    ..After challenge, vaccinated birds had average IgG (IgY) titers>15-fold higher than those in non-vaccinated birds. These results suggest that alpha toxin may serve as an effective immunogen, and, as such, may play a role in pathogenesis...
  15. ncbi request reprint Evaluation of two enzyme immunoassays for detection of Clostridium difficile toxins A and B in swine
    Michael A Anderson
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, AZ 85721, USA
    Vet Microbiol 128:204-6. 2008
    ..Its negative predictive value was 87, but its positive predictive value was 100. Thus, the Tox A/B II kit is apparently superior to the Gastro-tect Toxin A+B test for diagnosis of CDAD in neonatal pigs...
  16. pmc Ribosomal mutations in Arcanobacterium pyogenes confer a unique spectrum of macrolide resistance
    B Helen Jost
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, Arizona 85721, USA
    Antimicrob Agents Chemother 48:1021-3. 2004
    ..While these mutations conferred resistance to erythromycin, oleandomycin, and spiramycin, they did not confer resistance to tylosin...
  17. ncbi request reprint The gene encoding pyolysin, the pore-forming toxin of Arcanobacterium pyogenes, resides within a genomic islet flanked by essential genes
    Stefani T Rudnick
    Department of Veterinary Science and Microbiology, The University of Arizona, 1117 East Lowell Street, Tucson, AZ 85721, USA
    FEMS Microbiol Lett 225:241-7. 2003
    ..Regardless, the presence of the plo gene as part of a genomic islet inserted between genes essential for normal growth may provide selective pressure for the retention of this important virulence factor...
  18. pmc Immunization with genetic toxoids of the Arcanobacterium pyogenes cholesterol-dependent cytolysin, pyolysin, protects mice against infection
    B Helen Jost
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, Arizona 85721, USA
    Infect Immun 71:2966-9. 2003
    ..Furthermore, in a mouse model of infection, A. pyogenes carrying the F(497) mutation was as attenuated as a PLO-deficient strain, indicating that the cytolytic activity of PLO is important in virulence...
  19. pmc Widespread distribution of a tet W determinant among tetracycline-resistant isolates of the animal pathogen Arcanobacterium pyogenes
    Stephen J Billington
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, Arizona 85721, USA
    Antimicrob Agents Chemother 46:1281-7. 2002
    ..The mobile nature of this determinant and the presence of A. pyogenes in the gastrointestinal tract of cattle and pigs suggest that A. pyogenes may have inherited this determinant within the gastrointestinal tracts of these animals...
  20. pmc Atypical cpb2 genes, encoding beta2-toxin in Clostridium perfringens isolates of nonporcine origin
    B Helen Jost
    Department of Veterinary Science and Microbiology, University of Arizona, 1117 East Lowell St, Tucson, AZ 85721, USA
    Infect Immun 73:652-6. 2005
    ..However, the identification of apparently nonexpressed, atypical cpb2 genes raises the question of whether this protein plays the same role in enteritis in other animal species...
  21. pmc The Arcanobacterium pyogenes collagen-binding protein, CbpA, promotes adhesion to host cells
    Paula A Esmay
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, Arizona 85721, USA
    Infect Immun 71:4368-74. 2003
    ..9- and 5.7-fold, respectively. These data indicate that CbpA, a collagen-binding protein of A. pyogenes, plays a role in the adhesion of this organism to host cells...
  22. ncbi request reprint The variant undecapeptide sequence of the Arcanobacterium pyogenes haemolysin, pyolysin, is required for full cytolytic activity
    Stephen J Billington
    Department of Veterinary Science and Microbiology, The University of Arizona, 1117 East Lowell Street, Tucson, AZ 85721, USA
    Microbiology 148:3947-54. 2002
    ....
  23. doi request reprint Virulence of Clostridium perfringens in an experimental model of poultry necrotic enteritis
    Kerry K Cooper
    Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ 85721, USA
    Vet Microbiol 142:323-8. 2010
    ..In addition, in vivo passage apparently increases strain virulence. Virulence varies from strain-to-strain; NetB-producing strains were virulent, as were some NetB non-producing strains...
  24. doi request reprint Necrotic enteritis in chickens: a paradigm of enteric infection by Clostridium perfringens type A
    Kerry K Cooper
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, 85721, USA
    Anaerobe 15:55-60. 2009
    ..Future progress may be based in large part on genomic and proteomic analyses...
  25. ncbi request reprint Clostridium perfringens: insight into virulence evolution and population structure
    Youhanna S Sawires
    Department of Veterinary Science and Microbiology, University of Arizona, Room 207, 1117 East Lowell Street, Tucson AZ 85721, USA
    Anaerobe 12:23-43. 2006
    ..Finally, C. perfringens proved to have a dynamic population and availability of more genome sequences and use of comparative proteomics and animal modeling would provide more insight into the virulence of this organism...
  26. ncbi request reprint Clostridial enteric infections in pigs
    J Glenn Songer
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson 85721, USA
    J Vet Diagn Invest 17:528-36. 2005
    ..Clostridium difficile can also be a normal inhabitant of the intestine of healthy pigs, and diagnosis of enteric infection with this microorganism is based on detection of its toxins in feces or intestinal contents...
  27. ncbi request reprint The emergence of Clostridium difficile as a pathogen of food animals
    J Glenn Songer
    Department of Veterinary Science and Microbiology, University of Arizona, Tucson, AZ 85721, USA
    Anim Health Res Rev 5:321-6. 2004
    ..Given the widespread occurrence of the disease, there is substantial effort to develop immunoprophylactic products...
  28. pmc Identification of a second Arcanobacterium pyogenes neuraminidase and involvement of neuraminidase activity in host cell adhesion
    B Helen Jost
    Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, Arizona 85721, USA
    Infect Immun 70:1106-12. 2002
    ..The wild-type adhesion phenotype was restored by providing nanP in trans. These data indicate that the neuraminidases of A. pyogenes play a role in adhesion of this organism to host epithelial cells...
  29. doi request reprint Presence of Clostridium perfringens in retail chicken livers
    Kerry K Cooper
    Department of Veterinary Science and Microbiology, University of Arizona, 1117 E Lowell St, Tucson, AZ 85721, USA Electronic address
    Anaerobe 21:67-8. 2013
    ..Results showed that 69.6% of sampled retail chicken livers were culture positive for C. perfringens. Genotyping of the isolates showed that all the isolates were type A, but were negative for the enterotoxin gene (cpe)...
  30. ncbi request reprint Susceptibility of Arcanobacterium pyogenes from different sources to tetracycline, macrolide and lincosamide antimicrobial agents
    Hien T Trinh
    Department of Veterinary Science and Microbiology, The University of Arizona, 1117 East Lowell Street, Tucson, AZ 85721, USA
    Vet Microbiol 85:353-9. 2002
    ..6% of porcine isolates were resistant to the tetracyclines, compared with 25.9% of bovine isolates. These data suggest that a large proportion of A. pyogenes field isolates may be resistant to these commonly used antimicrobial agents...
  31. ncbi request reprint Identification and role in virulence of putative iron acquisition genes from Corynebacterium pseudotuberculosis
    Stephen J Billington
    Department of Veterinary Science and Microbiology, University of Arizona, 1117 E Lowell Street, Tucson, AZ 85721, USA
    FEMS Microbiol Lett 208:41-5. 2002
    ..pseudotuberculosis fagB(C) mutant in vitro, this mutant showed reduced virulence compared to wild-type in a goat model of caseous lymphadenitis. Thus, expression of the fag genes in the host appears to contribute to virulence...
  32. ncbi request reprint Diagnosis of Clostridium perfringens intestinal infections in sheep and goats
    Francisco A Uzal
    California Animal Health and Food Safety Laboratory System, University of California, Davis, San Bernardino, CA 92408, USA
    J Vet Diagn Invest 20:253-65. 2008
    ..However, although such tests have a presumptive diagnostic value when positive, they cannot be used to rule out a diagnosis of enterotoxemia when negative...
  33. ncbi request reprint Evaluation of a test for Clostridium difficile toxins A and B for the diagnosis of neonatal swine enteritis
    Karen W Post
    North Carolina Department of Agriculture and Consumer Services, Rollins Animal Disease Diagnostic Laboratory, Raleigh 27607, USA
    J Vet Diagn Invest 14:258-9. 2002
    ..The EIA test is considered suitable as an aid for the diagnosis of C. difficile enteritis because of the high correlation between EIA results and those of the tissue culture cytotoxicity assay...
  34. pmc Regulation of type IV fimbrial biogenesis in Dichelobacter nodosus
    Dane Parker
    Australian Research Council Centre of Excellence for Structrral and Functional Microbial Genomics and Victorian Bioinformatics Consortium, Department of Microbiology, Monash University, Victoria 3800, Australia
    J Bacteriol 188:4801-11. 2006
    ..nodosus to cause ovine footrot is regulated, as we have shown that the biogenesis of type IV fimbriae in D. nodosus is regulated by a sigma 54-dependent PilR/S system that also indirectly controls protease secretion...
  35. pmc Mechanism of induction of complement susceptibility of erythrocytes by spider and bacterial sphingomyelinases
    Denise V Tambourgi
    Laboratório de Imunoquímica, Instituto Butantan, Sao Paulo, Brazil
    Immunology 107:93-101. 2002
    ..intermedia and C. pseudotuberculosis PLD is a result of exposure of phosphatidylserine, and the higher potency of P1 toxin can be explained by its additional effect of cleavage of glycophorins...
  36. pmc Genotyping and phenotyping of beta2-toxigenic Clostridium perfringens fecal isolates associated with gastrointestinal diseases in piglets
    Michael Waters
    Department of Microbiology, Oregon State University, Corvallis, Oregon 9731, USA
    J Clin Microbiol 41:3584-91. 2003
    ..Collectively, our present results support a significant association between CPB2-positive C. perfringens isolates and diarrhea in piglets...
  37. pmc Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens
    Garry S A Myers
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    Genome Res 16:1031-40. 2006
    ....
  38. ncbi request reprint Enteritis necroticans with recurrent enterocutaneous fistulae caused by Clostridium perfringens in a child with cyclic neutropenia
    Ding You Li
    Children s Mercy Hospital, Kansas City, Missouri 64108, USA
    J Pediatr Gastroenterol Nutr 38:213-5. 2004
  39. ncbi request reprint Fatal necrotizing colitis following a foodborne outbreak of enterotoxigenic Clostridium perfringens type A infection
    John Bos
    Oklahoma State Department of Health, Oklahoma City, OK 73117 1299, USA
    Clin Infect Dis 40:e78-83. 2005
    ..Enterotoxigenic Clostridium perfringens type A is the third leading cause of foodborne disease in the United States, resulting annually in an estimated 250,000 cases of a typically mild, self-limiting gastrointestinal illness...
  40. ncbi request reprint Necrotizing enterocolitis associated with clostridium perfringens type A in previously healthy north american adults
    Jeremy Sobel
    Foodborne and Diarrheal Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Am Coll Surg 201:48-56. 2005
    ..It is exceedingly rare in the developed world. C perfringens type A is a common cause of acute gastroenteritis and, in a handful of infections, has been reported in association with a syndrome resembling necrotizing enteritis...
  41. ncbi request reprint Sphingomyelinase D, a novel probe for cellular sphingomyelin: effects on cholesterol homeostasis in human skin fibroblasts
    Papasani V Subbaiah
    Department of Medicine, Rush Medical College, Chicago, IL 60612, USA
    J Lipid Res 44:1574-80. 2003
    ..Since ceramide phosphate does not appear to have such effects, we suggest that SMase D is a useful probe of membrane SM...
  42. ncbi request reprint Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus
    Garry S A Myers
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nat Biotechnol 25:569-75. 2007
    ..Screening of these proteins against ovine antisera identified eight immunogenic proteins that are candidate antigens for a cross-protective vaccine...

Research Grants1

  1. Functional analysis of C. perfringens epsilon toxin
    J Songer; Fiscal Year: 2006
    ..This information can be used to model the mode of action of ETX, and to define regions of the molecule that could be targeted for immunoprophylaxis and treatment. ..