Zhenyuan Song

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. doi request reprint Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease
    Zhenyuan Song
    Department of Medicine, University of Louisville, Louisville, KY, USA
    Hepatology 47:867-79. 2008
  2. ncbi request reprint Silymarin prevents palmitate-induced lipotoxicity in HepG2 cells: involvement of maintenance of Akt kinase activation
    Zhenyuan Song
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Louisville School of Medicine, 511 S Floyd Street, Louisville, KY 40202, USA
    Basic Clin Pharmacol Toxicol 101:262-8. 2007
  3. ncbi request reprint Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis
    Zhenyuan Song
    Dept of Medicine, Univ of Louisville Medical Center, Louisville, KY 40292, USA
    Am J Physiol Gastrointest Liver Physiol 293:G894-902. 2007
  4. pmc Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: possible involvement of mitochondrial S-adenosylmethionine transport
    Zhenyuan Song
    Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, United States
    Biochem Pharmacol 74:521-31. 2007
  5. pmc Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha
    Xinqin Kang
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Hepatology 50:1241-50. 2009
  6. ncbi request reprint Silymarin protects against acute ethanol-induced hepatotoxicity in mice
    Zhenyuan Song
    Department of Medicine, University of Louisville Health Center, Louisville, Kentucky, USA
    Alcohol Clin Exp Res 30:407-13. 2006
  7. pmc Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress
    Zhanxiang Zhou
    University of Louisville School of Medicine, Department of Medicine, 511 South Floyd St, MDR 529, Louisville, KY 40292, USA
    Am J Pathol 166:1681-90. 2005
  8. ncbi request reprint S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease
    Zhenyuan Song
    Department of Medicine, University of Louisville College of Medicine, Louisville, KY, USA
    Hepatology 40:989-97. 2004
  9. ncbi request reprint Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition
    Matthew Cave
    Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA
    J Nutr Biochem 18:184-95. 2007
  10. pmc Preservation of intestinal structural integrity by zinc is independent of metallothionein in alcohol-intoxicated mice
    Jason C Lambert
    Department of Pharmacology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Am J Pathol 164:1959-66. 2004

Collaborators

Detail Information

Publications36

  1. doi request reprint Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease
    Zhenyuan Song
    Department of Medicine, University of Louisville, Louisville, KY, USA
    Hepatology 47:867-79. 2008
    ..CONCLUSION: Chronic alcohol feeding caused abnormal accumulation of homocysteine in adipocytes, which contributes to decreased adiponectin production in ALD...
  2. ncbi request reprint Silymarin prevents palmitate-induced lipotoxicity in HepG2 cells: involvement of maintenance of Akt kinase activation
    Zhenyuan Song
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Louisville School of Medicine, 511 S Floyd Street, Louisville, KY 40202, USA
    Basic Clin Pharmacol Toxicol 101:262-8. 2007
    ..These data also provide a further rationale for exploration of the use of silymarin in the treatment of non-alcoholic steatohepatitis...
  3. ncbi request reprint Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis
    Zhenyuan Song
    Dept of Medicine, Univ of Louisville Medical Center, Louisville, KY 40292, USA
    Am J Physiol Gastrointest Liver Physiol 293:G894-902. 2007
    ..Our findings are the first to suggest that betaine might serve as a therapeutic tool to attenuate hepatic steatosis by targeting the hepatic AMPK system...
  4. pmc Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: possible involvement of mitochondrial S-adenosylmethionine transport
    Zhenyuan Song
    Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, United States
    Biochem Pharmacol 74:521-31. 2007
    ..In conclusion, our results demonstrate that depletion of the mitochondrial SAM pool by SAH, which is elevated during chronic alcohol consumption, plays a critical role in SAH induced sensitization to TNF hepatotoxicity...
  5. pmc Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha
    Xinqin Kang
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Hepatology 50:1241-50. 2009
    ..Consequently, zinc deprivation caused cellular accumulation of lipid droplets, triglycerides and free fatty acids in the HepG2 cells...
  6. ncbi request reprint Silymarin protects against acute ethanol-induced hepatotoxicity in mice
    Zhenyuan Song
    Department of Medicine, University of Louisville Health Center, Louisville, Kentucky, USA
    Alcohol Clin Exp Res 30:407-13. 2006
    ..We investigated the effects and the possible mechanism(s) of silymarin on liver injury induced by acute ethanol (EtOH) administration...
  7. pmc Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress
    Zhanxiang Zhou
    University of Louisville School of Medicine, Department of Medicine, 511 South Floyd St, MDR 529, Louisville, KY 40292, USA
    Am J Pathol 166:1681-90. 2005
    ..In conclusion, zinc supplementation prevents alcoholic liver injury in an metallothionein-independent manner by inhibiting the generation of reactive oxygen species (P450 2E1) and enhancing the activity of antioxidant pathways...
  8. ncbi request reprint S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease
    Zhenyuan Song
    Department of Medicine, University of Louisville College of Medicine, Louisville, KY, USA
    Hepatology 40:989-97. 2004
    ..These data further support improving the S-adenosylmethionine-to-SAH ratio and removal of intracellular SAH as potential therapeutic options in alcoholic liver disease...
  9. ncbi request reprint Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition
    Matthew Cave
    Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA
    J Nutr Biochem 18:184-95. 2007
    ..Certain nutrients may also be of benefit. Important areas for future research are the effect(s) of nutritional supplements on NAFLD/NASH and the effects of industrial toxins...
  10. pmc Preservation of intestinal structural integrity by zinc is independent of metallothionein in alcohol-intoxicated mice
    Jason C Lambert
    Department of Pharmacology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Am J Pathol 164:1959-66. 2004
    ..These results thus demonstrate that zinc preservation of intestinal structural integrity is associated with suppression of endotoxemia and liver injury induced by acute exposure to ethanol and the zinc protection is independent of MT...
  11. ncbi request reprint Dysregulated cytokine metabolism, altered hepatic methionine metabolism and proteasome dysfunction in alcoholic liver disease
    Craig McClain
    Department of Internal Medicine, Department of Pharmacology and Toxicology, University of Louisville Medical Center, Louisville, KY 40202, USA
    Alcohol Clin Exp Res 29:180S-8S. 2005
    ..This article reviews the interactions of cytokines, altered methionine metabolism, and proteasome dysfunction in the development of ALD...
  12. ncbi request reprint Modulation of endotoxin stimulated interleukin-6 production in monocytes and Kupffer cells by S-adenosylmethionine (SAMe)
    Zhenyuan Song
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Cytokine 28:214-23. 2004
    ..Our results demonstrate that SAMe administration may exert its anti-inflammatory and hepatoprotective effects, at least in part, by enhancing LPS-stimulated IL-6 production...
  13. ncbi request reprint Chronic ethanol-mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-kappaB activity and TNF expression: relevance to alcoholic liver disease
    Leila Gobejishvili
    Dept of Medicine, Pharmacology and Toxicology, Univ of Louisville Medical Center, 550 S Jackson St, ACB 3rd Floor, Louisville, KY 40292, USA
    Am J Physiol Gastrointest Liver Physiol 291:G681-8. 2006
    ..Furthermore, these data also support the notion that cAMP-elevating agents could constitute an effective therapeutic approach in attenuating or preventing the progression of liver disease in alcoholic patients...
  14. ncbi request reprint S-adenosylmethionine (SAMe) modulates interleukin-10 and interleukin-6, but not TNF, production via the adenosine (A2) receptor
    Zhenyuan Song
    Department of Medicine, University of Louisville College of Medicine, Louisville, KY 40292, USA
    Biochim Biophys Acta 1743:205-13. 2005
    ..Our results suggest that increased adenosine levels with subsequent binding to the A(2) receptor account, at least in part, for SAMe modulation of IL-10 and IL-6, but not TNF production, from LPS stimulated monocytes...
  15. pmc Abrogation of nuclear factor-kappaB activation is involved in zinc inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha production and liver injury
    Zhanxiang Zhou
    Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Am J Pathol 164:1547-56. 2004
    ..Thus, zinc may be beneficial in the treatment of LPS-induced liver injuries, such as sepsis and alcoholism...
  16. ncbi request reprint Preservation of hepatocyte nuclear factor-4alpha is associated with zinc protection against TNF-alpha hepatotoxicity in mice
    Zhanxiang Zhou
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Exp Biol Med (Maywood) 232:622-8. 2007
    ..These results suggest that zinc protects against TNF-alpha hepatotoxicity, at least partially, through preservation of the zinc finger protein HNF-4alpha...
  17. ncbi request reprint S-adenosylmethionine (SAMe) protects against acute alcohol induced hepatotoxicity in mice small star, filled
    Zhenyuan Song
    Department of Medicine, University of Louisville Medical Center, 40292, Louisville, KY, USA
    J Nutr Biochem 14:591-7. 2003
    ..SAMe may prove to be an effective therapeutic agent in many toxin-induced liver injuries including those induced by alcohol...
  18. pmc Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4alpha in mice subjected to long-term ethanol administration
    Xinqin Kang
    Department of Medicine, University of Louisville School of Medicine, 511 South Floyd Street, Louisville, KY 40292, USA
    Am J Pathol 172:916-25. 2008
    ....
  19. doi request reprint Tetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis
    Ming Song
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Louisville School of Medicine, 550 S Jackson St, Louisville, KY 40202, USA
    J Pharmacol Exp Ther 325:409-16. 2008
    ..The protective mechanism seems to be independent of oxidative stress. Our data provide further evidence that TM might be a potential therapy for hepatic fibrosis...
  20. ncbi request reprint Interactions of cytokines, S-Adenosylmethionine, and S-Adenosylhomocysteine in alcohol-induced liver disease and immune suppression
    Shirish Barve
    Department of Medicine, University of Louisville, Louisville, Kentucky 40292, USA
    J Gastroenterol Hepatol 21:S38-42. 2006
    ..It is the authors' working hypothesis that alcohol consumption leads to chronic activation of the immune system...
  21. doi request reprint Zinc supplementation inhibits hepatic apoptosis in mice subjected to a long-term ethanol exposure
    Zhanxiang Zhou
    The University of Louisville School of Medicine, Department of Medicine, 511 South Floyd Street, MDR Room 529, Louisville, KY 40292, USA
    Exp Biol Med (Maywood) 233:540-8. 2008
    ..In conclusion, zinc supplementation prevented hepatocyte apoptosis in mice subjected to long-term ethanol exposure, and the action of zinc is likely through suppression of oxidative stress and death receptor-mediated pathways...
  22. pmc A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-alpha production
    Zhanxiang Zhou
    Department of Medicine, University of Louisville School of Medicine, 511 South Floyd Street, MDR 525, Louisville, KY, USA
    Am J Pathol 163:1137-46. 2003
    ....
  23. ncbi request reprint Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation
    Jianxun Wang
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Circulation 113:544-54. 2006
    ..The present study therefore explored whether zinc supplementation can protect against diabetic cardiomyopathy through cardiac MT induction...
  24. ncbi request reprint Recent advances in alcoholic liver disease. IV. Dysregulated cytokine metabolism in alcoholic liver disease
    Craig J McClain
    Department of Internal Medicine, University of Louisville Medical Center, Louisville, Kentucky 40292, USA
    Am J Physiol Gastrointest Liver Physiol 287:G497-502. 2004
    ..Cytokines, such as transforming growth factor-beta, play a critical role in the fibrosis of ALD. Multiple new strategies are under investigation to modulate cytokine metabolism as a form of therapy for ALD...
  25. ncbi request reprint S-Adenosylmethionine protects against acetaminophen-induced hepatotoxicity in mice
    Zhenyuan Song
    Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA
    Pharmacology 71:199-208. 2004
    ..We conclude that SAMe at least in part protects the liver from APAP-induced injury by preventing intracellular GSH depletion and mitochondrial dysfunction...
  26. ncbi request reprint Diabetes enhances lipopolysaccharide-induced cardiac toxicity in the mouse model
    Ye Song
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA
    Cardiovasc Toxicol 3:363-72. 2003
    ..These results suggest that diabetes significantly enhances endotoxin-induced cardiac toxicity, possibly through mechanisms that involve inflammatory/acute-phase cytokines...
  27. ncbi request reprint S-adenosylmethionine (AdoMet) modulates endotoxin stimulated interleukin-10 production in monocytes
    Zhenyuan Song
    Department of Medicine, University of Louisville School of Medicine and Department of Veterans Affairs Medical Center, Louisville, Kentucky 40292, USA
    Am J Physiol Gastrointest Liver Physiol 284:G949-55. 2003
    ..On the basis of these results, we conclude that AdoMet administration may exert its anti-inflammatory and hepatoprotective effects, at least in part, by enhancing LPS-stimulated IL-10 production...
  28. pmc Ethanol exposure modulates hepatic S-adenosylmethionine and S-adenosylhomocysteine levels in the isolated perfused rat liver through changes in the redox state of the NADH/NAD(+) system
    Walter H Watson
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Biochim Biophys Acta 1812:613-8. 2011
    ..The data establish an initial link between the effects of ethanol on the NADH/NAD(+) redox couple and the effects of ethanol on methionine metabolism in the liver...
  29. ncbi request reprint Mechanisms of non-alcoholic steatohepatitis
    Craig J McClain
    Department of Internal Medicine, University of Louisville Medical Center, 530 South Jackson Street, ACB 3rd Floor, Louisville, KY 40292, USA
    Alcohol 34:67-79. 2004
    ....
  30. pmc Zinc deprivation mediates alcohol-induced hepatocyte IL-8 analog expression in rodents via an epigenetic mechanism
    Yantao Zhao
    Department of Medicine, The University of Louisville, Louisville, Kentucky, USA
    Am J Pathol 179:693-702. 2011
    ..In conclusion, inactivation of HDAC caused by zinc deprivation is a novel mechanism underlying IL-8 up-regulation in alcoholic hepatitis...
  31. ncbi request reprint Advances in alcoholic liver disease
    Zhenyuan Song
    Department of Internal Medicine, University of Louisville Medical Center, 550 South Jackson Street, ACB 3rd Floor, Louisville, KY 40292, USA
    Curr Gastroenterol Rep 6:71-6. 2004
    ....
  32. ncbi request reprint Prevention of alterations in intestinal permeability is involved in zinc inhibition of acute ethanol-induced liver damage in mice
    Jason C Lambert
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Pharmacol Exp Ther 305:880-6. 2003
    ..These results thus demonstrate that zinc prevention of increased intestinal permeability is importantly involved in the inhibition of acute ethanol-induced liver damage in mice...
  33. ncbi request reprint S-Adenosylmethionine, cytokines, and alcoholic liver disease
    Craig J McClain
    Department of Medicine, University of Louisville Medical Center, KY 40292, USA
    Alcohol 27:185-92. 2002
    ....
  34. pmc Genome-wide transcriptome expression in the liver of a mouse model of high carbohydrate diet-induced liver steatosis and its significance for the disease
    Ion V Deaciuc
    Division of Gastroenterology Hepatology, Department of Medicine, University of Louisville School of Medicine, 550 S Jackson Street, ACB Bldg, Third Floor, Louisville, KY, 40202, USA
    Hepatol Int 2:39-49. 2008
    ..To perform a large-scale gene profiling of the liver in a mouse model of fatty liver induced by high carbohydrate (sucrose) diet (HCD) to gain a deeper insight into potential mechanisms of diet-induced hepatic steatosis...
  35. ncbi request reprint 4-Hydroxynonenal-induced apoptosis in rat hepatic stellate cells: mechanistic approach
    Willem J S de Villiers
    Division of Digestive Diseases, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, USA
    J Gastroenterol Hepatol 22:414-22. 2007
    ..In this study we determined if: (i) 4-hydroxy-2,3-nonenal (HNE) induces apoptosis in two rat stellate cell lines, HSC-T6 and CFSC-2G; and (ii) if apoptosis is regulated at the transcriptional and/or translational level...
  36. ncbi request reprint Monocyte activation in alcoholic liver disease
    Craig J McClain
    Department of Medicine, University of Louisville Medical Center and the Veterans Administration, Louisville, KY 40292, USA
    Alcohol 27:53-61. 2002
    ..We postulate that activation of monocytes and macrophages with subsequent proinflammatory cytokine production plays an important role in certain metabolic complications of ALD and is a component of the liver injury of ALD...