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Genomes and GenesSpecies | Zhenyuan SongSummaryAffiliation: University of Louisville Country: USA Publications
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Publications
Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver diseaseZhenyuan Song
Department of Medicine, University of Louisville, Louisville, KY, USA
Hepatology 47:867-79. 2008..CONCLUSION: Chronic alcohol feeding caused abnormal accumulation of homocysteine in adipocytes, which contributes to decreased adiponectin production in ALD...
Silymarin prevents palmitate-induced lipotoxicity in HepG2 cells: involvement of maintenance of Akt kinase activationZhenyuan Song
Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Louisville School of Medicine, 511 S Floyd Street, Louisville, KY 40202, USA
Basic Clin Pharmacol Toxicol 101:262-8. 2007..These data also provide a further rationale for exploration of the use of silymarin in the treatment of non-alcoholic steatohepatitis...- Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosisZhenyuan Song
Dept of Medicine, Univ of Louisville Medical Center, Louisville, KY 40292, USA
Am J Physiol Gastrointest Liver Physiol 293:G894-902. 2007..Our findings are the first to suggest that betaine might serve as a therapeutic tool to attenuate hepatic steatosis by targeting the hepatic AMPK system... 
Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: possible involvement of mitochondrial S-adenosylmethionine transportZhenyuan Song
Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, United States
Biochem Pharmacol 74:521-31. 2007..In conclusion, our results demonstrate that depletion of the mitochondrial SAM pool by SAH, which is elevated during chronic alcohol consumption, plays a critical role in SAH induced sensitization to TNF hepatotoxicity...- Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alphaXinqin Kang
Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
Hepatology 50:1241-50. 2009.... - Silymarin protects against acute ethanol-induced hepatotoxicity in miceZhenyuan Song
Department of Medicine, University of Louisville Health Center, Louisville, Kentucky, USA
Alcohol Clin Exp Res 30:407-13. 2006..We investigated the effects and the possible mechanism(s) of silymarin on liver injury induced by acute ethanol (EtOH) administration... - Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stressZhanxiang Zhou
University of Louisville School of Medicine, Department of Medicine, 511 South Floyd St, MDR 529, Louisville, KY 40292, USA
Am J Pathol 166:1681-90. 2005..In conclusion, zinc supplementation prevents alcoholic liver injury in an metallothionein-independent manner by inhibiting the generation of reactive oxygen species (P450 2E1) and enhancing the activity of antioxidant pathways... - S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver diseaseZhenyuan Song
Department of Medicine, University of Louisville College of Medicine, Louisville, KY, USA
Hepatology 40:989-97. 2004..These data further support improving the S-adenosylmethionine-to-SAH ratio and removal of intracellular SAH as potential therapeutic options in alcoholic liver disease... - Nonalcoholic fatty liver disease: predisposing factors and the role of nutritionMatthew Cave
Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA
J Nutr Biochem 18:184-95. 2007..Certain nutrients may also be of benefit. Important areas for future research are the effect(s) of nutritional supplements on NAFLD/NASH and the effects of industrial toxins... - Preservation of intestinal structural integrity by zinc is independent of metallothionein in alcohol-intoxicated miceJason C Lambert
Department of Pharmacology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Am J Pathol 164:1959-66. 2004..These results thus demonstrate that zinc preservation of intestinal structural integrity is associated with suppression of endotoxemia and liver injury induced by acute exposure to ethanol and the zinc protection is independent of MT... - Dysregulated cytokine metabolism, altered hepatic methionine metabolism and proteasome dysfunction in alcoholic liver diseaseCraig McClain
Department of Internal Medicine, Department of Pharmacology and Toxicology, University of Louisville Medical Center, Louisville, KY 40202, USA
Alcohol Clin Exp Res 29:180S-8S. 2005..This article reviews the interactions of cytokines, altered methionine metabolism, and proteasome dysfunction in the development of ALD... - Modulation of endotoxin stimulated interleukin-6 production in monocytes and Kupffer cells by S-adenosylmethionine (SAMe)Zhenyuan Song
Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
Cytokine 28:214-23. 2004..Our results demonstrate that SAMe administration may exert its anti-inflammatory and hepatoprotective effects, at least in part, by enhancing LPS-stimulated IL-6 production... - Chronic ethanol-mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-kappaB activity and TNF expression: relevance to alcoholic liver diseaseLeila Gobejishvili
Dept of Medicine, Pharmacology and Toxicology, Univ of Louisville Medical Center, 550 S Jackson St, ACB 3rd Floor, Louisville, KY 40292, USA
Am J Physiol Gastrointest Liver Physiol 291:G681-8. 2006..Furthermore, these data also support the notion that cAMP-elevating agents could constitute an effective therapeutic approach in attenuating or preventing the progression of liver disease in alcoholic patients... - S-adenosylmethionine (SAMe) modulates interleukin-10 and interleukin-6, but not TNF, production via the adenosine (A2) receptorZhenyuan Song
Department of Medicine, University of Louisville College of Medicine, Louisville, KY 40292, USA
Biochim Biophys Acta 1743:205-13. 2005..Our results suggest that increased adenosine levels with subsequent binding to the A(2) receptor account, at least in part, for SAMe modulation of IL-10 and IL-6, but not TNF production, from LPS stimulated monocytes... - Abrogation of nuclear factor-kappaB activation is involved in zinc inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha production and liver injuryZhanxiang Zhou
Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
Am J Pathol 164:1547-56. 2004..Thus, zinc may be beneficial in the treatment of LPS-induced liver injuries, such as sepsis and alcoholism... - Preservation of hepatocyte nuclear factor-4alpha is associated with zinc protection against TNF-alpha hepatotoxicity in miceZhanxiang Zhou
Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
Exp Biol Med (Maywood) 232:622-8. 2007..These results suggest that zinc protects against TNF-alpha hepatotoxicity, at least partially, through preservation of the zinc finger protein HNF-4alpha... - S-adenosylmethionine (SAMe) protects against acute alcohol induced hepatotoxicity in mice small star, filledZhenyuan Song
Department of Medicine, University of Louisville Medical Center, 40292, Louisville, KY, USA
J Nutr Biochem 14:591-7. 2003..SAMe may prove to be an effective therapeutic agent in many toxin-induced liver injuries including those induced by alcohol... - Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4alpha in mice subjected to long-term ethanol administrationXinqin Kang
Department of Medicine, University of Louisville School of Medicine, 511 South Floyd Street, Louisville, KY 40292, USA
Am J Pathol 172:916-25. 2008.... - Tetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosisMing Song
Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Louisville School of Medicine, 550 S Jackson St, Louisville, KY 40202, USA
J Pharmacol Exp Ther 325:409-16. 2008..The protective mechanism seems to be independent of oxidative stress. Our data provide further evidence that TM might be a potential therapy for hepatic fibrosis... - Interactions of cytokines, S-Adenosylmethionine, and S-Adenosylhomocysteine in alcohol-induced liver disease and immune suppressionShirish Barve
Department of Medicine, University of Louisville, Louisville, Kentucky 40292, USA
J Gastroenterol Hepatol 21:S38-42. 2006..It is the authors' working hypothesis that alcohol consumption leads to chronic activation of the immune system... - Zinc supplementation inhibits hepatic apoptosis in mice subjected to a long-term ethanol exposureZhanxiang Zhou
The University of Louisville School of Medicine, Department of Medicine, 511 South Floyd Street, MDR Room 529, Louisville, KY 40292, USA
Exp Biol Med (Maywood) 233:540-8. 2008..In conclusion, zinc supplementation prevented hepatocyte apoptosis in mice subjected to long-term ethanol exposure, and the action of zinc is likely through suppression of oxidative stress and death receptor-mediated pathways... - A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-alpha productionZhanxiang Zhou
Department of Medicine, University of Louisville School of Medicine, 511 South Floyd Street, MDR 525, Louisville, KY, USA
Am J Pathol 163:1137-46. 2003.... - Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementationJianxun Wang
Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
Circulation 113:544-54. 2006..CONCLUSIONS: These results suggest that the prevention of diabetic cardiomyopathy by zinc supplementation is predominantly mediated by an increase in cardiac MT... - Recent advances in alcoholic liver disease. IV. Dysregulated cytokine metabolism in alcoholic liver diseaseCraig J McClain
Department of Internal Medicine, University of Louisville Medical Center, Louisville, Kentucky 40292, USA
Am J Physiol Gastrointest Liver Physiol 287:G497-502. 2004..Cytokines, such as transforming growth factor-beta, play a critical role in the fibrosis of ALD. Multiple new strategies are under investigation to modulate cytokine metabolism as a form of therapy for ALD... - S-Adenosylmethionine protects against acetaminophen-induced hepatotoxicity in miceZhenyuan Song
Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA
Pharmacology 71:199-208. 2004..We conclude that SAMe at least in part protects the liver from APAP-induced injury by preventing intracellular GSH depletion and mitochondrial dysfunction... - Diabetes enhances lipopolysaccharide-induced cardiac toxicity in the mouse modelYe Song
Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA
Cardiovasc Toxicol 3:363-72. 2003..These results suggest that diabetes significantly enhances endotoxin-induced cardiac toxicity, possibly through mechanisms that involve inflammatory/acute-phase cytokines... - S-adenosylmethionine (AdoMet) modulates endotoxin stimulated interleukin-10 production in monocytesZhenyuan Song
Department of Medicine, University of Louisville School of Medicine and Department of Veterans Affairs Medical Center, Louisville, Kentucky 40292, USA
Am J Physiol Gastrointest Liver Physiol 284:G949-55. 2003..On the basis of these results, we conclude that AdoMet administration may exert its anti-inflammatory and hepatoprotective effects, at least in part, by enhancing LPS-stimulated IL-10 production... - Ethanol exposure modulates hepatic S-adenosylmethionine and S-adenosylhomocysteine levels in the isolated perfused rat liver through changes in the redox state of the NADH/NAD(+) systemWalter H Watson
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
Biochim Biophys Acta 1812:613-8. 2011..The data establish an initial link between the effects of ethanol on the NADH/NAD(+) redox couple and the effects of ethanol on methionine metabolism in the liver... - Mechanisms of non-alcoholic steatohepatitisCraig J McClain
Department of Internal Medicine, University of Louisville Medical Center, 530 South Jackson Street, ACB 3rd Floor, Louisville, KY 40292, USA
Alcohol 34:67-79. 2004.... - Zinc deprivation mediates alcohol-induced hepatocyte IL-8 analog expression in rodents via an epigenetic mechanismYantao Zhao
Department of Medicine, The University of Louisville, Louisville, Kentucky, USA
Am J Pathol 179:693-702. 2011..In conclusion, inactivation of HDAC caused by zinc deprivation is a novel mechanism underlying IL-8 up-regulation in alcoholic hepatitis... - Advances in alcoholic liver diseaseZhenyuan Song
Department of Internal Medicine, University of Louisville Medical Center, 550 South Jackson Street, ACB 3rd Floor, Louisville, KY 40292, USA
Curr Gastroenterol Rep 6:71-6. 2004.... - Prevention of alterations in intestinal permeability is involved in zinc inhibition of acute ethanol-induced liver damage in miceJason C Lambert
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA
J Pharmacol Exp Ther 305:880-6. 2003..These results thus demonstrate that zinc prevention of increased intestinal permeability is importantly involved in the inhibition of acute ethanol-induced liver damage in mice... - S-Adenosylmethionine, cytokines, and alcoholic liver diseaseCraig J McClain
Department of Medicine, University of Louisville Medical Center, KY 40292, USA
Alcohol 27:185-92. 2002.... - Genome-wide transcriptome expression in the liver of a mouse model of high carbohydrate diet-induced liver steatosis and its significance for the diseaseIon V Deaciuc
Division of Gastroenterology Hepatology, Department of Medicine, University of Louisville School of Medicine, 550 S Jackson Street, ACB Bldg, Third Floor, Louisville, KY, 40202, USA
Hepatol Int 2:39-49. 2008..To perform a large-scale gene profiling of the liver in a mouse model of fatty liver induced by high carbohydrate (sucrose) diet (HCD) to gain a deeper insight into potential mechanisms of diet-induced hepatic steatosis... - 4-Hydroxynonenal-induced apoptosis in rat hepatic stellate cells: mechanistic approachWillem J S de Villiers
Division of Digestive Diseases, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, USA
J Gastroenterol Hepatol 22:414-22. 2007..In this study we determined if: (i) 4-hydroxy-2,3-nonenal (HNE) induces apoptosis in two rat stellate cell lines, HSC-T6 and CFSC-2G; and (ii) if apoptosis is regulated at the transcriptional and/or translational level... - Monocyte activation in alcoholic liver diseaseCraig J McClain
Department of Medicine, University of Louisville Medical Center and the Veterans Administration, Louisville, KY 40292, USA
Alcohol 27:53-61. 2002..We postulate that activation of monocytes and macrophages with subsequent proinflammatory cytokine production plays an important role in certain metabolic complications of ALD and is a component of the liver injury of ALD...