Sihong Song

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice
    Yuanqing Lu
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther 17:625-34. 2006
  2. ncbi The protective effects of plasma gelsolin on stroke outcome in rats
    Huong T Le
    Department of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
    Exp Transl Stroke Med 3:13. 2011
  3. ncbi Ex vivo transduced liver progenitor cells as a platform for gene therapy in mice
    Sihong Song
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    Hepatology 40:918-24. 2004
  4. ncbi DNA-dependent PK inhibits adeno-associated virus DNA integration
    Sihong Song
    Department of Pharmaceutics, Powell Gene Therapy Center, Genetics Institute, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 101:2112-6. 2004
  5. ncbi Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector
    Yuanqing Lu
    Department of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
    J Gene Med 8:730-5. 2006
  6. ncbi Efficient hepatic delivery and expression from a recombinant adeno-associated virus 8 pseudotyped alpha1-antitrypsin vector
    Thomas J Conlon
    Department of Pediatrics and Powell Gene Therapy Center, University of Florida, Gainesville, FL 32608, USA
    Mol Ther 12:867-75. 2005
  7. ncbi Ex vivo transduction and transplantation of bone marrow cells for liver gene delivery of alpha1-antitrypsin
    Hong Li
    Department of Pharmaceutics, University of Florida, Gainesville, FL, USA
    Mol Ther 18:1553-8. 2010
  8. ncbi Phase I trial of intramuscular injection of a recombinant adeno-associated virus serotype 2 alphal-antitrypsin (AAT) vector in AAT-deficient adults
    Mark L Brantly
    Department of Medicine, University of Florida, Gainesville, FL 32611, USA
    Hum Gene Ther 17:1177-86. 2006
  9. ncbi Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model
    Christian Grimstein
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    J Transl Med 9:21. 2011
  10. ncbi Adipose tissue-derived mesenchymal stem cell-based liver gene delivery
    Hong Li
    Departments of Pharmaceutics, University of Florida, Gainesville, FL, USA
    J Hepatol 54:930-8. 2011

Research Grants

  1. Anti-inflammatory Serpin(AAT and Elafin) Gene Transfers*
    Sihong Song; Fiscal Year: 2003
  2. Gene Therapy for Correction of PiZ Mutation
    Sihong Song; Fiscal Year: 2006

Collaborators

Detail Information

Publications21

  1. ncbi Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice
    Yuanqing Lu
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther 17:625-34. 2006
    ..These results strongly suggest that rAAV1-mediated AAT gene therapy may be useful as a novel approach to prevent type 1 diabetes...
  2. ncbi The protective effects of plasma gelsolin on stroke outcome in rats
    Huong T Le
    Department of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
    Exp Transl Stroke Med 3:13. 2011
    ..abstract:..
  3. ncbi Ex vivo transduced liver progenitor cells as a platform for gene therapy in mice
    Sihong Song
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    Hepatology 40:918-24. 2004
    ....
  4. ncbi DNA-dependent PK inhibits adeno-associated virus DNA integration
    Sihong Song
    Department of Pharmaceutics, Powell Gene Therapy Center, Genetics Institute, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 101:2112-6. 2004
    ..In summary, we have provided evidence that DNA-PK inhibits AAV integration both in vitro and in vivo...
  5. ncbi Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector
    Yuanqing Lu
    Department of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
    J Gene Med 8:730-5. 2006
    ..These results provide strong support for the functionality of AAT in ongoing clinical studies of muscle-directed AAT gene therapy...
  6. ncbi Efficient hepatic delivery and expression from a recombinant adeno-associated virus 8 pseudotyped alpha1-antitrypsin vector
    Thomas J Conlon
    Department of Pediatrics and Powell Gene Therapy Center, University of Florida, Gainesville, FL 32608, USA
    Mol Ther 12:867-75. 2005
    ..Therefore, pseudotyped AAV8 provides a vehicle to infect a high percentage of hepatocytes stably and thereby express therapeutic molecules to modify AAT PiZ transcripts...
  7. ncbi Ex vivo transduction and transplantation of bone marrow cells for liver gene delivery of alpha1-antitrypsin
    Hong Li
    Department of Pharmaceutics, University of Florida, Gainesville, FL, USA
    Mol Ther 18:1553-8. 2010
    ..These results demonstrated that rAAV vector-mediated BM cell-based liver gene therapy is feasible for the treatment of AAT deficiency and implies a novel therapy for the treatment of liver diseases...
  8. ncbi Phase I trial of intramuscular injection of a recombinant adeno-associated virus serotype 2 alphal-antitrypsin (AAT) vector in AAT-deficient adults
    Mark L Brantly
    Department of Medicine, University of Florida, Gainesville, FL 32611, USA
    Hum Gene Ther 17:1177-86. 2006
    ....
  9. ncbi Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model
    Christian Grimstein
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    J Transl Med 9:21. 2011
    ..In the present study we investigated the feasibility of hAAT monotherapy for the treatment of chronic arthritis in collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA)...
  10. ncbi Adipose tissue-derived mesenchymal stem cell-based liver gene delivery
    Hong Li
    Departments of Pharmaceutics, University of Florida, Gainesville, FL, USA
    J Hepatol 54:930-8. 2011
    ..In the present study, we investigated the feasibility of AT-MSC-based liver gene delivery for the treatment of alpha 1-antitrypsin deficiency...
  11. ncbi Alpha1-antitrypsin protects beta-cells from apoptosis
    Bin Zhang
    Department of Pharmaceutics, University of Florida, Gainsville, FL 32610, USA
    Diabetes 56:1316-23. 2007
    ..These results propose a novel biological function for this molecule and suggest it may represent an effective candidate for attempts seeking to prevent or reverse type 1 diabetes...
  12. ncbi Distinct immune responses to transgene products from rAAV1 and rAAV8 vectors
    Yuanqing Lu
    Department of Pharmaceutics, Powell Gene Therapy Center, Genetics Institute, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 106:17158-62. 2009
    ..These results demonstrate the immunogenic differences of rAAV1 and rAAV8 and imply tremendous potential for these vectors in different applications, where an immune response to transgene is to be either elicited or avoided...
  13. ncbi Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion
    Kevin S Goudy
    Department of Pathology, Powell Gene Therapy Center, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
    J Immunol 171:2270-8. 2003
    ..This study indicates the potential for immunomodulatory gene therapy to prevent autoimmune diseases, including type 1 diabetes, and implicates IL-10 as a molecule capable of increasing the percentages of regulatory cells in vivo...
  14. ncbi Glucose transporter-2 (GLUT2) promoter mediated transgenic insulin production reduces hyperglycemia in diabetic mice
    Brant R Burkhardt
    Department of Pathology, University of Florida College of Medicine, Gainesville, 32610, USA
    FEBS Lett 579:5759-64. 2005
    ..These findings indicate that the GLUT2 promoter may be a potential candidate for regulating transgenic insulin production for hepatic insulin gene therapy in the treatment of type I diabetes...
  15. ncbi Intramuscular administration of recombinant adeno-associated virus 2 alpha-1 antitrypsin (rAAV-SERPINA1) vectors in a nonhuman primate model: safety and immunologic aspects
    Sihong Song
    Powell Gene Therapy Center of the University of Florida Genetics Institute, University of Florida, Gainesville, Florida 32615, USA
    Mol Ther 6:329-35. 2002
    ..These studies indicate that the risks of immune reaction and germline transmission after intramuscular injection of rAAV-SERPINA1 in nonhuman primates are relatively low within the range of vector doses studied...
  16. ncbi Combination of alpha-1 antitrypsin and doxycycline suppresses collagen-induced arthritis
    Christian Grimstein
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    J Gene Med 12:35-44. 2010
    ..In order to develop a new treatment option, the present study employs a gene therapy-based combination therapy using doxycycline and human alpha-1 antitrypsin (hAAT)...
  17. ncbi The effect of DNA-dependent protein kinase on adeno-associated virus replication
    Young Kook Choi
    Department of Pharmaceutics, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 5:e15073. 2010
    ..DNA-dependent protein kinase (DNA-PK) is a DNA repair enzyme and plays an important role in determining the molecular fate of the rAAV genome. However, the effect this cellular enzyme on rAAV DNA replication remains elusive...
  18. ncbi Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice
    Matthew J Parker
    Department of Pathology, University of Florida, Gainesville, Florida, USA
    Diabetes 58:2277-84. 2009
    ....
  19. ncbi Improved method of recombinant AAV2 delivery for systemic targeted gene therapy
    Cathryn Mah
    Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA
    Mol Ther 6:106-12. 2002
    ..These studies demonstrate a novel method to deliver rAAV vectors more effectively that could prove to be a successful alternative mode of virus-mediated human gene therapy...
  20. ncbi A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema
    Irina Petrache
    Division of Pulmonary and Critical Care, Department of Medicine, John Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 173:1222-8. 2006
    ..The association of alpha1-antitrypsin deficiency with the development of emphysema has supported the concept that protease/antiprotease imbalance mediates cigarette smoke-induced emphysema...
  21. ncbi Enhancing rAAV vector expression in the lung
    Isabel Virella-Lowell
    Department of Pediatrics of the University of Florida College of Medicine, USA
    J Gene Med 7:842-50. 2005
    ..Although the advantage of rAAV5 over rAAV2 in the lung has already been described, the availability of another serotype (rAAV1) capable of efficient gene transfer in the lung could be useful...

Research Grants2

  1. Anti-inflammatory Serpin(AAT and Elafin) Gene Transfers*
    Sihong Song; Fiscal Year: 2003
    ..abstract_text> ..
  2. Gene Therapy for Correction of PiZ Mutation
    Sihong Song; Fiscal Year: 2006
    ..Liver pathology will be examined. We anticipate achieving the therapeutic correction in PiZ transgenic mouse model. The success of this project may lead to a novel gene therapy for clinical treatment of human AAT deficiency. ..