GREG ALAN SOMERVILLE

Summary

Affiliation: University of Nebraska
Country: USA

Publications

  1. pmc Staphylococcal response to oxidative stress
    Rosmarie Gaupp
    School of Veterinary Medicine and Biomedical Sciences, University of Nebraska Lincoln, Lincoln NE, USA
    Front Cell Infect Microbiol 2:33. 2012
  2. pmc Reductive evolution and the loss of PDC/PAS domains from the genus Staphylococcus
    Neethu Shah
    Department of Computer Science and Engineering, University of Nebraska, Lincoln, NE 68588 0115, USA
    BMC Genomics 14:524. 2013
  3. pmc Cultivation conditions and the diffusion of oxygen into culture media: the rationale for the flask-to-medium ratio in microbiology
    Greg A Somerville
    School of Veterinary Medicine and Biomedical Sciences, University of Nebraska, Lincoln, NE 68583 0905, USA
    BMC Microbiol 13:9. 2013
  4. pmc At the crossroads of bacterial metabolism and virulence factor synthesis in Staphylococci
    Greg A Somerville
    Department of Veterinary and Biomedical Sciences, University of Nebraska Lincoln, Lincoln, Nebraska 68583 0905, USA
    Microbiol Mol Biol Rev 73:233-48. 2009
  5. pmc Tricarboxylic acid cycle-dependent attenuation of Staphylococcus aureus in vivo virulence by selective inhibition of amino acid transport
    Yefei Zhu
    Department of Veterinary and Biomedical Sciences, University of Nebraska, 155 VBS, Fair St and East Campus Loop, Lincoln, NE 68583 0905, USA
    Infect Immun 77:4256-64. 2009
  6. pmc RpiR homologues may link Staphylococcus aureus RNAIII synthesis and pentose phosphate pathway regulation
    Yefei Zhu
    School of Veterinary Medicine and Biomedical Sciences, University of Nebraska Lincoln, 155 VBS, Fair St and East Campus Loop, Lincoln, NE 68583 0905, USA
    J Bacteriol 193:6187-96. 2011
  7. pmc Tricarboxylic acid cycle-dependent regulation of Staphylococcus epidermidis polysaccharide intercellular adhesin synthesis
    Marat R Sadykov
    Department of Veterinary and Biomedical Sciences, University of Nebraska Lincoln, 155 VBS, Fair St and East Campus Loop, Lincoln, NE 68583 0905, USA
    J Bacteriol 190:7621-32. 2008
  8. pmc Tricarboxylic acid cycle-dependent synthesis of Staphylococcus aureus Type 5 and 8 capsular polysaccharides
    Marat R Sadykov
    Department of Veterinary and Biomedical Sciences, University of Nebraska, 155 VBS, Fair St and East Campus Loop, Lincoln, NE 68583 0905, USA
    J Bacteriol 192:1459-62. 2010

Collaborators

  • PAUL FEY
  • A S Bayer
  • Yefei Zhu
  • Marat R Sadykov
  • Rosmarie Gaupp
  • Chia Y Lee
  • Neethu Shah
  • Thanh T Luong
  • Hideaki Moriyama
  • Kent M Eskridge
  • Etsuko N Moriyama
  • Nagender Ledala
  • Renu Nandakumar
  • Nandakumar Madayiputhiya
  • Shandra R Day
  • Theodoric A Mattes
  • Costi D Sifri
  • Mei G Lei
  • Yan Q Xiong
  • Robert Powers
  • Steven Halouska
  • Michael E Olson

Detail Information

Publications8

  1. pmc Staphylococcal response to oxidative stress
    Rosmarie Gaupp
    School of Veterinary Medicine and Biomedical Sciences, University of Nebraska Lincoln, Lincoln NE, USA
    Front Cell Infect Microbiol 2:33. 2012
    ..When possible, special attention is given to how the oxidative stress defense mechanisms help staphylococci control oxidative stress in the host...
  2. pmc Reductive evolution and the loss of PDC/PAS domains from the genus Staphylococcus
    Neethu Shah
    Department of Computer Science and Engineering, University of Nebraska, Lincoln, NE 68588 0115, USA
    BMC Genomics 14:524. 2013
    ....
  3. pmc Cultivation conditions and the diffusion of oxygen into culture media: the rationale for the flask-to-medium ratio in microbiology
    Greg A Somerville
    School of Veterinary Medicine and Biomedical Sciences, University of Nebraska, Lincoln, NE 68583 0905, USA
    BMC Microbiol 13:9. 2013
    ..Microbiologists can do this by altering the flask-to-medium ratio, rpm of agitation, and/or the concentration of atmospheric oxygen, or by using baffled flasks...
  4. pmc At the crossroads of bacterial metabolism and virulence factor synthesis in Staphylococci
    Greg A Somerville
    Department of Veterinary and Biomedical Sciences, University of Nebraska Lincoln, Lincoln, Nebraska 68583 0905, USA
    Microbiol Mol Biol Rev 73:233-48. 2009
    ....
  5. pmc Tricarboxylic acid cycle-dependent attenuation of Staphylococcus aureus in vivo virulence by selective inhibition of amino acid transport
    Yefei Zhu
    Department of Veterinary and Biomedical Sciences, University of Nebraska, 155 VBS, Fair St and East Campus Loop, Lincoln, NE 68583 0905, USA
    Infect Immun 77:4256-64. 2009
    ..These data confirm the close linkage of TCA cycle activity and virulence factor production and establish that this metabolic linkage can be manipulated to alter infectious outcomes...
  6. pmc RpiR homologues may link Staphylococcus aureus RNAIII synthesis and pentose phosphate pathway regulation
    Yefei Zhu
    School of Veterinary Medicine and Biomedical Sciences, University of Nebraska Lincoln, 155 VBS, Fair St and East Campus Loop, Lincoln, NE 68583 0905, USA
    J Bacteriol 193:6187-96. 2011
    ..These data confirm the close linkage of central metabolism and virulence determinant synthesis, and they establish a metabolic override for quorum-sensing-dependent regulation of RNAIII transcription...
  7. pmc Tricarboxylic acid cycle-dependent regulation of Staphylococcus epidermidis polysaccharide intercellular adhesin synthesis
    Marat R Sadykov
    Department of Veterinary and Biomedical Sciences, University of Nebraska Lincoln, 155 VBS, Fair St and East Campus Loop, Lincoln, NE 68583 0905, USA
    J Bacteriol 190:7621-32. 2008
    ..In addition, these data lead us to propose that the TCA cycle acts as a signal transduction pathway to translate external environmental cues into intracellular metabolic signals that modulate the activity of transcriptional regulators...
  8. pmc Tricarboxylic acid cycle-dependent synthesis of Staphylococcus aureus Type 5 and 8 capsular polysaccharides
    Marat R Sadykov
    Department of Veterinary and Biomedical Sciences, University of Nebraska, 155 VBS, Fair St and East Campus Loop, Lincoln, NE 68583 0905, USA
    J Bacteriol 192:1459-62. 2010
    ..Consistent with this hypothesis, S. aureus tricarboxylic acid cycle mutants fail to make capsule...

Research Grants2

  1. Environmental Regulation of Staphylococcus epidermidis PIA Synthesis
    GREG SOMERVILLE; Fiscal Year: 2007
    ..The work contained in this proposal is a first step toward inhibiting the formation of this complex sugar, preventing the formation of a bacterial biofilm, and providing physicians a way to treat patients. ..
  2. Citric acid cycle regulation of exopolysaccharide synthesis in staphylococci
    GREG ALAN SOMERVILLE; Fiscal Year: 2010
    ..abstract_text> ..